Publications by authors named "XiaoLin Yang"

This paper presents a large publicly available benchmark dataset (TCMEval-SDT) for the thought process involved in syndrome differentiation in traditional Chinese medicine (TCM). The dataset consists of 300 TCM syndrome diagnosis cases sourced from the internet, classical Chinese medical texts, and medical records from hospitals, with metadata adhering to the Findable, Accessible, Interoperable, and Reusable (FAIR) principles. Each case has been annotated and curated by TCM experts and includes medical record ID, clinical data, explanatory summary, TCM syndrome, clinical information, and TCM pathogenesis, to support algorithms or models in emulating the diagnostic process of TCM clinicians.

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Metabolic syndrome encompasses a cluster of predictive metabolic risk factors, including obesity, insulin resistance, dyslipidemia, hyperglycemia and hypertension. It is strongly associated with the development of type 2 diabetes and cardiovascular disease. Given the increasing morbidity and mortality associated with metabolic syndrome, along with the limited availability of drug treatments, it is high time to investigate the pathogenesis of this condition and explore potential pharmacotherapies.

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In this research, we investigate the impact of implantable cuff electrodes on the vagus nerve stimulation threshold due to the gradient fields during MR scans. We employ electromagnetic simulations in conjunction with the NEURON model for our study. Preliminary findings suggest that the cuff electrodes can substantially reduce the stimulation threshold for the specific configuration examined in this research.

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Background: Non-cystic fibrosis bronchiectasis is associated with frequent and diverse microbial infections, yet an overall understanding of microbial presence across different disease stages is lacking.

Methods: A meta-analysis assessed lung microbes in adults with non-CF bronchiectasis, collecting data using both culture-based and sequencing approaches through three international databases and three Chinese databases. Subgroups were categorized by disease stage: the stable group (S), the exacerbation group (E), and unclassified data consolidated into the undetermined group (U).

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Antibiotics have limited capacities to penetrate and eliminate intracellular bacteria. This study developed a drug delivery system to surmount the cell-membrane barrier and achieve efficient intracellular antibiotic accumulation for intracellular-bacterial eradication. Ceftiofur (CEF) was encapsulated in hen egg-yolk-extracted low-density lipoproteins (heLDLs) to generate CEF-heLDLs.

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Genetic modification via gene editing has become a widely adopted and demonstrably effective method in functional gene research within entomology. However, the optimal efficiency and simplicity of delivering exogenous guide RNA-clustered regularly interspaced short palindromic repeats-associated protein 9 complexes into target tissues are crucial for successful gene editing. The Receptor-Mediated Ovary Transduction of Cargo (ReMOT) strategy, which simplifies the delivery process, target-site selection, technical requirements, and delivery cost compared with embryonic microinjection, enabling efficient editing at the germline level, is gaining increasing attention.

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Purpose: This study investigates the impact of orthopedic plates on peripheral nerve stimulation (PNS) during MRI, focusing on how the presence of implants affects PNS thresholds.

Methods: A combination of anatomical electromagnetic and neurophysiological modeling was utilized. Electromagnetic fields in human body models were simulated, both with and without orthopedic plates.

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With the increase of the construction depth for ultra-deep shaft development blasting, it is prone to occur problems such as reduced driving efficiency, frequent dynamic disasters, wellbore instability and fracture under the coupling effect of deep high stress and strong blasting disturbance. In this paper, the dynamic evolution process of surrounding rock stress field and the propagation law of explosion stress wave in the process of ultra-deep shaft development blasting were studied by combining theoretical analysis with physical model test. The theoretical analysis model of ultra-deep shaft blasting excavation was established based on elastic mechanics, and the stress distribution and failure mechanism of surrounding rock under the coupling effect of deep high stress and blasting load were explored.

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Background: The associations between the monthly rate of topological property change (mrTPC) in the structural and functional connectivity network (SCN, FCN) and achieving no evidence of disease activity (NEDA) in relapsing-remitting multiple sclerosis (RRMS) patients taking oral disease-modifying therapies (DMTs) remain insufficiently explored.

Methods: This was a retrospective study conducted with RRMS patients treated with oral DMTs or untreated between January 2019 and June 2023. All participants underwent baseline and follow-up clinical evaluations and MRI scans.

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The complete genome sequence of , a goldthread anthracnose pathogen, was sequenced using PacBio Revio and MGI DNBSEQ-T7 PE150. It contains 10 chromosomes, 5 mini chromosomes, a circular mitochondrial chromosome, and 13,129 genes predicted with RNA-Seq data in a 52.13-Mb genome with an of 5.

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Objectives: To investigate glymphatic function in idiopathic normal pressure hydrocephalus (iNPH) using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) method and to explore the associations of ALPS index with ventriculomegaly and white matter hyperintensities (WMH).

Materials And Methods: This study included 41 patients with iNPH and 40 age- and sex-matched normal controls (NCs). All participants underwent brain MRI.

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Although disturbances in the gut microbiome have been implicated in multiple sclerosis (MS), little is known about the changes and interactions between the gut microbiome and blood metabolome, and how these changes affect disease-modifying therapy (DMT) in preventing the progression of MS. In this study, the structure and composition of the gut microbiota were evaluated using 16S rRNA gene sequencing and an untargeted metabolomics approach was used to compare the serum metabolite profiles from patients with relapsing-remitting MS (RRMS) and healthy controls (HCs). Results indicated that RRMS was characterized by phase-dependent α-phylogenetic diversity and significant disturbances in serum glycerophospholipid metabolism.

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Empathy plays a crucial role in social communication and the perception of affective states and behavioral processes. In this study, we observed that empathic interaction with a mouse experiencing pain resulted in decreased mechanical pain thresholds and anxiety-like behaviors in its bystander, though the underlying mechanisms remain unknown. We demonstrated that CD38 expression in the paraventricular nucleus (PVN) was upregulated during empathic pain, and the pain and emotions of CD38 knockout (CD38KO) mice as bystanders were not affected.

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Background: Burn-hemorrhagic shock combined injury, a severe condition causing complex stress responses and metabolic disturbances that significantly affect clinical outcomes in both military and civilian settings, was modeled in swine to investigate the associated metabolomic and proteomic changes and identify potential biomarkers for disease prognosis.

Methods: Eight clean-grade adult male Landrace pigs (4-5 months, average weight 60-70 kg) were used to model burn-hemorrhagic shock combined injury. Serum samples collected at 0 h and 2 h post-injury were analyzed using metabolomic and proteomic measurements.

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Objective: This systematic review and meta-analysis aimed to evaluate the efficacy of combination scalp acupuncture in treating post-stroke cognitive impairment.

Methods: A comprehensive search was conducted across eight databases: PubMed, Web of Science, Cochrane Database, Embase, CBM, CNKI, WanFang, and VIP, targeting randomized controlled trials (RCTs) published from the inception of these databases until October 24, 2024. The inclusion criteria focused on RCTs that compared scalp acupuncture with conventional treatments as therapeutic interventions for patients suffering from post-stroke cognitive impairment (PSCI).

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Background: The fecal immunochemical test (FIT) has been widely used in colorectal cancer (CRC) screening, yet the practical performance of FIT combined with questionnaire-based risk assessment (QRA) remains undetermined. Moreover, risk factors for distinct CRC precursors identified in screening have been rarely compared.

Methods: This study was based on a population-based CRC screening in China, with 2,120,340 participants completing both FIT and QRA.

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Gene expression levels serve as valuable markers for assessing prognosis in cancer patients. To understand the mechanisms underlying prognosis and explore potential therapeutics across diverse cancers, we developed CancerPro (https:/medcode.link/cancerpro).

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This study aimed to assess the associations between sprint force-velocity profile variables with change of direction (COD) performance and to investigate the impact of these variables on asymmetries in COD speed performance. Ninety-nine participants (volleyball players: n = 44, basketball players: n = 55) performed 40 m sprints for Fv relationship calculation, two COD tests (Modified Agility T-test and 505 test). A partial least squares (PLS) regression analysis was conducted to determine the relationships between the variables.

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Objective: This study aimed to evaluate the cardiorenal effect of combining sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) when compared with monotherapy of either agent in patients with type 2 diabetes (T2D).

Methods: PubMed, Web of Science, Embase, the Cochrane Central Register of Controlled Trials and Clinicaltrial.gov were systematically searched from inception to June 2024.

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Triterpenoid saponins are crucial natural products widely distributed in various medicinal plants, with Dipsacus asperoides being particularly rich in these compounds. However, the glycosyltransferases responsible for the biosynthesis of α-hederin, one of the primary bioactive secondary metabolites in D. asperoides, have not been elucidated.

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Article Synopsis
  • * Researchers identified ten new genetic variants (SNPs) linked to fat mass response, with four of them also showing consistent effects in individuals of European descent.
  • * A genetic score derived from these SNPs and other factors explained 40.3% of the variation in fat loss, particularly highlighting that those with lower genetic scores tended to lose more fat, while also identifying key biological pathways involved, such as insulin secretion and fat cell differentiation.
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The aim of this study was to assess the relationship between variant loci significantly associated with sports-related traits in the GWAS Catalog database and sprint/power athlete status, as well as to explore the polygenic profile of elite athletes. Next-generation sequencing and microarray technology were used to genotype samples from 211 elite athletes who had achieved success in national or international competitions in power-based sports and from 522 non-athletes, who were healthy university students with no history of professional sports training. Variant loci collected from databases were extracted after imputation.

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Article Synopsis
  • This study investigates the genetic factors linked to improved power from resistance training by using Genome-Wide Association Analysis (GWAS) on 193 Han Chinese adults who participated in a 12-week training program.
  • The results showed a significant increase in countermovement jump height, with individual changes varying widely, and identified 38 key genetic markers that correlate with these changes.
  • The predictive model created accounted for 62.6% of the variations in training outcomes, suggesting that both genetic markers and physical traits play a role in how individuals respond to resistance training.
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Rice false smut, caused by , threatens rice production by reducing yields and contaminating grains with harmful ustiloxins. However, studies on resistance genes are scarce. In this study, the resistance level of IR28 (resistant cultivar) to was validated through artificial inoculation.

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