A 4-fold or greater decrease in TPPA titers may indicate effective BPG treatment in primary syphilis.

Background: In the majority of clinical environments, the treponema pallidum particle agglutination (TPPA) test is known for its higher specificity compared to the rapid plasma reagin (RPR) test and is commonly employed for the diagnosis of syphilis, but their use for serological monitoring after syphilis therapy is controversial.

Objectives: We aim to evaluate whether the TPPA titers is suitable for monitoring syphilis treatment efficacy.

Methods: At first, 232 patients with primary syphilis were recruited.

Treponema pallidum promoted microglia apoptosis and prevented itself from clearing by human microglia via blocking autophagic flux.

Treponema pallidum (Tp) has a well-known ability to evade the immune system and can cause neurosyphilis by invading the central nervous system (CNS). Microglia are resident macrophages of the CNS that are essential for host defense against pathogens, this study aims to investigate the interaction between Tp and microglia and the potential mechanism. Here, we found that Tp can exert significant toxic effects on microglia in vivo in Tg (mpeg1: EGFP) transgenic zebrafish embryos.

[Psychological Status and Influencing Factors of Staff at Centers for Disease Control and Prevention in Sichuan Province during the Outbreak of Coronavirus Disease 2019].

Objective To assess the psychological status of staff at the centers for disease control and prevention(CDC) in Sichuan during the outbreak of coronavirus disease 2019(COVID-19) and explore the influencing factors. Methods The staff at Sichuan provincial,municipal,and county(district)-level CDC were selected by convenience sampling.Their basic information,work status,training status,work difficulties,and support from the work group were collected from the self-filled questionnaires online.

Upregulates to Inhibit IFN-γ Expression and Promote T Cell Apoptosis in Neurosyphilis.

Long non-coding RNAs are involved in many infectious diseases. Our previous studies showed that expression is increased in T lymphocytes of neurosyphilis patients compared to healthy controls. However, whether has biological functions remains unclear.

Tp47 induces cell death involving autophagy and mTOR in human microglial HMO6 cells.

Background: Tp47 can induce immune cells to produce numerous inflammatory factors, some of which can trigger autophagy. Increased autophagy has a dual effect on cell survival. However, whether Tp47 induces autophagy in microglia is unknown.

Changes of T lymphocyte subsets in patients with HIV-negative symptomatic neurosyphilis.

Objectives: The host immune response could be an imperative factor in the pathogenesis of neurosyphilis, but the role of T lymphocyte subsets remains unclear. In the present study, we assessed the CD4 T and CD8 T cell subsets in the peripheral blood of patients with HIV-negative symptomatic neurosyphilis and then explored the clinical application value of neurosyphilis.

Methods: In total, 24 patients with HIV-negative symptomatic neurosyphilis and 22 patients with syphilis/non-neurosyphilis were included in this study and cerebrospinal fluid (CSF) and blood samples were obtained.

LncRNA Expression in CD4+ T Cells in Neurosyphilis Patients.

Recent studies have shown that several long noncoding RNAs (lncRNAs) are involved in regulating the immune response to cope with pathogenic invasion. To date, the roles of lncRNAs in the CD4+ T cell response to () infection in neurosyphilis patients remain unknown. The mRNA and lncRNA expression profiles of CD4+ T cells that were isolated from neurosyphilis patients and healthy controls were analyzed by microarray.

[The pulmonary CT manifestations of acute moderate or severe hydrogen sulphide poisoning fishermen].

Objective: To discuss the clinical manifestations and CT features of acute moderate or severe hydrogen sulphide poisoning fishermen.

Methods: The clinic and CT datas of 8 acute moderate or severe hydrogen sulphide poisoning cases were retrospectively analysed.

Results: The lesions located at two pulmonary each leaf in 3 cases, located at both lower lungs in 3 cases and asymmetry leaves in 2 cases.