Publications by authors named "Xiao-xia Niu"
Drug-induced liver injury (DILI) is a potentially serious adverse drug reaction. Due to the lack of definite etiology, specific clinical manifestations, and diagnostic methods, its prediction and diagnosis are challenging. Elderly individuals are deemed to be at high risk for DILI due to abnormal pharmacokinetics, aging tissue repair function, comorbidities, and taking multiple drugs.
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- There are currently no effective noninvasive methods for diagnosing fibrosis in patients suffering from chronic drug-induced liver injury (DILI).
- The study aimed to create a predictive algorithm called LAC to enhance diagnostic accuracy for significant fibrosis by analyzing data from 1,130 patients and comparing various biomarkers.
- The LAC score outperformed traditional measures like LSM, CHE, and APRI, demonstrating strong potential for accurately assessing disease progression and guiding treatment for chronic DILI patients.
Background And Aim: The incidence of hepatocellular carcinoma (HCC) decreases significantly in chronic hepatitis C (CHC) patients with sustained virologic response (SVR) after pegylated-interferon plus ribavirin (PR) or direct-acting antiviral (DAAs) therapy. We follow-up a single cohort of CHC patients to identify risk factors associated with HCC development post-SVR.
Method: CHC patients with SVR in Beijing/Hong Kong were followed up at 12-24 weekly intervals with surveillance for HCC by ultrasonography and alpha-fetoprotein (AFP).
Background And Aims: About 20% of patients receiving nucleos(t)ide analogues treatment experienced low-level viraemia (LLV), which is associated with progression of liver fibrosis and high risk of hepatocellular carcinoma. We aimed to evaluate the effectiveness and safety of switching from entecavir (ETV) to tenofovir alafenamide fumarate (TAF) in ETV-treated patients with LLV.
Methods: In this prospective study, ETV-treated patients with LLV, presented to our hospital from December 2018 to October 2019, were enrolled.
Article Synopsis
- * A study of 161 individuals revealed that Ebola Virus Disease (EVD) survivors exhibited the highest psychological distress, followed by medical staff, logistics staff, medical students, and Chinese medical staff.
- * Five psychological symptoms were notably severe in EVD survivors, and higher education levels were linked to lower general severity index scores, highlighting the need for mental health considerations in emergency response plans for future outbreaks.
Background: Treatment-experienced chronic hepatitis C (CHC) genotype (GT) 1b represents a major medical burden in China. We evaluate the efficacy, safety and cost-effectiveness of ribavirin (RBV)-free pan-oral direct-acting antivirals (DAAs) in treatment-experienced Chinese with GT1b CHC, including patients with cirrhosis.
Methods: One hundred forty treatment-experienced GT1b CHC Chinese with and without cirrhosis were included in this study.
Background: Little is known on the cost-effectiveness of novel regimens for hepatitis C virus (HCV) compared with standard-of-care with pegylated interferon (pegIFN) and ribavirin (RBV) therapy in developing countries. We evaluated cost-effectiveness of sofosbuvir/ledipasvir for 12 weeks compared with a 48-week pegIFN-RBV regimen in Chinese patients with genotype 1b HCV infection by economic regions.
Methods: A decision analytic Markov model was developed to estimate quality-adjusted-life-years, lifetime cost of HCV infection and incremental cost-effectiveness ratios (ICERs).
[Development and evaluation of a quantitative double antibodies sandwich ELISA assay for rIFN-alpha1b].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
December 2012
Objective: To develop a double antibody sandwich ELISA assay for quantitative determination of recombinant human interferon alpha1b.
Methods: Mouse monoclonal antibodies with different binding site on rIFN-alpha1b were screened to select optimized candidates as coating and HRP-labeled index antibodies respectively. And a double antibodies sandwich ELISA was assembled; the reliable lower detection limit, specificity, accuracy and reproducibility were evaluated and validated.
[Expression, purification and identification of recombinant human lymphotoxin alpha deletant (rhLT-alphaDeltaN27)].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
January 2004
Aim: To construct prokaryotic expression vector of recombinant human lymphotoxin alpha deletant (rhLT-alphaDeltaN27) and express the protein in E.coli.
Methods: The rhLT-alphaDeltaN27 gene was amplified by RT-PCR using total RNA extracted from Jurkat cells,cloned into prokaryotic expression vector pET-23b, and transformed into E.