Publications by authors named "Xiao-xian Ye"
Clinical significance of K-ras and BRAF mutations in Chinese colorectal cancer patients.
World J Gastroenterol
February 2011
Article Synopsis
- - The study focused on identifying mutations in the K-ras and BRAF genes in 118 Chinese colorectal cancer patients to see how these mutations relate to clinical features and patient outcomes.
- - Results showed that 34.7% of patients had K-ras mutations, primarily at codons 12 and 13, with a significant association found between K-ras mutations and female gender; however, other clinical factors and patient survival were not linked to these mutations.
- - Only two patients had BRAF mutations, indicating that such mutations are rare in this population, while K-ras mutations appear common but do not serve as independent prognostic indicators for CRC.
[K-ras gene mutation in colorectal cancer and its clinicopathologic significance].
Zhonghua Wai Ke Za Zhi
August 2010
Objective: To establish a simple, rapid and economical method in detecting mutations of oncogene K-ras and to investigate its mutations in colorectal cancer tissues and its relationship with clinicopathologic characteristics of colorectal carcinoma.
Methods: Forty colorectal cancer tissues were tested for K-ras mutations at codon 12 and codon 13 using polymerase chain reaction (PCR) followed by direct sequencing and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) followed by sequence analysis. The other 113 colorectal cancer tissues were tested for K-ras mutations at codon 12 and codon 13 using PCR-RFLP followed by sequence analysis only.