Discovery, screening and evaluation of a plasma biomarker panel for subjects with psychological suboptimal health state using (1)H-NMR-based metabolomics profiles.

Individuals in the state of psychological suboptimal health keep increasing, only scales and questionnaires were used to diagnose in clinic under current conditions, and symptoms of high reliability and accuracy are destitute. Therefore, the noninvasive and precise laboratory diagnostic methods are needed. This study aimed to develop an objective method through screen potential biomarkers or a biomarker panel to facilitate the diagnosis in clinic using plasma metabolomics.

[Discovering potential biomarkers of depression and drug intervention of paroxetine based on (1)H NMR metabolomics].

The purpose of this study was to find potential biomarkers in the serum of patients with depression and provide the basis for clinical diagnosis of depression. Sixteen patients of severe depression were selected according to the inclusion criteria and 16 healthy people were used in the control group. The depression patients took paroxetine for two weeks.