Hsa_circ_0006006 is a potential biomarker for prognosis and cisplatin resistance in non-small cell lung cancer.

Background And Objective: Platinum-based drugs, such as cisplatin (DDP), are the standard treatment, yet drug resistance has become a key challenge. Previous studies have shown that hsa_circ_0006006 promotes non small cell lung cancer (NSCLC) progression. This study aimed to reveal the role of specific circRNAs in DDP resistance in NSCLC and their potential clinical applications.

Assessment of Syphilitic Optic Neuropathy: A Prospective Cross-Sectional Study.

Purpose: To evaluate the clinical features of syphilis optic neuropathy (SON) and explore its underlying pathogenesis by measuring the peripapillary retinal nerve fiber layer (pRNFL).

Methods: This was a prospective cross-sectional study. Syphilitics, regardless of ocular complaints, in the ophthalmology department in 2020 were screened for SON, which was defined as isolated optic neuropathy without overt signs of syphilitic uveitis.

Size-dependent catalytic reactivity of NO reduction by CO mediated by RhVO clusters ( = 2-5).

A fundamental understanding of the precise structural characteristics of interfacial active sites present in heterogeneous catalysts is pivotal to construct a vigorous metal-support boundary. Herein, a series of RhVO ( = 2-5) clusters was theoretically designed, and we demonstrated that RhVO can catalytically reduce NO into N selectively by CO. We identified that in the structure of RhVO, Rh moieties were dispersed on a VO "support" anchored by two V atoms.

Characteristics of transcriptome and chromatin accessibility in the peripheral blood after acute hypoxia exposure.

Background: Human responses and acclimation to the environmental stresses of high altitude and low oxygen are multifaceted and regulated by multiple genes. However, the mechanism of how the body adjusts in a low-oxygen environment is not yet clear.

Results: Hence, we performed RNA sequencing (RNA-seq) and ATAC sequencing (ATAC-seq) to observe the changes of transcriptome and chromatin accessibility in the peripheral blood of eight individuals at 1 h post adaptation in a simulated plateau environment with 3500 m and 4500 m altitude, respectively.

Observation of Aromatic B(CO) ( = 1-7) as Boron Carbonyl Analogs of Benzene.

CO as a typical σ-donor is one of the most important ligands in chemistry, while planar B is experimentally known as the most prominent magic-number boron cluster analogous to benzene. Joint gas-phase mass spectroscopy, collision-induced dissociation, and first-principles theory investigations performed herein indicate that B reacts with CO successively under ambient conditions to form a series of boron carbonyl complexes B(CO) up to = 7, presenting the largest boron carbonyl complexes observed to date with a quasi-planar B core at the center coordinated by CO ligands around it. Extensive theoretical analyses unveil both the chemisorption pathways and bonding patterns of these aromatic B(CO) monocations which, with three delocalized π bonds well-retained over the slightly wrinkled B moiety, all prove to be boron carbonyl analogs of benzene tentatively named as boron carbonyl aromatics (BCAs).

Selective Reduction of NO into N Catalyzed by the RhMO Clusters (M = Ta, V, and Al): Importance of the Triatomic Lewis Acid-Base-Acid M-Rh-M Site.

Catalytic NO reduction by CO into N and CO is imperative owing to the increasingly rigorous emission regulation. Identifying the nature of active sites that govern the reactivity and selectivity of NO reduction is pivotal to tailor catalysts, while it is extremely challenging because of the complexity of real-life systems. Guided by our newly discovered triatomic Lewis acid-base-acid (LABA, Ce-Rh-Ce) site that accounts for the selective reduction of NO into N catalyzed by the RhCeO cluster in gas-phase experiments, the reactivity of the RhMO (M = Ta, V, and Al) clusters in catalytic NO reduction by CO was explored.

Diphenylamino-Modified Neutral Pt(II) Complexes: Their Aggregation-Induced Phosphorescent Emission and Picric Acid-Sensing Properties.

Three neutral Pt(II) complexes with diphenylamino-modified 2-phenylpyridine derivatives as cyclometalating ligands and acetylacetone as the ancillary ligand exhibit aggregation-induced phosphorescent emission (AIPE) properties in THF/HO. The crystal structures of the complexes highlight the contributions of non-covalent Pt···Pt interactions and hydrogen bonds to the AIPE properties. These AIPE-active Pt(II) complexes - have been successfully applied to detect picric acid (PA) in aqueous media, affording the lowest limit of detection at 70 nM.

BSA-stabilized selenium nanoparticles ameliorate intracerebral hemorrhage's-like pathology by inhibiting ferroptosis-mediated neurotoxicology via Nrf2/GPX4 axis activation.

Intracerebral hemorrhage (ICH) is a prevalent hemorrhagic cerebrovascular emergency. Alleviating neurological damage in the early stages of ICH is critical for enhancing patient prognosis and survival rate. A novel form of cell death called ferroptosis is intimately linked to hemorrhage-induced brain tissue injury.

Reverse water-gas shift catalyzed by RhVO ( = 3-7) cluster anions under variable temperatures.

A fundamental understanding of the exact structural characteristics and reaction mechanisms of interface active sites is vital to engineering an energetic metal-support boundary in heterogeneous catalysis. Herein, benefiting from a newly developed high-temperature ion trap reactor, the reverse water-gas shift (RWGS) (CO + H → CO + HO) catalyzed by a series of compositionally and structurally well-defined RhVO ( = 3-7) clusters were identified under variable temperatures (298-773 K). It is discovered that the RhVO clusters can function more effectively to drive RWGS at relatively low temperatures.

Pivotal Role of GSTO2 in Ferroptotic Neuronal Injury After Intracerebral Hemorrhage.

Previous research has found that an adaptive response to ferroptosis involving glutathione peroxidase 4 (GPX4) is triggered after intracerebral hemorrhage. However, little is known about the mechanisms underlying adaptive responses to ferroptosis. To explore the mechanisms underlying adaptive responses to ferroptosis after intracerebral hemorrhage, we used hemin-treated HT22 cells to mimic brain injury after hemorrhagic stroke in vitro to evaluate the antioxidant enzymes and performed bioinformatics analysis based on the mRNA sequencing data.

Intestinal tuberculosis with small bowel stricture and hemorrhage as the predominant manifestation: Three case reports.

Background: Intestinal tuberculosis is a chronic disease caused by that mainly affects the ileum and cecum. Small bowel tuberculosis, characterized by predominant involvement of the small intestine, is an extremely rare condition with highly atypical clinical presentations, making diagnosis even more challenging.

Case Summary: We report three cases of small intestinal tuberculosis, two of the patients presented primarily with abdominal pain, and one presented with gastrointestinal bleeding.

CO Oxidation Promoted by NO Adsorption on RhMnO Cluster Anions.

CO oxidation represents an important model reaction in the gas phase to provide a clear structure-reactivity relationship in related heterogeneous catalysis. Herein, in combination with mass spectrometry experiments and quantum-chemical calculations, we identified that the RhMnO cluster cannot oxidize CO into gas-phase CO at room temperature, while the NO preadsorbed products RhMnO[(NO)] are highly reactive in CO oxidation. This discovery is helpful to get a fundamental understanding on the reaction behavior in real-world three-way catalytic conditions where different kinds of reactants coexist.

Selective Reduction of NO into N Catalyzed by Rh-Doped Cluster Anions RhCeO.

Catalytic conversion of toxic nitrogen oxide (NO) and carbon monoxide (CO) into nitrogen (N) and carbon dioxide (CO) is imperative under the weight of the increasingly stringent emission regulations, while a fundamental understanding of the nature of the active site to selectively drive N generation is elusive. Herein, in combination with state-of-the-art mass-spectrometric experiments and quantum-chemical calculations, we demonstrated that the rhodium-cerium oxide clusters RhCeO can catalytically drive NO reduction by CO and give rise to N and CO. This finding represents a sharp improvement in cluster science where NO is commonly produced in the rarely established examples of catalytic NO reduction mediated with gas-phase clusters.

Size-Dependent Reactivity of Co ( = 5-25) Cluster Anions toward Carbon Dioxide.

A fundamental understanding of the reactivity evolution of nanosized clusters at an atomically precise level is pivotal to assemble desired materials with promising candidates. Benefiting from the tandem mass spectrometer coupled with a high-temperature ion-trap reactor, the reactions of mass-selected Co ( = 5-25) clusters with CO were investigated and the increased reactivity of Co was newly discovered herein. This finding marks an important step to understand property evolution of subnanometer metal clusters (Co, ∼0.

Catalytic NO Reduction by Noble-Metal-Free Vanadium-Aluminum Oxide Cluster Anions.

By using state-of-the-art mass spectrometry and guided by the newly discovered single-electron mechanism (SEM; e.g., Ti + 2NO → Ti-O + NO), we determined experimentally that the vanadium-aluminum oxide clusters VAlO ( = 1-3) can catalyze the reduction of NO by CO and substantiated theoretically that the SEM still prevails in driving the catalysis.

Filtration of the preferred catalyst for reverse water-gas shift among Rh ( = 3-11) clusters by mass spectrometry under variable temperatures.

The key to optimizing energy-consuming catalytic conversions lies in acquiring a fundamental understanding of the nature of the active sites and the mechanisms of elementary steps at an atomically precise level, while it is challenging to capture the crucial step that determines the overall temperature of a real-life catalytic reaction. Herein, benefiting from a newly-developed high-temperature ion trap reactor, the reverse water-gas shift (CO + H → CO + HO) reaction catalyzed by the Rh ( = 3-11) clusters was investigated under variable temperatures (298-783 K) and the critical temperature that each elementary step (Rh + CO and RhO + H) requires to take place was identified. The Rh cluster strikingly surpasses other Rh clusters to drive the catalysis at a mild starting temperature (∼440 K).

Simple and feasible detection of hepatitis a virus using reverse transcription multienzyme isothermal rapid amplification and lateral flow dipsticks without standard PCR laboratory.

Hepatitis A virus (HAV) is mainly transmitted contaminated food and water. HAV infection is a major global public health problem. Thus, developing a simple, rapid detection method is crucial for containing HAV epidemics, particularly in developing regions with limited laboratory resources.

Gas-phase reactions driven by polarized metal-metal bonding in atomic clusters.

Multimetallic catalysts exhibit great potential in the activation and catalytic transformation of small molecules. The polarized metal-metal bonds have been gradually recognized to account for the reactivity of multimetallic catalysts due to the synergistic effect of different metal centers. Gas-phase reactions on atomic clusters that compositionally resemble the active sites on related condensed-phase catalysts provide a widely accepted strategy to clarify the nature of polarized metal-metal bonds and the mechanistic details of elementary steps involved in the catalysis driven by this unique chemical bonding.

AIPE-active cationic Ir(III) complexes for efficient detection of 2,4,6-trinitrophenol and oxygen.

A cationic Ir(III) complex, Ir2, with a diphenylamino (DPA)-substituted 2-phenylbenzothiazole derivative as the cyclometalating ligand was designed and synthesized. Ir2 shows obvious aggregation-induced phosphorescent emission (AIPE) in HO/CHCN, compared with a non-DPA-substituted Ir1. The AIPE-active Ir2 demonstrates efficient detection of 2,4,6-trinitrophenol, providing a higher quenching constant ( = 2 644 330 M.

Facile CO bond cleavage on polynuclear vanadium nitride clusters VN.

Identifying the structural configurations of precursors for CO dissociation is fundamentally interesting and industrially important in the fields of, , Fischer-Tropsch synthesis. Herein, we demonstrated that CO could be dissociated on polynuclear vanadium nitride VN clusters at room temperature, and a key intermediate, with CO in a N-assisted tilted bridge coordination where the C-O bond ruptures easily, was discovered. The reaction was characterized by mass spectrometry, photoelectron spectroscopy, and quantum-chemistry calculations, and the nature of the adsorbed CO on product VNCO was further characterized by a collision-induced dissociation experiment.