The clinicopathologic features of uterine inflammatory myofibroblastic tumor: A case report.

Rationale: Inflammatory myofibroblastic tumor (IMT) is a rare soft tissue neoplasm with low malignant potential. These patients present with a certain probability of malignant potential. The management of IMT has not been standardized, especially for the patients with fertility needs.

Association of Organophosphorus Pesticide and Glyphosate Exposure with Nasal Flora and Total IgE in Solar Greenhouse Workers: A Unique Farmer Group.

Studies have shown that the presence of allergens, including insecticides, significantly increases the risk of occupational allergic diseases among solar greenhouse workers. However, no studies have yet investigated the relationship between organophosphorus pesticide use by greenhouse workers and allergic diseases, and the role of the flora in this context remains unclear. Therefore, this study aimed to investigate the relationship between combined exposure to organophosphorus pesticides (OPs) and Glyphosate (GLY) and changes in total immunoglobulin E (IgE) levels, as well as to analyze the role of nasal flora in allergic status.

Dietary N-6 Polyunsaturated Fatty Acid Intake and Brain Health in Middle-Aged and Elderly Adults.

Background: Dietary intake of polyunsaturated fatty acids (PUFA) plays a significant role in the onset and progression of neurodegenerative diseases. Since the neuroprotective effects of n-3 PUFA have been widely validated, the role of n-6 PUFA remains debated, with their underlying mechanisms still not fully understood.

Methods: In this study, 169,295 participants from the UK Biobank were included to analyze the associations between dietary n-6 PUFA intake and neurodegenerative diseases using Cox regression models with full adjustments for potential confounders.

A Novel MZI Fiber Sensor with Enhanced Curvature and Strain Sensitivity Based on Four-Core Fiber.

We present a high-sensitivity curvature and strain Mach-Zehnder interferometer (MZI) fiber sensor based on a configuration of no-core fiber (NCF) and four-core fiber (FCF). We used an optical fiber fusion splicer to directly splice a segment of FCF between two segments of NCF, with both the FCF and NCF made of SiO, where the FCF exhibits multi-path interference characteristics that allow for higher sensitivity. The NCF, with its self-focusing property, excites higher-order modes, which split and transmit it into the four cores of the FCF.

Digital-based emergency prevention and control system: enhancing infection control in psychiatric hospitals.

Background: The practical application of infectious disease emergency plans in mental health institutions during the ongoing pandemic has revealed significant shortcomings. These manifest as chaotic management of mental health care, a lack of hospital infection prevention and control (IPC) knowledge among medical staff, and unskilled practical operation. These factors result in suboptimal decision-making and emergency response execution.

Development and validation of a novel immune-related prognostic model and the potential metastatic mechanism in synovial sarcoma.

Background: Several clinical trials have shown that immunotherapy plays a pivotal role in the treatment of patients with metastatic synovial sarcoma. Immune-related genes (IRGs) have been demonstrated to predict the immunotherapy response in certain malignant tumours. However, the clinical significance of IRGs in patients with synovial sarcoma (SS) is still unclear.

Mechanical prediction method of strata movement and surface subsidence in backfill-strip mining.

Underground coal excavation has caused a series of geological disasters and environmental problems, especially coal mining subsidence. Backfill-strip mining, which combines the advantages of strip mining and backfill mining, can reduce subsidence and improve the recovery rate of coal. Therefore, predicting the impact of backfill-strip mining on the surface environment and strata structure is essential for the better development of backfill-strip mining technology.

Optimizing load scheduling and data distribution in heterogeneous cloud environments using fuzzy-logic based two-level framework.

Cloud environment handles heterogeneous services, data, and users collaborating on different technologies and resource scheduling strategies. Despite its heterogeneity, the optimality in load scheduling and data distribution is paused due to unattended requests for a prolonged time. This article addresses the aforementioned issue using a Two-level Scheduling and Distribution Framework (TSDF) using Fuzzy Logic (FL).

Nickel-titanium alloy porous scaffolds based on a dominant cellular structure manufactured by laser powder bed fusion have satisfactory osteogenic efficacy.

Nickel-titanium (NiTi) alloy is a widely utilized medical shape memory alloy (SMA) known for its excellent shape memory effect and superelasticity. Here, laser powder bed fusion (LPBF) technology was employed to fabricate a porous NiTi alloy scaffold featuring a topologically optimized dominant cellular structure that demonstrates favorable physical and superior biological properties. Utilizing a porous structure topology optimization method informed by the stress state of human bones, two types of cellular structures-compression and torsion-were designed, and porous scaffolds were produced via LPBF.

Retrospective analysis of the clinical outcomes of paraspinal soft-tissue sarcoma.

Background Context: Due to the rarity and heterogeneity, paraspinal soft-tissue sarcomas represent a unique and challenging clinical entity for musculoskeletal oncologist. Reports on the treatment of paraspinal soft-tissue sarcoma are limited and the best treatment modality for this rare sarcoma type has not yet been well defined.

Purpose: To introduce a modified classification of paraspinal sarcoma, review the outcome of patients treating in our center and determine the effective treatment for paraspinal soft-tissue sarcoma.

Predictive efficacy of machine-learning algorithms on intrahepatic cholestasis of pregnancy based on clinical and laboratory indicators.

Objectives: Intrahepatic cholestasis of pregnancy (ICP), a condition exclusive to pregnancy, necessitates prompt identification and intervention to improve the perinatal outcomes. This study aims to develop suitable machine-learning models for predicting ICP based on clinical and laboratory indicators.

Methods: This study retrospectively analyzed data from 1092 pregnant women, with 537 diagnosed with ICP and 555 healthy cases as a control.

Milk fat globule membranes ameliorate diet-induced obesity in mice by modulating glucolipid metabolism, body inflammation, and oxidative stress.

This study aimed to explore the lipid-lowering effect and the mechanism of action of the milk fat globule membrane (MFGM) in obese mice. All findings indicated that MFGM supplementation impeded weight gain in mice with obesity. qPCR and western blot analysis further revealed that MFGM could reduce lipid deposition and improve lipid metabolism by downregulating the expression levels of Fas, Scd1, PPARγ, and Srebp-1c and increasing the expression levels of Mcad, Cpt-1c, and PPAR-α.

Exosomal miRNAs as Participators of Hexavalent Chromium-Induced Genotoxicity and Immunotoxicity: A Two-Stage Population Study.

Genotoxic and immunosuppressive characteristics are central to the carcinogenic profile of hexavalent chromium [Cr(VI)], with dysregulation of circulating exosomal miRNA potentially acting as oncogenes or tumor suppressors or participating in the carcinogenic landscape of heavy metals through immunomodulation. In this two-stage epidemiological investigation, we unveiled for the first time the perturbations of exosomal miRNAs among individuals exposed to Cr(VI), alongside their significant correlations with biomarkers of genetic injury (γ-H2AX positivity in circulating lymphocytes and the urinary 8-OHdG levels) and immunological indicators (immunosuppressive PD-1 expression), which was supported by validation in an external cohort. Employing a support vector machine model, we discerned that exosomal miRNAs, particularly miR-4467, miR-345-5p, miR-144-3p, and miR-206, exhibited a remarkable capacity to delineate the genetic damage stratum within the population with high precision, and the target genes predicted of these miRNAs further elucidated their intricate regulatory interplay with the effector biomarkers.

Uterine first-pass effect: Unlocking the potential of vaginally administered ritodrine-loaded thermosensitive gel for uterine drug delivery.

Preterm birth (PTB) remains a leading cause of infant mortality and morbidity, significantly affecting the long-term health, welfare, and development of newborns. Tocolytics, such as ritodrine, a β-adrenergic receptor agonist, are widely used in developing countries due to their affordability for preventing PTB by inhibiting uterine contractions. However, ritodrine's short half-life necessitates frequent administration, and prolonged high-dose usage often leads to serious maternal side effects, prompting discontinuation.

Health risks of rare earth elements exposure: Impact on mitochondrial DNA copy number and micronucleus frequency.

Toxic effects in terms of mitochondria and hereditary substances have been characterized in vitro for individual rare earth elements, while, the joint effects of mixed elements exposure in the population remain ambiguous. Based on the Occupational Chromate Exposure Dynamic Cohort of China, this study investigated the relationship between 15 blood rare earth elements (cerium, dysprosium, erbium, europium, gadolinium, holmium, lanthanum, lutetium, neodymium, praseodymium, samarium, terbium, thulium, yttrium, and ytterbium) and mitochondrial DNA copy number (MtDNACN) as well as peripheral blood lymphocyte micronucleus frequency (MNF). The elastic net was used to select elements highly correlated with effect indicators, whose dose-response relationships were further illustrated by restricted cubic splines.

Robot-assisted partial splenectomy for benign splenic tumors: Four case reports.

Background: Robotic-assisted partial splenectomy (RAPS) is a superior approach for treating splenic cysts and splenic hemangiomas, as it preserves the immune function of the spleen and reduces the risk of overwhelming post splenectomy infection. Currently, there are no standardized guidelines for performing a partial splenectomy.

Case Summary: Four patients with splenic cysts or splenic hemangiomas were treated by RAPS.

Associations between multi-metal joint exposure and decreased estimated glomerular filtration rate (eGFR) in solar greenhouse workers: A study of a unique farmer group.

Background: Solar greenhouse workers, a unique farmer group, have been reported to have a higher risk of chronic kidney disease (CKD) compared to the general population, possible due to exposure to multiple metals.

Objective: This study aimed to investigate the associations between exposure to multiple metals and the estimated glomerular filtration rate (eGFR).

Methods: A cross-sectional study was conducted in the Northwest China.

All-fiber tunable mode converter for a mini-two-arm Mach-Zehnder interferometer.

In this Letter, an all-fiber tunable mode converter for a mini-two-arm Mach-Zehnder interferometer (MTA-MZI) is proposed and realized for the first time to our knowledge. Employing an electric arc discharge technology, we couple a multi-mode fiber (MMF) and a single-mode fiber (SMF), resulting in an MZI characterized by centimeter-scale arms. The varied sensitivity of fiber modes to curvature makes the high-order modes of the MMF more prone to leakage when subjected to bending, leading to alterations in the output interference fringe pattern of the MZI.

Camrelizumab in combination with doxorubicin, cisplatin, ifosfamide, and methotrexate in neoadjuvant treatment of resectable osteosarcoma: A prospective, single-arm, exploratory phase II trial.

Background: The poor overall survival of osteosarcoma (OS) underscores the need to explore new therapeutic avenues. Tumor necrosis rate (TNR) after neoadjuvant chemotherapy predicts prognosis.

Aims: The study was to investigate safety and activity of neoadjuvant chemotherapy with camrelizumab (a humanized antibody against PD-1) in patients with resectable OS.

Roles of LncRNA ARSR in tumor proliferation, drug resistance, and lipid and cholesterol metabolism.

Cancer is one of the most serious diseases that threaten human life and health. Among all kinds of diseases, the mortality rate of malignant tumors is the second highest, second only to cardio-cerebrovascular diseases. Cancer treatment typically involves imaging, surgery, and pathological analysis.

High-Sensitivity Curvature Fiber Sensor Based on Miniature Two-Path Mach-Zehnder Interferometer.

This paper introduces a new high-sensitivity curvature fiber sensor based on a miniature two-path Mach-Zehnder interferometer (MTP-MZI). The sensor is fabricated by coupling and fusing the multimode fiber (MMF) with the single-mode fiber (SMF) using arc fusion technology (AFT), resulting in a centimeter-level two-path MZI structure. The sensor represents an innovative approach to MZI coupling technology, which reduces device size, simplifies manufacturing, and lowers costs.

Manipulation and applications of ultrafast all-optical switching based on transient absorption and dispersion in KTN crystals.

Potassium tantalate niobate (KTN) represents a noteworthy category of optical crystals known for their superior nonlinear optical properties. In this study, we conducted measurements of femtosecond time-resolved transient absorption (TA) spectra in KTaNbO crystals. Notably, a rapid and pronounced "plateau" phase, ∼1.

Design and validation of a novel 3D-printed glenohumeral fusion prosthesis for the reconstruction of proximal humerus bone defects: a biomechanical study.

Background: All available methods for reconstruction after proximal humerus tumor resection have disadvantages, and the optimal reconstruction method remains uncertain. This study aimed to design a novel 3D-printed glenohumeral fusion prosthesis and verify its feasibility and safety using biomechanical methods.

Methods: We verified the feasibility and safety of the 3D-printed glenohumeral fusion prosthesis by finite element analysis and biomechanical experimentation.