Publications by authors named "XiaoLei Liang"
Endometrial cancer (EC) is a common gynecological cancer, characterized by increasing incidence and mortality rates. Maackiain (MA), a natural flavonoid compound, has multiple biological activities, but little is known about how it affects EC cells. In the present study, CCK-8, EdU, colony formation, and flow cytometry assays were used to evaluate the effects of MA on EC cell proliferation, apoptosis, and reactive oxygen species (ROS) levels.
View Article and Find Full Text PDFBackground: Participation in cardiac rehabilitation is low in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Although existing rehabilitation methods have achieved certain results, patient participation in exercise rehabilitation is not ideal. The Patient Health Engagement (PHE) model is designed to ensure that patients improve their participation in cognitive, emotional, behavioral, and other aspects in all phases of exercise rehabilitation.
View Article and Find Full Text PDFPregnancy Metabolic Adaptation and Changes in Placental Metabolism in Preeclampsia.
Geburtshilfe Frauenheilkd
November 2024
Article Synopsis
- Pregnancy causes significant changes in how a woman's body processes nutrients like glucose, lipids, and amino acids to support the developing fetus.
- Proper regulation of nutrient metabolism is crucial for maintaining homeostasis; failure to adapt can lead to complications like fetal growth issues and preeclampsia.
- Exploring treatment options for preeclampsia that focus on addressing metabolic changes may offer new ways to manage this condition.
Article Synopsis
- - Endometrial cancer (EC) is a prevalent type of cancer in women, and its death rates have been rising over the last two decades.
- - Research indicates that circulating tumor cells (CTCs) can provide valuable information for understanding and managing EC, potentially leading to better personalized treatment options.
- - This review emphasizes the significance of CTCs and disseminated tumor cells (DTCs) in predicting EC outcomes and highlights the potential diagnostic role of tumor cells found in urine from EC patients.
Stress urinary incontinence (SUI), characterized by involuntary urine leakage during increased abdominal pressure, remains poorly understood regarding its pathophysiology and treatment. In this study, we utilized single-cell sequencing to analyze the transcriptomic profiles of different cell types in anterior vaginal wall of SUI patients, aiming to explore the heterogeneity of the extracellular matrix (ECM) and immune microenvironment in SUI pathogenesis. Our results identified eleven cell types, including connective tissue cells, immune cells, and glial cells.
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- Glucose metabolism is vital for the functioning of granulosa cells and the development of ovarian follicles, and disruptions in this process may affect female fertility, particularly in young women with diminished ovarian reserve (DOR).
- The study compares granulosa cells from 72 DOR patients to 75 women with normal ovarian reserve, using various analytical methods to assess changes in glucose-energy metabolism.
- Findings indicate downregulation of key genes and metabolites related to glucose metabolism in DOR patients, reduced mitochondrial function, and impaired energy production, which collectively hinder follicle development and maturation.
Potential mechanisms and therapeutic strategies for LPS-associated female fertility decline.
J Assist Reprod Genet
October 2024
Article Synopsis
- Lipopolysaccharide (LPS), found in the outer membrane of Gram-negative bacteria, triggers inflammation by activating toll-like receptors (TLRs) through pathways like MyD88 and TRIF.
- Research indicates that LPS-related inflammatory responses can lead to ovarian dysfunction and reduced female fertility, though the reasons are complicated.
- This review explores various studies on LPS and fertility decline, aiming to clarify how LPS affects female reproductive health and proposes potential therapeutic strategies to mitigate its impact.
Article Synopsis
- Endometrial cancer (EC) is a common gynecological cancer linked to chronic inflammation, and ATP5F1D plays a role in mitochondrial function, which is crucial in cancer development.
- The study identified ATP5F1D expression in EC tissues and cell lines, revealing its connection to better clinical outcomes and negative impacts on cancer cell behavior when ATP5F1D is silenced.
- Knocking down ATP5F1D reduced mitochondrial ROS production and pyroptosis in EC cells, suggesting that targeting ATP5F1D could be a potential new treatment approach to slow down EC progression.
Article Synopsis
- Premature ovarian insufficiency (POI) is a complex condition linked to low estrogen levels, leading to symptoms like insomnia and infertility, with recent research indicating a relationship between autoimmune diseases (AIDs) and POI.
- * This study utilized Mendelian randomization (MR) to analyze data from various sources, including genetic studies and the FinnGen Study, to investigate the causal links between AIDs and POI.
- * Findings suggested that Systemic lupus erythematosus (SLE) increases POI risk while POI may also contribute to the risk of Crohn's disease (CD), with statistical analyses supporting these relationships.
Article Synopsis
- 4-Vinylcyclohexene diepoxide (VCD) is a harmful chemical that disrupts reproductive health in women, causing conditions like premature ovarian insufficiency (POI).
- A study used female mice to investigate how VCD affects ovarian function, showing that exposure led to significant changes in sex hormones, follicle counts, and estrous cycles over time.
- Key findings indicated that damage from VCD interferes with hormone synthesis and follicle development, contributing to overall ovarian dysfunction and infertility.
The NFκB Signaling Pathway Is Involved in the Pathophysiological Process of Preeclampsia.
Geburtshilfe Frauenheilkd
April 2024
Article Synopsis
- * Currently, the only effective way to manage preeclampsia is by terminating the pregnancy, highlighting a need for more research on its causes and new treatments.
- * The NFκB family of transcription factors plays a key role in inflammation and immunity, and this review explores their involvement in both normal pregnancies and preeclampsia, along with current and potential treatment options targeting NFκB.
Article Synopsis
- Delaying childbearing age has become more common, leading to increased cases of diminished ovarian reserve (DOR) in reproductive medicine, making treatment challenging for physicians.
- The exact mechanisms behind DOR remain unknown, but studies indicate that genetic variants, regulatory gene changes, and protein expression levels all impact ovarian function.
- This paper reviews these genetic factors and their influence on ovarian development and aims to improve future treatments for individuals experiencing reduced ovarian reserve.
Article Synopsis
- Endometrial cancer (EC) is the most common gynecological cancer in developed countries, and the study focuses on the role of the gene ATP5F1D, a part of the mitochondrial electron transport chain.
- Researchers analyzed tissue samples from 20 EC patients using data-independent acquisition mass spectrometry (DIA-MS) and found that ATP5F1D showed a significant 2.903-fold change in expression, indicating its potential as a diagnostic and prognostic biomarker.
- The study revealed that higher ATP5F1D expression correlates with better immune treatment responses and chemotherapy sensitivity, highlighting its importance in guiding personalized treatment strategies for EC patients.
Article Synopsis
- * Results revealed that women with T2DM had lower Anti-Müllerian Hormone (AMH) levels, needed higher doses of gonadotropins, and achieved fewer retrieved oocytes compared to non-T2DM patients, leading to poorer pregnancy outcomes.
- * The findings concluded that T2DM significantly decreases ovarian reserve and contributes to lower clinical pregnancy rates and higher abortion rates among these women when undergoing ART.
Data-independent acquisition for proteomic applications in early-stage endometrial cancer progression.
J Obstet Gynaecol Res
February 2024
Article Synopsis
- The study investigates the molecular changes in high-grade early-stage endometrial cancer (EC) patients, who often have poor outcomes despite an early diagnosis, focusing on proteome analysis to identify dysregulated pathways.
- Using data-independent acquisition (DIA) proteomics, the researchers analyzed tissue samples from 20 EC patients and identified significant differences in protein expression, particularly the upregulation of oxidative phosphorylation (OXPHOS) pathways in high-grade tumors.
- The findings suggest that high-grade EC is linked to metabolic reprogramming, with OXPHOS-related proteins being potential biomarkers for diagnosis and possible targets for new treatment strategies.
Article Synopsis
- The ovarian reserve refers to the number of oocytes (eggs) in the ovaries and can be influenced by various factors like hormones, health conditions, and environmental issues.
- Diminished ovarian reserve (DOR) has become increasingly common due to societal trends of delaying pregnancy, posing challenges in reproductive medicine.
- This review analyzes the factors affecting ovarian reserve and aims to identify the mechanisms behind DOR, hoping to guide future research and treatment options.
Article Synopsis
- This study focused on how malignant peritoneal cytology relates to survival outcomes in patients with uterine leiomyosarcoma and endometrial stromal sarcoma.
- Out of 733 patients analyzed, those with malignant cytology had significantly lower 5-year overall survival rates, especially in advanced cases, indicating a serious prognosis.
- The findings suggest that assessing peritoneal cytology during hysterectomy could be beneficial for predicting patient outcomes and improving prognosis evaluation.
Article Synopsis
- Nicotinamide adenine dinucleotide (NAD+) is important for tumor progression, but its specific role in endometrial cancer (EC) is not fully understood, prompting this study.
- Researchers developed a risk signature based on NAD+ metabolic-related genes (NMRGs) to predict prognosis and responses to treatments in EC patients, using data from established cancer databases.
- The study identified six key NMRGs related to patient risk levels, demonstrating that a high-risk group faced poorer outcomes and showed a connection to specific biological pathways and immune responses, highlighting the signature's potential for guiding EC patient management.
Studying the effect of hyperoside on recovery from cyclophosphamide induced oligoasthenozoospermia.
Syst Biol Reprod Med
October 2023
Article Synopsis
- Oligoasthenozoospermia, characterized by low sperm counts and motility, is a growing concern with few treatment options available.
- A study explored the potential of hyperoside, a compound from traditional Chinese medicine, in a mouse model of oligoasthenozoospermia induced by cyclophosphamide (CTX).
- Results showed that hyperoside significantly improved sperm density and testicular function, enhanced testosterone production, and regulated key genes involved in spermatogenesis and meiosis.
Endometrial cancer (EC) is a common malignant tumor that lacks any therapeutic target and, in many cases, recurrence is the leading ca use of morbidity and mortality in women. Widely known EC has a strongly positive correlation with abnormal lipid metabolism. Squalene epoxidase (SQLE), a crucial enzyme in the cholesterol synthesis pathway regulating lipid metabolic processes has been found to be associated with various cancers in recent years.
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- The study investigates how salt-inducible kinase 2 (SIK2) influences glucose and lipid metabolism in ovarian cancer, aiming to inform potential inhibitors for personalized treatment.
- By reviewing SIK2's roles in processes like glycolysis and lipid synthesis, the research highlights its contribution to cancer cell growth, invasion, and resistance to therapies.
- The findings suggest that targeting SIK2 could offer new treatment options for ovarian cancer and other cancers, leading to further exploration of its molecular mechanisms and the development of more effective inhibitors.
Article Synopsis
- Structure modification of drugs, particularly late-stage functionalization (LSF), is effective for optimizing lead compounds, and this study focused on Cu-catalyzed C-H LSF of 5-nitrofuran drugs.
- Multiple modifications were performed on the 5-nitrofuran drugs, including hydroxylation, methylation, azidination, cyanation, and arylation, and the antibacterial activities of the new compounds were tested.
- Among the modified compounds, compounds 1 and 18 showed the highest antibacterial activity, while cell cytotoxicity assays were conducted on potent compounds and the parent drug to assess safety.
Article Synopsis
- Diminished ovarian reserve (DOR) is a complex disorder that leads to poor reproductive outcomes, and the study aims to understand if there's a common cause among its different types.
- Two mouse models were created to study age-related DOR (AR-DOR) and cyclophosphamide-induced DOR (CTX-DOR), with RNA sequencing used to analyze gene expression in ovarian tissues.
- Findings revealed that both types have a shared inflammatory/immune response, but AR-DOR is linked to DNA damage repair issues while CTX-DOR is more associated with cell apoptosis, highlighting potential targets for future treatments.
Article Synopsis
- This study emphasizes the importance of enhancing low-performing yet cost-effective catalysts to create top-tier electrocatalysts, focusing on improving their intrinsic catalytic activity through heteroatom doping.
- A series of fluorine-doped lanthanum cobaltate (F-LaCoO) was synthesized, demonstrating impressive electrocatalytic performance, including a low overpotential of 390 mV for the oxygen evolution reaction (OER) and a significant half-wave potential of 0.68 V for the oxygen reduction reaction (ORR).
- The research shows that the enhanced performance results from the spin state transition of cobalt, facilitated by the incorporation of fluorine atoms, paving the way for innovative designs of high-performing electrocatalysts in per
Article Synopsis
- The study aimed to determine the effectiveness of adjuvant radiotherapy on overall survival (OS) in patients with uterine sarcoma, particularly identifying those who would benefit from it using a nomogram-based prognostic stratification.
- Researchers analyzed data from 2871 uterine sarcoma patients without distant metastases and found that, while adjuvant radiotherapy didn't improve OS overall, high-risk patients experienced significant survival benefits.
- The developed nomogram effectively categorized patients into three risk groups, showing that only high-risk patients gained improved 5-year OS with radiotherapy, suggesting a targeted approach in treatment.