Single-dose suraxavir marboxil for acute uncomplicated influenza in adults and adolescents: a multicenter, randomized, double-blind, placebo-controlled phase 3 trial.

Suraxavir marboxil (GP681) is an antiviral drug inhibiting the polymerase acidic protein (PA) of RNA polymerase, of influenza. It has shown therapeutic activity against influenza A and B virus infections in preclinical studies. In this multicenter randomized, double-blind, placebo-controlled, phase 3 trial, we aimed to investigate the efficacy and safety of single-dose suraxavir marboxil (40-mg oral dose) in otherwise healthy outpatients aged 5-65 years with uncomplicated influenza unaccompanied by severe issues.

Gold nanoparticles supported onto zwitterionic polymer capillary monoliths meant for efficient enrichment of microcystins in water.

The release of microcystin (MCs) in aquatic ecosystems poses a substantial risk to the safety of irrigation and drinking water. In view of the challenges associated with monitoring MCs in water bodies, given their low concentration levels (μg/L to ng/L) and the presence of diverse matrix interferences, there is an urgent need to develop an efficient, cost-effective and selective enrichment technique for MCs prior to its quantification. In this work, a gold nanoparticles (AuNPs)-functionalized zwitterionic polymer monolith was described and further applied for the affinity enrichment of MCs.

Predictive model for HBsAg clearance rate in chronic hepatitis B patients treated with pegylated interferon α-2b for 48 weeks.

Background And Aims: Chronic hepatitis B (CHB) is a major global health concern. This study aims to investigate the factors influencing hepatitis B surface antigen (HBsAg) clearance in CHB patients treated with pegylated interferon α-2b (Peg-IFNα-2b) for 48 weeks and to establish a predictive model.

Methods: This analysis is based on the "OASIS" project, a prospective real-world multicenter study in China.

Shikonin induces the apoptosis and pyroptosis of EGFR-T790M-mutant drug-resistant non-small cell lung cancer cells via the degradation of cyclooxygenase-2.

Background: The T790M mutation in the epidermal growth factor receptor (EGFR) gene is the primary cause of resistance to EGFR-tyrosine kinase inhibitor (TKI) therapy in non-small cell lung cancer (NSCLC) patients. Previous research demonstrated that certain traditional Chinese medicine (TCM) monomers exhibit anti-tumor effects against various malignancies. This study aims to investigate the potentials of shikonin screened from a TCM monomer library containing 1060 monomers in killing EGFR-T790M drug-resistant NSCLC cells and elucidate the underlying mechanisms.

Gonadal transcriptome analysis of Opsariichthys bidens reveals sex-associated genes.

Opsariichthys bidens is a unique economically important freshwater fish in China. Male O. bidens grow faster than females, and male fish have attractive blue-green stripes on the body surface during the breeding period.

A selective small-molecule agonist of G protein-gated inwardly-rectifying potassium channels reduces epileptiform activity in mouse models of tumor-associated and provoked seizures.

Tumor associated epilepsy is a common and debilitating co-morbidity of brain tumors, for which inadequate treatments are available. Additionally, animal models suggest a potential link between seizures and tumor progression. Our group has previously described a mouse model of diffusely infiltrating glioma and associated chronic epilepsy.

Diagnostic and prognostic potential of FBXO8 expression in kidney renal clear cell carcinoma and its regulation of renal adenocarcinoma cells.

Background: The F-box protein 8 Gene (FBXO8) has been shown to suppress invasion and metastasis in various cancer types. Recurrence and drug resistance pose significant challenges in renal cell carcinoma (RCC). Identifying novel biomarkers is crucial for addressing these issues.

Comparison of clinical and para-clinical characteristics between children and adults with the Omicron variant of COVID-19.

Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant is associated with higher transmissibility, but lower disease severity, compared to some other variants. However, its exact pathogenicity among children is still largely unknown. This study was conducted to determine the differences in clinical characteristics between children and adults infected with this variant.

YAP1 preserves tubular mitochondrial quality control to mitigate diabetic kidney disease.

Renal tubule cells act as a primary site of injury in diabetic kidney disease (DKD), with dysfunctional mitochondrial quality control (MQC) closely associated with progressive kidney dysfunction in this context. Our investigation delves into the observed inactivation of yes-associated protein 1 (YAP1) and consequential dysregulation of MQC within renal tubule cells among DKD subjects through bioinformatic analysis of transcriptomics data from the Gene Expression Omnibus (GEO) dataset. Receiver operating characteristic curve analysis unequivocally underscores the robust diagnostic accuracy of YAP1 and MQC-related genes for DKD.

Establishing a predictive nomogram for 21‑day transplant-free survival in drug-induced liver failure.

Background: The high prevalence of drug-induced liver failure (DILF) have drawn great attention from clinicians.

Aim: To further delineate the clinical features of DILF and develop an easily applicable nomogram, based on readily-discernable clinical data, to predict transplant-free survival (TFS) at different time points.

Methods: 202 DILF patients were enrolled between January 2016 and December 2022, and were followed up from DILF diagnosis to death, liver transplantation, or 91 days afterward, whichever came first.

Optimized Liquid Medium Formulation for and Biological Activity of the Exopolysaccharides.

Aims: () is a rare medicinal mushroom that is rich in polysaccharides, triterpenes, flavonoids, and other bioactive compounds. It has good potential development value.

Methods And Results: We performed single factor experiments and Box-Behnken response surface methodology to optimize the liquid fermentation medium formulation for with mycelial biomass as the indicator.

Denoising complex-valued diffusion MR images using a two-step non-local principal component analysis approach.

Purpose: to propose a two-step non-local principal component analysis (PCA) method and demonstrate its utility for denoising diffusion tensor MRI (DTI) with a few diffusion directions.

Methods: A two-step denoising pipeline was implemented to ensure accurate patch selection even with high noise levels and was coupled with data preprocessing for g-factor normalization and phase stabilization before data denoising with a non-local PCA algorithm. At the heart of our proposed pipeline was the use of a data-driven optimal shrinkage algorithm to manipulate the singular values in a way that would optimally estimate the noise-free signal.

A 128-channel receive array with enhanced SNR performance for 10.5 tesla brain imaging.

Purpose: To develop and characterize the performance of a 128-channel head array for brain imaging at 10.5 tesla and evaluate the potential of brain imaging at this unique, >10 tesla magnetic field.

Methods: The coil is composed of a 16-channel self-decoupled loop transmit/receive array with a 112-loop receive-only (Rx) insert.

Parallel-transmission spatial spectral pulse design with local specific absorption rate control: Demonstration for robust uniform water-selective excitation in the human brain at 7 T.

Purpose: To propose a novel method for parallel-transmission (pTx) spatial-spectral pulse design and demonstrate its utility for robust uniform water-selective excitation (water excitation) across the entire brain.

Theory And Methods: Our design problem is formulated as a magnitude-least-squares minimization with joint RF and k-space optimization under explicit specific-absorption-rate constraints. For improved robustness against off-resonance effects, the spectral component of the excitation target is prescribed to have a water passband and a fat stopband.

A Fluorescent Probe Containing Triphenylamine-Benzofuranone Moiety for Detecting Cysteine and Imaging in Living Pulmonary Cells Under Hypercapnia.

In this work, a fluorescent probe TPB-Cys derived from triphenylamine-benzofuranone was developed for monitoring the cysteine (Cys) level and imaging in living pulmonary cells under hypercapnia condition. A systematic hypoxia module was tried to cover both the in-solution test and pulmonary cellular imaging. The hypoxia condition did not obviously affect the fluorescence response signal during the in-solution test.

Application of nondestructive techniques for peach (Prunus persica) quality inspection: A review.

Peaches are highly valued for their rich nutritional content. Traditional fruit quality accessing methods (i.e.

Surface amphiphilic hybrid porous polymers based on cage-like organosiloxanes for pipette tip solid-phase extraction of microcystins in water.

The occurrence of microcystins (MCs) during harmful algal blooms (HABs) represents a major threat to freshwater environments. In this work, a novel surface amphiphilic hybrid porous polymers based on cage-like organosiloxanes (PCSs) was prepared for the enrichment of MCs. The copolymerization of bifunctional amphiphilic monomers, 2-methacryloyloxyethyl phosphorylcholine (MPC) and N-benzylquininium chloride (BQN), with the cross-linker methacryl substituted polyhedral oligomeric silsesquioxane (POSS) was achieved in an ionic liquid-based porogenic medium.

Response surface methodology-based optimization of ' liquid fermentation medium and evaluation of its exopolysaccharide activities.

Introduction: , commonly referred to as the Sanghuang mushroom, is a species that is consumed as a tea. To date, this is the only species of the same fungus that has been successfully cultivated.

Methods: A single-factor test was conducted using MS-5 and MS-9 as test materials.

Taohong Siwu decoction enhances the chemotherapeutic efficacy of doxorubicin by promoting tumor vascular normalization.

Background: Instead of completely suppressing blood vessels inside tumors, vascular normalization therapy is proposed to normalize and prune the abnormal vasculature in tumor microenvironment (TME) to acquire a normal and stable blood flow and perfusion. The theoretical basis for the use of "blood-activating and stasis-resolving" formulas in Traditional Chinese Medicine to treat cancer is highly consistent with the principle of vascular normalization therapy, suggesting the potential application of these traditional formulas in vascular normalization therapy.

Purpose: To study the underlying mechanisms of a classical "blood-activating and stasis-resolving" formula, Taohong Siwu decoction (TSD), in enhancing the efficacy of chemotherapy for breast cancer treatment.

Visual Analysis of Hot Topics and Trends in Nutrition for Decompensated Cirrhosis Between 1994 and 2024.

Objective: An updated summary of the research profile of nutrition for the last 30 years for decompensated cirrhosis is lacking. This study aimed to explore the literature on nutrition for decompensated cirrhosis, draw a visual network map to investigate the research trends, and provide suggestions for future research. The Web of Science database retrieves the literature on nutrition for decompensated cirrhosis between 1994 and 2024.

A fluorescent probe for monitoring carboxylesterases in pulmonary cells under permissive hypercapnia condition.

Herein, by combining the benzofuranone-derived fluorophore and the carbamate recognition group, a fluorescent probe named BFO-CarE was developed for monitoring the carboxylesterase (CarE) level in pulmonary cells under the permissive hypercapnia condition. It showed a notable fluorescence response towards CarE at 570 nm under the excitation of 510 nm. The in-solution tests revealed the advantages of BFO-CarE including high sensitivity, high specificity, relatively rapid response, and high steadiness.

Stable Cu/CuO/CuN@NC Catalysts for Aqueous Phase Reforming of Methanol.

Aqueous-phase reforming of methanol represents a promising avenue for hydrogen (H) production. However, developing highly efficient and low-cost nonprecious catalysts remains challenging. Here, we report the synthesis of Cu-based catalysts with Cu, CuO, and CuN nanoparticles anchored on the nitrogen-doped carbon, forming Cu/Cu/Cu-N active sites.