Neuronal cathepsin S increases neuroinflammation and causes cognitive decline via CX3CL1-CX3CR1 axis and JAK2-STAT3 pathway in aging and Alzheimer's disease.

Aging is an intricate process involving interactions among multiple factors, which is one of the main risks for chronic diseases, including Alzheimer's disease (AD). As a member of cysteine protease, cathepsin S (CTSS) has been implicated in inflammation across various diseases. Here, we investigated the role of neuronal CTSS in aging and AD started by examining CTSS expression in hippocampus neurons of aging mice and identified a significant increase, which was negatively correlated with recognition abilities.

Effect of Preventive Nursing on Male Children with Hypospadias in Preventing Postoperative Complications.

Objective: To determine the clinical impact of preventive nursing on children with hypospadias and the intervention effect on postoperative complications.

Study Design: Comparative study. Place and Duration of the Study: Department of Urology Surgery, Beijing Children's Hospital Affiliated to Capital Medical University Baoding Hospital, Hebei, China, from August 2019 to July 2021.

The clinical significance of macrolide resistance in pediatric infection during COVID-19 pandemic.

Background: (MP) is a commonly occurring pathogen causing community-acquired pneumonia (CAP) in children. The global prevalence of macrolide-resistant MP (MRMP) infection, especially in Asian regions, is increasing rapidly. However, the prevalence of MRMP and its clinical significance during the COVID-19 pandemic is not clear.

Association of left ventricular systolic dysfunction with coronary artery dilation in Kawasaki disease patients: Assessment with cardiovascular magnetic resonance.

Purpose: To quantify global and regional left ventricular (LV) strain parameters in patients with Kawasaki disease (KD) using cardiovascular magnetic resonance (CMR) tissue tracking and assess the association of coronary artery dilation (CA dilation) with LV systolic dysfunction.

Methods: Thirty-one KD patients with CA dilation, 22 patients without CA dilation and 27 age- and sex-matched normal controls underwent 3.0 T CMR examination.

[Predicting the Recycling Potential and Evaluating the Environmental Benefits of Waste Electrical and Electronic Equipment in Beijing-Tianjin-Hebei].

Waste electrical and electronic equipment (WEEE or e-waste) is a significant urban mine in the Beijing-Tianjin-Hebei region. A comprehensive and systematic assessment of the amount of e-waste generated in the region and the resources and environmental benefits of e-waste recycling can provide scientific basis and methods to support collaborative and accurate management of e-waste in the region to solve resource and environmental problems. Based on the improved ownership coefficient method, material coefficient method, market value method, and pollution coefficient method, this study predicted and evaluated the recycling potential and environmental benefits of e-waste in Beijing-Tianjin-Hebei from 2010 to 2025 by estimating the production, amount of recyclable resources, resource recycling value, and environmental benefits of waste televisions, refrigerators, air conditioners, washing machines, and computers (five major e-wastes).

Pulmonary hypertension in late-onset Methylmalonic Aciduria and Homocystinemia: a case report.

Background: Methylmalonic Aciduria and Homocystinemia, cobalamin C (cblC) is an inherited disease of vitamin B metabolism with a wide spectrum of clinical manifestations. cblC presenting with pulmonary hypertension (PH) as leading sympotom is rare and easily misdiagnosed because of limited awareness. Timely diagnosis is crucial by the relentless progression without appropriate treatment.

Metabolic and genetic assessments interpret unexplained aggressive pulmonary hypertension induced by methylmalonic acidemia: A case report.

Background: Pulmonary hypertension (PH) causes significant morbidity and mortality in diverse childhood diseases. However, limited information has been reported to obtain a good understanding of pediatric PH. Gaps exist between genome sequencing and metabolic assessments and lead to misinterpretations of the complicated symptoms of PH.

Meta-analysis of the association of IL1-RN variable number of tandem repeats polymorphism with osteoarthritis risk.

Objective: The aim of this meta-analysis was to clarify the role of Interleukin-1 receptor antagonist gene (IL1-RN) Variable Number of Tandem Repeats (VNTR) polymorphism on the risk of OA by means of meta-analysis.

Methods: Eligible articles were retrieved from PubMed, Web of science and Google scholar with a total of 1187 OA cases and 2659 controls. The strength of the association between the IL1-RN VNTR polymorphism and the risk of OA was assessed by odds ratios (ORs) with the corresponding 95% confidence interval (CI) for each study.

The complete chloroplast genome of (Malvaceae).

S. Y. Hu is an ornamental plant of , native to Taiwan.

[Diagnostic Value of Cystain C in Contrast Associated Acute Kidney Injury after Transcatheter Closure for Children with Congenital Heart Disease].

Objectives: To investigate the diagnostic value of cystain C (SCys-C) in contrast associated acute kidney injury (AKI) after transcatheter closure for children with congenital heart disease.

Methods: There were 128 children with congenital heart disease (interventricular septal defect or patent ductus arteriosus) underwent transcatheter closure in West China Second University Hospital during 2013. Blood urea nitrogen (BUN), serum creatinine (SCr) and SCys-C were examined before surgery and at 24 and 48 h after surgery.

[Laboratory Investigation of DNAPL Migration Behavior and Distribution at Varying Flow Velocities Based on Light Transmission Method].

The migration and distribution of dense non-aqueous phase liquid (DNAFL) in subsurtace are attectea ny many factors. We selected PCE as the substitute contaminant, and performed several well-controlled two-dimensional sandbox experiments to investigate the effect of flow velocity on DNAPL infiltration and redistribution. Light transmission method (LTM) was used to monitor the transport process of DNAPL in the sandbox and quantitatively measure DNAPL saturation.

[Comparative life cycle environmental assessment between electric taxi and gasoline taxi in Beijing].

Tailpipe emission of internal combustion engine vehicle (ICEV) is one of the main sources leading to atmospheric environmental problems such as haze. Substituting electric vehicles for conventional gasoline vehicles is an important solution for reducing urban air pollution. In 2011, as a pilot city of electric vehicle, Beijing launched a promotion plan of electric vehicle.

[Perinatal integrative intervention for critical pulmonary artery valve stenosis].

Objective: To investigate the effect of different operation time to percutaneous balloon pulmonic valvuloplasty (PBPV) to critical pulmonary valve stenosis (CPS).

Method: Twenty-one infants (age ≤ 60 days at operating day) suffered from CPS, diagnosed by fetal echocardiogram and confirmed by echocardiography after birth, were enrolled in this case-control-study with written informed consent during April 2007 to December 2011. Of the 21 cases, 7 had prenatal diagnosis in our prenatal diagnosis center (prenatal group, Pre) and 14 were referred from other hospitals, who were divided into postpartum group A (Post A, referred within 28 days after birth) and postpartum group B (Post B, referred 29 to 60 days after birth).

Do specialized flowers promote reproductive isolation? Realized pollination accuracy of three sympatric Pedicularis species.

Background And Aims: Interest in pollinator-mediated evolutionary divergence of flower phenotype and speciation in plants has been at the core of plant evolutionary studies since Darwin. Specialized pollination is predicted to lead to reproductive isolation and promote speciation among sympatric species by promoting partitioning of (1) the species of pollinators used, (2) when pollinators are used, or (3) the sites of pollen placement. Here this last mechanism is investigated by observing the pollination accuracy of sympatric Pedicularis species (Orobanchacae).

Floral isolation in Pedicularis: how do congeners with shared pollinators minimize reproductive interference?

To minimize interspecific pollination, it has been suggested that pollen is placed on different parts of a pollinator's body corresponding to the conspecific location of pollen pickup by the stigma. Although Pedicularis is regarded as a classic example of pollinator-mediated floral isolation, such reciprocal pollen placement has not been demonstrated experimentally. This leads us to question previous observations of pollen release in Pedicularis species.

[Research on carbon reduction potential of electric vehicles for low-carbon transportation and its influencing factors].

Transportation is the key industry of urban energy consumption and carbon emissions. The transformation of conventional gasoline vehicles to new energy vehicles is an important initiative to realize the goal of developing low-carbon city through energy saving and emissions reduction, while electric vehicles (EV) will play an important role in this transition due to their advantage in energy saving and lower carbon emissions. After reviewing the existing researches on energy saving and emissions reduction of electric vehicles, this paper analyzed the factors affecting carbon emissions reduction.

[Effect of resveratrol on myocardial fibrosis in mice with chronic viral myocarditis].

Objective: Some research has shown that resveratrol can ameliorate myocardial injury and improve cardiac function in mice with acute viral myocarditis (VMC), and can inhibit cardiac fibroblast proliferation and myofibroblast differentiation in vitro. This study was designed to investigate whether resveratrol has similar effects in the mouse model of chronic VMC.

Methods: One hundred mice were inoculated with 0.

[The research of animal model setting-up in human intra-utero fetal cardiac intervention].

Objective: To research the techniques and correlated issues during analogous procedure of human intro-utero fetal cardiac intervention in animal model, so as to impulse the clinical utilizing of cardiac intervention in human fetus with severe cardiovascular malformations.

Methods: Eight bigeminal pregnant ewes in latter 2nd-trimester and 3rd- trimester were taken into the research of fetal cardiac intervention. Under continuous ultrasound guidance, advanced an cannula and stylet needle through the maternal abdomen, uterine wall, and fetal lamb chest wall and into the fetal LV, then imitate human balloon aortic valvuloplasty at valve ring level.

[Interventional approach to the treatment of aneurysms of the perimembranous ventricular septal defects].

Objectives: To explore applicable protocol for the positioning of ventricular septal defect (VSD) occluder and the selection of the device by retrospective analysis of transcatheter closure approach to the aneurysms of the perimembranous VSD.

Methods: Thirty-five cases of perimembranous VSD with septal aneurysm (19 males and 16 females) from May, 2004 to May, 2005 were included, with a mean age of 5.3 y and mean weight of 17.

[The analysis of T cell receptor Vbeta gene usage of cytolytic T-lymphocytes in coxsackievirus B3-induced myocarditis].

Objective: To analyze the T cell receptor (TCR) Vbeta gene usage of the cytolytic T-lymphocytes which result in immune-mediated myocyte injury in Coxsackievirus B3-induced myocarditis.

Methods: An experimental murine model with a myocarditic variant of Coxsackievirus B, type 3 has been developed with newborn Balb/c male mice. Mice were killed on day 7 after virus inoculated, which was the time when T cells show significant differentiation.

Dynamic analysis and assessment for sustainable development.

The assessment of sustainable development is crucial for constituting sustainable development strategies. Assessment methods that exist so far usually only use an indicator system for making sustainable judgement. These indicators rarely reflect dynamic characteristics.