Outcomes of allogeneic hematopoietic stem cell transplantation in Shwachman-Diamond syndrome: a systematic review and meta-analysis.

We conducted a systematic review and meta-analysis to evaluate the outcomes of Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) in the treatment of Shwachman-Diamond syndrome (SDS). A literature search was performed on PubMed, Embase, and Web of Science. After screening 397 articles, 10 studies were included.

Effects of the addition of cassava starch and the size of water clusters on physicochemical and cooking properties of rice noodles.

It is meaningful to explore the addition of additives and the structural characteristics of water on the quality of rice noodles. Herein, the effects of the addition of cassava starch and the size of water clusters on physicochemical and cooking properties of rice noodles were systematically studied. The addition of 25 % cassava starch effectively enhanced the swelling performance and textural properties of rice noodles.

Injectable dual-network hyaluronic acid nanocomposite hydrogel for prevention of postoperative breast cancer recurrence and wound healing.

High locoregional recurrence rates and potential wound infections remain a significant challenge for postoperative breast cancer patients. Herein, we developed a dual-network hyaluronic acid (HA) nanocomposite hydrogel composed of herring sperm DNA (hsDNA) bridged methacrylated HA (HAMA) and FeMg-LDH-ppsa nanohybrid chelated catechol-modified HA (HADA) for the prevention of breast cancer recurrent, anti-infection, and promoting wound healing. Dynamic reversible hsDNA cross-linking combined with metal-catechol chelating renders the hydrogel injectability, rapid self-healing ability, and enhanced mechanical properties.

Amplified growth and heavy metal toxicity of Chlorococcum sp. from exposure to low-dose lanthanum(III).

Rare earth elements (REEs) are extensively utilized in industry, agriculture, advanced materials and other fields, leading to their dispersion in water bodies as emerging contaminants. Meanwhile, the coexistence of REEs and heavy metals (HMs) has become a novel form of water contamination (REE-HM co-contamination), though scientists have limited understanding of its hazards. Here, Chlorococcum sp.

Lighthouses illuminating tumor metastasis: The application of fluorescent probes in the localization and imaging metastatic lymph nodes across various tumors.

The significance of metastatic lymph nodes in tumor diagnosis and prognosis is self-evident. With the deepening of research on the lymphatic system and the advancement of imaging technology, an increasing number of near-infrared fluorescent probes targeting tumor metastatic lymph nodes have been developed. These probes can identify tumors while further detecting lymph nodes (LNs), showcasing great potential in image-guided surgery.

Short-Term Zinc Supplementation Stimulates Visceral Adipose Catabolism and Inflammation in Mice.

Background: Zinc (Zn), a fundamental trace element in human biology, exhibits pivotal roles in sustaining vital physiological processes and regulating metabolic homeostasis. Insufficient zinc intake has been linked to deleterious consequences on growth, reproductive functions, metabolic activities, and immune responses in both humans and animals. Oral zinc supplementation is usually performed to meet zinc requirement.

Single Vesicle Surface Protein Profiling and Machine Learning-Based Dual Image Analysis for Breast Cancer Detection.

Single-vesicle molecular profiling of cancer-associated extracellular vesicles (EVs) is increasingly being recognized as a powerful tool for cancer detection and monitoring. Mask and target dual imaging is a facile method to quantify the fraction of the molecularly targeted population of EVs in biofluids at the single-vesicle level. However, accurate and efficient dual imaging vesicle analysis has been challenging due to the interference of false signals on the mask images and the need to analyze a large number of images in clinical samples.

Microbe-immune interactions: new perspectives on coagulation deficiencies, purpura, and other hemorrhagic conditions under the regulation of the gut microbiota.

Background: The relationship between gut microbiota and coagulation defects, purpura, and other hemorrhagic conditions (CPH) is currently unclear, with causal links yet to be firmly established.

Objective: The causal relationships between gut microbiota and CPH, along with the potential mediating role of immune cells, were studied using Mendelian randomization analysis.

Methods: Data on 412 gut microbiota species, 731 immune cell types, and CPH were methodologically compiled from genome-wide association studies and the FinnGen database.

Sparse cross-transformer network for surface defect detection.

Quality control processes with automation ensure that customers receive defect-free products that meet their needs. However, the performance of real-world surface defect detection is often severely hindered by the scarcity of data. Recently, few-shot learning has been widely proposed as a solution to the data sufficiency problem by leveraging a limited number of base class samples.

Environmental level of lanthanum increased phytoextraction of co-occurring cadmium and polystyrene nanoplastics by Sedum alfredii.

Phytoextraction based on hyperaccumulators is a sustainable bioremediation technology. However, hyperaccumulators can only accumulate a single type of pollutants and need long remediation times, inhibiting simultaneous phytoextraction of co-occurring inorganic and organic pollutants. Here, the study indicated that the environmental level of lanthanum, as an emerging pollutant, was absorbed by leaves and induced endocytosis from leaves to roots (systemic endocytosis) in Sedum alfredii.

A Machine Learning-Based Investigation of Integrin Expression Patterns in Cancer and Metastasis.

Background: Integrins, a family of transmembrane receptor proteins, play complex roles in cancer development and metastasis. These roles could be better delineated through machine learning of transcriptomic data to reveal relationships between integrin expression patterns and cancer.

Methods: We collected publicly available RNA-Seq integrin expression from 8 healthy tissues and their corresponding tumors, along with data from metastatic breast cancer.

Transcriptome and Metabolomic Analyses Reveal Tissue-Specific Glycosylation of Phenylpropanoids and Flavonoids in Toxicodendron vernicifluum.

Toxicodendron vernicifluum (Stokes) F. A. Barkley is a tree species used primarily for lacquer production.

Dialdehyde cellulose nanofibrils/polyquaternium stabilized ultra-fine silver nanoparticles for synergistic antibacterial therapy.

Dialdehyde cellulose nanofibrils (DACNF) and Polyquaternium-10 (PQ: chloro-2-hydroxy-3-(trimethylamino) propyl polyethylene glycol cellulose) have become increasingly favored as antibacterial substances due to their advantageous characteristics. DACNF exhibits exceptional mechanical properties and biocompatibility, whereas PQ demonstrates a positive charge that enhances its antibacterial activity. Combined in a DACNF/PQ mixture, they provide an excellent template material for preparing and stabilizing ultra-fine (~ 10.

Investigations on the EPR g factors and local structures for the orthorhombic and tetragonal Cu centers in Pb[ZrTi]O.

The defect models of the orthorhombical and tetragonal Cu centers in Pb[ZrTi]O are attributed to Cu ions occupying the sixfold coordinated octahedral Ti site with and without charge compensation, respectively. The electron paramagnetic resonance (EPR) g factors g (i = x, y, z) of the Cu centers in Pb[ZrTi]O are theoretically studied by using the perturbation formulas of a 3d ion under orthorhombically and tetragonally elongated octahedra. Based on the calculation, the impurity off-center displacements are about 0.

Lanthanum interferes with the fundamental rhythms of stomatal opening, expression of related genes, and evapotranspiration in Arabidopsis thaliana.

The accumulation of rare earth elements (REEs) in the global environment poses a threat to plant health and ecosystem stability. Stomata located on leaves serve as the primary site for plant responses to REE-related threats. This study focused on lanthanum [La(III)], a prevalent REE in the atmospheric environment.

Risk Prediction of Type 2 Diabetes Mellitus by MRI-based Pancreatic Morphology and Clinical Characteristics: A Cross-sectional Study.

Objectives: This study aimed to investigate the pancreatic morphology and clinical characteristics to predict risk factors of type 2 diabetes mellitus (T2DM) based on magnetic resonance imaging.

Methods: A total of 89 patients (T2DM group) and 68 healthy controls (HC group) were included. The T2DM group was divided into a long-term T2DM group and a short-term T2DM group according to whether the illness duration was more than 5 years.

Atmospheric deposition of microplastics at a western China metropolis: Relationship with underlying surface types and human exposure.

The issue of atmospheric microplastic (AMP) contamination is gaining increasing attention, yet the influencing factors and human exposure are not well-understood. In this study, atmospheric depositions were collected in the megacity of Chengdu, China, to investigate the pollution status and spatial disparities in AMP distribution. The relationship between AMP abundance and underlying surface types was then analyzed with the aid of back trajectory simulation.

Probabilistic Estimation of Airborne Micro- and Nanoplastic Intake in Humans.

Little research exists on the magnitude, variability, and uncertainty of human exposure to airborne micro- and nanoplastics (AMNPs), despite their critical role in human exposure to MNPs. We probabilistically estimate the global intake of AMNPs through three main pathways: indoor inhalation, outdoor inhalation, and ingestion during indoor meals, for both children and adults. The median inhalation of AMPs is 1,207.

Deep Learning-Based Fish Detection Using Above-Water Infrared Camera for Deep-Sea Aquaculture: A Comparison Study.

Long-term, automated fish detection provides invaluable data for deep-sea aquaculture, which is crucial for safe and efficient seawater aquafarming. In this paper, we used an infrared camera installed on a deep-sea truss-structure net cage to collect fish images, which were subsequently labeled to establish a fish dataset. Comparison experiments with our dataset based on Faster R-CNN as the basic objection detection framework were conducted to explore how different backbone networks and network improvement modules influenced fish detection performances.

Plasmonic couplings in Ag-Au heterodimers.

The plasmonic coupling between silver (Ag) and gold (Au) nanoparticles (NPs) under four polarization modes was examined: a longitudinal mode (L-mode), where the electric field of a linearly polarized incident light parallels the dimer axis, and three transverse modes (T-modes), where the electric field of the light is perpendicular to the dimer axis. The coupling was studied using the discrete dipole approximation followed by an in-house postprocessing code that determines the extinction (Qext), absorption (Qabs), and near-field (Qnf) spectra from the individual NPs as well as the whole system. In agreement with the literature results, the extinction/absorption spectra of the whole dimer have two peaks, one near the Ag localized surface plasmon resonance (LSPR) region and the other at the Au LSPR region, with the peak at Ag LSPR being reduced in all modes and the peak at Au LSPR being red-shifted and increased in the L-mode but not in the T-modes.

Response of aerobic granular sludge under acute inhibition by polystyrene microplastics: Activity, aggregation performance, and microbial analysis.

In this study, the activity, aggregation performance, microbial community and functional proteins of aerobic granular sludge (AGS) in response to acute inhibition by different concentrations of polystyrene microplastics (PS-MPs) were investigated. As the PS-MPs concentration increased from 0 mg/L to 200 mg/L, the specific nitrogen removal rate and the activity of enzymes were inhibited. The inhibition of specific nitrite reduction rate (SNIRR) and specific nitrate reduction rate (SNRR) was most obvious at the PS-MPs concentration of 100 mg/L, and that of nitrite reductase (NIR) and nitrate reductase (NR) was most obvious at the concentration of 50 mg/L.