Publications by authors named "XiaoJia Xu"

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  • The study focuses on enhancing the performance of PtSe in photodetectors by utilizing hydrophobic bonding for high-quality n-Si/SOI wafer bonding.
  • The resulting p-PtSe/i-Si/n-Si pin photodetector exhibits impressive spectral detection (532 to 2200 nm) and a high rectification ratio (2.1 × 10), indicating effective device functionality.
  • This research represents a novel method for merging wafer bonding techniques with 2D material transfer, paving the way for improved Si-based photodetector designs.
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  • * It highlights how different cytokines can change IgG-glycosylation patterns, which in turn affects antibody activity and inflammatory responses.
  • * Understanding this relationship provides insights that could lead to better diagnostic tools and treatment options for inflammatory diseases.
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Humans are ubiquitously exposed to crotonaldehyde (CRA) endogenously and exogenously. Deeper knowledge of the pharmacological and toxicological characteristics and the mechanisms of CRA on vasculature is urgently needed for prevention of its harmfulness. The effects of acute and prolonged exposure to CRA were studied in rat isolated arteries and arterial smooth muscle cells (ASMCs).

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  • Palladium diselenide (PdSe) is a 2D material with unique properties that make it promising for electronic and optoelectronic applications, but its performance varies with thickness.
  • A novel PdSe structure featuring a quantum island is developed using a simple method, leading to the creation of an innovative photodetector with a vertical PIN-like structure.
  • This device demonstrates broad spectral absorption and improved performance, achieving a high rectification ratio and a maximum 3 dB frequency of approximately 25 kHz, enhancing its responsivity and carrier collection efficiency.
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Microgels have been widely used for stabilizing emulsions due to their softness and stimulus responsiveness. Although ultrastable emulsions have been prepared by microgel nanoparticles, the role of electrostatic interactions on emulsion stability is still a controversial topic and further investigation of the effect of microgel deformability is required. In the present study, neutral poly(-vinylcaprolactam) (PVCL) and charged poly(-vinylcaprolactam)methacrylic acid (P(VCLMAA)) microgels were synthesized and further used as emulsifiers to stabilizing emulsion.

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  • Tea is a globally popular drink, and its extracts, particularly EGCG from green tea, are studied for their effects on vascular health, necessitating further investigation into Anji white tea's properties.
  • The study aimed to assess the vasomotion effects of Anji white tea and EGCG, focusing on the roles of voltage-gated calcium and potassium channels in these effects.
  • Results showed that Anji white tea significantly relaxed various rat arteries, while EGCG appeared to enhance precontraction in many cases, indicating a complex relationship between tea components and vascular response.
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Few research discuss whether the body measurement indexs of obesity in general populations is applicable to patients with type 2 diabetes. We explore the optimal cutoffs of visceral fat area (VFA) and subcutaneous fat area (SFA) in the diagnosis of central obesity and the cutoffs of corresponding waist circumference (WC) and body mass index (BMI) in patients with Type 2 Diabetes (T2D). Cross-sectional cohort study.

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Glutamate-induced oxidative stress is well-known to play a crucial role in the development of neurodegenerative diseases, such as stroke. Genipin, a natural iridoid compound, has demonstrated potential neuroprotective properties but is unstable in physiological conditions. The present study aimed to develop new derivatives of genipin that exhibit improved stability and activity for the treatment of stroke.

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Cardiovascular diseases (CVDs) are a major global health concern, and oxidative stress is known to play a central role in their pathogenesis. The identification of new agents capable of inhibiting oxidative stress presents a promising strategy for preventing and treating CVDs. Natural products and their derivatives offer a valuable source for drug discovery, and isosteviol, a readily available natural product, is known to exhibit cardioprotective effects.

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In this paper, betaine (Bet) was used as a hydrogen bond acceptor (HBA), and acrylic acid (AA) and acrylamide (AM) were used as hydrogen bond donors (HBD) and mixed to form a deep eutectic solvent (DES). Different concentrations of β-cyclodextrin (β-CD) were dispersed in the DES, and a novel β-CD/P(AA--AM) hydrogel was prepared by frontal polymerization (FP). The characteristic structure and morphology of the hydrogels were analyzed using Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM), and the properties of the hydrogels were investigated.

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  • Glycan-based therapies have gained significant traction in modern medicine since the 20th century, thanks in part to advancements in research and new tools for studying carbohydrates.
  • The emergence of glycomics, a new field focused on the study of glycans, offers exciting potential for understanding and treating complex diseases while enhancing diagnostic and therapeutic development.
  • This review highlights the recent progress that has elevated glycan-based therapies to a prominent position in medicine, showcasing the technologies that have driven these advancements as pivotal successes of the 21st century.
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Cardiovascular diseases (CVDs) remain the leading cause of death globally. Inhibiting ferroptosis and thus preventing cardiac cell death is a promising and effective strategy for cardiomyopathy prevention and therapy. Steviol, an ent-kaurene diterpenoid, possesses broad-spectrum bioactivity.

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  • Steviol is a compound with potential as an anticancer drug, but many of its derivatives have poor selectivity for tumor cells compared to normal cells.
  • In this study, 32 steviol derivatives were synthesized, with some showing improved cytotoxic selectivity and effectiveness against cancer cells.
  • One promising new compound was found to effectively target tumor cells while having low toxicity to normal cells, indicating its potential for further development in cancer treatment.
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  • Deep eutectic solvents (DES) were made using acrylic acid and acrylamide as donors and choline chloride as a receptor, forming composite hydrogels with nitrogen-doped carbon nanotubes (N-CNTs).
  • The mechanical properties, pH response, and conductivity of the resulting N-CNTs/P(AA--AM) hydrogels were significantly enhanced with more N-CNTs, achieving impressive tensile and compressive strengths.
  • The hydrogels displayed strong pH responsiveness and conductivity, with a notable increase in electrical conductivity when N-CNTs were added, enabling use in applications like lighting.
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Trimetazidine exhibits great therapeutic potential in cardiovascular diseases and mitochondria-mediated cardioprotection by trimetazidine has been widely reported. In this study, to enhance its cardioprotection, the triphenylphosphonium-based modification of trimetazidine was conducted to deliver it specifically to mitochondria. Fifteen triphenylphosphonium (TPP) conjugated trimetazidine analogs were designed and synthesized.

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A deep eutectic solvent (DES) was synthesized from urea (U), acrylamide (AM), and choline chloride (ChCl). ZnO was dispersed in the DES as a filler, and nanocomposite hydrogels (ZnO/P(U-AM-ChCl)) were successfully prepared by frontal polymerization (FP). The hydrogels were verified by Fourier infrared spectroscopy to contain ZnO nanoparticles (ZnO-NPs).

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Article Synopsis
  • A new eco-friendly method was developed for creating nanocomposite hydrogels using frontal polymerization in about 4 minutes, which resulted in materials with great mechanical strength and pH responsiveness.
  • The method involves using acrylamide (AM) and choline chloride (ChCl) to produce deep eutectic monomers (DEMs), which are combined with nitrogen-doped carbon nanotubes (N-CNTs) as fillers.
  • Tests confirmed that the PAM/N-CNT hydrogels exhibited improved compressive strength and sensitivity to pH changes, particularly in acidic conditions, due to the interactions between the hydrogels and the N-CNTs.
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A series of mitochondria-targeted triphenylphosphonium conjugated C-3 modified betulin were synthesized and evaluated against tumor cells. As a result, a new derivative 13 i, the conjugate of 3-O-(3'-acetylphenylacetate)-betulin with triphenylphosphonium, was identified as the one with the best anti-tumor effect. Conjugate 13 i significantly inhibited HCT116 cells with IC at 0.

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  • The study evaluated the accuracy of flash continuous glucose monitoring (FCGM) in detecting nocturnal hypoglycemia among Type 2 Diabetes Mellitus (T2DM) patients.
  • A total of 307 out-of-range cases were analyzed from 25,886 FCGM and fingertip blood glucose data, revealing significant differences in "low" and "high" readings at different times of the day, particularly peaking at 3 AM.
  • Results showed that the FCGM's ability to accurately identify low glucose levels is much lower compared to its performance in identifying high levels, suggesting caution in interpreting low FCGM data due to potential adverse implications for patient care.
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Background: Severe acidosis deteriorates cardiac injury. Rat coronary arteries (RCAs) are unusually hypercontractive to extracellular (o) acidosis (EA). TMEM16A-encoded anoctamin 1 (ANO1), a Ca-activated chloride channel (CaCC), plays an important role in regulating coronary arterial tension.

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Cesium lead iodide (CsPbI) perovskite is a promising photovoltaic material with a suitable bandgap and high thermal stability. However, it involves complicated phase transitions, and black-phase CsPbI is mostly formed and stabilized at high temperatures (200-360 °C), making its practical application challenging. Here, for the first time, we have demonstrated a feasible route for growing high quality black-phase CsPbI thin films under mild conditions by using a neutral molecular additive of 4(1)-pyridinethione (4-PT).

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Based on self-assembly, novel electron extraction layers (EELs) composed of naphthalimide (NPI) derivatives are constructed for application in n-i-p perovskite solar cells. Upon molecular energy level modulation, the power conversion efficiencies have been largely improved from 5.4% to 16%.

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The construction of state-of-the-art hole-transporting materials (HTMs) is challenging regarding the appropriate molecular configuration for simultaneously achieving high morphology uniformity and charge mobility, especially because of the lack of appropriate building blocks. Herein a semi-locked tetrathienylethene (TTE) serves as a promising building block for HTMs by fine-tuning molecular planarity. Upon incorporation of four triphenylamine groups, the resulting TTE represents the first hybrid orthogonal and planar conformation, thus leading to the desirable electronic and morphological properties in perovskite solar cells (PSCs).

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  • A systematic review and meta-analysis were conducted to assess Berberine’s impact on blood glucose levels in type 2 diabetes patients, analyzing 28 randomized controlled trials involving 2,313 patients.
  • The findings indicated significant reductions in fasting plasma glucose (FPG), postprandial plasma glucose (PPG), and glycated haemoglobin (HbA1c) levels with Berberine treatment compared to control groups.
  • The study revealed that the effectiveness of Berberine diminished after 90 days of treatment, at dosages over 2 g/d, and in patients older than 60; it also noted that combining Berberine with other hypoglycemics produced better results.
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