Non-cytotoxic levels of resveratrol enhance the anticancer effects of cisplatin by increasing the methyltransferase activity of CARM1 in human cancer cells.

Background: Resveratrol (RSVL) is a plant-derived polyhydroxyphenolic compound with excellent anticancer properties, alone or in combination with other chemotherapeutic drugs. However, the anticancer mechanism of RSVL is diverse and high concentrations are often required for RSVL to exert its anticancer effect, which would also adversely affect normal cells.

Purpose: The main objective of this study is to investigate the molecular mechanism of how non-cytotoxic concentrations of RSVL enhance the anticancer effect of cisplatin involving a newly identified RSVL-binding protein.

Functional outcome following spontaneous intracerebral hemorrhage between ultrasound guidance endoscopic surgery and conventional craniotomy: A retrospective population-based study.

Objectives: Ultrasound guidance endoscopic surgery (ES) has been widely used in the treatment of cerebral hemorrhage in recent years, but relevant research articles are still scarce. Our study aims to investigate the effect of ES compared with conventional craniotomy (CC) on the postoperative complications, and prognosis of patients with intracerebral hemorrhage.

Materials And Methods: The clinical data of 1201 patients with ICH treated in our hospital from January 2017 to January 2020 were collected.

Cross-sectional study of characteristics of body composition of 24,845 children and adolescents aged 3-17 years in Suzhou.

Background: We aimed to analyze the characteristics of the body composition of children and adolescents aged 3-17 in Suzhou, China.

Methods: A cross-sectional study between January 2020 and June 2022 using bioelectrical impedance was conducted to determine the fat mass (FM), fat-free mass (FFM), skeletal muscle mass, and protein and mineral contents of 24,845 children aged 3-17 who attended the Department of Child and Adolescent Healthcare, Children's Hospital of Soochow University, China. Measurement data was presented in tables as mean ± SD, and groups were compared using the independent samples t-test.

Perfect Core-Shell Octahedral B@B , Be@B , and Zn@B with an Octa-Coordinate Center as Superatoms Following the Octet Rule.

The front cover artwork is provided by Prof. Si-Dian Li's group at Shanxi University, China. The image shows the smallest perfect core-shell octahedral borospherene O B@B and its endohedral metallo-borospherene analogs O Be@B and O Zn@B obtained at first-principles theory.

The Atypical MAP Kinase MAPK15 Is Required for Lung Adenocarcinoma Metastasis via Its Interaction with NF-κB p50 Subunit and Transcriptional Regulation of Prostaglandin E2 Receptor EP3 Subtype.

Studying the relatively underexplored atypical MAP Kinase MAPK15 on cancer progression/patient outcomes and its potential transcriptional regulation of downstream genes would be highly valuable for the diagnosis, prognosis, and potential oncotherapy of malignant tumors such as lung adenocarcinoma (LUAD). Here, the expression of MAPK15 in LUAD was detected by immunohistochemistry and its correlation with clinical parameters such as lymph node metastasis and clinical stage was analyzed. The correlation between the prostaglandin E2 receptor EP3 subtype (EP3) and MAPK15 expression in LUAD tissues was examined, and the transcriptional regulation of EP3 and cell migration by MAPK15 in LUAD cell lines were studied using the luciferase reporter assay, immunoblot analysis, qRT-PCR, and transwell assay.

Identification of Sodium- and Chloride-Sensitive Sites in the Slack Channel.

The Slack channel (KCNT1, Slo2.2) is a sodium-activated and chloride-activated potassium channel that regulates heart rate and maintains the normal excitability of the nervous system. Despite intense interest in the sodium gating mechanism, a comprehensive investigation to identify the sodium-sensitive and chloride-sensitive sites has been missing.

Relationship between the Height of Alveolar Bone Resorption and Sex and Age in Adolescents.

Objectives: To explore the relationship between the height of alveolar bone resorption and sex and age in the adolescent dentition.

Methods: Multi-slice computed tomography (MSCT) was used to measure the height of alveolar bone resorption at labial, lingual, mesial and distal sites of teeth in 149 adolescents aged from 10 to 20 years. SPSS 25.

Perfect Core-Shell Octahedral B@B , Be@B , and Zn@B with an Octa-Coordinate Center as Superatoms Following the Octet Rule.

Planar, tubular, cage-like, and bilayer boron clusters B (n=3∼48) have been observed in joint experimental and theoretical investigations in the past two decades. Based on extensive global searches augmented with first-principles theory calculations, we predict herein the smallest perfect core-shell octahedral borospherene O B@B (1) and its endohedral metallo-borospherene analogs O Be@B (2), and O Zn@B (3) which, with an octa-coordinate B, Be or Zn atom located exactly at the center, turn out to be the well-defined global minima of the systems highly stable both thermodynamically and dynamically. B@B (1) represents the first boron-containing molecule reported to date which contains an octa-coordinate B center covalently coordinated by eight face-capping boron atoms at the corners of a perfect cube in the first coordination sphere.

Boron-lead multiple bonds in the PbBO and PbBO clusters.

Despite its electron deficiency, boron can form multiple bonds with a variety of elements. However, multiple bonds between boron and main-group metal elements are relatively rare. Here we report the observation of boron-lead multiple bonds in PbBO and PbBO, which are produced and characterized in a cluster beam.

Effects of CYP3A43 Expression on Cell Proliferation and Migration of Lung Adenocarcinoma and Its Clinical Significance.

The cytochrome P450s (CYP450s) include key oxidative enzymes involved in the metabolism of various carcinogens and anticancer drugs. Bioinformatic studies have demonstrated the association of CYP3A43 with liver cancer and ovarian cancer. However, the biological function of CYP3A43 in tumor progression remains unclear.

Transcriptional upregulation of MAPK15 by NF-κB signaling boosts the efficacy of combination therapy with cisplatin and TNF-α.

The efficacy of cisplatin in treating advanced non-small cell lung cancer is limited mainly because of insensitivity and/or acquired resistance. MAPK15, previously shown by us to enhance the sensitivity of the anti-cancer drug arsenic trioxide, could also enhance the sensitivity of other anti-cancer drugs. Here, we explore the potential role of MAPK15 in chemosensitivity to cisplatin in human lung cancer cells.

Cytochrome P450 27C1 Level Dictates Lung Cancer Tumorigenicity and Sensitivity towards Multiple Anticancer Agents and Its Potential Interplay with the IGF-1R/Akt/p53 Signaling Pathway.

Cytochrome P450 enzymes (CYP450s) exert mighty catalytic actions in cellular metabolism and detoxication, which play pivotal roles in cell fate determination. Preliminary data shows differential expression levels of CYP27C1, one of the "orphan P450s" in human lung cancer cell lines. Here, we study the functions of CYP27C1 in lung cancer progression and drug endurance, and explore its potential to be a diagnostic and therapeutic target for lung cancer management.

ACC2 is under-expressed in lung adenocarcinoma and predicts poor clinical outcomes.

Purpose: Acetyl-CoA Carboxylases (ACCs) are key fatty acid metabolic enzymes responsible for catalyzing the carboxylation of acetyl-CoA to malonyl-CoA. The role of ACC1 has been associated with tumor biology, but the role of ACC2 in cancer remains largely uncharacterized.

Methods: We conducted a transcriptomic analysis using GEPIA and Oncomine to study the expression of ACC2 in different cancers.

Donor-acceptor duality of the transition-metal-like B core in core-shell-like metallo-borospherenes La&[B@B] and La&[B@B].

Transition-metal doping induces dramatic structural changes and leads to earlier planar → tubular → spherical → core-shell-like structural transitions in boron clusters. Inspired by the newly discovered spherical trihedral metallo-borospherene La&B (1) (Chen, , Nat. Commun.

From inverse sandwich TaB and TaB to spherical trihedral TaB : prediction of the smallest metallo-borospherene.

Transition-metal-doped boron nanoclusters exhibit interesting structures and bonding. Inspired by the experimentally discovered inverse sandwich TaB and spherical trihedral LaB and based on extensive first-principles theory calculations, we predict herein the structural transition from perfect di-metal-doped inverse sandwich TaB (1) and TaB (2) to tri-metal-doped spherical trihedral TaB (3). As the smallest metallo-borospherene reported to date, TaB (3) contains three octa-coordinate Ta atoms as integral parts of the cage surface coordinated in three equivalent η-B rings which share two eclipsed equilateral B triangles on the top and bottom interconnected by three B units on the waist.

Resveratrol Promotes Tumor Microvessel Growth via Endoglin and Extracellular Signal-Regulated Kinase Signaling Pathway and Enhances the Anticancer Efficacy of Gemcitabine against Lung Cancer.

The synergistic anticancer effect of gemcitabine (GEM) and resveratrol (RSVL) has been noted in certain cancer types. However, whether the same phenomenon would occur in lung cancer is unclear. Here, we uncovered the molecular mechanism by which RSVL enhances the anticancer effect of GEM against lung cancer cells both in vitro and in vivo.

Potency and Selectivity of SMAC/DIABLO Mimetics in Solid Tumor Therapy.

Aiming to promote cancer cell apoptosis is a mainstream strategy of cancer therapy. The second mitochondria-derived activator of caspase (SMAC)/direct inhibitor of apoptosis protein (IAP)-binding protein with low pI (DIABLO) protein is an essential and endogenous antagonist of inhibitor of apoptosis proteins (IAPs). SMAC mimetics (SMs) are a series of synthetically chemical compounds.

Sea-shell-like B and B: two new axially chiral members of the borospherene family.

Since the discovery of the cage-like borospherenes B and the first axially chiral borospherenes / B , a series of fullerene-like boron clusters in different charge states have been reported in theory. Based on extensive global minimum searches and first-principles theory calculations, we present herein two new axially chiral members B (I) and B (VI) to the borospherene family. B (I) features two equivalent heptagons on the top and one octagon at the bottom on the cage surface, while B (VI) possesses two equivalent heptagons on top and two equivalent heptagons at the bottom.

Planar B and B clusters with double-hexagonal vacancies.

Since the discovery of the B borospherene, research interests have been directed to the structural evolution of even larger boron clusters. An interesting question concerns if the borospherene cages persist in larger boron clusters like the fullerenes. Here we report a photoelectron spectroscopy (PES) and computational study on the structures and bonding of B and B, the largest boron clusters characterized experimentally thus far.

B and B: chiral quasi-planar boron clusters.

Chirality plays an important role in nature. Nanoclusters can also exhibit chiral properties. We report herein a joint experimental and theoretical investigation on the geometric and electronic structures of B31- and B32- clusters, using photoelectron spectroscopy in combination with first-principles calculations.

p38MAPK/SGK1 signaling regulates macrophage polarization in experimental autoimmune encephalomyelitis.

Multiple sclerosis (MS) is characterized with multifocal demyelination resulting from activation and infiltration of inflammatory cells into the central nerve system. Recent reports suggest that p38 mitogen-activated protein kinase (MAPK) / serum- and glucocorticoid-inducible protein kinase 1 (SGK1) signaling pathway contributes to the pathology of MS through regulation of immunity. However, the role of this signaling pathway in MS-related macrophage activation and polarization has not been studied.

Changes in peroxisome proliferator-activated receptor alpha target gene expression in peripheral blood mononuclear cells associated with non-alcoholic fatty liver disease.

Objective: To identify differences in the expression of peroxisome proliferator-activated receptor alpha (PPARα) target genes in human peripheral blood mononuclear cells (PBMCs) associated with non-alcoholic fatty liver disease (NAFLD) among Chinese individuals.

Methods: Thirty healthy subjects were selected as the control group (CN), and 43 patients newly diagnosed with NAFLD were subdivided into two groups, non-obese group (NF, n = 21) and obese group (OF, n = 22). Expression of PPARα and its target genes was determined in PBMCs.

Fluxional Bonds in Planar B , Tubular Ta@B , and Cage-Like B.

Based on detailed bonding analyses on the fluxional behaviors of planar B , tubular Ta@B , and cage-like B , we propose the concept of fluxional bonds in boron nanoclusters as an extension of the classical localized bonds and delocalized bonds in chemistry. © 2018 Wiley Periodicals, Inc.

High-symmetry tubular Ta@B, Ta@B, and Ta@B as embryos of α-boronanotubes with a transition-metal wire coordinated inside.

Transition-metal doping leads to dramatic structural changes and results in novel bonding patterns in small boron clusters. Based on the experimentally derived mono-ring planar C9v Ta©B92- (1) and extensive first-principles theory calculations, we present herein the possibility of high-symmetry double-ring tubular D9d Ta@B183- (2) and C9v Ta2@B18 (3) and triple-ring tubular D9h Ta2@B27+ (4), which may serve as embryos of single-walled metalloboronanotube α-Ta3@B48(3,0) (5) wrapped up from the recently observed most stable free-standing boron α-sheet on a Ag(111) substrate with a transition-metal wire (-Ta-Ta-) coordinated inside. Detailed bonding analyses indicate that, with an effective dz2-dz2 overlap on the Ta-Ta dimer along the C9 molecular axis, both Ta2@B18 (3) and Ta2@B27+ (4) follow the universal bonding pattern of σ + π double delocalization with each Ta center conforming to the 18-electron rule, providing tubular aromaticity to these Ta-doped boron complexes with magnetically induced ring currents.

Regulatory Effect of General Anesthetics on Activity of Potassium Channels.

General anesthesia is an unconscious state induced by anesthetics for surgery. The molecular targets and cellular mechanisms of general anesthetics in the mammalian nervous system have been investigated during past decades. In recent years, K channels have been identified as important targets of both volatile and intravenous anesthetics.