Carrier-Induced Room-Temperature Half-Metallicity in an Exfoliable Two-Dimensional Cr(TCNB) Metal-Organic Framework.

Half-metallicity, enabling 100% spin polarization, is pivotal for spintronics but remains challenging to achieve in low-dimensional materials. Using first-principles calculations, we theoretically propose an experimentally feasible two-dimensional (2D) metal-organic framework (MOF) magnetic semiconductor, Cr(TCNB) (TCNB = 1,2,4,5-tetracyanobenzene). This monolayer can be exfoliated from a Ag(100) substrate due to its low exfoliation energy of 0.

A novel conditioning regimen with pre-transplantation immunosuppression reduces the complication rates in hematopoietic stem cell transplantation in transfusion-dependent β-thalassemia.

Background: Allo-HSCT is a curative therapy for patients with transfusion-dependent thalassemia (TDT). The high incidence of transplant-related complications is becoming an obstacle to safe and effective unrelated donor (URD) transplantation.

Methods: In this retrospective study, we reported the survival outcomes and complications of transplantation in thalassemia patients using a novel regimen consisting of pre-transplantation immunosuppression (PTIS) and modified myeloablative conditioning based on intravenous busulfan, cyclophosphamide, fludarabine, and rabbit anti-human thymocyte immunoglobulin.

Spintronic terahertz metasurface emission characterized by scanning near-field nanoscopy.

Understanding the ultrafast excitation, detection, transportation, and manipulation of nanoscale spin dynamics in the terahertz (THz) frequency range is critical to developing spintronic THz optoelectronic nanodevices. However, the diffraction limitation of the sub-millimeter waves - THz wavelengths - has impaired experimental investigation of spintronic THz nano-emission. Here, we present an approach to studying laser THz emission nanoscopy from W|CoFeB|Pt metasurfaces with ∼60-nm lateral spatial resolution.

Percutaneous hepatic artery infusion chemotherapy with oxaliplatin and fluoropyrimidines in treatment-resistant colorectal cancer patients with unresectable liver metastases: a retrospective cohort study.

Background: Subsequent lines of therapy for chemotherapy-resistant metastatic colorectal cancer (CRC) have shown limited efficacy. Herein, we retrospectively investigated the efficacy and safety of hepatic artery infusion chemotherapy (HAIC) using oxaliplatin plus 5-FU/FUDR in patients with unresectable colorectal liver metastases (CRLM) who progressed following standard chemotherapy regimens.

Methods: From March 2017 to April 2023, CRC patients with unresectable CRLM who progressed following standard chemotherapy and subsequently received HAIC oxaliplatin plus 5-FU/FUDR were evaluated.

Choice of communication mode at home and speechreading performance of adolescents with hearing impairment in China.

The ability to speechread is often critical for persons with hearing impairment (HI), who may depend on speechreading to access the spoken language and interact with the hearing world. It is not clear, however, whether the primary mode of communication at home will influence speechreading abilities of young adults with HI even when they are enrolled in the same school with the same communication or instructional methods. Thirty-two hearing-impaired adolescents whose parents chose spoken language as the primary mode of communication of the family (the SPOKEN group) and thirty-two hearing-impaired adolescents with sign language as the primary mode of communication of the family (the SIGN group) were administered a Chinese speechreading battery consisting of tests at monosyllabic word, disyllabic word and sentence levels.

TENet: Targetness entanglement incorporating with multi-scale pooling and mutually-guided fusion for RGB-E object tracking.

There is currently strong interest in improving visual object tracking by augmenting the RGB modality with the output of a visual event camera that is particularly informative about the scene motion. However, existing approaches perform event feature extraction for RGB-E tracking using traditional appearance models, which have been optimised for RGB only tracking, without adapting it for the intrinsic characteristics of the event data. To address this problem, we propose an Event backbone (Pooler), designed to obtain a high-quality feature representation that is cognisant of the innate characteristics of the event data, namely its sparsity.

Simultaneous Regulating the Surface, Interface, and Bulk via Phosphating Modification for High-Performance Li-Rich Layered Oxides Cathodes.

Li-rich Mn-based layered oxides (LRMOs) are regarded as the leading cathode materials to overcome the bottleneck of higher energy density. Nevertheless, they encounter significant challenges, including voltage decay, poor cycle stability, and inferior rate performance, primarily due to irreversible oxygen release, transition metal dissolution, and sluggish transport kinetics. Moreover, traditionally single modification strategies do not adequately address these issues.

Safety and efficacy of adjuvant FOLFOX/FOLFIRI with versus without hepatic arterial infusion of floxuridine in patients following colorectal cancer liver metastasectomy (HARVEST trial): A randomized controlled trial.

Background: Hepatic artery infusion (HAI) chemotherapy, particularly with floxuridine (FUDR), has previously shown effectiveness in improving recurrence-free survival (RFS) in colorectal cancer (CRC) patients with colorectal liver metastases (CRLM). Nonetheless, its adjuvant use alongside modern systemic chemotherapy remains unevaluated.

Patients And Methods: The HARVEST trial is an open-label, randomized, controlled study conducted from May 2018 to August 2021.

Tauroursodeoxycholic acid mitigates depression-like behavior and hippocampal neuronal damage in a corticosterone model of female mice.

Depression, a complex mental disorder influenced by both psychological and physiological factors, predominantly affects females. Studies have indicated that elevated levels of cortisol/corticosterone (CORT) under stress conditions can lead to hippocampal neuronal damage, thereby contributing to depression. Tauroursodeoxycholic acid (TUDCA), a bile acid, possesses anti-apoptotic, antioxidant, and anti-inflammatory properties.

Flexible bioelectronic systems with large-scale temperature sensor arrays for monitoring and treatments of localized wound inflammation.

Continuous monitoring and closed-loop therapy of soft wound tissues is of particular interest in biomedical research and clinical practices. An important focus is on the development of implantable bioelectronics that can measure time-dependent temperature distribution related to localized inflammation over large areas of wound and offer in situ treatment. Existing approaches such as thermometers/thermocouples provide limited spatial resolution, inapplicable to a wearable/implantable format.

Qualitative and Quantitative Luminescence Detection of 2,6-Dipicolinic Acid and Levofloxacin Based on a High-Nuclearity Eu(III) Nanomolecular Sensor.

Rapid and accurate testing of 2,6-dipicolinic acid (DPA) and levofloxacin (LFX) has been attracting much attention due to the fact that the former is an important biomarker of anthrax spores and the latter is a third-generation fluoroquinolone drug and has been recognized as an important environmental pollutant. Herein, we report the preparation of a 13-metal Eu(III) nanomolecular sensor (molecular sizes: 2.0 × 2.

Rapid and sensitive detection of vanillylmandelic acid based on a luminescent fourteen-metal Tb(III) planar nanocluster.

A 14-metal Tb(III) nanocluster with four CO anions as templates was constructed for the quantitative and qualitative detection of vanillylmandelic acid (VMA) with high sensitivity and selectivity. The luminescence response time to VMA is less than ten seconds, and the limit of detection is as low as 0.32 nM in CHCN.

Dan-shen Yin attenuates myocardial fibrosis after myocardial infarction in rats: Molecular mechanism insights by integrated transcriptomics and network pharmacology analysis and experimental validation.

Ethnopharmacological Relevance: Dan-shen Yin (DSY) originated from the "Shi Fang Ge Kuo" is a Chinese formula composed of three medicines: Salvia miltiorrhiza (Dan-shen), Santalum album L. (Tan-xiang) and Amomum villosum Lour. (Sha-ren).

Unlocking Topological Effects in Covalent Organic Frameworks for High-Performance Photosynthesis of Hydrogen Peroxide.

Covalent organic frameworks (COFs) offer a compelling platform for the efficient photosynthesis of hydrogen peroxide (HO). Constructed with diverse topologies from various molecular building units, COFs can exhibit unique photocatalytic properties. In this study, three π-conjugated 2D sp carbon-linked COFs with distinctly different topologies (hcb, sql, and hxl) are designed to investigate the topological effect on the overall photosynthesis of HO from water and oxygen.

Interfacial Electric Field Enhanced Free-Standing VO/rGO Aerogel Anode with Ultra High Mass Energy Density for Aqueous Ammonium Ion Battery.

Aqueous batteries have become a promising means of energy storage due to its environmental friendliness. Nevertheless, it often exhibits limited energy density that hinder their application. Considering that ammonium ion (NH ) has a low mass and a small hydration radius, aqueous ammonium ion batteries (AAIBs) are expected to solve the problem of low energy density.

Recanalization of anastomotic occlusion following rectal cancer surgery using a rendezvous endoscopic technique with transillumination: A case report.

Background: Colorectal anastomotic occlusion is a serious complication of colorectal cancer surgery. Although several treatment strategies have been proposed, the management of anastomotic occlusion remains challenging. In this report, we present a case of anastomotic occlusion recanalization performed using a novel technique involving two endoscopes, one for radial incision and the other serving as a guide light.

Interactions and communications in the prostate tumour microenvironment: evolving towards effective cancer therapy.

Prostate cancer is one of the most common malignancies in men. The tumour microenvironment (TME) has a critical role in the initiation, progression, and metastasis of prostate cancer. TME contains various cell types, including cancer-associated fibroblasts (CAFs), endothelial cells, immune cells such as macrophages, lymphocytes B and T, natural killer (NK) cells, and other proteins such as extracellular matrix (ECM) components.

Balancing Potassiophilicity and Catalytic Activity of Artificial Interface Layer for Dendrite-Free Sodium/Potassium Metal Batteries.

Potassium metal batteries (PMBs), with high energy density and low cost, are considered a promising option for grid-scale energy storage systems. However, challenges such as the uneven nucleation of K and instability of the solid electrolyte interphase (SEI) layer result in dendrite growth and poor cyclic performance, limiting practical application. To address them, constructing an artificial interface layer with rich defects can enhance the potassium affinity and promote the uniform nucleation of potassium, yet this can also catalyze electrolyte to decompose, leading to unstable SEI formation and poor cycle stability.

Neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy for initially unresectable locally advanced colon cancer: short-term outcomes of an open-label, single-centre, randomised, controlled, phase 3 trial.

Background: Neoadjuvant chemotherapy (NACT) is commonly used to downstage the tumor in locally advanced colon cancer (LACC) and improve the R0 resection rate. Neoadjuvant chemoradiotherapy (NACRT) is the standard treatment for locally advanced rectal and esophageal cancers, but its benefits in LACC remain poorly understood. This study aimed to compare the effects and safety of NACRT and NACT on R0 resection and survival rates in initially unresectable LACC.

Enhancing Magnetic Ordering in Two-Dimensional Metal-Organic Frameworks via Frontier Molecular Orbital Engineering.

Two-dimensional (2D) metal-organic frameworks (MOFs) have promise for use in lightweight permanent magnets in contrast to inorganic solid- or molecule-based magnets, but the realization of 2D MOF magnets with a high ordering temperature is limited by the typically weak spin exchange interactions. Here, we have proposed a frontier molecular orbital engineering strategy for modulating magnetism in 2D MOFs. It shows that the magnetic ground state can be mediated by two intra-atomic spin exchange pathways in organic ligands, akin to the Bloch and Heisenberg models, depending on the shape of the frontier orbitals of the organic ligands.

Dried bear bile exerts its antidepressant effect by modulating adrenal FXR to reduce peripheral glucocorticoid levels.

Depression is a psychological disorder associated with prolonged stress, which involves abnormal activation of the hypothalamic-pituitary-adrenal (HPA) axis, leading to elevated levels of glucocorticoids (GC). Excessive GC can cause damage to the structure and function of the hippocampus, thereby triggering depressive symptoms. Studies suggest that the bile acid receptor farnesoid X receptor (FXR) may play a role in adrenal GC synthesis.

Prebiotic inulin controls Th17 cells mediated central nervous system autoimmunity through modulating the gut microbiota and short chain fatty acids.

Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory demyelination occurring in the central nervous system (CNS). Inulin is a common prebiotic that can improve metabolic disorders by modulating the gut microbiota. However, its capacity to affect CNS autoimmunity is poorly recognized.