Trophoblastic mitochondrial DNA induces endothelial dysfunction and NLRP3 inflammasome activation: Implications for preeclampsia.

Aims: Preeclampsia (PE) is characterised by systemic vascular endothelium dysfunction. Circulating trophoblastic secretions contribute to endothelial dysfunction, resulting in PE; however, the underlying mechanisms remain unclear. Herein, we aimed to determine the potential correlation between the release of trophoblastic mitochondrial deoxyribonucleic acid (DNA) (mtDNA) and endothelium damage in PE.

[Characteristics of soil anti-scouribility in gully head wall of grass-covering on the gullied Loess Plateau, Northwest China].

Vegetation restoration in the Chinese Loess Plateau has significantly changed soil erosion process of gully head wall. In order to investigate the characteristics and controlling factors of soil anti-scour properties of gully head covered by grasses, we carried out indoor undamaged soil trench scouring tests. By using barren gully head as the control, the physical and chemical properties and anti-scouring characteristics of soil in different soil layers (0-10, 10-20, 20-40, 40-60, 60-80, 80-100 cm) of the vertical wall of gully with grass cover were analyzed.

Osmotic water permeability diversification in primary trophoblast cultures from aquaporin 1-deficient pregnant mice.

Aim: Aquaporins (AQP) are water channel proteins, and some play an important role in maternal-fetal fluid exchange. The present study aimed to measure the osmotic water permeability in primary cultures of trophoblast cells from AQP1-deficient (AQP1(-/-) ) pregnant mice and to define the quantitative role of AQP1 in water transport across the trophoblast plasma membrane.

Material And Methods: Trophoblast cells were obtained from placental tissue cell culture of AQP1(-/-) pregnant mice and were characterized by cytokeratin 7 immunostaining.

Pregnant phenotype in aquaporin 8-deficient mice.

Aim: Aquaporin 8 (AQP8) is expressed within the female reproductive system but its physiological function reminds to be elucidated. This study investigates the role of AQP8 during pregnancy using AQP8-knockout (AQP8-KO) mice.

Methods: Homozygous AQP8-KO mice were mated, and the conception rate was recorded.

Maternal-fetal fluid balance and aquaporins: from molecule to physiology.

Maternal-fetal fluid balance is critical during pregnancy, and amniotic fluid is essential for fetal growth and development. The placenta plays a key role in a successful pregnancy as the interface between the mother and her fetus. Aquaporins (AQPs) form specific water channels that allow the rapid transcellular movement of water in response to osmotic/hydrostatic pressure gradients.