Ultralight flexible 3D nickel micromesh decorated with NiCoP for high stability alkaline zinc batteries.

Rechargeable alkaline zinc batteries are emerging as promising candidates for next-generation energy storage systems, owing to their affordability, eco-friendliness and high energy density. However, their widespread application is hindered by stability challenges, particularly in alkaline environments, due to cathode corrosion and deformation, as well as dendrite formation and unwanted side reactions at the Zn anode. To address these issues, we successfully developed a 3D nickel micromesh-supported NiCoP (3D NM@NiCoP) electrode.

Corrigendum to "Selenium enhancement strategy under precise fertilization in foxtail millet rhizosphere" [Heliyon Volume , Issue 11, 15 June 2024, e32764].

[This corrects the article DOI: 10.1016/j.heliyon.

Benzoylaconine: Potential Therapeutic Agent for Cardiovascular Diseases From Fuzi.

Modern pharmacological studies have elucidated the presence of aconitine (AC) alkaloids, polysaccharides, and saponins as the primary bioactive constituents of Fuzi. Among these, benzoylaconine, a pivotal active compound, demonstrates notable pharmacological properties including antitumor, anti-inflammatory, and cardiovascular protective effects. In recent years, benzoylaconine has garnered significant attention in basic research on heart diseases, emerging as a focal point of investigation.

Synthesis of ultra-large diameter graphene oxide flakes from natural flake graphite.

Graphene and its derivatives are widely used in various fields due to their unique two-dimensional lamellar structure. This study aims to synthesize ultra-large graphene oxide (GO) sheets from natural flake graphite and investigate the factors influencing their size. Using a two-intercalation method based on the modified Hummers' method, we address the challenge of intercalating large-diameter graphene oxide by employing a secondary intercalation technique.

Overexpression of KPC contributes to ceftazidime-avibactam heteroresistance in clinical isolates of carbapenem-resistant .

Ceftazidime-avibactam (CZA) is one of the effective antibiotics used for the treatment of carbapenem-resistant (CRKP) infections, but its resistance rate has increased recently. Previous studies have focused on the mechanisms of CZA resistance, while its heteroresistance in CRKP remains poorly understood. This study aimed to investigate the characteristics and mechanisms of CZA heteroresistance in CRKP isolates.

Single-cell analysis reveals the loss of FABP4-positive proliferating valvular endothelial cells relates to functional mitral regurgitation.

Background: Functional mitral regurgitation (MR) is a common form of mitral valve dysfunction that often persists even after surgical intervention, requiring reoperation in some cases. To advance our understanding of the pathogenesis of functional MR, it is crucial to characterize the cellular composition of the mitral valve leaflet and identify molecular changes in each cell subtype within the mitral valves of MR patients. Therefore, we aimed to comprehensively examine the cellular and molecular components of mitral valves in patients with MR.

Comparison of postoperative radiotherapy and definitive radiotherapy for non-metastatic adenoid cystic carcinoma of the head and neck, a propensity score matching based on the SEER database.

Background: Treating patients with head and neck adenoid cystic carcinoma (HNACC) presents surgical problems in various scenarios. Limited studies explore definitive radiation's impact on patient survival, with inadequate data correlating it to postoperative radiotherapy. Using the Surveillance, Epidemiology, and End Results (SEER) program, we conducted an objective analysis to evaluate the impact of definitive radiation on the survival of HNACC patients without distant metastases, aiming to uncover its nuanced pros and cons.

High-Entropy Rock-Salt Surface Layer Stabilizes the Ultrahigh-Ni Single-Crystal Cathode.

Single-crystalline Ni-rich layered oxides are one of the most promising cathode materials for lithium-ion batteries due to their superior structural stability. However, sluggish lithium-ion diffusion kinetics and interfacial issues hinder their practical applications. These issues intensify with increasing Ni content in the ultrahigh-Ni regime (≥90%), significantly threatening the practical viability of the single-crystalline strategy for ultrahigh-Ni layered oxide cathodes.

A trinity STING-activating nanoparticle harnesses cancer cell STING machinery for enhanced immunotherapy.

The cGAS-STING axis is a promising therapeutic target against cancer. However, most activators require STING signaling in the host, especially within antigen-presenting cells, which are rare in a cold tumor microenvironment. The cGAS-STING cascade is also present within cancer cells but with suppressed activity.

Activation of protein kinase B rescues against thapsigargin-elicited cardiac dysfunction through regulation of NADPH oxidase and ferroptosis.

Endoplasmic reticulum (ER) stress is a known contributor to cardiac remodeling and contractile dysfunction. Although NADPH oxidase has been implicated in ER stress-induced organ damage, its specific role in myocardial complications resulting from ER stress remains unclear. This study aimed to investigate the possible involvement of NADPH oxidase in ER stress-induced myocardial abnormalities and to evaluate the impact of Akt constitutive activation on these myocardial defects.

CCL21 Induces Plasmacytoid Dendritic Cell Migration and Activation in a Mouse Model of Glioblastoma.

Dendritic cells (DCs) are professional antigen-presenting cells that are traditionally divided into two distinct subsets: myeloid DCs (mDCs) and plasmacytoid DCs (pDCs). pDCs are known for their ability to secrete large amounts of cytokine type I interferons (IFN- α). In our previous work, we have demonstrated that pDC infiltration promotes glioblastoma (GBM) tumor immunosuppression through decreased IFN-α secretion via TLR-9 signaling and increased suppressive function of regulatory T cells (Tregs) via increased IL-10 secretion, resulting in poor overall outcomes in mouse models of GBM.

A dual-STING-activating nanosystem expands cancer immunotherapeutic temporal window.

Stimulator of interferon genes (STING) is a promising antitumor target via bridging innate and adaptive immunity, yet the transient nature of immune signal transduction renders small-molecule agonists susceptible to short time effectiveness. Here, we report a dual-STING-activating micelle system (D-SAM) to dynamically program STING kinetics. Mechanistically, the natural ligand cGAMP encapsulated in D-SAM initiates STING signaling, while the pH-sensitive polymeric agonist PC7A disassembled from micelle shell buffers lysosomal protons and retards STING degradation.

Gelatin Methacrylic Acid Hydrogel-Based Nerve Growth Factors Enhances Neural Stem Cell Growth and Differentiation to Promote Repair of Spinal Cord Injury.

Background: The challenge in treating irreversible nerve tissue damage has resulted in suboptimal outcomes for spinal cord injuries (SCI), underscoring the critical need for innovative treatment strategies to offer hope to patients.

Methods: In this study, gelatin methacrylic acid hydrogel scaffolds loaded with nerve growth factors (GMNF) were prepared and used to verify the performance of SCI. The physicochemical and biological properties of the GMNF were tested.

One-Dimensional Flexible Capacitive Sensor with Large Strain and High Stability for Human Motion Monitoring.

Flexible capacitive sensors have attracted the attention of researchers owing to their simple structure, ease of realization, and wearability. Currently, flexible capacitive sensors mainly have three-dimensional and two-dimensional structures, which are subject to several limitations in their applications. A low-cost, high-efficiency, and continuously processable process was used to wrap nylon DTY (PA) filaments on the surface of silver-coated nylon (SCN) core yarns and impregnate them with waterborne polyurethane (WPU) to obtain SCN/PA/WPU composite yarns, which were then utilized in the design of SCN/PA/WPU for the preparation of one-dimensionally structured flexible capacitive sensors.

A High Gain Circularly Polarized Slot Antenna Array for 5G Millimeter-Wave Applications.

An air-filled substrate-integrated waveguide (AF-SIW) circularly polarized (CP) 1 × 8 mm wave antenna array is presented for fifth-generation (5G) applications. The presented slot antenna array consists of three layers of PCB and one layer of aluminum, which serve as the AF-SIW feeding network and the metal cavity radiation element, respectively. The CP characteristic is achieved by the use of an -shaped aluminum radiation cavity on the top of the AF-SIW feeding network.

Electric field simulation, structure and properties of nanofiber- coated yarn prepared by multi-needle water bath electrospinning.

To address the issue of low yield in the preparation of nanofiber materials using single-needle electrospinning technology, multi-needle electrospinning technology has emerged as a crucial solution for mass production. However, the mutual interference of multiple electric fields between the needles can cause significant randomness in the morphology of the produced nanofibers. To better predict the influence of electric field distribution on nanofiber morphology, simulation analysis of the multi-needle arrangement was conducted using finite element analysis (FEA) software.

Virucidal effects of eucalyptus essential oil on porcine reproductive and respiratory syndrome virus.

Currently, the efficacy of vaccination for preventing and controlling PRRSV is insufficient. Therefore, there is an urgent need for novel effective preventive strategies. This study aimed to investigate the antiviral effect of Eucalyptus essential oil (EEO) against PRRSV .

Densification of Cathode/Electrolyte Interphase to Enhance Reversibility of LiCoO at 4.65 V.

For LiCoO (LCO) operated beyond 4.55 V (vs Li/Li), it usually suffers from severe surface degradation. Constructing a robust cathode/electrolyte interphase (CEI) is effective to alleviate the above issues, however, the correlated mechanisms still remain vague.

Inhibition of OLR1 reduces SASP of nucleus pulposus cells by targeting autophagy-GATA4 axis.

Targeting cellular senescence and Senescence Associated Secretory Phenotype (SASP) through autophagy has emerged as a promising intervertebral disc (IVD) degeneration (IDD) treatment strategy in recent years. This study aimed to clarify the role and mechanism of autophagy in preventing IVD SASP. Methods involved in vitro experiments with nucleus pulposus (NP) tissues from normal and IDD patients, as well as an in vivo IDD animal model.