Theoretical Study on the Kinetics of Secondary Oxygen Addition Reactions for N-Butyl Radicals.

Chemical kinetics for second oxygen addition reactions (·QOOH + O) of long-chain alkanes are of great importance in low-temperature combustion technologies. However, kinetic data for key reactions of ·QOOH + O systems are often difficult to obtain experimentally and are primarily estimated or calculated by using theoretical methods. In this work, barrier heights (BHs), reaction energies (Δs), and relative energies (REs) of stationary points for key reactions of two representative ·QOOH + O systems in the low-temperature oxidation of -butyl as well as pressure-dependent rate constants for the involved reactions are calculated with the high-level quantum chemical method CCSD(T)-F12b/CBS.

Addiction Memory, Family Functioning, and Depression in Illicit Drug Users: Self-Esteem as a Mediator.

Depression is a common issue among illicit drug users. However, the interaction between addiction memory, family functioning, and depressive symptoms remains insufficiently examined. This study investigates the relationship between addiction memory, family functioning, and depressive symptoms, with self-esteem serving as a mediator.

Advanced Bioresponsive Drug Delivery Systems for Promoting Diabetic Vascularized Bone Regeneration.

The treatment of bone defects in diabetes mellitus (DM) patients remains a major challenge since the diabetic microenvironments significantly impede bone regeneration. Many abnormal factors including hyperglycemia, elevated oxidative stress, increased inflammation, imbalanced osteoimmune, and impaired vascular system in the diabetic microenvironment will result in a high rate of impaired, delayed, or even nonhealing events of bone tissue. Stimuli-responsive biomaterials that can respond to endogenous biochemical signals have emerged as effective therapeutic systems to treat diabetic bone defects via the combination of microenvironmental regulation and enhanced osteogenic capacity.

Improved fractional-order gradient descent method based on multilayer perceptron.

The fractional-order gradient descent (FOGD) method has been employed by numerous scholars in Artificial Neural Networks (ANN), with its superior performance validated both theoretically and experimentally. However, current FOGD methods only apply fractional-order differentiation to the loss function. The application of FOGD based on Autograd to hidden layers leverages the characteristics of fractional-order differentiation, significantly enhancing its flexibility.

A super soft thermoplastic biodegradable elastomer with high elasticity for arterial regeneration.

Elastomers with innovative performance will provide new opportunities for solving problems in soft tissue repair, such as arterial regeneration. Herein, we present a thermoplastic biodegradable elastomer (PPS) that differs from the rigid, low-elastic traditional ones. It shows super softness (0.

Dual-biomimetic curved compound-eye camera system for multi-target distance measurement in a large field of view.

Biomimetic curved compound-eye cameras (BCCECs) have attracted great attention for their potential applications in a variety of fields such as target recognition, monitor and three-dimensional localization in military due to their unique optical properties such as large field of view (FOV) and small size. In this work, we proposed a multi-target distance measurement method based on a dual-BCCEC system in a large FOV. To guarantee the precise measurement of the distance of multiple targets, a feature point searching and matching algorithm is developed for the dual-BCCEC system to improve the localizing efficiency of common feature points.

ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma.

Cholesterol metabolism reprogramming plays essential roles in hepatocellular carcinoma (HCC). However, precisely how cholesterol metabolism is dysregulated is not clear. Here, we show that the palmitoyltransferase ZDHHC3 and depalmitoylase ABHD17A regulate HCC cell cholesterol biosynthesis by dynamically S-acylating SREBP cleavage-activating protein (SCAP).

Advancing characterization of VOC diffusion in indoor fabrics: A dual-porosity modeling approach.

Volatile organic compounds (VOCs) are major chemical pollutants in indoor air. Indoor fabrics, such as curtains, carpets, sofas, and clothes, strongly adsorb VOCs due to their high loading rates and large specific surface areas. The desorption of VOCs from these fabrics can act as a secondary source, worsening indoor air pollution and prolonging its effects.

Meticulously engineered three-dimensional-printed scaffold with microarchitecture and controlled peptide release for enhanced bone regeneration.

The repair of large load-bearing bone defects requires superior mechanical strength, a feat that a single hydrogel scaffold cannot achieve. The objective is to seamlessly integrate optimal microarchitecture, mechanical robustness, vascularisation, and osteoinductive biological responses to effectively address these critical load-bearing bone defects. To confront this challenge, three-dimensional (3D) printing technology was employed to prepare a polycaprolactone (PCL)-based integrated scaffold.

Deep Ensemble Learning-Based Sensor for Flotation Froth Image Recognition.

Froth flotation is a widespread and important method for mineral separation, significantly influencing the purity and quality of extracted minerals. Traditionally, workers need to control chemical dosages by observing the visual characteristics of flotation froth, but this requires considerable experience and operational skills. This paper designs a deep ensemble learning-based sensor for flotation froth image recognition to monitor actual flotation froth working conditions, so as to assist operators in facilitating chemical dosage adjustments and achieve the industrial goals of promoting concentrate grade and mineral recovery.

CDC6 overexpression contributes to the malignant phenotype of glioma via IL6/JAK2/STAT3 signaling.

Glioma, a prevalent primary tumor of the central nervous system, is targeted by molecular therapies aiming to intervene in specific genes and signaling pathways to inhibit tumor growth and spread. Our previous bioinformatics study revealed that significant CDC6 overexpression in gliomas was closely correlated with poor patient prognosis. Through qPCR, western blotting, and immunohistochemistry, we will further validate CDC6 expression in clinical glioma specimens, while the effects of silencing and overexpressing CDC6 in the U87 and LN229 glioma cell lines on malignancy will be assessed through MTS, EdU, transwell, and migration assays.

Study on the Resistance of Concrete to High-Concentration Sulfate Attack: A Case Study in Jinyan Bridge.

Concrete structures face significant challenges in sulfate-rich environments, where sulfate attack can affect their durability and structural integrity. This study explores innovative approaches to enhancing concrete performance by integrating hydrophobic and densification technologies. It emphasizes the critical role of anti-sulfate erosion inhibitors in mitigating sulfate-induced damage, reducing water absorption, and inhibiting corrosive reactions.

Designing Microneedle Patch for Prophylaxis of Postoperative Atrial Fibrillation.

Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery, which often occurs within 30 postoperative days, especially peaking at 2-3 days. Antiarrhythmic medications such as amiodarone are recommended in clinical practice for the prophylaxis and treatment of POAF. However, conventional oral administration is hindered due to delayed drug action and high risks of systemic toxicity, and emerging localized delivery strategies suffer from a limited release duration (less than 30 days).

Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer.

Tumor cells reprogram their metabolism to produce specialized metabolites that both fuel their own growth and license tumor immune evasion. However, the relationships between these functions remain poorly understood. Here, we report CRISPR screens in a mouse model of colo-rectal cancer (CRC) that implicates the dual specificity phosphatase 18 (DUSP18) in the establishment of tumor-directed immune evasion.

The effectiveness of positive psychological interventions for patients with cancer: A systematic review and meta-analysis.

Aims And Objectives: To evaluate the effectiveness of positive psychological interventions on quality of life, positive psychological outcomes and negative psychological outcomes in patients with cancer.

Background: Patients with cancer often suffer from various psychological problems and have a poor quality of life. Positive psychological interventions have been increasingly applied to patients with cancer, but the results of these studies have not been synthesized.

Psychometric properties and measurement invariance of the Chinese version of the cognitive emotion regulation questionnaire-short in patients with cancer.

Objective: The study aimed to evaluate the psychometric properties and measurement invariance (MI) of the Chinese version of the cognitive emotion regulation questionnaire-short (CERQ-short) in cancer patients.

Methods: This cross-sectional study included 505 cancer patients from mainland China. In addition to sociodemographic and clinical characteristics, the CERQ-short and the distress thermometer were included in the study measures.

Designing prepacked aggregate concrete for improved mechanical properties and its field application in constructing steel tube concrete.

Prepacked aggregate concrete (PAC) is made by placing coarse aggregates of various sizes into a formwork and then filling the voids between coarse aggregate and grout. The mechanical performance of PAC is dominated by the compactness due to grout filling, but few study considered the pouring methods and grout performance synchronously. The coupled effect of pouring methods and grout performance on the compactness of PAC is investigated in this study.

Investigating the Effects of AL049796.1 Silencing in Inhibiting High Glucose-Induced Colorectal Cancer Progression.

Patients with colorectal cancer (CRC) and diabetes share many risk factors. Despite a strong association between diabetes and CRC being widely studied and confirmed, further genetic research is needed. This study found higher AL049796.

Characterization of the gut butyrate-producing bacteria and lipid metabolism in African green monkey as a natural host of simian immunodeficiency virus infection.

Objective: Natural hosts of simian immunodeficiency virus (SIV), such as the African green monkey (AGM), possess the ability to avoid acquired immune deficiency syndrome (AIDS) despite lifelong infection. The underlying mechanisms are not completely understood. This study aimed to characterize the gut microbiome and metabolite profiles of different nonhuman primates (NHPs) to provide potential insight into AIDS resistance.

C/EBPβ-Lin28a positive feedback loop triggered by C/EBPβ hypomethylation enhances the proliferation and migration of vascular smooth muscle cells in restenosis.

Background: The main cause of restenosis after percutaneous transluminal angioplasty (PTA) is the excessive proliferation and migration of vascular smooth muscle cells (VSMCs). Lin28a has been reported to play critical regulatory roles in this process. However, whether CCAAT/enhancer-binding proteins β (C/EBPβ) binds to the Lin28a promoter and drives the progression of restenosis has not been clarified.

The association between dietary vitamin B1 intake and constipation: a population-based study.

Background: Numerous researches have indicated a correlation between the intake of dietary micronutrients and the occurrence of constipation. Nevertheless, the correlation between constipation and vitamin B1 remains uninvestigated. The main aim of this research was to examine the association between chronic constipation and the consumption of vitamin B1 in the diet among adult participants of the National Health and Nutrition Examination Survey (NHANES).

Modified Composite Biodegradable Mulch for Crop Growth and Sustainable Agriculture.

Using biodegradable films as a substitute for conventional polyolefin films has emerged as a crucial technology to combat agricultural white pollution. To address the shortcomings in the tensile strength, water vapor barrier properties, and degradation period of PBAT-based biodegradable films, this investigation aimed to create a composite film that could improve the diverse properties of PBAT films. To achieve this, a PBAT/PLA-PPC-PTLA ternary blend system was introduced in the study.

Widely targeted metabolomics reveals differences in metabolites of Paeonia lactiflora cultivars.

Introduction: Paeonia lactiflora contains diverse active constituents and exhibits various pharmacological activities. However, only partial identification of biologically active substances from P. lactiflora has been achieved using low-throughput techniques.