Publications by authors named "Xiao-ying Zhu"
Background: Wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) is an uncommon ocular motor disorder which is featured by binocular exotropia and bilateral internuclear ophthalmoplegia.
Methods: A 71-year-old man with hypertension presented to the emergency department with sudden-onset diplopia. Neurological examination, neuroimaging, blood and cerebrospinal fluid (CSF) testing were performed.
Background: The dysregulation of tissue inhibitor of metalloproteinase-3 (TIMP3) was positively correlated with the progression of hepatocellular carcinoma (HCC). However, it is not clear whether TIMP3 expression is associated with the clinicopathological features and prognosis of aflatoxin B1 (AFB1)-related HCC (AHCC).
Aim: To assess the effects of TIMP3 expression on the clinicopathological features and prognosis of AHCC.
Background: Among the numerous studies on physical activity and sleep disorders, few have focused on physical activity and sleep disorders in middle-aged people who are particularly stressed. A restricted cubic web (RCS) technique was applied to determine whether physical activity and the self-rated prevalence of sleep disorders exhibit a dose-response relationship in middle-aged adults.
Methods: This study analyzed 8880 middle-aged adults aged 40-65 years who participated in the National Health and Nutrition Examination Survey (NHANES) 2007-2018.
An inferior vena cava-priority approach in laparoscopic isolated hepatic caudate lobectomy.
Langenbecks Arch Surg
April 2024
Purpose: Laparoscopic isolated caudate lobectomy is still a challenging operation for surgeons. The access route of the operation plays a vital role during laparoscopic caudate lobectomy. There are few references regarding this technique.
View Article and Find Full Text PDFSoil microorganisms play important roles in vegetation establishment and soil biogeochemical cycling. Ammodendron bifolium is a dominant sand-fixing (i.e.
View Article and Find Full Text PDFArticle Synopsis
- Soil microorganisms are crucial for plant growth and nutrient cycling, and this study focuses on the bacterial communities in the rhizosphere of the endangered plant Ammodendron bifolium in the salinity-rich Takeermohuer Desert.* -
- The researchers discovered that the rhizosphere of A. bifolium is more nutrient-rich (eutrophic) compared to the surrounding bulk soil, leading to higher abundances of specific bacteria like Proteobacteria and Planctomycetes.* -
- Key factors influencing the bacterial community include electrical conductivity and soil organic matter, with significant diversity observed in the rhizosphere compared to deeper soil layers, indicating the importance of soil depth in community structure.*
A Double Suspension Technique for Laparoscopic Isolated Caudate Lobectomy.
J Laparoendosc Adv Surg Tech A
October 2022
Laparoscopic isolated caudate lobectomy is still a challenging procedure for hepatobiliary surgeons because of its deep location and narrow operating space. Hilar exposure and adequate operation space play an important role during laparoscopic caudate lobectomy. Very few references are available on this technique, and in this study, we present a new suspension technique to assist laparoscopic caudate lobectomy.
View Article and Find Full Text PDFThe predictive potential of genetic single nucleotide polymorphisms in for hepatocellular carcinoma survival.
Front Biosci (Landmark Ed)
November 2021
: Our previous studies have reported that polycomb chromobox 4 () has a potential promoting hepatocellular carcinoma (HCC) angiogenesis and tumor progression. However, it is unclear whether genetic single-nucleotide polymorphisms (SNPs) in this gene are associated with HCC prognosis. : We conducted a hospital-based two-phase study, including 598 patients with pathologically diagnosed HCC for the SNPs screening phase and 328 HCC patients for clinic significance validating phase, to elucidate the association between SNPs of and the survival of HCC.
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- Tyrosine kinase inhibitors (TKIs) have improved survival rates for chronic myeloid leukaemia (CML) patients, but issues like drug resistance and TKI-insensitive leukaemic stem cells (LSCs) still hinder a complete cure.
- Recent research highlights the potential of targeting mitochondrial metabolism in CML as a therapeutic approach.
- The study found that drugs AICAR and decitabine improved mitochondrial function in CML cells, increased ATP levels, and enhanced the effectiveness of imatinib, suggesting a combined treatment strategy could be beneficial.
SNCA-Rep1 polymorphism correlates with susceptibility and iron deficiency in restless legs syndrome.
Parkinsonism Relat Disord
December 2020
Background: Brain iron disequilibrium and dopaminergic dysfunction are key pathophysiological features of Restless Legs Syndrome (RLS). Rep1 polymorphism in the promotor region of SNCA is associated with risk of Parkinson's disease, however its association with RLS and iron status is unclear.
Objective: To investigate SNCA-Rep1 polymorphism in RLS and its phenotypes.
Article Synopsis
- Essential tremor (ET) is primarily characterized by bilateral arm tremors, while Parkinson's disease (PD) is a more complex neurodegenerative disorder featuring symptoms like slow movement and resting tremors.
- Recent research suggests that individuals with ET may be at an increased risk of developing PD, challenging the notion that ET is an isolated condition.
- One promising prodromal marker for predicting PD in ET patients is Substantia nigra hyperechogenicity, along with other potential markers; however, more extensive research is needed to confirm these findings and develop effective therapies.
Article Synopsis
- The study focuses on restless abdomen, a sensory disorder similar to restless legs syndrome (RLS), which causes restlessness in the abdomen instead of the legs.
- It involved 10 patients diagnosed with restless abdomen, all of whom exhibited RLS-like symptoms and met the RLS diagnostic criteria.
- The results indicate that patients responded well to dopaminergic therapy, suggesting that medical professionals should recognize that RLS-related symptoms can occur in areas other than the legs without worsening the condition.
Article Synopsis
- * Women are at a significantly higher risk for IDNA, showing younger ages both at diagnosis and onset of RLS symptoms compared to those without iron deficiency.
- * IDNA RLS patients experience greater severity in tiredness and longer durations of RLS compared to those with iron deficiency anemia (IDA), highlighting the need for regular iron screening even in patients with normal blood counts.
Article Synopsis
- Abnormal epigenetic modifications are linked to Parkinson's disease (PD), with TET2 levels increasing in dopaminergic neurons, which are crucial for movement.
- Genome-wide studies reveal that changes in DNA hydroxymethylation (5-hmC) impact genes related to the cell cycle, particularly the Cdkn2A gene.
- Reducing TET2 expression can alleviate cell damage and motor deficits in PD, indicating that targeting TET2 may provide new therapeutic strategies for the disease.
Impulse control disorders in very elderly patients with restless legs syndrome.
Clin Park Relat Disord
August 2019
Background: The clinical spectrum of restless legs syndrome (RLS) has not been described in a Chinese population. We aim to evaluate the detailed clinical profile in a cohort of unselected RLS patients in China.
Methods: We enrolled RLS patients continuously according to the diagnostic criteria.
Article Synopsis
- The study investigates the genetic differences between two closely related human pathogens and nonpathogenic species to better understand their unique pathogenic characteristics and niche adaptations.
- A comparative genomics analysis revealed 1111 conserved gene families and identified unique gene families in each species that could be linked to their pathogenicity.
- Functional annotation showed that a significant portion of the unique gene families lacked clear functional information, and high levels of simple sequence repeats (SSR) were found, indicating their potential role in adapting to diverse host environments.
Article Synopsis
- - The study investigated ping-pong gaze (PPG) by examining 14 patients at Shanghai General Hospital, revealing that acute ischemic stroke was the most common cause, followed by post-seizure states and hypoxic-ischemic encephalopathy.
- - Most patients with consistent whole-field PPG had similar damage in both hemispheres, while those with hemifield PPG showed damage primarily on one side, indicating a potential relationship between gaze pattern and brain lesions.
- - Outcomes for patients varied, with some achieving neurologic remission, while others ended up in vegetative states or died, highlighting the importance of underlying causes and initial prognoses in PPG cases.
Background: Rapid eye movement sleep behavior disorder (RBD) and Parkinson's disease (PD) are two distinct clinical diseases but they share some common pathological and anatomical characteristics. This study aims to confirm the clinical features of RBD in Chinese PD patients.
Methods: One hundred fifty PD patients were enrolled from the Parkinson`s disease and Movement Disorders Center in Department of Neurology, Shanghai General Hospital from January 2013 to August 2014.
[Comparison of open versus laparoscopic surgeries for adrenal tumor: a meta-analysis].
Nan Fang Yi Ke Da Xue Xue Bao
November 2016
Article Synopsis
- A systematic review was conducted to compare the effectiveness and safety of open versus laparoscopic surgeries for adrenal tumors, analyzing clinical trials from 1999 to 2016.
- The meta-analysis included data from 2340 patients and found laparoscopic surgery to be beneficial in terms of quicker recovery, shorter hospital stays, fewer complications, and less blood loss compared to open surgery.
- However, there was no significant difference in the cost of surgery between the two approaches, leading to the conclusion that laparoscopic surgery is generally more advantageous.
Article Synopsis
- The study aimed to explore how electroacupuncture (EA) might protect against neurotoxicity in a mouse model of Alzheimer's disease (AD) caused by the anesthetic isoflurane.
- Researchers used 24 transgenic mice that model AD and 24 normal mice, administering EA therapy for 15 minutes daily over three days before exposing them to isoflurane.
- Results indicated that EA improved memory performance and reduced markers of neuronal damage, such as activated Caspase-3 and Bax protein levels, compared to the group exposed only to isoflurane, highlighting EA's potential neuroprotective effects against AD.
Objective: There is limited data on motor restlessness in Parkinson's disease (PD). Here we evaluate for clinical differences between cohorts of idiopathic Restless Legs Syndrome (iRLS), PD patients with leg restlessness, and PD with RLS.
Methods: We examined 276 consecutive PD patients for leg restlessness symptoms, we compared clinical features of PD patients with RLS, PD patients with leg restlessness but not meeting RLS criteria, PD patient without RLS and iRLS.
Article Synopsis
- The study aimed to investigate how needle pricking therapy affects the expression of certain proteins and mRNAs related to asthma in mice, particularly focusing on TSLP, T-bet, and GATA-3.
- Thirty BALB/c mice with asthma were divided into three groups: control, model, and treatment (needle pricking), with asthma induced using Ovalbumin.
- Results showed that needle pricking significantly reduced GATA-3 mRNA and TSLP protein levels while increasing T-bet mRNA levels, leading to improvements in lung pathology associated with asthma.