Genetic variations in sterol regulatory element binding protein cleavage-activating protein (SCAP) are associated with blood pressure in overweight/obese Chinese children.

Objective: Previous studies demonstrated a role of variations in sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) in obesity and blood lipids. But the associations between SCAP polymorphisms and blood pressure (BP) are not clear. This study aimed to investigate the relationship between genetic variations in SCAP and BP phenotypes in a Chinese pediatric population.

GWAS-Identified Common Variants With Nonalcoholic Fatty Liver Disease in Chinese Children.

Objectives: Three genome-wide association studies were previously done for nonalcoholic fatty liver disease (NAFLD) among individuals of Western countries and identified several genetic variants associated with NAFLD. The study aimed to identify whether 7 GWAS-identified common variants (GCKR rs780094, PDGFA rs343064, FDFT1 rs2645424, COL13A1 rs1227756, EHBP1L1 rs6591182, NCAN rs2228603, and PNPLA3 rs738409) were associated with NAFLD in Chinese children.

Methods: This case-control study recruited 1027 Chinese children of age 7 to 18 years, including 162 children with NAFLD and 865 children without NAFLD.

The gene-gene interaction of INSIG-SCAP-SREBP pathway on the risk of obesity in Chinese children.

Background: Childhood obesity has become a global public health problem in recent years. This study aimed to explore the association of genetic variants in INSIG-SCAP-SREBP pathway with obesity in Chinese children.

Methods: A case-control study was conducted, including 705 obese cases and 1,325 nonobese controls.

Association study of childhood obesity with eight genetic variants recently identified by genome-wide association studies.

Background: Being overweight or obese is becoming increasingly common in low- and middle-income countries. The present study aimed to examine association of eight genetic variants with obesity and to estimate the cumulative effects of these variants in Chinese children.

Methods: We conducted the case-control study in a total of 2,030 subjects.

[Association of rs2228314 polymorphism in SREBP2 with serum lipid levels and obesity among children and adolescents].

Objective: To study the relationship between rs2228314 polymorphism in sterol regulatory element binding protein 2 gene (SREBP2) and obesity, serum lipid levels in children and adolescents.

Methods: In our study, 2 030 children and adolescents aged from 7 to 18 years participated. Anthropometric measurements, including height and weight, were performed.

Association of INSIG2 rs9308762 with ALT level independent of BMI.

Objectives: An increasing number of people are at risk for developing nonalcoholic fatty liver disease (NAFLD). Because obesity is a risk factor for NAFLD, the common variants of obesity-susceptible genes may be associated with NAFLD. Our aim was to identify whether the obesity-susceptible gene variants (rs9939609, rs9930506, and rs4783819 in fat mass and obesity-associated gene (FTO); rs12970134 and rs17782313 in melanocortin-4 receptor gene (MC4R); and rs7566605, rs13428113, and rs9308762 in insulin-induced gene 2 [INSIG2]) were associated with NAFLD.

[Association between early onset of menarche and anthropometry measurements among adolescent girls in China].

Objective: To explore the association between early menarche with anthropometry measurements among adolescent girls in China.

Methods: Research material was selected from the data of 2010 Chinese National Surveys on Students Constitution and Health. Probability unit regression method was used to calculate the age of 10th percentile (P 10) at menarche and menarche age before the P 10 was defined as early menarche(9.

[Influence of diet behaviors on height among children and adolescents in China: a multiple level analysis].

Objective: To categorize growth and development stages among children and adolescents based on height, and to explore the influences of diet behaviors on height during different growth and development stages.

Methods: Children and adolescents (7 to 18 years) with normal weights were selected using "Reference Norm for Screening Overweight and Obesity in Chinese Child and Adolescent" set up by WGOC in 2003 and "Reference Norm for Screening Underweight in Chinese Child and Adolescent" from the "2010 National Physical Fitness and Health Surveillance" data, and the variables of height and diet behaviors sorted. The growth and development stages were categorized using the hierachical cluster analysis, and the multilevel model was used to analyze influences of diet behaviors on height at different growth and development stages.

[Effects of overweight and obesity on physical function among children and adolescents: a multilevel analysis].

Objective: To analyze the influence of overweight and obesity on body function among children and adolescents using a multilevel model, and to provide the basis for understanding their influence.

Methods: According to the "Reference Norms for Screening Overweight and Obesity in Chinese Children and Adolescents" set up by Working Group Obesity in China (WGOC) in 2003, we screened out individuals with overweight and obesity from the data obtained from the body and health survey of Chinese children and adolescents in 2005. The samples of the non-overweight group and the overweight group were randomly selected from the screened data by 1:1 match with samples of the obesity group by gender and city/rural area, then underwent the multilevel model to explore the influence of overweight and obesity on body function.