Mechanosensitive stacking structure with continuous solar controllability for real-time thermal management.

Adaptive control of solar light based on an optical switching strategy is essential to tune thermal gain, while real-time solar regulation and hence on-demand thermal management coupled with dynamic conditions still faces a formidable challenge. Herein, we develop a stacking structure which is mechanosensitive and can be finely tuned depending on the dynamic cavitation effect. Specifically, the stacking structure transfers from a solid monolith state to porous layered state progressively under mechanical stretching, and the resulting porous layered state gradually goes back to the solid monolith state once the load is released.

Binding of to dystrophin impairs the membrane trafficking of Nav1.5 protein and increases ventricular arrhythmia susceptibility.

Dystrophin is a critical interacting protein of Nav1.5 that determines its membrane anchoring in cardiomyocytes. Long noncoding RNAs (lncRNAs) are involved in the regulation of cardiac ion channels, while their influence on sodium channels remains unexplored.

Network intervention analysis to assess the trajectory of change and intervention effects associated with the use of self-control training for ego depletion aftereffects.

Purpose: The purpose of this study was to use the advanced technique of Network Intervention Analysis (NIA) to investigate the trajectory of symptom change associated with the effects of self-control training on youth university students' chronic ego depletion aftereffects.

Methods: The nine nodes of chronic ego depletion aftereffects and integrated self-control training were taken as nodes in the network and analyzed using NIA. Networks were computed at the baseline, at the end of treatment, at 1-, 3-, 6-, 9- and 12-month follow up.

Synthesis, anti-oomycete and anti-fungal activities of novel paeonol ester derivatives containing a schiff base.

To discover biorational natural product-based pesticides, a series of paeonol ester derivatives containing a Schiff base (, , , and ) were prepared, and their structures were well characterised by H NMR and HRMS. Furthermore, bioactivities of these compounds as anti-oomycete and anti-fungal agents against two serious agricultural diseases, and we assessed. Amongst evaluated compounds, 1) Compounds and displayed good anti-oomycete against , with EC values of 116.

Exploring insulin resistance and pancreatic function in individuals with overweight and obesity: Insights from OGTTs and IRTs.

To investigate insulin resistance and pancreatic β-cell function in overweight or obese people under the same glucose tolerance conditions. The subjects were categorized based on the results of the oral glucose tolerance test (OGTT) and the BMI classification criteria. Basal and postprandial glucose concentrations, insulin concentrations, pancreatic β-cell function (HOMA-β), the insulin resistance index (HOMA-IR), and the insulin early secretion index (ΔI30/ΔG30) were compared between the different weight groups.

Multigenerational toxic effects in Daphnia pulex are induced by environmental concentrations of tire wear particle leachate.

Microplastic pollution has emerged as the second most significant scientific issue in environmental science and ecology. Similarly, the biological effects of tire wear particles (TWPs) have garnered considerable research attention; however, studies on chronic TWP leachate toxicity at environmentally relevant concentrations remain sparse. Here, we investigated the effects of TWP leachate at environmentally relevant concentrations (0.

High-yield upcycling of feather wastes into solid-state ultra-long phosphorescence carbon dots for advanced anticounterfeiting and information encryption.

Recently, biomass-derived carbon dots (CDs) have attracted considerable attention in high-technology fields due to their prominent merits, including brilliant luminescence, superior biocompatibility, and low toxicity. However, most of the biomass-derived CDs only show bright fluorescence in diluted solution because of aggregation-induced quenching effect, hence cannot exhibit solid-state long-lived room-temperature phosphorescence (RTP) in ambient conditions. Herein, matrix-free solid-state RTP with an average lifetime of 0.

Overcoming Gas Mass Transfer Limitations Using Gas-Conducting Electrodes for Efficient Nitrogen Reduction.

Electrocatalytic nitrogen reduction reaction (NRR) is a very attractive strategy for ammonia synthesis due to its energy savings and sustainability. However, the ammonia yield and Faraday efficiency of electrocatalytic nitrogen reduction have been challenges due to low nitrogen solubility and competitive hydrogen evolution reaction (HER) in electrolyte solution. Herein, inspired by the asymmetric wetting behavior, i.

Mesenchymal stem cell-derived extracellular vesicles for human diseases.

Stem cell therapy is a novel approach for treating various severe and intractable diseases, including autoimmune disorders, organ transplants, tumors, and neurodegenerative diseases. Nevertheless, the extensive utilization of stem cells is constrained by potential tumorigenicity, challenges in precise differentiation, rejection concerns, and ethical considerations. Extracellular vesicles possess the ability to carry diverse bioactive factors from stem cells and deliver them to specific target cells or tissues.

The impacts of noise and air pollution on breast cancer risk in European and East Asian populations: Insights from genetic evidence.

Objectives: Previous studies have reported associations of noise and air pollution with breast cancer (BC) risk, but the causality remains unclear. This study aimed to explore the effects of noise and air pollution on BC from a genetic perspective.

Study Design: Genetic association study.

SGLT2 inhibitor downregulates ANGPTL4 to mitigate pathological aging of cardiomyocytes induced by type 2 diabetes.

Background: Senescence is recognized as a principal risk factor for cardiovascular diseases, with a significant association between the senescence of cardiomyocytes and inferior cardiac function. Furthermore, type 2 diabetes exacerbates this aging process. Sodium-glucose co-transporter 2 inhibitor (SGLT2i) has well-established cardiovascular benefits and, in recent years, has been posited to possess anti-aging properties.

[Response of Microbiological Properties to Short-term Nitrogen Addition in Perennial Alpine Cultivated Grassland].

Removing nitrogen limitation is necessary to increase plant productivity in alpine grasslands. A short-term nitrogen addition experiment was conducted to understand the effects of nitrogen addition on the soil physicochemical properties and microbial community structure of perennial alpine cultivated grassland in the region around Qinghai Lake. From June to August 2022, four N application gradients （T0： 0 kg·hm·a, T1： 22.

IL-1β-induced pericyte dysfunction with a secretory phenotype exacerbates retinal microenvironment inflammation via Hes1/STAT3 signaling pathway.

Retinal pericytes are mural cells surrounding capillaries to maintain the integrity of blood-retina barrier and regulate vascular behaviors. Pericyte loss has been considered as the hallmark of diabetic retinopathy (DR), which is a major complication of diabetes and the leading cause of blindness in adults. However, the precise function of pericytes in regulating the retinal microenvironment and the underlying mechanism remains largely unknown.

Lubricating and Dual-Responsive Injectable Hydrogels Formulated From ZIF-8 Facilitate Osteoarthritis Treatment by Remodeling the Microenvironment.

Osteoarthritis (OA) is a progressively developing condition primarily characterized by the deterioration of articular cartilage and the proliferation of bone, along with ongoing inflammation. Although the precise pathogenesis remains somewhat elusive, restoring the homeostatic balance of the intra-articular microenvironment is crucial for the management of OA. Intra-articular injection of medication is one of the most direct and effective treatment methods; however, most injectable drugs used for osteoarthritis treatment, due to their rapid breakdown, quick release, poor biological activity, and frequent injections, leading to increased risk of infection and suboptimal therapeutic outcomes.

Underwater polarization image de-scattering utilizing a physics-driven deep learning method.

The remarkable ability of polarization imaging to suppress the backscattered light makes it a highly attractive solution for various underwater applications. In recent years, emerging learning-based polarization technologies have shown significant potential for application and achieved great success. However, the majority of learning-based studies primarily employ data-driven approaches, which lack interpretability and generalizability.

Multi-scaled regulation for cholesteric organization of cellulose nanocrystals based on internal and external factors.

Cellulose nanocrystals (CNCs), as one of the most promising bio-sourced materials, have been drawing increasing attention as they offer an attractive route for the rational design and sustainable manufacturing of photonic materials owing to their cholesteric self-assembly from the suspension to solid state. Such an organization process can be readily regulated depending on either internal factors or external forces. In this review, recent advances in the control over the self-assembly process and photonic organizations of CNCs are summarized.

Visualization and quantitative evaluation of aerosol deposition using 3D-printed adult nose cavities.

Local steroid medication is one of the most important treatment options for chronic rhinosinusitis. Regional deposition has a higher clinical value compared with total deposition in predicting treatment outcomes or evaluating adverse reactions. The goal of this project is to propose an effective technique for visualizing and quantifying aerosol deposition in a three-dimensional adult nasal cavity, and to verify the practicality of this method.

Fibroblast growth factor 21 improves diabetic cardiomyopathy by inhibiting ferroptosis via ferritin pathway.

Background: Diabetic cardiomyopathy (DCM) is a serious complication in patients with type 2 diabetes mellitus, and its mechanisms are complex and poorly understood. Despite growing evidence suggesting that ferroptosis plays a significant role in cardiovascular disease, it has been less extensively studied in DCM. Fibroblast growth factor 21 (FGF21), whose mechanism of action is closely related to ferroptosis, is widely utilized in studies focused on the prevention and treatment of glucolipid metabolism-related diseases and cardiovascular diseases.

Electrically switched asymmetric interfaces for liquid manipulation.

External field driven fluid manipulation, in particular electric field, offers the advantages of real-time control and exceptional flexibility, rendering it highly promising for applications in microfluidic devices, liquid separation and energy catalysis. However, it is still challenging for controlled liquid transport and fine control of droplet splitting. Herein, we demonstrate a strategy to achieve direction-controlled liquid transport and fine droplet splitting on an anisotropic groove-microstructured electrode surface an electrically switched asymmetric interface.

HSPD1 Supports Osteosarcoma Progression through Stabilizing ATP5A1 and thus Activation of AKT/mTOR Signaling.

Malignant transformation is concomitant with excessive activation of stress response pathways. Heat shock proteins (HSPs) are stress-inducible proteins that play a role in folding and processing proteins, contributing to the non-oncogene addiction of stressed tumor cells. However, the detailed role of the HSP family in osteosarcoma has not been investigated.