Microhaplotype and Y-SNP/STR (MY): A novel MPS-based system for genotype pattern recognition in two-person DNA mixtures.

Backgrounds: Y-chromosomal haplotypes based on Y-short tandem repeats (STRs) and Y-single nucleotide polymorphisms/insertion and deletion polymorphisms (SNPs/InDels) are used to characterize paternal lineages of unknown male trace donors. However, Y-chromosomal genetic markers are not currently sufficient for precise individual identification. Microhaplotype (MH), generally < 200 bp on autosomes and consisting of two or more SNPs, was recently introduced in forensic genetics with the development of massive parallel sequencing technology and may facilitate identification and DNA mixture deconvolution.

Icariside II Attenuates Methamphetamine-Induced Neurotoxicity and Behavioral Impairments via Activating the Keap1-Nrf2 Pathway.

Chronic and long-term methamphetamine (METH) abuse is bound to cause damages to multiple organs and systems, especially the central nervous system (CNS). Icariside II (ICS), a type of flavonoid and one of the main active ingredients of the traditional Chinese medicine , exhibits a variety of biological and pharmacological properties such as anti-inflammatory, antioxidant, and anticancer activities. However, whether ICS could protect against METH-induced neurotoxicity remains unknown.

Effect of Gallium as an Additive Over Corresponding Ni-Mo/γ-AlO Catalysts on the Hydrodesulfurization Performance of 4,6-DMDBT.

Experiments were carried out to research the different contents of GaO modification effects on the hydrodesulfurization (HDS) performance of 4,6-dimethyldibenzothiophene (4,6-DMDBT) catalyzed by the stepwise impregnation method. Characterization techniques such as XRD, BET, HRTEM, NH-TPD, and Py-FTIR were performed to determine the effects of each modification of the catalyst by Ga on the properties of the prepared supports and catalysts. The catalytic effect of gallium is reflected in the fact that the empty d-orbitals of Ga elements participate in the formation of molecular orbitals in the active center and change their orbital properties, thus generating a direct desulfurization active phase suitable for complex sulfides for endpoint adsorption.

Comparison Between China and Brazil in the Two Waves of COVID-19 Prevention and Control.

Objective: This study analyzes the effectiveness of COVID-19 prevention and control in China and Brazil from the perspectives of policy and meteorological conditions, and provides experience for epidemic prevention and control.

Methods: This study collects data on meteorological conditions, vaccination and mutant strains in the two countries to analyze the reasons for the differences in epidemic status between the two countries and extracts public data on COVID-19 through various official websites, summarizes the prevention and control policies implemented by the two countries, and evaluates their effectiveness.

Results: As of August 12, 2021, the total number of COVID-19 cases and the daily number of new COVID-19 cases in China have been growing steadily, showing remarkable results in epidemic control.

Chromosome-scale genome assembly provides insights into speciation of allotetraploid and massive biomass accumulation of elephant grass (Pennisetum purpureum Schum.).

Elephant grass (Pennisetum purpureum Schum) is an important forage, biofuels and industrial plant widely distributed in tropical and subtropical areas globally. It is characterized with robust growth and high biomass. We sequenced its allopolyploid genome and assembled 2.

Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing.

CRISPR/RfxCas13d (CasRx) editing system can specifically and precisely cleave single-strand RNAs, which is a promising treatment for various disorders by downregulation of related gene expression. Here, we tested this RNA-editing approach on Beethoven (Bth) mice, an animal model for human DFNA36 due to a point mutation in Tmc1. We first screened 30 sgRNAs in cell cultures and found that CasRx with sgRNA3 reduced the Tmc1 transcript by 90.

Platinum Cluster/Carbon Quantum Dots Derived Graphene Heterostructured Carbon Nanofibers for Efficient and Durable Solar-Driven Electrochemical Hydrogen Evolution.

Large scale solar-driven hydrogen production is a crucial step toward decarbonizing society. However, the solar-to-hydrogen (STH) conversion efficiency, long-term stability, and cost-effectiveness in hydrogen evolution reaction (HER) still need to be improved. Herein, an efficient approach is demonstrated to produce low-dimensional Pt/graphene-carbon nanofibers (CNFs)-based heterostructures for bias-free, highly efficient, and durable HER.

Genotype and Phenotype Interaction between and BLB after pv. Inoculation in the Field.

Bacterial leaf blight (BLB) is an important and devastating rice disease caused by the pathogen pv. (). In particular, in recent years, the occurrence of abnormal climate and warming phenomena has produced a good environment for the occurrence of BLB, and the rice yield due to the occurrence of BLB continues to decrease.

A Simple and Efficient Method to Cryopreserve Human Ejaculated and Testicular Spermatozoa in -80°C Freezer.

Human autologous sperm freezing involves ejaculated sperm, and testicular or epididymal puncture sperm freezing, and autologous sperm freezing is widely used in assisted reproductive technology. In previous studies, researchers have tried to cryopreserve sperm from mammals (rats, dogs, etc.) using a -80°C freezer and have achieved success.

Origin and seed coat color differently affect the concentrations of metabolites and antioxidant activities in soybean (Glycine max (L.) Merrill) seeds.

In this study, 54 soybean germplasms of different seed coat colors originated from America, China, Japan, and Korea were cultivated in Korea and analyzed for the contents of total oil, total protein, total phenolic, five fatty acids, and five isoflavones, and antioxidant activities using three assays. The soybeans showed significant variations (p < 0.05) of metabolite contents and antioxidant activities.

First Chinese ultraviolet-visible hyperspectral satellite instrument implicating global air quality during the COVID-19 pandemic in early 2020.

In response to the COVID-19 pandemic, governments worldwide imposed lockdown measures in early 2020, resulting in notable reductions in air pollutant emissions. The changes in air quality during the pandemic have been investigated in numerous studies via satellite observations. Nevertheless, no relevant research has been gathered using Chinese satellite instruments, because the poor spectral quality makes it extremely difficult to retrieve data from the spectra of the Environmental Trace Gases Monitoring Instrument (EMI), the first Chinese satellite-based ultraviolet-visible spectrometer monitoring air pollutants.

Total Synthesis of the Tetrasaccharide Haptens of MO6-24 and BO62316 and Immunological Evaluation of Their Protein Conjugates.

is a human pathogen that can cause fatal septicemia and necrotizing infections with a high lethal rate exceeding 50%. MO6-24 and BO62316 are two predominant virulent strains associated with approximately one-third of the clinical infections. The capsular polysaccharides (CPSs) of consist of several structurally unique sugars and are excellent targets for developing effective glycoconjugate vaccines.

Simultaneously enhanced treatment efficiency of simulated hypersaline azo dye wastewater and membrane antifouling by a novel static magnetic field membrane bioreactor (SMFMBR).

Operation performance and membrane fouling of a novel static magnetic field membrane bioreactor (SMFMBR) for treatment of hypersaline azo dye wastewater was investigated. The results showed that SMFMBRs possessed higher efficiency of dye decolorization, COD removal and detoxification than the control MBR without SMF. The (3#) SMFMBR equipped with 305.

Core policies disparity response to COVID-19 among BRICS countries.

Objective: To provide experience for formulating prevention and control policies, this study analyzed the effectiveness of the Coronavirus disease 2019(COVID-19) prevention and control policies, and evaluated health equity and epidemic cooperation among BRICS countries.

Methods: This study summarized the pandemic prevention and control policies in BRICS countries and evaluated the effectiveness of those policies by extracting COVID-19 related data from official websites.

Result: As of May 4, 2021, responding to COVID-19.

A Comparative Retrospective Study of COVID-19 Responses in Four Representative Asian Countries.

Purpose: This study compared the government policies and non-pharmaceutical interventions adopted by South Korea, Japan, India, and China in response to COVID-19 during 2020-2021 and assessed their effectiveness. We hope that our research will help control the COVID-19 waves and a future crisis of this nature.

Methods: COVID-19 case data were obtained from Our World in Data database.

Poly-γ-glutamic acid enhanced the drought resistance of maize by improving photosynthesis and affecting the rhizosphere microbial community.

Background: Compared with other abiotic stresses, drought stress causes serious crop yield reductions. Poly-γ-glutamic acid (γ-PGA), as an environmentally friendly biomacromolecule, plays an important role in plant growth and regulation.

Results: In this project, the effect of exogenous application of γ-PGA on drought tolerance of maize (Zea mays.

The Antecedents and Consequences of Metacognitive Knowledge in Mathematics Learning: A Self-Determination Perspective.

Grounded in the self-determination theory and the metacognitive and affective model of self-regulated learning, this study investigated the longitudinal relationship of self-determined motivation as the antecedent and academic performance as the consequence of metacognitive knowledge (MK) in mathematics learning. Two waves of data were collected from senior high school students ( = 327) in the second semester in Grades 10 and 11. A longitudinal mediation model was analyzed using structural equation modeling.

Towards Better Caption Supervision for Object Detection.

As training high-performance object detectors requires expensive bounding box annotations, recent methods resort to free-available image captions. However, detectors trained on caption supervision perform poorly because captions are usually noisy and cannot provide precise location information. To tackle this issue, we present a visual analysis method, which tightly integrates caption supervision with object detection to mutually enhance each other.

A Correlation Study on In Vitro Physiological Activities of Soybean Cultivars, 19 Individual Isoflavone Derivatives, and Genetic Characteristics.

The functionality of soybeans is an important factor in the selection and utilization of excellent soybean cultivars, and isoflavones are representative functional substances in soybeans, which exhibit effects on antioxidants, estrogen activity, and cancer, and prevent cardiovascular diseases. This study analyzed ABTS, DPPH, estrogen, ER (ER) alpha, UCP-1, and NO inhibition activities in 48 types of soybean cultivars, as well as the relationship with 19 isolated types of individual isoflavone derivatives. Statistical analysis was conducted to find individual isoflavone derivatives affecting physiological activities, revealing the high correlation of three types of derivatives: genistein 7-O-(6″-O-acetyl)glucoside (6″-O-acetylgenistin), genistein 7-O-(2″-O-apiosyl)glucoside, and glycitein.

Buzhong Tiaogan Formula for delaying colorectal liver metastasis (liver depression spleen deficient type): A multicenter randomized controlled trial: A study protocol.

Introduction: Colorectal cancer has been ranked third among the most common cancers worldwide and raised to the second leading cause of cancer death with nearly one-tenth of cancer-related deaths globally, and nearly half of colorectal cancer patients present with or develop colorectal cancer liver metastasis (CRLM). Buzhong Tiaogan Formula (BTF) has been proven to treat CRLM in our team, but there are lacking of evidence on its effective in delaying colorectal liver metastasis (liver depression spleen deficiency type), so we will evaluate the efficacy and safety of BTF in preventing the occurrence of CRLM.

Methods: This randomized controlled trial (RCT) will be carried out in 3 different hospitals in Shanxi Province planning to recruit 150 CRLM patients with the type of liver depression spleen deficiency.

De novo mutations in childhood cases of sudden unexplained death that disrupt intracellular Ca regulation.

Sudden unexplained death in childhood (SUDC) is an understudied problem. Whole-exome sequence data from 124 "trios" (decedent child, living parents) was used to test for excessive de novo mutations (DNMs) in genes involved in cardiac arrhythmias, epilepsy, and other disorders. Among decedents, nonsynonymous DNMs were enriched in genes associated with cardiac and seizure disorders relative to controls (odds ratio = 9.

Synthesis of Nickel Modified SAPO-11 Molecular Sieves and Hydroisomerization Performance of Their NiWS Supported Catalysts.

SAPO-11 molecular sieves were modified with different Ni contents by the modification method. The Ni-modified SAPO-11 molecular sieves were used as the supports to prepare the corresponding NiW-supported catalysts for the hydroisomerization of n-hexadecane. The Ni-modified SAPO-11 and the corresponding NiW-supported catalysts were characterized by X-ray diffraction, scanning electron microscopy, N adsorption-desorption, NH-temperature-programmed desorption, pyridine adsorbed infrared, high-resolution transmission electron microscopy, and X-ray photoelectron spectroscopy.

Midinfrared Tunable Laser with Noncritical Frequency Matching in Box Resonator Geometry.

Monolithic optical parametric oscillators extend laser frequencies in compact architectures, but normally guide and circulate all pump, signal, and idler beams. Critical frequency matching is raised among these resonances, limiting operation stability and continuous tuning. Here, we develop a box resonator geometry that guides all beams but only resonates for signal.

Association of sexually transmitted infection with semen quality in men from couples with primary and secondary infertility.

This study aims to compare the prevalence of sexually transmitted infections (STIs) with semen quality in men from couples with primary and secondary infertility. Semen samples were collected from 133 men who requested fertility evaluation. Seminal tract infection with Ureaplasma spp.