Publications by authors named "XiaoDan Tang"

Objectives: To evaluate positive health outcomes among children born at < 32 weeks of gestation and to determine whether children with three common neonatal morbidities and 2 neurodevelopmental impairments would have similar positive health outcomes to children and adolescents without these exposures and impairments.

Study Design: In this secondary analysis of prospectively acquired data derived from 3 multicenter cohorts of children born very preterm (the Extremely Low Gestational Age Newborn cohort [birth years 2001 to 2004], the Neurobehavior And Outcomes in Very Preterm Infants cohort [birth years 2014 to 2016], and the Developmental Impact of Neurobehavior And Outcomes in Very Preterm Infants Exposures cohort [birth years 2010 to 2020]), we examined associations between the 3 common neonatal morbidities (bronchopulmonary dysplasia, necrotizing enterocolitis, and intraventricular hemorrhage, diagnosed before hospital discharge), 2 neurodevelopmental impairments (developmental delays and cerebral palsy, diagnosed at preschool age follow-up), and perceptions of physical, mental, and social well-being (in either early childhood or adolescence), using the Patient-Reported Outcomes Measurement Information System scales for positive health.

Results: After adjusting for confounders, bronchopulmonary dysplasia, intraventricular hemorrhage, and cerebral palsy were associated with lower positive health scores, reported by parent-proxy during early childhood.

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  • COVID-19 vaccines are vital for public health, yet the specific changes in RNA editing caused by these vaccines are not fully understood.
  • A study analyzed RNA-Seq data from 260 blood samples and found significant RNA editing changes, identifying 5592 differential RNA editing sites across 1820 genes, which were mostly linked to immune responses.
  • The results suggest that RNA editing influenced by the vaccines affects the expression of key genes involved in immune and antiviral functions, indicating that the effects vary depending on the number of vaccine doses received.
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Previous studies have demonstrated the roles of both microglia homeostasis and RNA editing in sepsis-associated encephalopathy (SAE), yet their relationship remains to be elucidated. In this study, we analyzed bulk and single-cell RNA-seq (scRNA) datasets containing 107 brain tissue and microglia samples from mice with microglial depletion and repopulation to explore canonical RNA editing associated with microglia homeostasis and evaluate its role in SAE. Analysis of mouse brain RNA-Seq revealed hallmarks of microglial repopulation, including peak expressions of Apobec1 and Apobec3 at Day 5 of repopulation and dramatically altered B2m RNA editing.

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  • FGFR genomic alterations are found in 5-10% of human cancers, and erdafitinib has shown promise in treating various advanced solid tumors but its effectiveness in Asian patients was unclear.
  • A phase IIa study was conducted to assess the efficacy of erdafitinib in Asian patients with FGFR-altered advanced cholangiocarcinoma, non-small cell lung cancer (NSCLC), and esophageal cancer by evaluating various response rates and survival metrics.
  • Results indicated a 40.9% objective response rate in cholangiocarcinoma patients, while NSCLC did not show any objective responses; however, all patients experienced adverse effects, highlighting the need for further safety assessment.
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  • The study analyzed data from 2,518 participants in the NIH ECHO Program to assess the reliability of a brief caregiver support and cognitive stimulation scale for infants and toddlers.
  • The children in the study had a mean age of 1.51 years, with 48% being female and 43% identifying as Black.
  • An analysis plan confirmed the development of a reliable 10-item scale, demonstrating high precision, especially for children with lower cognitive stimulation levels (reliability >0.7).
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Electron transfer pathways have been verified as overriding regimes when peroxydisulfate (PDS) was activated by porous carbon. The incorporation of graphitic structure into carbon matrix was favorable to the rapid electron transfer, but excessive graphitization would deteriorate the specific surface area (SSA), weakening the catalytic performance. The reasonable trade-off between SSA and graphitization degree was necessary and challenging for the preparation of efficient carbon based PS-activators.

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  • Malignant atrophic papulosis (MAP) is a rare vascular disease with no known cause or established treatment, affecting multiple body systems, particularly the gastrointestinal tract and central nervous system; it generally has a poor prognosis.
  • A case study of a 20-year-old male with MAP showed severe symptoms like abdominal pain, bowel perforation, and abscesses, and he was treated with various medications and surgeries but ultimately died within five months.
  • The study emphasizes the need for early surgical evaluation and aggressive treatment options like eculizumab and treprostinil for patients with MAP to improve survival rates, particularly those with abdominal symptoms.
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Background: This study aims to evaluate the agreement in substance use on both binary and ordinal scales between 3-month and 6-month recall periods with samples from different communities, demographic backgrounds, and HIV status.

Methods: We administered the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) to 799 participants from three different North American cohorts focused on substance use and HIV. We conducted a within-person agreement analysis by calculating the agreement levels and Kappa statistic between data collected using the 3-month recall ASSIST and 6-month custom substance use surveys as well as different terminology for each substance in multiple cohorts.

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Introduction: Aligned with the increasing need for standardized assessment of physical function in older individuals with cancer and other conditions, several patient-reported outcome measures (PROMs) have been developed and published. The aim of this study is to link the Strength, Assistance with walking, Rising from a chair, Climbing stairs, and Falls questionnaire (SARC-F), and the Patient-Reported Outcomes Measurement Information System® (PROMIS®) Physical Function Short Form 8c (PROMIS PF 8c), and make their scores convertible, in order to expand the use of both instruments in research and inform clinicians and researchers about the interchangeability of critical cut-off scores.

Materials And Methods: The sample included 300 participants recruited from an online panel.

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Catalase (CAT) is often phosphorylated and activated by protein kinases to maintain hydrogen peroxide (H2O2) homeostasis and protect cells against stresses, but whether and how CAT is switched off by protein phosphatases remains inconclusive. Here, we identified a manganese (Mn2+)-dependent protein phosphatase, which we named PHOSPHATASE OF CATALASE 1 (PC1), from rice (Oryza sativa L.) that negatively regulates salt and oxidative stress tolerance.

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Objectives: This study aimed to examine the ability of classical test theory (CTT) and item response theory (IRT) scores assessed by Patient-Reported Outcomes Measurement Information System® (PROMIS®) measures to identify significant individual changes in the setting of clinical studies, using both simulated and empirical data.

Methods: We used simulated data to compare the estimation of significant individual changes between CTT and IRT scores across different conditions and a clinical trial data set to verify the simulation results. We calculated reliable change indexes to estimate significant individual changes.

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Perovskite film-quality is a crucial factor to improve the photovoltaic properties of perovskite solar cells, which is closely related to the morphology of crystallization grain size of the perovskite layer. However, defects and trap sites are inevitably generated on the surface and at the grain boundaries of the perovskite layer. Here, we report a convenient method for preparing dense and uniform perovskite films, employing g-CN quantum dots doped into the perovskite layer by regulating proper proportions.

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Purpose: To compare NFOSI-18 Disease Related Symptoms - Physical (DRSP), Total score, and side effect bother between maintenance rucaparib (600 mg twice daily) vs. placebo in the phase III ARIEL3 trial.

Methods: ARIEL3 (NCT01968213) included patients with ovarian carcinoma who responded to second-line or later platinum-based chemotherapy.

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Background: Soil salinization is a major abiotic environmental stress factor threatening crop production throughout the world. Salt stress drastically affects the growth, development, and grain yield of rice (Oryza sativa L.), and the improvement of rice tolerance to salt stress is a desirable approach for meeting increasing food demand.

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Background: Studies have reported mixed findings regarding the impact of the coronavirus disease 2019 (COVID-19) pandemic on pregnant women and birth outcomes. This study used a quasi-experimental design to account for potential confounding by sociodemographic characteristics.

Methods: Data were drawn from 16 prenatal cohorts participating in the Environmental influences on Child Health Outcomes (ECHO) program.

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Efficiency and stability are key factors determining the final cost of electricity that perovskite solar cells (PSCs) generate. To date, effective strategy to progress in achieving efficient and stable PSCs is still a difficult problem that researchers continue to explore. This study reports a useful way to improve the quality of SnO film by introducing potassium citrate (PC) into SnO nanoparticles solution.

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Objective: We sought to evaluate the impact of the coronavirus disease 2019 (COVID-19) pandemic on perinatal outcomes while accounting for maternal depression or perceived stress and to describe COVID-specific stressors, including changes in prenatal care, across specific time periods of the pandemic.

Study Design: Data of dyads from 41 cohorts from the National Institutes of Health Environmental influences on Child Health Outcomes Program ( = 2,983) were used to compare birth outcomes before and during the pandemic ( = 2,355), and a partially overlapping sample ( = 1,490) responded to a COVID-19 questionnaire. Psychosocial stress was defined using prenatal screening for depression and perceived stress.

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Reducing the interfacial defects of perovskite films is key to improving the performance of perovskite solar cells (PSCs). In this study, two kinds of perylene monoimide (PMI) derivative phosphonium bromide salts were designed and used as a multifunctional interface-modified layer in PSCs. These two molecules are inserted between SnO and perovskite to produce a bidirectional passivation effect.

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Importance: The primary outcomes of the COVID-19 pandemic on the mental health of women with children remain largely unknown.

Objectives: To identify and describe clusters of mothers of children participating in the Environmental influences on Child Health Outcomes (ECHO) Program that characterize pandemic-associated hardships, coping mechanisms, and behaviors, and to evaluate associations between pandemic-associated hardships, coping strategies, and behavior changes with pandemic-associated traumatic stress symptoms.

Design, Setting, And Participants: This multicenter cohort study investigated experiences during the COVID-19 pandemic between April 2020 and August 2021 among maternal caregivers of children participating in the ECHO Program.

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Sudan dyes are strictly prohibited from being added to edible products as carcinogens and tetracycline hydrochloride (TC) remaining in animal-derived food may cause harm to the human body. Therefore, it is necessary to establish a high-sensitivity, simple and convenient method for the detection of Sudan dyes and TC in foods for safety purposes. In this work, multifunctional blue fluorescent carbon dots (B-CDs) were prepared by a one-step hydrothermal synthesis using glucose as the carbon source.

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A linking procedure establishes a "bridge" between the scores from different patient-reported outcome (PRO) instruments that measure similar constructs. After developing a linking relationship however, it is critical to evaluate whether this relationship can be generalized to different groups. Our study aims to validate a published crosswalk for score conversion between the Brief Symptom Inventory Depression subscale and the Patient-Reported Outcomes Measurement Information System Depression 8a using an independent sample.

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Problem: In recent years, the incidence of female infertility has risen sharply, which is affected by many factors. It was recognized that female reproductive tract microbes play a role in the process of female conception. If the reproductive tract microbes could solve a certain proportion of infertility, it would certainly reduce the pain and economic burden of many patients.

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Perovskite films with few defects play a key role in preparing high-performance perovskite solar cells (PSCs). Here, cesium chloride (CsCl) was introduced as a modulator into a perovskite precursor for manipulating the crystallization of perovskite films. By introducing CsCl, dense homogeneous perovskite films with high crystallinity, preferential orientation, and a pure black perovskite phase were prepared.

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Introduction: Linking scores on patient-reported outcome measures can enable data aggregation for research, clinical care, and quality. We aimed to link scores on the Hip Disability and Osteoarthritis Outcome Score-Physical Function Short Form (HOOS-PS) and the Patient-reported Outcomes Measurement Information System Physical Function (PROMIS PF).

Methods: A retrospective study was conducted from 2017 to 2020 evaluating patients with hip osteoarthritis who received routine clinical care from an orthopaedic surgeon.

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