Ambient PM orchestrates M1 polarization of alveolar macrophages via activating glutaminase 1-mediated glutaminolysis in acute lung injury.

The temporary explosive growth events of atmospheric fine particulate matter (PM) pollution during late autumn and winter seasons still frequently occur in China. High-concentration exposure to PM aggravates lung inflammation, leading to acute lung injury (ALI). Alveolar macrophages (AMs) participate in PM-induced pulmonary inflammation and injury.

Silencing KPNA2 Promotes Ferroptosis in Laryngeal Cancer by Activating the FoxO Signaling Pathway.

We aim to clarify the specific role of Karyopherin α2 (KPNA2) in the progression of laryngeal cancer, a kind of malignant tumor with a poor curative effect. We performed the bioinformatic analysis to obtain the ferroptosis-related differentially expressed genes. KPNA2 was screened out.

Sustainable release of LiNO in carbonate electrolytes for stable lithium metal anodes.

LiNO is recognized as an effective additive, forming a dense, nitrogen-rich solid electrolyte interphase (SEI) on lithium's surface, which safeguards it from parasitic reactions. However, its use is limited due to the poor solubility in carbonate electrolytes. Herein, we introduce a bilayer separator designed to release LiNO sustainably.

Stabilizing Lithium-Metal Host Anodes by Covalently Binding MgF Nanodots to Honeycomb Carbon Nanofibers.

Constructing lithiophilic carbon hosts has been regarded as an effective strategy for inhibiting Li dendrite formation and mitigating the volume expansion of Li metal anodes. However, the limitation of lithiophilic carbon hosts by conventional surface decoration methods over long-term cycling hinders their practical application. In this work, a robust host composed of ultrafine MgF nanodots covalently bonded to honeycomb carbon nanofibers (MgF/HCNFs) is created through an in situ solid-state reaction.

Overexpression of Enhances Aluminum Tolerance in by Stimulating Organic Acid Secretion and Reactive Oxygen Species Scavenging.

Aluminum (Al) toxicity and low pH are major factors limiting plant growth in acidic soils. Sensitive to Proton Rhizotoxicity 1 (STOP1) transcription factors respond to these stresses by regulating the expression of multiple Al- or low pH-responsive genes. , a STOP1-like protein from maize (), was localized to the nucleus and showed transactivation activity.

Peripheral substitution effects on unnatural base pairs: A case of brominated TPT3 to enhance replication fidelity.

The high fidelity poses a central role in developing unnatural base pairs (UBPs), which means the high pairing capacity of unnatural bases with their partners, and low mispairing with all the natural bases. Different strategies have been used to develop higher-fidelity UBPs, including optimizing hydrophobic interaction forces between UBPs. Variant substituent groups are allowed to fine tune the hydrophobic forces of different UBPs' candidates.

Macrophage-derived exosomal TNF-α promotes pulmonary surfactant protein expression in PM-induced acute lung injury.

Short-term high-concentration exposure to airborne fine particulate matter (PM) is strongly associated with the risk of acute lung injury (ALI). It has been recently reported that exosomes (Exos) involve in the progression of respiratory diseases. However, the molecular mechanisms by which exosome-mediated intercellular signaling exacerbate PM-induced ALI remains largely unaddressed.

Prediction model for gestational diabetes mellitus using the XG Boost machine learning algorithm.

Objective: To develop the extreme gradient boosting (XG Boost) machine learning (ML) model for predicting gestational diabetes mellitus (GDM) compared with a model using the traditional logistic regression (LR) method.

Methods: A case-control study was carried out among pregnant women, who were assigned to either the training set (these women were recruited from August 2019 to November 2019) or the testing set (these women were recruited in August 2020). We applied the XG Boost ML model approach to identify the best set of predictors out of a set of 33 variables.

Dimethylarginine dimethylaminohydrolase 1 protects PM exposure-induced lung injury in mice by repressing inflammation and oxidative stress.

Background: Airborne fine particulate matter with aerodynamic diameter ≤ 2.5 μm (PM) pollution is associated with the prevalence of respiratory diseases, including asthma, bronchitis and chronic obstructive pulmonary disease. In patients with those diseases, circulating asymmetric dimethylarginine (ADMA) levels are increased, which contributes to airway nitric oxide deficiency, oxidative stress and inflammation.

Advances in the Emerging Gradient Designs of Li Metal Hosts.

Developing host has been recognized a potential countermeasure to circumvent the intrinsic drawbacks of Li metal anode (LMA), such as uncontrolled dendrite growth, unstable solid electrolyte interface, and infinite volume fluctuations. To realize proper Li accommodation, particularly bottom-up deposition of Li metal, gradient designs of host materials including lithiophilicity and/or conductivity have attracted a great deal of attention in recent years. However, a critical and specialized review on this quickly evolving topic is still absent.

TGF-β-Containing Small Extracellular Vesicles From PM-Activated Macrophages Induces Cardiotoxicity.

Numerous epidemiological and experimental studies have demonstrated that the exposure to fine particulate matter (aerodynamic diameter <2.5 μm, PM) was closely associated with cardiovascular morbidity and mortality. Our previous studies revealed that PM exposure induced cardiac dysfunction and fibrosis.

The Association Between Family Environment and Adolescent Alcohol Drinking Behavior: A Cross-Sectional Study of Six Chinese Cities.

Objective: Adolescents' alcohol consumption has lifetime adverse physical and mental health effects. Family environment factors have a significant influence in shaping adolescents' beliefs and habits. We conducted the multicenter cross-sectional study aiming to investigate the association between family environment factors and adolescent drinking behavior in China.

Ultra-Robust and Extensible Fibrous Mechanical Sensors for Wearable Smart Healthcare.

Fibrous material with high strength and large stretchability is an essential component of high-performance wearable electronic devices. Wearable electronic systems require a material that is strong to ensure durability and stability, and a wide range of strain to expand their applications. However, it is still challenging to manufacture fibrous materials with simultaneously high mechanical strength and the tensile property.

Changes in Fitness of Rural Primary School Students from Southwest China after Two-Year's Nutrition Intervention.

Children in China's poor rural areas often have insufficient protein and micronutrient intake. There is little research about the effect of milk and egg supplementation published on these children. A prospective randomized controlled trial was applied to evaluate the effect of milk and egg supplementation on the growth and fitness of poor rural primary school students in southwest China whose physical development was below national averages.

ZmXTH, a xyloglucan endotransglucosylase/hydrolase gene of maize, conferred aluminum tolerance in Arabidopsis.

Aluminum (Al) toxicity is one of the primary factors limiting crop production in acid soils worldwide. The cell wall is the major target of Al toxicity owing to the presence of many Al binding sites. Previous studies have found that XTH, encoding xyloglucan endohydrolase (XEH) and xyloglucan endotransglucosylase (XET), could participate in cell wall extension and affect the binding ability of the cell wall to Al by impeding the activities of these two enzymes.

Association between milk consumption and the nutritional status of poor rural Chinese students in 2016.

Background And Objectives: Milk promotes the growth of children's height. However, the relationship between milk consumption and anemia or obesity remain unclear. We explored the association between milk consumption and the nutritional status of poor rural Chinese students, including anemia, height, weight, malnutrition, and overweight/obesity.

A Maize Gene Confers Aluminum Tolerance Reactive Oxygen Species Scavenging.

Aluminum (Al) toxicity is the primary limiting factor that affects crop yields in acid soil. However, the genes that contribute to the Al tolerance process in maize are still poorly understood. Previous studies have predicted that ZmAT6 is a novel protein which could be upregulated under Al stress condition.

A long-wavelength turn-on fluorescent probe for intracellular nanomolar level peroxynitrite sensing with second-level response.

As a typical kind of endogenous reactive nitrogen species, peroxynitrite (ONOO) is believed heavily involved in the pathogenesis of many diseases such as inflammation, neurodegenerative conditions, and cardiovascular disorders. Precisely estimating ONOO level in cell compartments is crucial for unraveling the biological relevance of ONOO and enabling effective control of ONOO-associated pathogenicity but suffers from serious difficulty owing to the daunting elusive features of ONOO, namely nanomolar level physiological concentration and millisecond level biological half-life. A new fluorescent probe capable of detecting ONOO with limit of detection down to 1.

Promoting healthy lifestyle considerations during pregnancy in Midwifery clinics in China: a best practice implementation project.

Objectives: The aim of this project was to initiate and promote formal and individualized evidence-based education on healthy lifestyle choices during pregnancy for pregnant women.

Introduction: Evidence suggests that lifestyle choices during pregnancy can have a profound influence on many pregnancy complications and chronic diseases such as preterm birth, diabetes, obesity, fetal growth restriction, breast cancer and hypertensive diseases in both pregnant women and their babies. It is widely accepted that formal, individualized, hospital-directed education about lifestyle choices during pregnancy should commence as early as the first consultation between pregnant women and maternal healthcare workers.

Effect of equipment layout on bioaerosol temporal-spatial distribution and deposition in one BSL-3 laboratory.

Reasonable equipment layout is essential for creating a healthy and safe environment, especially in a three-level biosafety laboratory with high potential risk factors of infection. Since 2019, COVID-19, an emerging infection has swept the world and caused severe losses. Biosafety laboratories are mandatory sites for detecting high-risk viruses, so related research is urgently needed to prevent further laboratory-acquired infections of operators.

The effect of comprehensive intervention for childhood obesity on dietary diversity among younger children: Evidence from a school-based randomized controlled trial in China.

Background: Little evidence from developing countries on dietary transition demonstrates the effects of comprehensive childhood obesity interventions on dietary diversity and food variety among younger children. This study aimed to evaluate the effects of comprehensive childhood obesity interventions on dietary diversity among younger children.

Methods: A total of 4846 children aged 7-13 years were included based on a multicenter randomized controlled trial for childhood obesity interventions in 38 primary schools.

Independent and Interactive Associations of Fitness and Fatness With Changes in Cardiometabolic Risk in Children: A Longitudinal Analysis.

Findings for associations between cardiorespiratory fitness (CRF) and cardiometabolic risk (CMR) factors are inconsistent, and the interactive association between CRF and fatness with CMR factors is unclear in children. Our study aimed to examine whether CRF and fatness are independently and interactively associated with CMR factors. We included 5,869 children aged 6-13 years in the analysis.

Healthy breakfast habits and changes in obesity-related cardiometabolic markers in children: a longitudinal analysis.

Background: Data on the association of breakfast habits and changes in cardiometabolic markers in children are limited.

Methods: In total, 6964 children aged 6-13 years from Beijing, Shanghai, Chongqing, Jinan, Harbin, and Guangzhou were included in the final analysis. Daily consumption, consumption of ≥3 food groups, and at-home consumption were defined as healthy breakfast habits.