Publications by authors named "Xiao-qing Guo"

Background & Aims: Sleep disorders (SDs) are common in chronic liver diseases (CLDs). Some SDs arise from impaired internal clock and are hence circadian rhythm SDs (CRSDs). Bile acids (BAs), whose levels are increased in many CLDs, reciprocally interact with circadian rhythm.

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Controlled self-assembly of predetermined multi-nuclear lanthanide organic polyhedra (LOPs) still presents a challenge, primarily due to the unpredictable coordination numbers and labile coordination geometries of lanthanide ions. In this study, through introducing triazole-based chelates to increase the chelating angle of -symmetric linear ligands and stabilize the coordination geometry of Eu(III) centers, ML-type (M = Eu, L = ligand) tetrahedra were efficiently synthesized, especially a biphenyl-bridged ligand which is well known to form ML-type helicates. A series of LOPs were formed and characterized by high-resolution electrospray ionization time-of-flight mass spectroscopy (ESI-TOF-MS) and X-ray crystallography.

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Upconversion (UC) is a fascinating anti-Stokes-like optical process with promising applications in diverse fields. However, known UC mechanisms are mainly based on direct energy transfer between metal ions, which constrains the designability and tunability of the structures and properties. Here, we synthesize two types of LnL-type (Ln for lanthanide ion; L for organic ligand L or L) lanthanide-organic complexes with assembly induced excited-multimer states.

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Well-defined 3d-4f heterometallic supramolecular architectures have attracted attention because of their applications in the field of luminescence and magnetism. However, covalent metallo-supramolecular discrete complexes, decorated with hetero-metallic vertices, have never been reported because of the difficulties in design and control. Herein, we report a series of covalent metallo-supramolecular discrete complexes with 3d-4f vertices synthesized by hierarchical subcomponent self-assembly of tris(2-aminoethyl)amine, 2,6-diformyl--cresol, and lanthanide ions (Ln) with different amines and transition metal ions.

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We designed and synthesized a semi-rigid bis-tridentate ligand which could undergo a -to- conformational transition when coordinated onto lanthanum ions through the rotation of the single bond on the central terphenyl bridge. By adjusting the metal/ligand ratio, a single-ligand bridged dinuclear complex La and an infinitely extending two-dimensional layered metal organic polymer (La) can be obtained. Through the induction of the chiral auxiliary ligand , these two achiral assemblies could both be transformed into the chiral mononuclear three-component complex La.

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Background And Aim: Controversy remains as to pegylated interferon-α (PEG-IFNα) antiviral therapy to renal function in chronic hepatitis B (CHB) patients. The aim of this study was to evaluate the influence of PEG-IFNα2b (Y shape, 40 kD) add-on treatment for renal function in CHB patients who received entecavir therapy.

Methods: This was a retrospective observational study to investigate factors related to renal function in 114 CHB patients who received PEG-IFNα2b add-on therapy to entecavir for 48 weeks.

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Purpose: Primary immune thrombocytopenia (ITP) is an immune disease with a diagnosis of exclusion, since no validated biomarkers have been identified. In this study, we explored biomarkers associated with the development of ITP from an immune perspective to inform the clinical diagnosis.

Patients And Methods: Differentially expressed genes (DEGs) between normal and ITP samples were analyzed using limma package.

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Chiral luminescent lanthanide-organic cages have many potential applications in enantioselective recognition, sensing, and asymmetric catalysis. However, due to the paucity of structures and their limited cavities, host-guest chemistry with lanthanide-organic cages has remained elusive so far. Herein, we report a guest-driven self-assembly and chiral induction approach for the construction of otherwise inaccessible LnL-type (Ln = lanthanide ions, i.

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Spin-crossover (SCO) active compounds have received much attention due to their potential application in molecular devices. Herein, a family of solvent-free Fe compounds, formulated as (A)[FeL], (HL = pyridine-2,6-bi-tetrazolate, A = (Me)N1, EtNH2, PrNH3 and PrNH4), were synthesized and characterized. Single-crystal X-ray diffraction studies reveal that 1-4 are all supramolecular frameworks containing the same [FeL] center, which is arranged into two packing modes inter-molecular interactions, that is, a 3D architecture in 1 and 1D chain in 2-4.

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Luminescent supramolecular hydrogels have shown extensive potential for a variety of applications due to their unique optical properties and biocompatibility. Coordination self-assembly provides a promising strategy for the preparation of supramolecular hydrogels. In this contribution, a series of luminescent lanthanide (Ln) supramolecular hydrogels HG-LnL are synthesized by coordination self-assembly of Ln ions and V shaped bis-tetradentate ligands (HL and HL) with different bent angles (∠).

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Atherosclerosis is a chronic inflammatory disease. Pathophysiological similarities between chronic infections and atherosclerosis triggered interests between these conditions. The seroepidemiological study showed that Helicobacter pylori strains that express cytotoxin-associated gene A (CagA), an oncoprotein and a major virulence factor, was positively correlated with atherosclerosis and related clinical events.

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Water-stable anionic Ln2L2-type (Ln = LaIII and EuIII) lanthanide-organic macrocycles have been constructed by deprotonation self-assembly of a bis-tridentate ligand consisting of two 2,6-bis-(1,2,4-triazole)-pyridine chelation arms bridged by a dibenzofuran chromophore, of which the luminescent Eu2L2 macrocycle can be used for enantiomeric excess (ee) detection toward pybox-type chiral ligands and selective colorimetric sensing of omethoate (OMA) in water.

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Biological macromolecules always function through a collective behavior of the aggregated constituents, which usually are self-assembled together via noncovalent interactions. Likewise, artificial supramolecular assemblies, whose properties and functions are mainly derived from their primary and secondary structures, may also aggregate into high-order architectures with emergent functions not available on the individual components. Here we report the first example of an insulin-like hexamerization of lanthanide triple helicates toward a 4 nm diameter hexameric capsule via consecutive metal-directed and anion-directed assembly processes.

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Objective: To investigate the clinicopathological features of intestinal diffuse large B-cell lymphoma (DLBCL).

Methods: The clinical features, pathological morphology, immunophenotype, and EBER in situ hybridization of 136 DLBCL patients diagnosed in Jinan People's Hospital Affiliated to Shandong First Medical University from January 2007 to October 2014 were analyzed retrospectively. A total of 136 DLBCL samples were obtained, the DLBCL sites were categorized as: duodenum (n=23), ileocecal region (n=63), other small intestine (n=29), rectum (n=7), and other large intestine (n=14).

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Precision medicine for gastric cancer (GC) is still an unsolved issue, because most available target drugs are not specifically designed for GC. Exploring novel signaling molecules with target value for GC is in urgent need. This study aimed to reveal that interleukin-2 receptor subunit gamma (IL2RG) is such a key molecule in human GC progression.

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Background: Acute kidney injury (AKI) is a severe and common complication in critically ill patients and is associated with increased morbidity and mortality. At present, there is not a tool to predict the prognosis of critically ill patients with AKI and treated with continuous renal replacement therapy (CRRT).

Methods: A retrospective cohort study was to construct a prediction model for the 28-day mortality of patients with AKI and treated with CRRT.

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A series of multinuclear lanthanide-covalent organic polyhedra (LnCOPs), including pillar-typed triangular prisms and tetrahedra (Ln = La, Sm, Eu), have been constructed for the first time, through either one-pot subcomponent self-assembly or postassembly metalation. In contrast to the known tetrahedral cages based on transition metals, the pillar-typed polyhedra were favored from the same organic components in the presence of lanthanides. Besides this, facile transmetalations between the polyhedra endow cascade chameleonic luminescence.

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Objective: To observe the effect of ginger-partitioned moxibustion intervention on gastrointestinal reaction, the quality of life, the counts of blood platelet (PLT) and white blood cells (WBC) after chemotherapy in lung cancer patients.

Methods: The lung cancer patients treated with chemotherapy were randomized into observation group (30 cases) and control group (30 cases). In the control group, the intravenous injection with Tropisetron(5 mg) was given 1 h before chemotherapy.

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Background: Previous studies have shown that DNA methylation plays a significant role in myelodysplastic syndrome (MDS). In addition to hypermethylation, aberrant hypomethylation can result in the transcriptional activation of oncogenes in cancer, including MDS. Therefore, drugs targeting DNA hypomethylation are needed for the treatment of MDS.

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Ribonuclease (RNase) reportedly exerts organ-protective effects in several pathological conditions, including ischemia reperfusion (I/R), but whether it can exhibit protective effect on intestinal I/R injury and potential mechanisms remain unknown. The present study was aimed to evaluate the effects of RNase on intestinal I/R injury and explore the underlying mechanisms. Thirty-two wild-type C57BL/6J adult male mice were evenly divided into a sham group, a sham + RNase group, an I/R group and an I/R + RNase group.

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Aristolochic acid (AA) is a group of structurally related nitrophenanthrene carboxylic acids found in many plants that are widely used by many cultures as traditional herbal medicines. AA is a causative agent for Chinese herbs nephropathy, a term replaced later by AA nephropathy. Evidence indicates that AA is nephrotoxic, genotoxic, and carcinogenic in humans; and it also induces tumors in the forestomach, kidney, renal pelvis, urinary bladder, and lung of rats and mice.

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A post-synthetic transmetallation self-assembly strategy was developed for the preparation of near infrared (NIR) emitting YbL cubes, which could not be synthesized through direct metal-ligand assembly procedures. Metal-adaptive critical structural transformations from LaL triangular prism to LnL cubes were observed along the lanthanide series, the latter of which showed size-selective guest binding behaviour toward poly-aromatic hydrocarbon (PAH) molecules.

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Objective: To analyze the overall survival (OS) of elderly acute myeloid leukemia (AML) patients treated with oral arsenic-containing Qinghuang Powder (, QHP) or low-intensity chemotherapy (LIC).

Methods: Forty-two elderly AML patients treated with intravenous or subcutaneous LIC (1 month for each course, at least 3 courses) or oral QHP (3 months for each course, at least 2 courses) were retrospectively analyzed from January 2015 to December 2017. The main endpoints of analysis were OS and 1-, 2-, 3-year OS rates of patients, respectively.

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Objective: To observe the effect of acupuncture in different time on nausea and vomiting induced by chemotherapy of lung cancer.

Methods: A total of 150 patients with chemotherapy for lung cancer were randomized into a No.1 observation group, a No.

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Objective: To investigate the relation of blood arsenic concentration (BAC) with clinical effect and safety of arsenic-containing Qinghuang Powder (, QHP) in patients with myelodysplastic syndrome (MDS).

Methods: Totally 163 patients with MDS were orally treated with QHP for 2 courses of treatment, 3 months as 1 course. The BACs of patients were detected by atomic fluorescence spectrophotometry at 1, 3, and 6 months during the treatment, and the effective rate, hematological improvement and safety in patients after treatment with QHP were analyzed.

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