Current research status of transarterial therapies for hepatocellular carcinoma.

With continuous advancements in interventional radiology, considerable progress has been made in transarterial therapies for hepatocellular carcinoma (HCC) in recent years, and an increasing number of research papers on transarterial therapies for HCC have been published. In this editorial, we comment on the article by Ma published in the recent issue of the "Efficacy and predictive factors of transarterial chemoembolization combined with lenvatinib plus programmed cell death protein-1 inhibition for unresectable HCC". We focus specifically on the current research status and future directions of transarterial therapies.

Three new Mn-[Mo(CN)] molecular magnets constructed from chiral bidentate chelating ligands.

Three new cyanide-bridged compounds {[Mn((,)-Dpen)][Mn((,)-Dpen)(HO)][Mo(CN)]·4HO·4CHN} (1-SS), {[Mn((,)-Dpen)][Mn((,)-Dpen)(HO)][Mo(CN)]·4.5HO·4CHN} (1-RR), and {[Mn(Chxn)][Mn(Chxn)(HO)][Mo(CN)]·HO·4CHN} (2) (/-Dpen = (,)/(,)-1,2-diphenylethylenediamine and Chxn = 1,2-cyclohexanediamine) have been successfully synthesized from the self-assembly reaction of the [Mo(CN)] unit, the Mn ions, and two chiral bidentate chelating ligands. Single-crystal structure determinations show that compounds 1-SS and 1-RR containing ligands /-Dpen are enantiomers and crystallize in the chiral space group 2.

A correlative study between IVIM-DWI parameters and VEGF and MMPs expression in hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related death worldwide. Angiogenic factors may be valuable indices of tumor recurrence and treatment and potentially useful markers for predicting the response to antiangiogenesis therapy. Vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) are major drivers of tumor angiogenesis.

A porous cobalt(II)-organic framework exhibiting high room temperature proton conductivity and field-induced slow magnetic relaxation.

A two-dimensional (2D) cobalt(II) metal-organic framework (MOF) constructed by a ditopic organic ligand, formulated as {[Co(Hbic)(HO)]·4HO} (1) (Hbic = 1-benzimidazole-5-carboxylic acid), was hydrothermally synthesized and structurally characterized. Single-crystal X-ray diffraction shows that the distorted octahedral Co ions, as coordination nodes, are bridged to form 2D honeycomb networks, which are further organized into a 3D supramolecular porous framework through multiple hydrogen bonds and interlayer π-π interactions. Dynamic crystallography experiments reveal the anisotropic thermal expansion behavior of the lattice, suggesting a flexible hydrogen-bonded 3D framework.

A single-ion magnet building block strategy toward Dy single-molecule magnets with enhanced magnetic performance.

A molecular dysprosium(III) complex [Dy(DClQ)(HO)] (1) was used as a building unit for the construction of lanthanide SMMs, leading to the isolation of two dinuclear Dy(III) complexes, namely [Dy(DClQ)(MeOH)] (2) and [Dy(DClQ)(bpmo)]·6MeCN (3) ( = 5,7-dichloro-8-hydroxyquinoline, = 4,4'-dipyridine-oxide). Structural analyses revealed the same NO coordination environment of the Dy(III) centers with a distorted biaugmented trigonal prism ( symmetry) and triangular dodecahedron ( symmetry) for 2 and 3, respectively. Magnetic studies revealed the presence of ferromagnetic and weak antiferromagnetic exchange interactions between the Dy centers in 2 and 3, respectively.

Supramolecular encapsulation of hexaaquacobalt(II) cations in a hydrogen-bonded framework for slow magnetic relaxation and high proton conduction.

The supramolecular assembly of hexaaquacobalt(II) nitrate and a tetradentate carboxylate ligand resulted in the isolation of a cobalt hydrogen-bonded organic framework (HOF). Variable-temperature X-ray diffraction experiments reveal high thermal stability of the framework sustained by charge-assisted, multiple hydrogen bonding interactions with the co-former. Interestingly, the material shows field-induced slow relaxation of magnetization originating from the magnetically anisotropic Co ions within the supramolecular framework, revealing a rare single-ion magnet (SIM) HOF.

A Proton Conducting Cobalt(II) Spin Crossover Complex.

Spin crossover (SCO) complexes have been extensively explored as bistable materials and recently used as molecular modules for the development of new multifunctional molecular magnetic materials. Herein, we present the synthesis, crystal structure, magnetic, and electrical properties of a mononuclear cobalt complex constructed by a halogen-functionalized terpyridine derivative and organosulfonate. A complete and gradual spin transition with the T =200 K was observed for the Co ions through both the magnetic measurement and dynamic crystallographic experiments.

Progress of MRI Radiomics in Hepatocellular Carcinoma.

Background: Hepatocellular carcinoma (HCC) is the sixth most common cancer in the world and the third leading cause of cancer-related death. Although the diagnostic scheme of HCC is currently undergoing refinement, the prognosis of HCC is still not satisfactory. In addition to certain factors, such as tumor size and number and vascular invasion displayed on traditional imaging, some histopathological features and gene expression parameters are also important for the prognosis of HCC patients.

Enhanced Single-Chain Magnet Behavior via Anisotropic Exchange in a Cyano-Bridged Mo -Mn Chain.

Anisotropic magnetic exchange is of great value for the design of high performance molecular nanomagnets. In the present work, enhanced single-chain magnet (SCM) behavior is observed for a Mo -Mn chain that exhibits anisotropic magnetic exchange. Self-assembly of the pentagonal bipyramidal [Mo(CN) ] anion and the Mn unit with a tridentate ligand results in a neutral double zigzag 2,4-ribbon structure which exhibits SCM behavior with a high relaxation barrier of 178(4) K.

Reversible On-Off Switching of the Hysteretic Spin Crossover in a Cobalt(II) Complex via Crystal to Crystal Transformation.

Reversible controlling and switching of magnetic bistability remains relatively difficult. Here, reversible on-off switching of a hysteretic spin transition in a Co complex via a single-crystal to single-crystal (SC-SC) transformation during dehydration and rehydration was reported. Upon dehydration, a switching from a basically low spin state to an abrupt and hysteretic spin crossover (SCO) with broad hysteresis loops was achieved.

Two three-dimensional [Mo(CN)]-based magnets showing new topologies and ferrimagnetic ordering below 80 K.

The rational design and synthesis of heptacyanomolybdate-based magnets remain a challenge due to the complexity of this system. Here, we reported the crystal structures and magnetic properties of two three-dimensional (3D) frameworks prepared from the self-assembly of the [Mo(CN)] unit with Mn ions in the presence of different amide ligands, namely Mn(DMF)(HO)[Mo(CN)]·HO·CHOH (1) and Mn(DEF)(HO)[Mo(CN)] (2) (DMF = N,N'-dimethylformamide and DEF = N,N'-diethylformamide). Single-crystal structure determinations showed that compound 1 crystallizes in the triclinic space group Pī, while 2 crystallizes in the monoclinic space group P2/n.

Heterometallic MLn (M = Co/Zn; Ln = Dy/Y) Complexes with Pentagonal Bipyramidal 3d Centers: Syntheses, Structures, and Magnetic Properties.

We herein reported the syntheses, structures, and magnetic properties of three dinuclear heterometallic MLn complexes, namely, [MLn(HL)(CHOH)(NO)](NO)·S (M = Co, Ln = Dy, S = MeOH (1); M = Zn, Ln = Dy, S = MeOH (2); M = Co, Ln = Y, S = MeNO (3), HL = 2,6-diacetylpyridine bis[2-(semicarbazono) propionylhydrazone]. Synthesized from the predesigned multidentate ligand HL, which has two different coordination pockets (smaller NO and larger NO pockets) suitable for either a 3d or a 4f metal center, all these complexes have very similar structures, where the M centers possess a pentagonal bipyramidal (PBP) geometry and the Ln sites have a tetradecahedron geometry. Magnetic measurements on these compounds revealed the existence of weak ferromagnetic coupling between the Co and Dy centers and the field-induced slow magnetic relaxation of all three complexes.

Syntheses, structures, and magnetic properties of three new Mn-[Mo(CN)] molecular magnets.

By reaction of K4[MoIII(CN)7]·2H2O, Mn(ClO4)2·6H2O and bidentate chelating ligands, three new cyano-bridged compounds, namely Mn2(3-pypz)(H2O)(CH3CN)[Mo(CN)7] (1), Mn2(1-pypz)(H2O)(CH3CN)[Mo(CN)7] (2) and Mn2(pyim)(H2O)(CH3CN)[Mo(CN)7] (3) (3-pypz = 2-(1H-pyrazol-3-yl)pyridine, 1-pypz = 2-(1H-pyrazol-1-yl)pyridine, pyim = 2-(1H-imidazol-2-yl)pyridine), have been synthesized and characterized structurally and magnetically. Single crystal X-ray analyses revealed that although the chelating ligands are different, compounds 1 to 3 are isomorphous and crystallize in the same monoclinic space group C2/m. Connected by the bridging cyano groups, one crystallographically unique [Mo(CN)7]4- unit and three crystallographically unique MnII ions of different coordination environments form similar three-dimensional frameworks, which have a four-nodal 3,4,4,7-connecting topological net with a vertex symbol of {43}{44·62}2{410·611}.

Single-ion magnetism in seven-coordinate Yb complexes with distorted D coordination geometry.

Two seven-coordinate compounds with pentagonal bipyramidal Yb centers, namely, [Yb(HBmshp)(DMF)Cl]·DMF·1.5HO (1) and [Yb(HBmshp)(DMF)Cl]·HBmshp (2) (HBmshp = (2,6-bis[(3-methoxysalicylidene)hydrazinecarbonyl]-pyridine)) were synthesized by changing the molar ratio of reactants in DMF. The structures of compounds 1 and 2 are very similar, except for the existence of different lattice molecules: one DMF and one and a half water molecules in 1, and one neutral uncoordinated ligand in 2.

Reversible On-Off Switching of a Single-Molecule Magnet via a Crystal-to-Crystal Chemical Transformation.

Dynamic molecular crystals are of high interest due to their potential applications. Herein we report the reversible on-off switching of single-molecule magnet (SMM) behavior in a [Mo(CN)] based molecular compound. Upon dehydration and rehydration, the trinuclear MnMo molecule [Mn(L)(HO)][Mo(CN)]·2HO (1) undergoes reversible crystal-to-crystal transformation to a hexanuclear MnMo compound [Mn(L)(HO)][Mn(L)][Mo(CN)] (2).

Slow Magnetic Relaxation in One-Dimensional Azido-Bridged Co Complexes.

Crystal structures and magnetic properties of three one-dimensional (1D) azido-bridged cobalt(II) chains with different amide ligands (L), [Co(N)(DMF)] (1), [Co(N)(DEF)] (2), and [Co(N)(DIPF)] (3) (DMF = N,N-dimethylformamide, DEF = N,N-diethylformamide, and DIPF = N,N-diisopropylformamide), are reported to investigate the influence of L on their structures and magnetic properties. Single-crystal X-ray crystallographic analysis revealed that, although 1-3 all consist of cobalt chains bridged by end-on (EO) azides, the coordination geometry of the Co ions and the repeating units of the 1D structures are quite different. As the size of L increases, the ratio of L to Co decreases from 6:4 in 1 to 5:4 and 4:4 in 2 and 3, respectively.

Three-Dimensional Fe-[Mo(CN)] Magnets with Ordering below 65 K and Distinct Topologies Induced by Cation Identity.

Two cyanide-bridged compounds based on the Fe cation and the anisotropic [Mo(CN)] anion, namely, {Fe(HO)[Mo(CN)]·5HO} (1) and {[NH(CH)]Fe(HO)[Mo(CN)]·8HO} (2), have been prepared. Single crystal X-ray analyses revealed that their structures exhibit different three-dimensional topologies as a result of the addition of [NH(CH)] during the synthesis of 2. For both 1 and 2, the geometry of the [Mo(CN)] unit is a slightly distorted capped trigonal prism; all Fe centers are hexacoordinate and adopt a distorted octahedral configuration.

A One-Dimensional Magnet Based on [Mo(III)(CN)7](4.).

Self-assembly of the [Mo(III)(CN)7](4-) anion and the Mn(II) unit with a macrocyclic ligand results in the first example of a one-dimensional (1D) chain compound based on the heptacyanomolybdate, [Mn(LN5C10)]2[Mo(CN)7]·2H2O (LN5C10 = 1,4,7,10,13-pentaazacyclopentadecane). Because of the existence of the interchain magnetic coupling, long-rang magnetic ordering was observed in this compound.

[Spatio-temporal variation of drought condition during 1961 to 2012 based on composite index of meteorological drought in Altay region, China].

Based on the daily meteorological data of seven stations in Altay region, China, this study investigated the temporal ( seasonal, inter-annual and decadal) and spatial variations of drought by using composite index of meteorological drought, as well as trend analysis, M-K abrupt analysis, wavelet analysis and interpolation tools in ArcGIS. The results indicated that the composite index of meteorological drought could reflect the drought condition in Altay region well. Although the frequency and the covered area of both inter-annual and seasonal droughts presented decreasing trends in the recent 52 a, the drought was still serious when considering the annual drought.

Decolorization of azo dye Orange G by aluminum powder enhanced by ultrasonic irradiation.

In this work, the decolorization of azo dye Orange G (OG) in aqueous solution by aluminum powder enhanced by ultrasonic irradiation (AlP-UI) was investigated. The effects of various operating operational parameters such as the initial pH, initial OG concentration, AlP dosage, ultrasound power and added hydrogen peroxide (H2O2) concentration were studied. The results showed that the decolorization rate was enhanced when the aqueous OG was irradiated simultaneously by ultrasound in the AlP-acid systems.