Oral Lactoferrin-Responsive Formulation Anchoring around Inflammatory Bowel Region for IBD Therapy.

Oral formulation is the ideal treatment method for inflammatory bowel disease (IBD) therapy, but the mucosal damage and diarrhea symptoms impede the drug retention around the inflammatory region, severely limiting IBD therapeutic efficacy. To address this, an oral astaxanthin (Ast) precise delivery formulation is developed with the selective Ast anchoring around the inflammatory region by the novel lactoferrin (LF)-responsive flocculation. This formulation also heightens the apparent solubility of Ast with the minimized edible safety risks for the edible raw materials.

Distribution dynamics, spatial differences, and convergence of synergistic pollution and carbon reduction in China.

Carbon and pollution reduction are highly synergistic elements of green development, and the detailed derivation of the synergistic relationship is urgently needed. Based on the research perspective of coupling coordination, this paper firstly bases on the research perspective of coupling synergy, takes 30 provinces in China as the research object from 2011 to 2022, and constructs a coupling coordination degree model to measure the synergistic effect of pollution reduction and carbon reduction; secondly, kernel density and Dagum coefficient are used to analyze the spatial and temporal characteristics, spatial differences and sources of differences in the synergistic effects of pollution reduction and carbon reduction in China as a whole, in the three major regions and in each province; finally, the Moran index is applied to test the spatial agglomeration characteristics of the synergistic effect of pollution reduction and carbon reduction, and the spatial panel model is applied to test its β-convergence. The study shows that (1) during the study period, the level of synergistic effect on carbon reduction in China changed from good coordination to good coordination, and the synergistic effect in the western region was significantly better than that in the eastern and central regions; (2) the synergistic effect of pollution reduction and carbon reduction in China as a whole and the three regions showed obvious spatial differences, but the differences were gradually narrowing, and the supervariable density was the dominant factor of the overall differences; (3) as a whole, the synergistic effect of pollution reduction and carbon reduction among provinces has a spatial agglomeration effect, and the level of synergistic effect of pollution reduction and carbon reduction across the country and east and west regions has a significant absolute β convergence trend, while there is a significant conditional β convergence trend across the country and the three major regions, and the eastern and central regions with a low synergy level have a higher convergence rate, indicating that as time goes by, under the influence of various factors, the synergistic effect will converge to the steady state level.

Mapping retracted articles and exploring regional differences in China, 2012-2023.

Background: China is one of the top countries with the most significant number or proportion of retracted publications, which has garnered significant attention.

Methods: Using the Retraction Watch Database, we collected retracted articles written by Chinese authors from 31 provinces in mainland China, spanning the period between January 1, 2012, and December 31, 2023. We used Geographical Information Science to analyze spatial distribution characteristics of retracted articles by Chinese authors and identify high-risk clusters of retracted areas.

Furan-based renewable elastomers as effective tougheners for PLA: Enhanced mechanical properties and water vapor barrier properties.

There is a great need for versatile biomass additives sourced from renewable materials to enhance the performance of polylactic acid (PLA) composites. This study introduces a furan-based polyester elastomer called PNF-PBC that is designed to improve the mechanical and water vapor barrier characteristics of PLA. By incorporating PNF-PBC into PLA, the toughness of the PLA/PNF-PBC biocomposites was considerably enhanced through various intermolecular interactions.

Developing a risk model for early diagnosis of metabolic syndrome in Chinese adults aged 40 years and above based on BMI/HDL-C: a cross-sectional study.

Background: This study aimed to compare the diagnostic accuracy of four indicators, including waist-to-height ratio (WHTR), vascular adiposity index (VAI), TG/HDL-C, and BMI/HDL-C for metabolic syndrome (MS) in Chinese adults aged 40 years and above. Additionally, the study aimed to develop an efficient diagnostic model displayed by a nomogram based on individual's BMI and circulating HDL-C level.

Methods: A cross-sectional study was conducted on 699 participants aged 40 years and above.

Probiotic powder with polysaccharides from Wolfiporia cocos alleviates antibiotic-associated diarrhea by modulating immune activities and gut microbiota.

To enhance immunomodulatory effects of lyophilized probiotics, we screened a new lyophilizing protective agent, that is Wolfiporia cocos polysaccharide (WP). This study demonstrated WP significantly increased the survival rate among seven polysaccharides, with the optimal dosage being 10 % (w/v). The ratio of bacterial suspension to lyophilizing protective agent was 1:2, in the condition, the probiotic survival rate of probiotics reached 83.

The effect of blood flow-restrictive resistance training on the risk of atherosclerotic cardiovascular disease in middle-aged patients with type 2 diabetes: a randomized controlled trial.

Introduction: The aim of this study was to investigate the effects of blood flow-restrictive resistance training (BFR-RT) on improving metabolic abnormalities, blood pressure (BP), obesity, and 10-year atherosclerotic cardiovascular disease (ASCVD) risk in middle-aged patients with type 2 diabetes mellitus (T2DM).

Method: We conducted a parallel-group, single blind randomized controlled trial. Participants who met the inclusion criteria were randomly divided into control group, BFR-RT group and aerobic exercise (AE) group.

Regulatory Effects of Chlormequat Chloride on the Yield and Chemical Composition of Radix.

Chlormequat chloride (CCC), as a commonly used plant growth regulator in the production of rhizomatous medicinal herbs, can effectively control the bolting phenomenon in , significantly increasing the yield of underground rhizomes (medicinal part). However, its specific effects on the intrinsic quality of , especially medicinal components, require further investigation. The objective of this study is to conduct a thorough examination of CCC residue and its influence on the yield and medicinal components of .

Pectins Rich in RG-I Extracted from Watermelon Peel: Physicochemical, Structural, Emulsifying, and Antioxidant Properties.

RG-I pectin has excellent health benefits, but its raw materials are relatively scarce, and its complex structure often breaks down its side-chain structure during the extraction process. In this study, the physicochemical and antioxidant properties of a branched-chain-rich pectin gained from watermelon peel were demonstrated, and the structure-function relationships of RG-I-enriched pectin and emulsification properties were investigated. Fourier transform infrared spectroscopy, high-performance anion exchange chromatography, high-performance gel permeation chromatography, nuclear magnetic resonance spectroscopy, and methylation analyses reveal it as acetylated, low-methoxylated pectin, rich in RG-I side chains (MW: 1991 kDa, RG-I = 66.

Comparison and mechanism analysis of MgO, CaO, and Portland cement for immobilization of heavy metals in MSWI fly ash.

The significant production of municipal solid waste incineration fly ash (MSWI FA) underscores the importance of developing efficient solidification materials. This study employed MgO and CaO for immobilizing MSWI FA (with a 70% fly ash incorporation), and the immobilization effect was compared with that of Portland cement (PC). Experimental findings revealed that MgO exhibited the most effective stabilization for heavy metals (Cd, Cu, Pb, and Zn) compared to CaO and PC.

Structural insights into the catalytic selectivity of glycosyltransferase SgUGT94-289-3 towards mogrosides.

Mogrosides constitute a series of natural sweeteners extracted from Siraitia grosvenorii fruits. These mogrosides are glucosylated to different degrees, with mogroside V (M5) and siamenoside I (SIA) being two mogrosides with high intensities of sweetness. SgUGT94-289-3 constitutes a uridine diphosphate (UDP)-dependent glycosyltransferase (UGT) responsible for the biosynthesis of M5 and SIA, by continuously catalyzing glucosylation on mogroside IIe (M2E) and on the subsequent intermediate mogroside products.

Study on the role and molecular mechanism of METTL3-mediated miR-29a-3p in the inflammatory response of spinal tuberculosis.

Background: Spinal Tuberculosis (STB) is a common cause of spinal malformation caused by extrapulmonary tuberculosis in developing countries, which seriously affects the quality of life of patients. It was found that the expression of miRNAs in macrophages was stable, specific and readily available after Mycobacterium tuberculosis (MTB) infection. Our research group determined the differential expression of miR-29a-3p in the vertebra of spinal tuberculosis and intervertebral disc lesions through RNAs chip screening and bioinformatics analysis.

Metabolic and Microbial Dysregulation in Preterm Infants with Neonatal Respiratory Distress Syndrome: An Early Developmental Perspective.

Neonatal respiratory distress syndrome (NRDS) is one of the most severe respiratory disorders in preterm infants (PTIs) due to immature lung development. To delineate the serum metabolic alterations and gut microbiota variations in NRDS and assess their implications on neonatal development, we enrolled 13 NRDS neonates and 12 PTIs and collected fecal and serum specimens after birth. Longitudinal fecal sampling was conducted weekly for a month in NRDS neonates.

DHA dietary intervention caused different hippocampal lipid and protein profile in ApoE-/- and C57BL/6J mice.

Background: Changes in protein and lipid levels may occur in the Alzheimer's disease brain, and DHA can have beneficial effects on it. To investigate the impact of DHA dietary intervention on brain protein and lipid profile in ApoE-/- mice and C57 mice.

Method: Three-month-old ApoE-/- mice and C57 mice were randomly divided into two groups respectively, and fed with control diet and DHA-fortified diet for five months.

SWI and CTP fusion model based on sparse representation method to predict cerebral infarction trend.

Objective: SWI image signal is related to venous reflux disorder and perfusion defect. Computed tomography perfusion (CTP) contains perfusion information in space and time. There is a complementary basis between them to affect the prognosis of cerebral infarction.

STaRNet: A spatio-temporal and Riemannian network for high-performance motor imagery decoding.

Brain-computer interfaces (BCIs), representing a transformative form of human-computer interaction, empower users to interact directly with external environments through brain signals. In response to the demands for high accuracy, robustness, and end-to-end capabilities within BCIs based on motor imagery (MI), this paper introduces STaRNet, a novel model that integrates multi-scale spatio-temporal convolutional neural networks (CNNs) with Riemannian geometry. Initially, STaRNet integrates a multi-scale spatio-temporal feature extraction module that captures both global and local features, facilitating the construction of Riemannian manifolds from these comprehensive spatio-temporal features.

Suboptimal diet quality is associated with the incidence of type 2 diabetes mellitus in middle-aged and older populations in China: evidence from a population-based cross-sectional study.

The association between dietary quality and type 2 diabetes mellitus (T2DM) based on the Chinese Dietary Balance Index (DBI-16) is seldom reported. We hypothesized that poor dietary quality might increase the risk of T2DM in the middle-aged and older populations. A total of 1816 individuals (≥50 years) were included in the study.