Diterpenoids and Triterpenoids from the Aerial Parts of and Their Biological Activities.

Five undescribed diterpenoids, serranins A-E (-), and four novel triterpenoids, serratic acids A-D (-), along with 32 known terpenoids (-) were isolated from the aerial parts of . The planar structures of - and their relative configurations were established on the basis of extensive spectroscopic analysis. Structurally, compounds - are the first examples of 18,19--ursane -coumaric or ferulic esters, while compounds - further enriched the plant's diterpene profile.

Equol exerts anti-tumor effects on choriocarcinoma cells by promoting TRIM21-mediated ubiquitination of ANXA2.

Choriocarcinoma is a malignant cancer that belongs to gestational trophoblastic neoplasia (GTN). Herein, serum metabolomic analysis was performed on 29 GTN patients and 30 healthy individuals to characterize the metabolic variations during GTN progression. Ultimately 24 differential metabolites (DMs) were identified, of which, Equol was down-regulated in GTN patients, whose VIP score is the 3rd highest among the 24 DMs.

Dual-nodes bridged cobalt-modified Keggin-type polyoxometalate-based chains for highly efficient CO photoconversion.

The design of efficient catalysts for photocatalytic CO conversion is of great importance for the sustainable development of society. Herein, three polyoxometalate (POM)-based crystalline materials were formulated prepared by substituting transition metals and adjusting solvent acidity with 2-(2-pyridyl) benzimidazole (pyim) as the light-trapping ligand, namely {[SiWO][Co(pyim)]}·2CHOH (SiW12Co2), {[SiWO][Ni(pyim)]}·2CHOH (SiW12Ni2), and {[SiWO][Mn(pyim)]}·2CHOH (SiW12Mn2). X-ray crystallography diffraction analysis indicates that the three complexes exhibit isostructural properties, and form a stable one-dimensional chain structure stabilized by two [M(pyim)] (M = Co, Ni, and Mn) fragments serving as dual-nodes to the adjacent SiW units.

The effect of telephone and short-message follow-ups on compliance and efficacy in asthmatic children treated with inhaled corticosteroid: A randomized controlled trial.

Background: This study aims to evaluate the effect of telephone and short-message follow-ups on compliance and efficacy in asthmatic children treated with inhaled corticosteroids.

Methods: A total of 120 children with moderate bronchial asthma who visited the Asthma Outpatient Department of the Affiliated Hospital of Qingdao University were enrolled in the study. They were divided randomly into 3 groups based on the type of follow-up given: a combined telephone and short-message service (Tel + SMS) group, a SMS group, and a control group.

Mechanistic study of Huangqi Guizhi Wuwu decoction amelioration of doxorubicin-induced cardiotoxicity by reducing oxidative stress and inhibiting cellular pyroptosis.

Huangqi Guizhi Wuwu Decoction (HQGZWWD) has shown promising potential in treating various cardiovascular diseases. This study aimed to elucidate the molecular basis and therapeutic role of HQGZWWD in the treatment of doxorubicin (DOX)-induced myocardial injury. The HPLC fingerprint of HQGZWWD was used to analyze the active components.

[Cerebral oxygen metabolism and brain electrical activity of healthy full-term neonates in high-altitude areas: a multicenter clinical research protocol].

Further evidence is needed to explore the impact of high-altitude environments on the neurologic function of neonates. Non-invasive techniques such as cerebral near-infrared spectroscopy and amplitude-integrated electroencephalography can provide data on cerebral oxygenation and brain electrical activity. This study will conduct multiple cerebral near-infrared spectroscopy and amplitude-integrated electroencephalography monitoring sessions at various time points within the first 3 days postpartum for healthy full-term neonates at different altitudes.

Hysteroscopic suture of levonorgestrel-releasing intrauterine system: learning curve for in vitro simulation training.

Objective: To simulate hysteroscopic suturing in vitro and analyze the learning curve of gynecologists with different experience levels.

Methods: Three gynecologists were trained on uterine models in a circulating water box. The posterior uterine wall was sutured 10 times under hysteroscopy for 5 consecutive days, and the time of each suture procedure was recorded.

Underwater power compensated white light source based on synthetic white laser.

The semiconductor white laser light source is used as a light source for underwater illumination. The required standard color temperature of white light is obtained at the underwater target surface. We studied the power compensation of a synthetic white laser source and its application to underwater illumination.

The prevalence and predictors of feeding difficulties in children at self-feeding transition stage.

Aim: To understand the prevalence of feeding difficulties (FD) in young children at self-feeding transition stage (6-24 months age), and the protective and risk predictors associated with FD are to be determined through this study.

Methods: A cross-sectional study was conducted within 5 representative Women's and Children's hospitals in Chengdu, Southwest China. Children age 6-24 months who underwent routine child health care examination at outpatient and their parents were enrolled, while the Montreal Children's Hospital Feeding Scale which is validated was used to determine whether these children have FD.

Nomogram for predicting the preoperative lymph node metastasis in resectable pancreatic cancer.

Background: Lymph node metastasis (LNM) is a critical prognostic factor in resectable pancreatic cancer (PC) patients, determining treatment strategies. This study aimed to develop a clinical model to adequately and accurately predict the risk of LNM in PC patients.

Methods: 13,200 resectable PC patients were enrolled from the SEER (Surveillance, Epidemiology, and End Results) database, and randomly divided into a training group and an internal validation group at a ratio of 7:3.

Chemical Constituents from the Fruits of and Their Role in Activating Alcohol Dehydrogenase.

Alcoholism is a worldwide health problem, and diseases caused by alcoholism are killing people every year. is a traditional Chinese medicine used to relieve hangovers. However, whether its bioactive components improve alcohol metabolism is not clear.

Gene Therapy Activates Retinal Pigment Epithelium Cell Proliferation for Age-related Macular Degeneration in a Mouse Model.

Objective: Age-related macular degeneration (AMD) is a degenerative retinal disease. The degeneration or death of retinal pigment epithelium (RPE) cells is implicated in the pathogenesis of AMD. This study aimed to activate the proliferation of RPE cells in vivo by using an adeno-associated virus (AAV) vector encoding β-catenin to treat AMD in a mouse model.

Blocking postsynaptic density-93 binding to C-X3-C motif chemokine ligand 1 promotes microglial phenotypic transformation during acute ischemic stroke.

We previously reported that postsynaptic density-93 mediates neuron-microglia crosstalk by interacting with amino acids 357-395 of C X3 C motif chemokine ligand 1 (CX3CL1) to induce microglia polarization. More importantly, the peptide Tat-CX3CL1 (comprising amino acids 357-395 of CX3CL1) disrupts the interaction between postsynaptic density-93 and CX3CL1, reducing neurological impairment and exerting a protective effect in the context of acute ischemic stroke. However, the mechanism underlying these effects remains unclear.

Compensatory effects of different exercise durations on non-exercise physical activity, appetite, and energy intake in normal weight and overweight adults.

To examine compensatory changes of different exercise durations on non-exercise physical activity (NEPA), appetite, and energy intake (EI) in normal and overweight adults, and to determine if different body mass index of individuals interact with these compensatory effects. Ten normal weight adults (nine females and one male; age: 24.0 ± 0.

High triiodothyronine levels induce myocardial hypertrophy via BAFF overexpression.

Activated B cells contribute to heart diseases, and inhibition of B-cell activating factor (BAFF) expression is an effective therapeutic target for heart diseases. Whether activated B cells participate in the development and progression of hyperthyroid heart disease, and what induces B cells activation in hyperthyroidism are unknown. The present study aimed to determine the roles of BAFF overexpression induced by high concentrations of triiodothyronine (T3) in the pathogenesis of hyperthyroid heart disease.

A Hypoxia-Regulated Retinal Pigment Epithelium-Specific Gene Therapy Vector Reduces Choroidal Neovascularization in a Mouse Model.

Background: Wet age-related macular degeneration (wAMD) is characterized by the presence of choroidal neovascularization (CNV). Although there are some clinical drugs targeting vascular endothelial growth factor (VEGF) and inhibiting CNV, two major side effects limit their application, including the excessive activity of anti-VEGF and frequent intraocular injections. To explore better treatment strategies, researchers developed a hypoxic modulator retinal pigment epithelium (RPE)- specific adeno-associated virus (AAV) vector expressing endostatin to inhibit CNV.

Two POM-based compounds containing Zn-capped Keggin anions as decent heterogeneous catalysts for sulfur oxidation and CO cycloaddition reactions.

Carbon dioxide (CO) and the combustion of sulfide in gasoline are the main causes of air pollution. A great deal of attention has been paid to solving the problem and the catalytic reaction seems to be a decent choice. Due to the high-density of Lewis acidic active sites, polyoxometalates are undoubtedly an ideal choice for the sulfur oxidation reaction.

A new family of boat-shaped Ln clusters exhibiting the magnetocaloric effect and slow magnetic relaxation.

Designing and synthesizing lanthanide clusters have always been a research hotspot. Herein, three lanthanide clusters with the formula [Ln(IN)(μ-OH)(μ-OH)(HO)]·HO (Ln = 1-Gd and = 11; Ln = 2-Dy and = 8; Ln = 3-Eu and = 8) have been isolated in the presence of isonicotinic acid under solvothermal conditions. Structural analysis indicates that those three compounds are isostructural, featuring boat-shaped {Ln} metal frameworks.

Two Ni-Substituted Trilacunary Keggin-Type Polyoxometalates: Syntheses, Crystal Structures, NLO Studies, and Magnetic Properties.

Two Ni-substituted polyoxometalates (NiSPs), [Ni(Py)(HO)(μ-OH)(PWO)]·10HO (), [Ni(Py)(Im)(HO)O(WO)(μ-OH)(HPWO)]·3HO () (Py = pyridine, Im = imidazole), were successfully hydrothermally synthesized. Compounds and have significantly different configurations by introducing different amounts of imidazole ligands. For compound , two malposed {Ni(Py)PW} units that are face to face are bridged by two Ni-O-W bonds to constitute an isolated dimeric structure.

A Purely Inorganic Quasi-Keggin Polyoxometalate for Photocatalytic Conversion of Carbon Dioxide to Carbon Monoxide.

A pure inorganic cluster, H Na Co Mo (PO ) O  ⋅ 15H O (denoted as {Co Mo }), has been successfully synthesized by hydrothermal method. Notably, the assembly of a central {Co PO } tetrahedron and four peripheral {Co[P Mo ]} fragments gives rise to a rare "quasi-Keggin" structure of {Co Mo }, in which Co linkers continue to bridge adjacent substructures, resulting in the generation of 3D framework with large cavities. Benefitting from the combination of strong reductive {P Mo } units and Co active centers, the photocatalytic system with {Co Mo } as heterogeneous catalyst exhibits excellent activity for CO conversion to CO, offering the CO formation rate of 1848.

Two three-dimensional polyanionic clusters [M(PMo)] (M = Co, Zn) exhibiting excellent photocatalytic CO reduction performance.

Two captivating {P4Mo6}-based compounds, formulated as (H2bbi)2{[Co2(bbi)][Co2.33(H2O)4][H9.33CoP8Mo12O62]}·4H2O (1) and (H2bbi){[Zn(Hbbi)]2[Zn0.