Colorimetric and fluorometric detection of cationic surfactants based on conjugated polydiacetylene supramolecules.

The polydiacetylenes derived from a hydroxybenzaldehyde substituted diacetylene monomer display a unique colorimetric change (blue to red) and large fluorescent enhancement in the presence of cetyl trimethylammonium salt.

An "Off-On" type UTP/UDP selective fluorescent probe and its application to monitor glycosylation process.

A New fluorescent sensor based on a perylene-dpa-Zn platform was synthesized. Selective "Off-On" type fluorescence changes were observed upon the addition of UTP and UDP, which was also applied to monitor glycosylation processes.

Atomically monodispersed and fluorescent sub-nanometer gold clusters created by biomolecule-assisted etching of nanometer-sized gold particles and rods.

Atomically monodispersed gold clusters were synthesized by etching gold nanocrystals (particles and rods) with the assistance of biomolecules (amino acids, peptides, proteins, and DNA) under sonication in water. The resulting gold clusters were exclusively composed of eight atoms, as demonstrated by photoluminescence, optical absorption, electrospray ionization mass spectrometry, and transmission electron microscopy measurements. The gold clusters exhibited solvent-dependent photoluminescence properties when exposed to organic solvents, such as chloroform, tetrahydrofuran, or N,N-dimethylformamide, which was attributed to the rich surface properties of the clusters.

Hg2+ selective fluorescent and colorimetric sensor: its crystal structure and application to bioimaging.

A Hg(2+)-selective rhodamine 6G derivative bearing thiolactone moiety was synthesized, and its crystal structure with Hg(2+) is presented to explain the binding mode. In addition, highly selective "off-on"-type fluorescent change upon the addition of Hg(2+) was also applied to bioimaging.

Efficient enhancement of DNA cleavage activity by introducing guanidinium groups into diiron(III) complex.

Inspired by the structures of natural nucleases, guanidinium groups were introduced into binuclear iron(III) systems. Compared with the corresponding analogue without guanidinium groups, the new diiron(III) system led to considerable rate enhancement on DNA cleavage. The cooperativity between metal ions and guanidine groups was evidenced by the fact that no significant cleavage was observed after incubating pBR322 plasmid DNA with non-metalated ligands or free Fe3+ ion.

[Synthesis of camptothecin glycosides by phase transfer-catalysis and its inhibitory activity against topo I].

Aim: To find new anticancer drug based on the structure of 10-hydroxy camptothecin.

Methods: Six camptothecin glycosides (7-12) were synthesized by phase transfer catalysis. The structures of all compounds synthesized were determined by 1H NMR, IR and MS.