Depression as a Risk Factor for Gynecological Cancers: Evidence from NHANES Data.

Purpose: Depression is one of the leading sources of disease burden globally and plays a significant role in the occurrence and development of many cancers, representing an important health risk. However, the relationship between depression and the risk of gynecologic cancers has not been fully assessed. This study aims to explore the association between depression and the risk of gynecologic cancers.

Ethanol-controlled release strategy induced local solvation polymerization of silicates for high-performance nano-silicon anode.

Silicon (Si) is a promising anode material for next-generation lithium-ion batteries (LIBs) due to its exceptionally high theoretical specific capacity (4200 mAh g), offering potential to replace traditional graphite in high-energy-density LIBs. However, Si anodes suffer from significant volume changes during lithiation/delithiation processes, posing a major challenge. In this study, we propose a reaction kinetics mechanism mediated by hydrogen-bond-induced local solvation effects for facilely obtaining coral-like nano-silicon (CN-Si).

Biomarkers of cell cycle arrest, microcirculation dysfunction, and inflammation in the prediction of SA-AKI.

Sepsis-associated acute kidney injury (SA-AKI) is a severe complication in critically ill patients, with a complex pathogenesis involving in cell cycle arrest, microcirculatory dysfunction, and inflammation. Current diagnostic strategies remain suboptimal. Therefore, this study aimed to evaluate pathophysiology-based biomarkers and develop an improved predictive model for SA-AKI.

Repurposing fenticonazole nitrate to restore colistin susceptibility in multidrug-resistant bacteria.

Aims: To explore the synergistic effect of the combination of FN and colistin on Escherichia coli and further elucidate the mechanism of this effect.

Main Methods: Antimicrobial efficacy of the combination of fenticonazole nitrate and colistin against Escherichia coli in vitro using MIC assays, checkerboard assays, growth curves, and time-kill curves. Crystalline violet staining for detection of biofilm.

Main features and treatments of cervical cysts in children from a single-center experience.

Background: The cervical cysts is one of the most common children ailments an ENT surgeon encountered, which often begins with painless masses in the neck. The present study summarizes main clinical features of various types of children cervical cysts and discusses the possible approaches and associated complications, with an aim to improve the diagnosis and treatment of this pediatric disease.

Methods: We retrospectively analyzed the clinical data of patients admitted with cervical cyst to Beijing Children's Hospital, Capital Medical University from January 2018 to December 2023.

Dysregulation of the SREBP pathway is associated with poor prognosis and serves as a potential biomarker for the diagnosis of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a severe disease associated with a poor prognosis. The role of aberrant lipid metabolism in the development and progression of HCC necessitates detailed characterization. Sterol regulatory element‑binding proteins (SREBPs), pivotal transcription factors governing lipogenesis, are central to this process.

A Comparative Investigation on Clinical Characteristics in Pediatric Obstructive Sleep Apnea Based on Two Distinct Guidelines.

Objective: To investigate the differences in assessment of clinical characteristics between children with obstructive sleep apnea (OSA) diagnosed according to the 2007 and 2020 guidelines and those without OSA, together with the relationships between polysomnography (PSG) parameters and cognitive tests scores in preschool and school-aged children with OSA.

Methods: Eighty children were totally recruited and divided into OSA and non-OSA groups based on two distinct guidelines, with further subclassification into preschool and school-aged subgroups. Differences in PSG parameters and cognitive tests scores between groups and subgroups were analyzed and compared, followed by partial correlation analysis to determine the correlations between these characteristics.

Metabolic reprogramming of glucose: the metabolic basis for the occurrence and development of hepatocellular carcinoma.

Primary liver cancer is a common malignant tumor of the digestive system, with hepatocellular carcinoma (HCC) being the most prevalent type. It is characterized by high malignancy, insidious onset, and a lack of specific early diagnostic and therapeutic markers, posing a serious threat to human health. The occurrence and development of HCC are closely related to its metabolic processes.

Aberrant Resting-State Effective Connectivity Between the Insula and Other Regions of the Whole Brain in Children With Obstructive Sleep Apnea.

To investigate the effective connectivity between the bilateral insulae and other regions of the whole brain in children with obstructive sleep apnea (OSA), and to reveal the relationships between these abnormal connections and cognitive dysfunction in this condition. Resting-state functional magnetic resonance imaging (rs-fMRI) data and clinical variables were collected from 55 children with OSA [5.0 (5.

Rhabdomyosarcoma of the Middle Ear and Mastoid in Children: Experience of the Beijing Children's Hospital-BCH.

Objectives: To conduct a retrospective analysis of the clinical characteristics and prognosis of rhabdomyosarcoma of the middle ear and mastoid (MERMS) in children.

Methods: Treatment and outcome of 37 children with MERMS from Beijing Children's Hospital (July 2016-April 2023) were evaluated.

Results: The median age of this cohort was 54 months.

Imidazolium-Functionalized Ionic Porous Organic Polymer for Efficient Removal of Oxo-Anions Pollutants from Water.

The development of highly efficacious materials for the removal of toxic heavy metal-based oxo-anions is of utmost importance. Herein, an ionic porous organic polymer (designated as HB-IPOP) was synthesized through a quaternization reaction between hexa(imidazole-1-yl)benzene and 5,5'-Bis(bromomethyl)-2,2'-bipyridine. HB-IPOP exhibited high saturation uptake capacities, specifically 292 mg·g for CrO and 531 mg·g for ReO, and demonstrated exceptional selectivity for both CrO and ReO.

Study on Hypervelocity Impact Characteristics of Polypropylene Spheres on Whipple Shields.

The hypervelocity impact characteristics of 7 mm diameter polypropylene spheres on Whipple shields with different bumper thicknesses at a velocity ranging from 2.257 to 4.012 km/s are studied in this work.

Lycorine attenuates lipopolysaccharide-induced inflammation and intestinal epithelial barrier dysfunction in Caco-2 cells through inhibiting the STING/NF-κB pathway.

Lycorine (LYC) is an isoquinoline alkaloid known for its various biological effects like anti-viral and anti-inflammatory. The purpose of this research was to offer a reference for the clinical application of LYC in inflammatory bowel disease. The toxicity of LYC on Caco-2 cells was assessed utilizing CCK-8 assay and Lactate dehydrogenase (LDH) kit.

Weight Management for Fertility-Preservation Therapy in Endometrial Cancer: Opportunities and Challenges.

Purpose Of Review: Obesity is increasingly recognized as a significant factor impacting the outcomes of fertility-preserving therapies for endometrial cancer (EC). This review explores the effects of glycolipid metabolism on EC and its relationship with body weight. We will examine how excess body weight influences the effectiveness of fertility-preserving treatments and discuss potential mechanisms for effective weight management.

A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity.

Background And Purpose: Nicotinic acetylcholine receptors (nAChRs), which are expressed throughout the mammalian brain, mediate a variety of physiological functions. Despite their widespread presence, the functions of nAChRs are not yet fully understood. α-Conotoxins, which are peptides derived from the venom of marine cone snails, target different subtypes of nAChRs.

Tomato B-cell lymphoma2 (Bcl2)-associated athanogene 5 (SlBAG5) contributes negatively to immunity against necrotrophic fungus Botrytis cinerea through interacting with SlBAP1 and modulating catalase activity.

The evolutionarily conserved and multifunctional B-cell lymphoma2 (Bcl2)-associated athanogene proteins (BAGs), serving as co-chaperone regulators, play a pivotal role in orchestrating plant stress responses. In this study, the possible involvement of tomato SlBAG genes in resistance to Botrytis cinerea was examined. The SlBAG genes respond with different expression change patterns to B.

Ethyl 2,2-difluoro-2-(2-oxo-2H-chromen-3-yl) acetate inhibits the malignant biological behaviors of colorectal cancer by restricting the phosphorylation and nuclear translocation of STAT3.

To investigate the effect of a novel coumarin derivative, ethyl 2,2-difluoro-2 - (2-oxo-2H-chromen-3-yl) acetate (C2F), on the malignant biological behaviors of colorectal cancer (CRC) and elucidate its mechanism. In vitro, the effects of C2F on the proliferation, apoptosis, migration, invasion, and cell cycle of CRC cells were analyzed by MTT assay, EdU staining, colony formation assay, flow cytometry, wound healing and transwell assay. The anti-CRC activity of C2F was evaluated in a nude mice xenograft model in vivo.

Rapid and Simultaneous Detection of Petroleum Hydrocarbons and Organic Pesticides in Soil Based on Electronic Nose.

The rapid detection of petroleum hydrocarbons and organic pesticides is an important prerequisite for precise soil management. It is also a guarantee for soil quality, environmental safety, and human health. However, the current rapid detection methods are prone to sample matrix interference, complex development processes, short lifespan, and low detection accuracy.

miR-134-3p Regulates Cell Proliferation and Apoptosis by Targeting INHBA via Inhibiting the TGF-β/PI3K/AKT Pathway in Sheep Granulosa Cells.

Inhibin β-A (), a TGF-β superfamily member, is crucial for developing follicles. Although miRNAs are essential for post-transcriptional gene regulation, it is not yet known how they affect the expression of during follicle development. Using bioinformatics analyses, miR-134-3p was found, in this investigation, to be a crucial microRNA that targets in sheep GCs.

In situ Polymerized Solid-State Electrolyte Enabling Inorganic-Organic Dual-Layered SEI Film for Stable Lithium Metal Batteries.

In situ polymerization of cyclic ethers is a promising strategy to construct solid-state lithium (Li) metal batteries with high energy density and safety. However, their practical applications are plagued by the unsatisfactory electrochemical properties of polymer electrolytes and the unstable solid electrolyte interphase (SEI). Herein, organic perfluorodecanoic acid (PFDA) is proposed as a new initiator to polymerize 1,3-dioxolane electrolyte (PDOL), which enables the as-obtained PDOL electrolyte to deliver greatly enhanced ionic conductivity and broadened electrochemical window.

An investigation into the zoning of ecosystem sensitivity control areas in Mentougou District (Beijing, China).

To achieve a more precise delineation of ecosystem sensitivity control areas, this study examines the Mentougou District in Beijing and introduces the Ecosystem Sensitivity Control Area Classification Method (ESCACM). This novel approach combines single-factor sensitivity analysis, multi-factor comprehensive sensitivity assessments, and strategies for zoning based on various ecological scenarios. The study categorizes the region into three specific zones: first-level management and control areas, second-level management and control areas, and non-management and control areas.

Correction: Enhanced and unenhanced: Radiomics models for discriminating between benign and malignant cystic renal masses on CT images: A multi-center study.

[This corrects the article DOI: 10.1371/journal.pone.

Association of Red Blood Cell Distribution Width to Albumin Ratio With the Prevalence of Kidney Stones Among the General Adult Population.

Background: The red blood cell distribution width (RDW) and serum albumin levels are potential indicators of inflammatory conditions. However, the relationship between the RDW to albumin ratio (RAR) and the prevalence of kidney stones in the general adult population is not yet established.

Methods: This study utilized data from the 2007 to 2018 National Health and Nutrition Examination Survey (NHANES) project.

The individual and combined effects of polycyclic aromatic hydrocarbons on asthma among US children: evidence from the NHANES study.

Polycyclic Aromatic Hydrocarbons (PAHs) exposure has been linked to asthma, but their individual and combined effects in children remain unclear. Using data from the 2003-2012 National Health and Nutrition Examination Survey (NHANES), we investigated the associations between PAHs and asthma through logistic regression, Weighted Quantile Sum (WQS) regression, Quantile g Computation (qg computation), and Bayesian Kernel Machine Regression (BKMR). Subgroup analyses revealed a significant impact of PAHs on asthma, particularly in males.