Impact of anesthetic methods on outcomes for patients with large core stroke undergoing endovascular treatment.

Background: The optimal anesthetic method for endovascular therapy in acute large core stroke remains unclear. This study aimed to evaluate the impact of anesthetic methods on outcomes in patients with large core stroke.

Methods: This study was a subanalysis of a prospective, multicenter registry at 38 stroke centers in China.

The number of recanalization attempts, procedure time and endovascular therapy outcomes in acute large core stroke patients.

Introduction: Landmark thrombectomy trials demonstrated improved functional outcomes after endovascular therapy (EVT) for large core strokes (LCSs). This study explored the impact of recanalization attempts and procedure time (PT) on outcomes in LCS patients.

Patients And Methods: This was a retrospective study of patients with LCSs who underwent EVT from a prospective multicentre cohort.

Clinical Outcomes in A Multi-center Cohort Involving 919 Patients with Hypertriglyceridemia-associated Acute Pancreatitis.

Objectives: Hypertriglyceridemia-associated acute pancreatitis (HTG-AP) is one of the most common etiologies of acute pancreatitis (AP) worldwide. Compared to other etiologies, patients with HTG-AP may develop more severe AP, but previous studies yielded controversial conclusion due to the lack of adequate adjustment for the confounders. Therefore, this study aimed to examine the possibility and risk factors of developing severe AP in HTG-AP.

Lattice defect engineering advances n-type PbSe thermoelectrics.

Te-free thermoelectrics have garnered significant interest due to their immense thermoelectric potential and low cost. However, most Te-free thermoelectrics have relatively low performance because of the strong electrical and thermal transport conflicts and unsatisfactory compatibility of interfaces between device materials. Here, we develop lattice defect engineering through Cu doping to realize a record-high figure of merit of ~1.

Enabling ultra-flexible inorganic thin-film-based thermoelectric devices by introducing nanoscale titanium layers.

Here, we design exotic interfaces within a flexible thermoelectric device, incorporating a polyimide substrate, Ti contact layer, Cu electrode, Ti barrier layer, and thermoelectric thin film. The device features 162 pairs of thin-film legs with high room-temperature performance, using p-BiSbTe and n-BiTeSe, with figure-of-merit values of 1.39 and 1.

Intra-Arterial Tenecteplase Following Endovascular Reperfusion for Large Vessel Occlusion Acute Ischemic Stroke: The POST-TNK Randomized Clinical Trial.

Importance: The impact of adjunctive intra-arterial tenecteplase administration following near-complete to complete reperfusion by endovascular thrombectomy (EVT) for acute ischemic stroke is unknown.

Objective: To assess the efficacy and adverse events of adjunctive intra-arterial tenecteplase in patients with large vessel occlusion stroke who had achieved near-complete to complete reperfusion (defined as a score on the expanded Thrombolysis in Cerebral Infarction [eTICI] scale of 2c to 3) after EVT.

Design, Setting, And Participants: Investigator-initiated, randomized, open-label, blinded outcome assessment trial implemented at 34 hospitals in China among 540 patients with stroke due to proximal intracranial large vessel occlusion within 24 hours of the time they were last known to be well, with an eTICI score of 2c to 3 after EVT, and without prior intravenous thrombolysis.

Solvothermally optimizing AgTe/AgS composites with high thermoelectric performance and plasticity.

Silver-based fast ionic conductors show promising potential in thermoelectric applications. Among these, AgS offers unique high plasticity but low electrical conductivity, whereas AgTe exhibits high intrinsic electrical conductivity yet faces limitations due to high thermal conductivity and poor plasticity. Developing a composite thermoelectric material that combines the benefits of both is therefore essential.

Proteomic patterns associated with ketamine response in major depressive disorders.

Background: Major depressive disorder (MDD) is characterized by persistent feelings of sadness and loss of interest. Ketamine has been widely used to treat MDD owing to its rapid effect in relieving depressive symptoms. Importantly, not all patients respond to ketamine treatment.

Efficacy and safety of tirofiban in acute ischemic stroke patients with ideal reperfusion: A cohort study of LAA and CE subgroups.

Background And Objectives: Despite achieving ideal reperfusion (eTICI = 3) through endovascular treatment (EVT), some acute ischemic stroke (AIS) patients still experience poor outcomes. This study aims to evaluate the efficacy and safety of tirofiban in AIS patients with ideal reperfusion, focusing on its effects in large artery atherosclerosis (LAA) and cardioembolic (CE) stroke.

Methods: A total of 474 AIS patients from the RESCUE-BT database were included.

The Role of Flavonoids from Aurantii Fructus Immaturus in the Alleviation of Allergic Asthma: Theoretical and Practical Insights.

Flavonoids derived from plants in the citrus family can have an alleviating effect on allergic asthma. The aim of this study was to provide insights into the mechanisms by which these compounds exert their effects on allergic asthma by combining theoretical and practical approaches. Aurantii Fructus Immaturus flavonoids (AFIFs) were obtained by solvent extraction and were determined by high performance liquid chromatography (HPLC).

Targeting Metabolic Adaptation of Colorectal Cancer with Vanadium-Doped Nanosystem to Enhance Chemotherapy and Immunotherapy.

The anti-tumor efficacy of current pharmacotherapy is severely hampered due to the adaptive evolution of tumors, urgently needing effective therapeutic strategies capable of breaking such adaptability. Metabolic reprogramming, as an adaptive survival mechanism, is closely related to therapy resistance of tumors. Colorectal cancer (CRC) cells exhibit a high energy dependency that is sustained by an adaptive metabolic conversion between glucose and glutamine, helping tumor cells to withstand nutrient-deficient microenvironments and various treatments.

Nanobinders advance screen-printed flexible thermoelectrics.

Limited flexibility, complex manufacturing processes, high costs, and insufficient performance are major factors restricting the scalability and commercialization of flexible inorganic thermoelectrics for wearable electronics and other high-end cooling applications. We developed an innovative, cost-effective technology that integrates solvothermal, screen-printing, and sintering techniques to produce an inorganic flexible thermoelectric film. Our printable film, comprising BiTe-based nanoplates as highly orientated grains and Te nanorods as "nanobinders," shows excellent thermoelectric performance for printable films, good flexibility, large-scale manufacturability, and low cost.

Role and mechanism of myonectin in severe acute pancreatitis: a crosstalk between skeletal muscle and pancreas.

Background: Severe acute pancreatitis (SAP) is characterized by high mortality rates and various complications, including skeletal muscle atrophy, which significantly exacerbates its outcomes. Despite its clinical relevance, the mechanistic understanding of the relationship between skeletal muscle and the pancreas in SAP remains limited. Our study aimed to elucidate this "organ crosstalk" and its potential implications.

Compound oolong tea ameliorates lipid accumulation through AMPK-PPAR pathway of hepatic lipid metabolism and modulates gut microbiota in HFD induced mice.

Based on the modified traditional Chinese formula, Compound Oolong tea (WLT) is composed of six herbal medicines which have beneficial effects. The present study aimed to assess the effects of WLT on lipid metabolism and gut microbiota in the mouse obesity model.Totally 32 mice were randomized into 4 groups including normal control (NC), high-fat diet model (HFD), positive control (PC) receiving atorvastatin 10 mg/kg/d, and WLT group with WLT water extra 300 mg/kg/d.

Research progress of the Hippo signaling pathway in renal cell carcinoma.

Objective: This review aimed to summarize the role of the Hippo signaling pathway in renal cell carcinoma (RCC), a urologic malignancy with subtle initial symptoms and high mortality rates due to metastatic RCC. The Hippo signaling pathway, which regulates tissue and organ sizes, plays a crucial role in RCC progression and metastasis. Understanding the involvement of the Hippo signaling pathway in RCC provides valuable insights for the development of targeted therapies and improved patient outcomes.

Defect Engineering Advances Thermoelectric Materials.

Defect engineering is an effective method for tuning the performance of thermoelectric materials and shows significant promise in advancing thermoelectric performance. Given the rapid progress in this research field, this Review summarizes recent advances in the application of defect engineering in thermoelectric materials, offering insights into how defect engineering can enhance thermoelectric performance. By manipulating the micro/nanostructure and chemical composition to introduce defects at various scales, the physical impacts of diverse types of defects on band structure, carrier and phonon transport behaviors, and the improvement of mechanical stability are comprehensively discussed.

Association Between Serum Galectin-3 and Parkinson's Disease: A Two-Sample Mendelian Randomization Study.

Background: Parkinson's disease (PD) is a prevalent neurodegenerative disorder with poor prognosis. Observational studies have demonstrated a significant correlation between serum galectin-3 and PD, suggesting a potential role of galectin-3 as a biomarker for PD. However, it is still unclear whether galectin-3 contributes to the risk of the disease.

Relationship between eating attitudes, depression, and insight in schizophrenic patients with and without type 2 diabetes mellitus: a comparative study in Guangdong, China.

Background: Schizophrenia, a severe mental disorder, is often complicated by Type 2 Diabetes Mellitus (T2DM), which can further impact patients' psychological health. This study investigated the differences in eating attitudes, depression, and insight between schizophrenic patients with and without comorbid T2DM and explored the correlations among these factors to provide empirical support for clinical interventions.

Methods: This case-control study was conducted in Guangdong Province, China.

A mendelian randomization analysis of the associations between haptoglobin and multiple sclerosis.

Background: Observational studies have suggested an association between plasma haptoglobin and multiple sclerosis (MS). Haptoglobin plays an important role in the pathogenesis of MS. However, whether it has a causal effect on MS remains unknown.

Adjunctive intra-arterial tenecteplase after successful endovascular thrombectomy in patients with large vessel occlusion stroke (POST-TNK): Study rationale and design.

Rationale: Adjunct intra-arterial alteplase has been shown to potentially improve clinical outcomes in patients with large vessel occlusion (LVO) stroke who have undergone successful endovascular thrombectomy. Tenecteplase, known for its enhanced fibrin specificity and extended activity duration, could potentially enhance outcomes in stroke patients after successful reperfusion when used as an adjunct intra-arterial therapy.

Aim: To explore the safety and efficacy of intra-arterial tenecteplase after successful endovascular thrombectomy in patients with LVO stroke.