Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives.

Background: Stem cell therapy has shown great potential for treating diabetic foot (DF).

Aim: To conduct a bibliometric analysis of studies on the use of stem cell therapy for DF over the past two decades, with the aim of depicting the current global research landscape, identifying the most influential research hotspots, and providing insights for future research directions.

Methods: We searched the Web of Science Core Collection database for all relevant studies on the use of stem cell therapy in DF.

Computed Tomography Study of the Retrosigmoid Craniotomy Keyhole Approach Using Surface Landmarks.

Background: Due to a lack of accessibility and individual differences in surgical procedures, many previous studies on keyholes are not practical.

Objective: To study the surface landmarks for optimal keyhole placement in the retrosigmoid approach.

Methods: The three-dimensional (3D) skull images of 79 patients were reconstructed using workstations, with a total of 149 hemiskull base 3D images then analyzed.

Relationship between nosocomial infections and coronavirus disease 2019 in the neurosurgery unit: clinical characteristics and outcomes from a Chinese Tertiary-Care Hospital.

Background: The COVID-19 pandemic has raised awareness of infection prevention and control. We found that the incidence of nosocomial infection in neurosurgery has changed. This study aimed to evaluate the impact of "coronavirus disease 2019 (COVID-19) prevention and control measures" on nosocomial infections in neurosurgery.

Evaluation of burnout among stay-behind healthcare workers during the current Omicron wave of COVID-19 in Taizhou, China.

Background: Since February 2022, a new Omicron wave of COVID-19 emerged in Shanghai, China. Many healthcare workers came to Shanghai from hospitals of other parts of China as aid workers. Hospitals in areas with mild COVID-19 outbreaks will inevitably be understaffed, it is likely to cause job burnout of stay-behind healthcare workers.

Asbestos Detection with Fluorescence Microscopy Images and Deep Learning.

Fluorescent probes can be used to detect various types of asbestos (serpentine and amphibole groups); however, the fiber counting using our previously developed software was not accurate for samples with low fiber concentration. Machine learning-based techniques (e.g.

Irradiance uniformity optimization for a photodynamic therapy treatment device with 3D scanner.

Significance: The light dose in photodynamic therapy (PDT) has a considerable influence on its treatment effect, and irradiance uniformity is an issue of much concern for researchers. However, achieving intelligent and personalized dosimetry adjustments remains a challenge for current PDT instruments.

Aim: To meet the requirements of intelligent and personalized dosimetry adjustments for the light dose on an irregular surface, a new PDT device with its optimal control method is proposed.

Validation of methods for effective orifice area measurement of prosthetic valves by two-dimensional and Doppler echocardiography following transcatheter self-expanding aortic valve implantation.

Background: The effective orifice area (EOA) is utilized to characterize the hemodynamic performance of the transcatheter heart valve (THV). However, there is no consensus on EOA measurement of self-expanding THV. We aimed to compare two echocardiographic methods for EOA measurement following transcatheter self-expanding aortic valve implantation.

IL-2mAb reduces demyelination after focal cerebral ischemia by suppressing CD8 T cells.

Aims: Demyelination, one of the major pathological changes of white matter injury, is closely related to T-cell-mediated immune responses. Thus, we investigate the role of an IL-2 monoclonal antibody (IL-2mAb, JES6-1) in combatting demyelination during the late phase of stroke.

Methods: IL-2mAb or IgG isotype antibody (0.

Reduced carbon use efficiency and increased microbial turnover with soil warming.

Global soil carbon (C) stocks are expected to decline with warming, and changes in microbial processes are key to this projection. However, warming responses of critical microbial parameters such as carbon use efficiency (CUE) and biomass turnover (rB) are not well understood. Here, we determine these parameters using a probabilistic inversion approach that integrates a microbial-enzyme model with 22 years of carbon cycling measurements at Harvard Forest.

Dynamic model of vascular-targeted photodynamic therapy.

Vascular-targeted photodynamic therapy has shown efficiency in treating port wine stains. A dynamic model that incorporates blood flow, kinetic diffusion, oxygen and photosensitizer consumption and reaction, and light modulation is proposed to reveal the interactions among light, photosensitizer, and oxygen. Simulation results show that pulse light modulation synchronized with heartbeats hold the advantage of increased singlet oxygen accumulation, higher oxygen concentration and lower temperature.

Effects of dietary oregano essential oil and vitamin E supplementation on meat quality, stress response and intestinal morphology in pigs following transport stress.

This study investigates the effects of dietary oregano essential oil (OEO) and vitamin E (Vit E) supplementation on meat quality, stress response and intestinal morphology in pigs following transport stress. A total of 288 finishing pigs were randomly assigned to three groups: a basal diet or a basal diet supplemented either with 200 mg/kg Vit E or 25 mg/kg OEO. After a 28-day feeding trial, total of 132 finishing pigs according diet and transport stress were assigned to one of four treatment groups: 1) control treatment without transport stress (Control group), 2) control treatment with 5-hr transport stress (Negative group), 3) Vit E treatment with 5-hr transport stress and 4) OEO treatment with 5-hr transport stress.

Caspase-3 in serum predicts outcome after aneurysmal subarachnoid hemorrhage.

Background: Caspase-3 represents a promising marker of apoptosis. This study was designed to investigate the serial change of serum caspase-3 activities and analyze the relationships between caspase-3 activities and the severity and prognosis of aneurysmal subarachnoid hemorrhage (aSAH).

Methods: We determined serum caspase-3 activities of 118 controls at study entry and 118 patients at admission and at days 1, 2, 3, 5 and 7 after aSAH.

Remote Ischemic Preconditioning-Mediated Neuroprotection against Stroke is Associated with Significant Alterations in Peripheral Immune Responses.

Aims: Remote ischemic preconditioning (RIPC) of a limb is a clinically feasible strategy to protect against ischemia-reperfusion injury after stroke. However, the mechanism underlying RIPC remains elusive.

Methods: We generated a rat model of noninvasive RIPC by four repeated cycles of brief blood flow constriction (5 min) in the hindlimbs using a tourniquet.

Ki-67 as a prognostic marker in early-stage non-small cell lung cancer in Asian patients: a meta-analysis of published studies involving 32 studies.

Background: Despite the large number of published papers analyzing the prognostic role of Ki-67 in NSCLC, it is still not considered an established factor for routine use in clinical practice. The present meta-analysis summarizes and analyses the associations between Ki-67 expression and clinical outcome in NSCLC patients.

Methods: PubMed, Cochrane, and Embase databases were searched systematically using identical search strategies.

Optimization of irradiance for photodynamic therapy of port-wine stain.

Controllable and effective irradiation of lesions is among the key factors that affect the potency of photodynamic therapy (PDT). An optimization method for the irradiance distribution of treatment was proposed which can be used to improve the efficacy of PDT and allow more lesions to receive the desired irradiance level in a single therapy session. With the proposed digital illumination binocular treatment system, the preferred surface normal vectors, irradiation angles, as well as area and weight coefficients of lesions can be achieved and used as characteristic parameters to optimize the irradiation direction.

Relationships between meteorological parameters and criteria air pollutants in three megacities in China.

Meteorological conditions play a crucial role in ambient air pollution by affecting both directly and indirectly the emissions, transport, formation, and deposition of air pollutants. In this study, the relationships between meteorological parameters and ambient air pollutants concentrations in three megacities in China, Beijing, Shanghai, and Guangzhou were investigated. A systematic analysis of air pollutants including PM2.

Ethyl pyruvate protects against blood-brain barrier damage and improves long-term neurological outcomes in a rat model of traumatic brain injury.

Aims: Many traumatic brain injury (TBI) survivors sustain neurological disability and cognitive impairments due to the lack of defined therapies to reduce TBI-induced long-term brain damage. Ethyl pyruvate (EP) has shown neuroprotection in several models of acute brain injury. The present study therefore investigated the potential beneficial effect of EP on long-term outcomes after TBI and the underlying mechanisms.

Splenic responses in ischemic stroke: new insights into stroke pathology.

In the past decade, the significant contribution of the spleen to ischemic brain damage has gained considerable attention in stroke research. As the largest natural reservoir of immune cells, the spleen establishes critical connections with the ischemic brain during the progression of stroke and mobilizes its cells to the site of injury. Multiple "alarm" signals released from the injured brain are essential for the initiation of brain-spleen communication.

Three-dimensional illumination procedure for photodynamic therapy of dermatology.

Light dosimetry is an important parameter that affects the efficacy of photodynamic therapy (PDT). However, the irregular morphologies of lesions complicate lesion segmentation and light irradiance adjustment. Therefore, this study developed an illumination demo system comprising a camera, a digital projector, and a computing unit to solve these problems.

Impact of the Loess Plateau on the atmospheric boundary layer structure and air quality in the North China Plain: a case study.

The North China Plain (NCP), to the east of the Loess Plateau, experiences severe regional air pollution. During the daytime in the summer, the Loess Plateau acts as an elevated heat source. The impacts of such a thermal effect on meteorological phenomena (e.

[Modeling nitrogen transformation in a novel circular-flow corridor wetland].

Nitrogen transformation and removal in a novel circular-flow corridor (CFC) wetland was simulated. A computer model covering 6 nitrogen forms, 3 media and 10 transferring pathways, was developed. The results show that the TN removal is attributed to zeolite adsorption (53.

Antenna-specific glutathione S-transferase in male silkmoth Bombyx mori.

Glutathione S-transferases (GSTs) are multifunctional enzymes that are widely distributed in different species. GSTs detoxify exogenous and endogenous substances by conjugation to reduced glutathione. We characterized BmGSTD4, an antenna-specific GST, in male silkmoths.

Plasma visfatin, a possible prognostic marker in aneurysmal subarachnoid hemorrhage.

Visfatin is linked to inflammation and associated with clinical outcomes of intracerebral hemorrhage. This study was designed to investigate whether visfatin might serve as a marker of severity and prognosis in aneurysmal subarachnoid hemorrhage. In this study, plasma visfatin levels of 172 consecutive patients and 172 sex and age-matched healthy subjects were determined using enzyme-linked immunosorbent assay.

Systems scale assessment of the sustainability implications of emerging green initiatives.

This paper demonstrates a systems framework for assessment of environmental impacts from 'green initiatives', through a case study of meso-scale, anthropogenic-biogenic interactions. The following cross-sectoral green initiatives, combining the emerging trends in the North East region of the United Kingdom, have been considered - increasing the vegetation cover; decarbonising road transport; decentralising energy production through biomass plants. Two future scenarios are assessed - Baseline_2020 (projected emissions from realisation of policy instruments); Aggressive_2020 (additional emissions from realisation of green initiatives).