NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer.

Lung cancer has a high mortality rate worldwide. Non‑SMC condensin I complex subunit H (NCAPH) has been identified to be one of the regulatory subunits of the condensin I complex, which is essential for the correct packaging and segregation of chromosomes in eukaryotes. NCAPH is abnormally overexpressed in various types of cancer.

Stimuli-Responsive Luminescent Properties of Tetraphenylethene-Based Strontium and Cobalt Metal-Organic Frameworks.

Herein we report two new TPE-based 3D MOFs, that is, Sr-ETTB and Co-ETTB (TPE=Tetraphenylethylene, H ETTB=4',4''',4''''',4'''''''-(ethene-1,1,2,2-tetrayl)tetrakis(([1,1'-biphenyl]-3,5-dicarboxylic acid))). Through tailoring outer shell electron configurations of Sr and Co cations, the fluorescence intensity of the MOFs is tuned from high emission to complete non-emission. Sr-ETTB with strong blue fluorescence shows reversible fluorescence variations in response to pressure and temperature, which is directly related to the reversible deformation of the crystal structure.

Triplet Therapy with PD-1 Blockade, Histone Deacetylase Inhibitor, and DNA Methyltransferase Inhibitor Achieves Radiological Response in Refractory Double-Expressor Diffuse Large B-cell Lymphoma with 17p Deletion.

Double-expressor diffuse large B-cell lymphoma (DLBCL) with deletion is an aggressive and refractory disease. Immune checkpoint blockade and epigenetic drugs have been widely used, but the efficacy of different combined applications varied. We report a case with "double-expressor" DLBCL treated with a combined regimen which consisted of programmed cell death protein 1 (PD-1) inhibitor, DNA methyltransferase inhibitor (DNMTi), and histone deacetylase inhibitor (HDACi).

Effective and Robust Parameter Identification Procedure of a Two-Site Langmuir Kinetics Model for a Gas Sensor Process.

Gas sensors have received plenty of attention due to various applications, and the methods to model the kinetic processes and estimate the corresponding parameters play a critical role in characterizing the sensor response behavior. In this work, a two-site Langmuir kinetics model is applied to describe the adsorption/desorption response processes of a SnO/reduced graphene oxide resistive gas sensor and the pertinent kinetic parameters are optimized based on the genetic algorithm (GA). For the robustness and fast convergence of the GA, the initial values and ranges of kinetic parameters are obtained step-by-step.

Atomic-scale phase separation induced clustering of solute atoms.

Dealloying typically occurs via the chemical dissolution of an alloy component through a corrosion process. In contrast, here we report an atomic-scale nonchemical dealloying process that results in the clustering of solute atoms. We show that the disparity in the adatom-substrate exchange barriers separate Cu adatoms from a Cu-Au mixture, leaving behind a fluid phase enriched with Au adatoms that subsequently aggregate into supported clusters.

Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.

FadE, an acyl-CoA dehydrogenase, introduces unsaturation to carbon chains in lipid metabolism pathways. Here, we report that FadE5 from (FadE5) and (FadE5) play roles in drug resistance and exhibit broad specificity for linear acyl-CoA substrates but have a preference for those with long carbon chains. Here, the structures of FadE5 and FadE5, in the presence and absence of substrates, have been determined.

[Use of Hybrid Stent in Management of Complex Malignant Airway Stenosisand Fistulas].

Background: Airway stents has been widely used in airway stenosis and fistula, yet clinical date of airway stents in reestablishment a complex airway is insufficient. The aim of this study is to evaluate the efficacy and safety to combine the silicon stent and the metal stent in reestablishment a complex malignant airway.

Methods: Patients with non-operable complex malignant airway stenosis and fistula were recruited in this study.

Robust Cooperative Multi-Vehicle Tracking with Inaccurate Self-Localization Based on On-Board Sensors and Inter-Vehicle Communication.

The fusion of on-board sensors and transmitted information via inter-vehicle communication has been proved to be an effective way to increase the perception accuracy and extend the perception range of connected intelligent vehicles. The current approaches rely heavily on the accurate self-localization of both host and cooperative vehicles. However, such information is not always available or accurate enough for effective cooperative sensing.

Reactions of CO and ethane enable CO bond insertion for production of C3 oxygenates.

Reacting CO and ethane to synthesize value-added oxygenate molecules represents opportunities to simultaneously reduce CO emissions and upgrade underutilized ethane in shale gas. Herein, we propose a strategy to produce C3 oxygenates using a tandem reactor. This strategy is achieved with a FeNi/CeO catalyst (first reactor at 600-800 °C) for CO-assisted dehydrogenation and reforming of ethane to produce ethylene, CO, and H, and a RhCo/MCM-41 catalyst (second reactor at 200 °C) enabling CO insertion for the production of C3 oxygenates (propanal and 1-propanol) via the heterogeneous hydroformylation reaction at ambient pressure.

Multi-Class ASD Classification Based on Functional Connectivity and Functional Correlation Tensor via Multi-Source Domain Adaptation and Multi-View Sparse Representation.

The resting-state functional magnetic resonance imaging (rs-fMRI) reflects functional activity of brain regions by blood-oxygen-level dependent (BOLD) signals. Up to now, many computer-aided diagnosis methods based on rs-fMRI have been developed for Autism Spectrum Disorder (ASD). These methods are mostly the binary classification approaches to determine whether a subject is an ASD patient or not.

A stable nanoscaled Zr-MOF for the detection of toxic mycotoxin through a pH-modulated ratiometric luminescent switch.

A stable nanoscaled single-excitation ratiometric luminescent pH sensor (MPDB-PCN) over a broad pH range from 2.5 to 8.6 is fabricated through post-synthetic modification of PCN-224 with naphthalimide-derived molecules.

Laser-speckle-projection-based handheld anthropometric measurement system with synchronous redundancy reduction.

Human body measurement is essential in modern rehabilitation medicine, which can be effectively combined with the technology of additive manufacturing. Digital image correlation based on laser speckle projection is a single-shot, accurate, and robust technique for human body measurement. In this paper, we present a handheld anthropometric measurement system based on laser speckle projection.

A toolbox for brain network construction and classification (BrainNetClass).

Brain functional network has been increasingly used in understanding brain functions and diseases. While many network construction methods have been proposed, the progress in the field still largely relies on static pairwise Pearson's correlation-based functional network and group-level comparisons. We introduce a "Brain Network Construction and Classification (BrainNetClass)" toolbox to promote more advanced brain network construction methods to the filed, including some state-of-the-art methods that were recently developed to capture complex and high-order interactions among brain regions.

Surface-reaction induced structural oscillations in the subsurface.

Surface and subsurface are commonly considered as separate entities because of the difference in the bonding environment and are often investigated separately due to the experimental challenges in differentiating the surface and subsurface effects. Using in-situ atomic-scale transmission electron microscopy to resolve the surface and subsurface at the same time, we show that the hydrogen-CuO surface reaction results in structural oscillations in deeper atomic layers via the cycles of ordering and disordering of oxygen vacancies in the subsurface. Together with atomistic calculations, we show that the structural oscillations in the subsurface are induced by the hydrogen oxidation-induced cyclic loss of oxygen from the oxide surface.

Paraxial lens design of double-telecentric anamorphic zoom lenses with variable magnifications or fixed conjugate.

This paper presents a paraxial lens design method for anamorphic zoom lenses with double telecentricity. Four types of such lens systems are provided, which are the Y-X-Y-Y type, the Y-Y-Y-X type, the Y-X-Y-X type, and the Y-X-X-Y type. For each lens type, it can work in two different conditions: (a) the distance between the object and the image is fixed during anamorphic zooming, or (b) the magnifications in the tangential plane and the sagittal plane can be changed independently by changing the interval lens distances.

Camera calibration using a planar target with pure translation.

This paper presents a novel camera calibration method using a planar target with pure translation and a known translation distance. It only requires the straightness and position accuracy of the one-axis translational platform. There are theoretically no constraints among the normal direction of the planar target, the optical axis direction of the camera, and the moving direction of the translational platform.

Nomogram For The Prediction Of Malignancy In Small (8-20 mm) Indeterminate Solid Solitary Pulmonary Nodules In Chinese Populations.

Purpose: This study aimed to develop and validate a nomogram for predicting the malignancy of small (8-20 mm) solid indeterminate solitary pulmonary nodules (SPNs) in a Chinese population by using routine clinical and computed tomography data.

Methods: The prediction model was developed using a retrospective cohort that comprised 493 consecutive patients with small indeterminate SPNs who were treated between December 2012 and December 2016. The model was independently validated using a second retrospective cohort comprising 216 consecutive patients treated between January 2017 and May 2018.

A non-luminescent Eu-MOF-based "turn-on" sensor towards an anthrax biomarker through single-crystal to single-crystal phase transition.

A porous NH-MOF-76(Eu) (MOF 1) with unexpected non-luminescence was designed and synthesized. It exhibits selective fluorescence recovery for sensing dipicolinic acid (DPA), a biomarker of Bacillus anthracis. Moreover, a new europium-based MOF (MOF 2) with evident channel changes was obtained through a single-crystal to single-crystal phase transition.

Safety and efficacy of sufentanil combined with midazolam in bronchoscopy under conscious sedation: retrospective study of 11,158 cases.

Background: The recommended conscious sedation for bronchoscopy is still lacking. The safety and efficacy of sufentanil combined with midazolam in bronchoscopy under conscious sedation is not well elucidated.

Methods: A retrospective analysis was conducted on patients who received bronchoscopy in the First Affiliated Hospital of Guangzhou Medical University from September 2013 to July 2017.

Defects-Induced In-Plane Heterophase in Cobalt Oxide Nanosheets for Oxygen Evolution Reaction.

Cobalt oxides as efficient oxygen evolution reaction (OER) electrocatalysts have received much attention because of their rich reserves and cheap cost. There are two common cobalt oxides, Co O (spinel phase, stable but poor intrinsic activity) and CoO (rocksalt phase, active but easily be oxidatized). Constructing Co O /CoO heterophase can inherit both characteristic features of each component and form a heterophase interface facilitating charge transfer, which is believed to be an effective strategy in designing excellent electrocatalysts.

Quinary Defect-Rich Ultrathin Bimetal Hydroxide Nanosheets for Water Oxidation.

The electronic structure of layered double hydroxides (LDHs) can be modulated by heteroatom doping and creating vacancies. The number of exposed active sites can be enriched by exfoliating the bulk structure into fewer layers. Herein, we successfully achieved multielement doping and exfoliation for CoFe LDHs by one SF-plasma etching step at room temperature (named as CoFe LDHs-SF).

Facile synthesis of a novel WO/AgMoO particles-on-plate staggered type II heterojunction with improved visible-light photocatalytic activity in removing environmental pollutants.

A novel WO/AgMoO heterojunction has been synthesized through a facile precipitation method with AgMoO particles firmly deposited on the surface of WO nanoplates, forming "particles-on-plate" type II heterojunction structures. This heterojunction exhibited improved photocatalytic activities for the degradation of rhodamine B (RhB), 4 chlorophenol (4-CP) and tetracycline hydrochloride (TC) under visible-light irradiation compared to pure AgMoO and WO. In addition, the heterojunction with 10 wt% AgMoO displays the best photocatalytic performance, which was about 2 times better than that of pure WO or AgMoO.

Strength and Similarity Guided Group-level Brain Functional Network Construction for MCI Diagnosis.

Sparse representation-based brain functional network modeling often results in large inter-subject variability in the network structure. This could reduce the statistical power in group comparison, or even deteriorate the generalization capability of the individualized diagnosis of brain diseases. Although group sparse representation (GSR) can alleviate such a limitation by increasing network similarity across subjects, it could, in turn, fail in providing satisfactory separability between the subjects from different groups (e.

Comparison of the Level of Free Hexafluoro-isopropanol in Adults' Blood and the Incidence of Emergence Agitation After Anesthesia With Different Concentrations of Sevoflurane in Laparoscopic Gastrointestinal Surgery: A Randomized Controlled Clinical Trial.

Purpose: The aim of the study is to compare the free hexafluoro-isopropanol (HFIP) concentration in adults' blood and the incidence of emergence agitation (EA) after inhaled different concentrations of sevoflurane.

Methods: Sixty adult patients planning to undergo laparoscopic gastrointestinal surgery were randomly assigned to 3 groups. Each group received sevoflurane as the volatile anesthetic at different concentrations: 0.