ECG changes following balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension: a retrospective study.

Purpose: This research evaluates the effect of balloon pulmonary angioplasty (BPA) on cardiac electrophysiological changes in patients with chronic thromboembolic pulmonary hypertension (CTEPH).

Methods: Involving a retrospective analysis of 39 CTEPH patients (average age 61 ± 11), who had at least two BPAs and paired ECGs pre- and post-surgery, we examined changes in ECG indicators of right ventricular hypertrophy and their correlation with hemodynamic results.

Results: BPA yielded marked improvements in cardiac function and hemodynamics.

Effects of epidural analgesia at 1 cm cervical dilatation on multiparae: A retrospective cohort study using propensity score-matching.

Objective: The aim of the present study was to investigate the effects of epidural analgesia (EA) administered at cervical dilatation of 1 cm on multiparae who underwent vaginal delivery.

Methods: This propensity score-matched retrospective cohort research was conducted between 2021 and 2022. All the singleton multiparae who had previous successful vaginal deliveries and epidural analgesia during this delivery were screened for eligibility.

Machine Learning-Based Design of Superhard High-Entropy Nitride Coatings.

Limited by the inefficiency of the conventional trial-and-error method and the boundless compositional design space of high-entropy alloys (HEAs), accelerating the discovery of superior-performing high-entropy nitride (HEN) coatings remains a formidable challenge. Herein, the superhard HEN coatings were designed and prepared using the rapidly developing data-driven model machine learning (ML). A database containing hardness and different features of HEN coatings was established and categorized into four subsets covering the information on composition, composition-physical descriptors, composition-technique parameters, and composition-physical descriptors-technique parameters.

[Reflections on the safety regulation of commercialization of synthetic biology products].

With the rapid development of synthetic biology, lots of synthetic biology technology achievements in various application fields have been commercialized, generating broad market prospects. The commercialization of products employing synthetic biology technology (hereinafter referred as synthetic biology products) has brought benefits to human beings, but it has also produced potential safety risks. At present, relevant laws and standards for regulation of biotechnology or genetically modified organisms have been adopted to regulate the safety risks of commercialization of synthetic biology products (CSBP).

Micro-Expression Recognition Based on Nodal Efficiency in the EEG Functional Networks.

Micro-expression recognition based on ima- ges has made some progress, yet limitations persist. For instance, image-based recognition of micro-expressions is affected by factors such as ambient light, changes in head posture, and facial occlusion. The high temporal resolution of electroencephalogram (EEG) technology can record brain activity associated with micro-expressions and identify them objectively from a neurophysiological standpoint.

Single-Cell Analyses Reveal Necroptosis's Potential Role in Neuron Degeneration and Show Enhanced Neuron-Immune Cell Interaction in Parkinson's Disease Progression.

Parkinson's disease (PD) is a common neuron degenerative disease among the old, characterized by uncontrollable movements and an impaired posture. Although widely investigated on its pathology and treatment, the disease remains incompletely understood. Single-cell RNA sequencing (scRNA-seq) has been applied to the area of PD, providing valuable data for related research.

Molecular subtyping and immune score system by a novel pyroptosis-based gene signature precisely predict immune infiltrating, survival and response to immune-checkpoint blockade in breast cancer.

Breast cancer is one of the most prevalent and lethal types of cancer affecting women globally. Pyroptosis is a recently elucidated form of inflammatory cell death mediated by the gasdermin family and is considered to be associated with the tumor immune microenvironment. However, the impact of pyroptosis on breast cancer patients remains unclear.

Vacuum sealing drainage to treat Fournier's gangrene.

Background: Vacuum sealing drainage (VSD) is widely applied in complex wound repair. We aimed to compare traditional debridement and drainage and VSD in treating Fournier's gangrene (FG).

Methods: Data of patients surgically treated for FG were retrospectively analyzed.

Standardized nursing mode effectively controls pain caused by radiotherapy and chemotherapy in patients with advanced cancer.

Objective: To explore the application value of a standardized nursing model in pain management of advanced cancer patients undergoing radiotherapy and chemotherapy.

Methods: The clinical data of 166 patients with advanced cancer who suffered pain after receiving radiotherapy and chemotherapy in the Oncology Department of Guang'an People's Hospital from June 2020 to June 2021 were retrospectively analyzed. Among them, 83 patients who received routine care were grouped as a control group, while the other 83 patients who received standardized cancer pain nursing based on routine nursing were set as the experimental group.

Advanced maternal age: copy number variations and pregnancy outcomes.

Adverse pregnancy outcomes are closely related to advanced maternal age (AMA; age at pregnancy ≥35 years). Little research has been reported on aneuploid abnormalities and pathogenic copy number variations (CNVs) affecting pregnancy outcomes in women with AMA. The purpose of this study was to assess CNVs associated with AMA in prenatal diagnosis to determine the characteristics of pathogenic CNVs and assist with genetic counseling of women with AMA.

Effects of epidural analgesia at 1 cm cervical dilatation on labor interventions in full-term primigravida: A retrospective cohort study.

Objective: This study aimed to investigate the effects of epidural analgesia administered as early as cervical dilatation of 1 cm on labor interventions and maternal and neonatal outcomes.

Methods: This retrospective research recruited 1007 full-term primigravidas, who were distributed to two separate cohorts for eligibility: epidural analgesia 1 (cervical dilatation = 1 cm) and epidural analgesia 2 (cervical dilatation >1 cm). Labor interventions (artificial rupture of membranes and oxytocin administration) and duration of labor were the primary outcomes.

Study on the Influence of Accelerated Aging on the Properties of an RTV Anti-Pollution Flashover Coating.

The purpose of this work is to study the accelerated aging behavior of a room-temperature vulcanized (RTV) silicone rubber anti-pollution flashover coating. Red, blue and gray RTV rubber samples were selected to prepare coatings on the surface of stainless-steel sheets. The accelerated aging test was carried out in an aging test chamber according to a four-step program cycle.

Affection of facial artifacts caused by micro-expressions on electroencephalography signals.

Macro-expressions are widely used in emotion recognition based on electroencephalography (EEG) because of their use as an intuitive external expression. Similarly, micro-expressions, as suppressed and brief emotional expressions, can also reflect a person's genuine emotional state. Therefore, researchers have started to focus on emotion recognition studies based on micro-expressions and EEG.

Study on the Antioxidant Effect of Tanshinone IIA on Diabetic Retinopathy and Its Mechanism Based on Integrated Pharmacology.

Aim: To explore the effect of tanshinone IIA on diabetic retinopathy (DR) and its mechanism.

Methods: GeneCards and OMM databases were used to mine DR-related genes. The chemical structure of tanshinone IIA was searched by PubChem, and the potential target was predicted by PharmMapper.

Responses of functional brain networks in micro-expressions: An EEG study.

Micro-expressions (MEs) can reflect an individual's subjective emotions and true mental state, and they are widely used in the fields of mental health, justice, law enforcement, intelligence, and security. However, one of the major challenges of working with MEs is that their neural mechanism is not entirely understood. To the best of our knowledge, the present study is the first to use electroencephalography (EEG) to investigate the reorganizations of functional brain networks involved in MEs.

Electrophysiological evidence for inhibition hypothesis of micro-expressions based on tensor component analysis and Physarum network algorithm.

The inhibition hypothesis advocated by Ekman (1985) states when an emotion is concealed or masked, the true emotion is manifested as a micro-expression (ME) which is a fleeting expression lasting for 40 to 500 ms. However, research about the inhibition hypothesis of ME from the perspective of electrophysiology is lacking. Here, we report the electrophysiological evidence obtained from an electroencephalography (EEG) data analysis method.

Norbisabolane-type sesquiterpenoid derivatives, benzofuran lignans and a phenolic glycoside from the roots of Glochidion wilsonii Hutch.

Three highly oxygenated norbisabolane sesquiterpenoid glycosides (glochiwilsonosides A-C), five benzofuran lignans (glochiwilsonises A-E) and a phenolic glycoside (glochiwilsophe-noside), together with forty-one known compounds, were isolated from the roots of Glochidion wilsonii Hutch. The chemical structures of the compounds were identified by spectroscopic methods and previous literature data. Glochiwilsonoside A displayed anti-proliferative activity on A-549 and RAW 264.

Influence of Family Sports Games on the Development of Early Communication Skills in Autistic Children.

With the development of society, the number of autistic children in China is increasing, which not only makes the family's happiness very low, but also seriously affects the development of teenagers and society. Among the symptoms of autistic children, early childhood communication skills have received extensive attention. In traditional rehabilitation training, with a lack of parents' participation, most of the training cannot arouse the interest of autistic children, so the treatment effect is not obvious.

Application of VIP Care in Patients with Advanced Tumors in the Western Region of China.

Objective: The objective of this study is to explore the application of a very important person (VIP) intervention mode in patients with advanced tumors in the western region of China.

Methods: One hundred and sixty-three patients were randomly divided into a control and experimental groups. The control group received routine care, and the experimental group received VIP future care.

Relationship Between Platelet Count and In-hospital Mortality in Adult Patients With COVID-19: A Retrospective Cohort Study.

Background: The coronavirus disease 2019 (COVID-19) has become a global pandemic. Systemic inflammation in COVID-19 patients has been associated with poor clinical outcome. This study aims to determine the relationship between platelet count and in-hospital mortality.

Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in Mice by the FGF Signaling Pathway.

As a Ku70-binding protein of the KUB family, Kub3 has previously been reported to play a role in DNA double-strand break repair in human glioblastoma cells in glioblastoma patients. However, the physiological roles of Kub3 in normal mammalian cells remain unknown. In the present study, we generated gene knockout mice and revealed that knockout (KO) mice died as embryos after E18.

Regulation and management of the biosecurity for synthetic biology.

Synthetic biology (SynBio) is a high-profile interdiscipline combining engineering with science. As a dual-purpose discipline, SynBio is bringing large changes to many fields and providing great benefits to humans. However, due to its characteristic of complexity and uncertainty, SynBio also presents potential biosafety and biosecurity risks.