Association between KLKB1 Polymorphisms and Pulmonary Thromboembolism.

Objective: To investigate the potential correlation between the single nucleotide polymorphisms (SNPs) in the KLKB1 region and pulmonary thromboembolism(PTE) in a Chinese Han population.

Methods: In this case-control study, 95 patients with confirmed PTE were enrolled as the PTE group and 90 healthy subjects as the control group. The genotypes, alleles, and haplotypes of the SNPs were analyzed with PLINK 1.

[Pulmonary mucormycosis: report of 5 cases and review of 46 cases reported in China].

Objective: To describe the clinical manifestations and diagnosis of pulmonary mucormycosis.

Methods: We presented 5 proven diagnosed cases of pulmonary mucormycosis in our hospital and reviewed all proven cases of pulmonary mucormycosis previously reported in mainland China. Publications in the form of case reports and articles between January 1982 and December 2011 were searched from Wan Fang Data and China Hospital Knowledge Database.

[Clinical analysis of 15 cases of saddle pulmonary embolism].

Objective: To improve recognition of saddle pulmonary embolism (SPE).

Methods: A retrospectively review was performed for patients diagnosed with SPE determined by CTPA from Jan 2004 to Jan 2012.

Results: Fifteen SPE patients(4.

[Clinicopathological diagnosis of hypersensitivity pneumonitis].

Objective: To enhance the understandings of clinical, radiological and pathological features of hypersensitivity pneumonitis (HP).

Methods: Six HP cases with pathological data, clinical and radiological data were retrospectively analyzed during the period from February 2009 to September 2011 at Beijing Hospital of Ministry of Health. There were 2 males and 4 females with a mean age of 51.

[Endobronchial lipoma: report of 2 cases and review of the Chinese literature].

Objective: To describe the epidemiology of endobronchial lipoma and to propose appropriate diagnostic and therapeutic policies for this tumor.

Methods: Two cases of endobronchial lipoma were presented and 38 cases reported in literatures published in mainland China were reviewed.

Results: Thirty-one male and 9 female patients were included, with a mean age of (53 ± 11) years.

[Dynamic contrast-enhanced CT patterns and pathologies of noncalcified pulmonary tuberculomas].

Objective: To analyze characteristic CT enhancement patterns of noncalcified pulmonary tuberculomas and their pathological basis.

Method: Fifty-six patients with noncalcified pulmonary tuberculomas underwent surgical resection of the tuberculomas. Enhanced CT images of these tuberculomas were reviewed and analyzed in relation to the histological findings.

[Three-dimensional reconstruction and image fusion between liver focal lesions and dynamic contrast-enhanced magnetic resonance angiography].

Background & Objectives: Identifying the correlation of focal lesions to the liver vessel system is a key factor in selecting treatment patterns for focal hepatic diseases. This study was to evaluate the feasibility of 3-dimensional reconstruction and the fusion image between the 3-dimensional dynamic contrast-enhanced magnetic resonance angiography (3D DCE MRA) and the focal hepatic lesions, and further, explore the clinical application of this method.

Methods: 3D DCE-MRA and conventional magnetic resonance imaging (MRI) were performed.

[The effect of montelukast, a leukotriene antagonist, on improvement of exercise-induced bronchoconstriction].

Objective: To study the efficacy of montelukast, a cysteinyl leukotriene receptor antagonist, in the treatment and prevention of exercise-induced bronchoconstriction (EIB) in mild asthmatic patients and patients with exercise-induced asthma (EIA).

Methods: Thirty mild asthmatic patients with positive standardized exercise challenge test were enrolled. The subjects received montelukast 10 mg once daily in the evening.

[Long-term evaluation of laser in situ keratomileusis for extremely high myopia].

Objective: To evaluate the long-term efficacy and safety of laser in situ keratomileusis (LASIK) for extremely high myopia (with a preoperative refraction more than -10.00 diopters).

Methods: 173 eyes of 99 patients with a mean spherical equivalent (SE) of (-13.

[The role of matrix metalloproteinases-9 and tissue inhibitor of metalloproteinaes-1 in chronic obstructive pulmonary disease].

Objective: To evaluate the role of matrix metalloproteinases-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in the pathogenesis of chronic obstructive pulmonary disease (COPD).

Methods: Five milliliters of peripheral venous blood were extracted form 36 patients with COPD, subdivided into stable group (CS group, n = 12), exacerbation group (CE group, n = 12), and exacerbation group with glucocorticosteroids treatment (CE + G group, n = 12), and 12 normal controls. The peripheral blood mononuclear cells (PBMCs) were isolated and the mRNA expressions of MMP-9 and TIMP-1 therein in each group were measured by RT-PCR quantitative analysis.