Engineering CuO@BN photocatalytic heterojunction for synchronous kinetic enhancement and reaction pathway regulation in peroxymonosulfate activation.

The robust redox cycle of the catalytic center is essential for enhancing sustainable water purification in Fenton-like catalysis. However, the unequal of electron donation and acceptance, especially slow reductive half-reactions, often limit the process. Herein, we developed a photocatalytic heterojunction by integrating cuprous oxide (CuO) with hexagonal boron nitride (h-BN).

[Dihydroartemisinin enhances doxorubicin-induced apoptosis of triple negative breast cancer cells by negatively regulating the STAT3/HIF-1α pathway].

Objectives: To investigate the effects of dihydroartemisinin (DHA) combined with doxorubicin (DOX) on proliferation and apoptosis of triple-negative breast cancer cells and explore the underlying molecular mechanism.

Methods: MDA-MB-231 cells were treated with 50, 100 or 150 μmol/L DHA, 0.5 μmol/L DOX, or with 50 μmol/L DHA combined with 0.

Low-Crosslinked Hyaluronic Acid Injections in the Superficial Fat Layer for Facial Rejuvenation in Chinese Patients: A Retrospective Clinical Study.

Objective To evaluate the clinical efficacy of low-crosslinked hyaluronic acid (HA) injections in the superficial fat layer for facial rejuvenation in Chinese patients. Methods A total of 30 patients were treated between July 2023 and October 2024, with three sessions of low-crosslinked HA injections spaced one month apart. The injections were administered using the fanning technique into the superficial fat layer.

One-Step Fabrication of Poly(vinylidene Fluoride-Co-Hexafluoropropylene)/Perfluorodecyltriethoxysilane Fibrous Membranes with Waterproof, Breathable, and Radiative Cooling Properties.

Functional membranes with waterproof, breathable, and thermal regulation capabilities are increasingly sought after across various industries. However, developing such functional membranes commonly involves complex multi-step preparation processes. Herein, we introduced perfluorodecyltriethoxysilane (FAS) into the poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) solution for one-step electrospinning, successfully fabricating membranes that combine these properties.

Cytological Diagnosis by Fine-needle Aspiration or Core Biopsy with Touch Preparation for Renal Cystic or Solid Lesions: A single center clinicopathological analysis.

Introduction: A retrospective study analyzed real-life data from a single center cohort of renal fine-needle aspiration (FNA) and core biopsy (CB) with touch preparation (TP) procedures over an 18-year period, aimed to provide a comprehensive overview of the evaluation of cytological diagnostic performance, challenges, and accuracy concerning renal cystic, solid, and mixed cystic-solid lesions.

Methods: All percutaneous ultrasound-guided FNA and CT-guided CB with TP performed at our institution from 2006 to 2024 were identified.

Results: A total of 89 renal cytology procedures were performed during the study period.

Glucocorticoid exposure-induced alterations in epigenetic age from human preterm infants and human lung fibroblasts and hippocampal neuronal cells.

Background: Maternal antenatal corticosteroid treatment is standard care to accelerate fetal maturation. However, there are growing concerns that antenatal corticosteroid administration may harm fetal neurodevelopment. Quantitative assessments of the effects of antenatal corticosteroid on the neonates have not been performed and poorly understood about their complex biology.

Analysis of the Formation of Eosinophilic Pleural Effusion.

Background: Eosinophilic pleural effusion constitutes a captivating and salient subject for exploration. In order to find out the reasons behind the formation of eosinophilic pleural effusion, we chose this study, hoping to gradually unravel its mysterious veil.

Methods: The absolute value and percentage of eosinophils in healthy people (normal control group), the peripheral blood of patients, and the pleural effusion of patients were compared to analyze their characteristics.

A rare epidermal growth factor receptor T790M/cis-C797S/L718Q compound mutation in a lung adenocarcinoma patient who did not derive any benefit from combination therapy with afatinib and bevacizumab.

The most common mutations in epidermal growth factor receptor () are exon 19 deletions and exon 21 L858R mutations, both of which respond effectively to tyrosine kinase inhibitors. However, the efficacy of tyrosine kinase inhibitors against rare mutations remains controversial. Many patients eventually develop resistance to tyrosine kinase inhibitors.

Global mercury dataset with predicted methylmercury concentrations in seafoods during 1995-2022.

Mercury exposure poses significant threats to human health, particularly in its organic form, methylmercury (MeHg). Diet is the main pathway for human MeHg exposure, especially through seafood consumption. In this context, numerous studies have established seafood MeHg concentration datasets to assess MeHg-related health risks from seafood consumption.

Carbon source dosage intelligent determination using a multi-feature sensitive back propagation neural network model.

The carbon reduction concept drives the development of low-carbon and sustainable wastewater treatment plant (WWTP) operation technologies. In the denitrification stage of WWTPs in China, there are widespread problems of uneconomical dosage consumption and unstable total nitrogen (TN) concentration in effluent through manual experience to add external carbon sources. Deep learning methods can deal with these problems.

Autophagy-Activating Nanoautophagosome-Tethering Compounds for Targeted Protein Degradation Specifically in Tumor Cells.

Autophagosome-tethering compounds (ATTECs) represent an emerging targeted protein degradation (TPD) technology that directly draws intracellular proteins of interest (POIs) into autolysosomes. Although ATTECs are currently dominated by small molecules, the poor cell-type specificity and pharmacokinetic profile limit their applications in certain diseases. Moreover, the suboptimal intrinsic autophagic activity of cells affects the ATTECs-mediated degradation capability.

[Clinical analysis of surgical treatment and postoperative efficacy in piriform sinus fistula with acute inflammatory period of children].

To discuss the clinical efficacy of low-temperature radiofrequency ablation assisted by endoscopy combined with resection and drainage of cervical abscess for the treatment of congenital pyriform sinus fistula （CPSF） in the acute inflammatory period of children. Clinical data of 30 patients with CPSF in the acute inflammatory period who received low-temperature radiofrequency ablation assisted by endoscopy under laryngoscope, combined with resection and drainage of cervical abscess, from January 2018 to December 2023 were reviewed. After the operation, patients were followed up closely at different stages.

Versatile nitrate-respiring heterotrophs are previously concealed contributors to sulfur cycle.

Heterotrophic denitrifiers play crucial roles in global carbon and nitrogen cycling. However, their inability to oxidize sulfide renders them vulnerable to this toxic molecule, which inhibits the key enzymatic reaction responsible for reducing nitrous oxide (NO), thereby raising greenhouse gas emissions. Here, we applied microcosm incubations, community-isotope-corrected DNA stable-isotope probing, and metagenomics to characterize a cohort of heterotrophic denitrifiers in estuarine sediments that thrive by coupling sulfur oxidation with denitrification through chemolithoheterotrophic metabolism.

Comparing spirometry, impulse oscillometry with computed tomography for assessing small airway dysfunction in subjects with and without chronic obstructive pulmonary disease.

Background: Studies on consistency among spirometry, impulse oscillometry (IOS), and histology for detecting small airway dysfunction (SAD) remain scarce. Considering invasiveness of lung histopathology, we aimed to compare spirometry and IOS with chest computed tomography (CT) for SAD detection, and evaluate clinical characteristics of subjects with SAD assessed by these three techniques.

Methods: We collected baseline data from the Early COPD (ECOPD) study.

Concoctive principles of detoxification and retention of the main toxicity of Tripterygium wilfordii and its anti-inflammatory efficacy by concocting with the medicinal excipient Spatholobi Caulis juice.

Tripterygium wilfordii (TW), which has severe hepatotoxicity, is commonly used as anti-rheumatism. Using the juice of auxiliary herbs in concocting poisonous herbs is a conventional method for toxicity reduction or efficacy enhancement. Traditional Chinese Pharmacy textbooks record that Spatholobi Caulis (SC) can alleviate the side effects caused by TW and also possesses excellent hepatoprotective effect.

Contamination and ecological risk of heavy metals in sediments of urban rivers in a typical economic development zone, southern China.

Urban rivers are one of the main water sources for local residents. However, the rapid industrialization and urbanization caused serious heavy metals pollution in urban rivers, which posed harmful impact on human health and ecosystem. In this study, 134 sediment samples were collected from urban rivers in a typical Economic and Technological Development Zone (ETDZ) to evaluate the contamination status, ecological risk, biotoxicity, and potential source of 8 heavy metals including arsenic (As), cadmium (Cd), chromium (Cr), copper (Cu), mercury (Hg), nickel (Ni), plumbum (Pb), and zinc (Zn).

Clew-like CuO/CuO Microsphere Adsorbents for Highly Efficient Anionic Dye Removal.

Adsorbents with high selectivity and adsorption capacity are of significant interest for the removal of dye pollutants. Herein, we report a facile low-temperature solvothermal synthesis of clew-like CuO/CuO microspheres by using cupric acetate monohydrate as the copper resource and ethylene glycol as the solvent and morphology modulator. The synthesized CuO/CuO microspheres showed high selective adsorption to anionic dyes (e.

A Phase-Transition-Free Sodium Vanadium Phosphate Cathode via Medium-Entropy Engineering for Superior Sodium Ion Batteries.

NaV(PO), based on multi-electron reactions between V/V/V, is a promising cathode material for SIBs. However, its practical application is hampered by the inferior conductivity, large barrier of V/V, and stepwise phase transition. Herein, these issues are addressed by constructing a medium-entropy material (NaVTiAlCrMnNi(PO), ME-NVP) with strong ME─O bond and highly occupied Na2 sites.

Association between impaired diffusion capacity and small airway dysfunction: a cross-sectional study.

Background: Small airway dysfunction (SAD) and impaired diffusion capacity of the lungs for carbon monoxide ( ) are positively associated with a worse prognosis. Individuals with both dysfunctions have been identified in clinical practice and it is unknown whether they have worse health status or need management. We conducted this study to explore the association between SAD and impaired , and the difference between the groups with two dysfunctions, with either one dysfunction and with no dysfunction.

Supervised analysis of alternative polyadenylation from single-cell and spatial transcriptomics data with spvAPA.

Alternative polyadenylation (APA) is an important driver of transcriptome diversity that generates messenger RNA isoforms with distinct 3' ends. The rapid development of single-cell and spatial transcriptomic technologies opened up new opportunities for exploring APA data to discover hidden cell subpopulations invisible in conventional gene expression analysis. However, conventional gene-level analysis tools are not fully applicable to APA data, and commonly used unsupervised dimensionality reduction methods often disregard experimentally derived annotations such as cell type identities.

Correction: Yan et al. Embryonic Lethal Phenotyping to Identify Candidate Genes Related with Birth Defects. 2024, , 8788.

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Radiomics of Periprostatic Fat and Tumor Lesion Based on MRI Predicts the Pathological Upgrading of Prostate Cancer from Biopsy to Radical Prostatectomy.

Rationale And Objectives: To assess the predictive value of MRI-based radiomics of periprostatic fat (PPF) and tumor lesions for predicting Gleason score (GS) upgrading from biopsy to radical prostatectomy (RP) in prostate cancer (PCa).

Methods: A total of 314 patients with pathologically confirmed prostate cancer (PCa) after radical prostatectomy (RP) were included in the study. The patients were randomly assigned to the training cohort (n = 157) and the validating cohort (n = 157) in a 1:1 ratio.

Causal relationship between genetically predicted mental disorders and frailty: a bidirectional and multivariable mendelian randomization study.

Background: In observational studies, frailty has been strongly associated with mental disorders. However, the mechanisms underlying the association between frailty and mental disorders remain unclear.

Methods: We conducted a two-sample Mendelian randomization (MR) study to assess the causal relationship between frailty, as measured by the frailty index (FI), and ten common mental disorders.

The impact of multidisciplinary collaborative bundled care on analgesia and sedation in ICU patients with endotracheal intubation.

Background: Effective analgesia and sedation management play a crucial role in reducing the intensity of coughing in patients with endotracheal intubation and improving clinical outcomes. However, current approaches are predominantly singular and lack comprehensive management strategies based on multidisciplinary collaboration. This study aims to evaluate the impact of multidisciplinary collaborative bundled care on analgesia and sedation in intensive care unit (ICU) patients with endotracheal intubation, providing evidence to inform clinical practice.