Trend and characteristics of endometrial cancer in Guangzhou from 2000 to 2020.

Objectives: To explore temporal trends in the age of endometrial cancer in Guangzhou over the past 21 years.

Study Design: We conducted a retrospective analysis of women diagnosed with endometrial cancer from 2000 to 2020 at a major teaching hospital in Guangzhou, China. One-way analysis of variance was utilized to compare the average age of onset for each year, while the t-test was employed to compare groups A (2000-2009) and B (2010-2020) over the 21-year period.

New flavonoid glycosides from the stems and leaves of Astragalus membranaceus.

Astragalus membranaceus, a well-known traditional medicine and food, has been extensively studied for its roots. However, comparatively little attention has been paid to its stems and leaves. In this study, we successfully isolated and identified three new flavonoid glycosides (1-3), and eight known analogues (4-11) from the stems and leaves of A.

New chromones from the roots of Saposhnikovia divaricata (Turcz.) Schischk with anti-inflammatory activity.

Fifteen new chromones, sadivamones A-E (1-5), cimifugin monoacetate (6), sadivamones F-N (7-15), together with fifteen known chromones (16-30), were isolated from the ethyl acetate portions of 70% ethanol extract of Saposhnikovia divaricata (Turcz.) Schischk roots. The structures of the isolates were determined using 1D/2D NMR data and electron circular dichroism (ECD) calculations.

Two new terpenoids with anti-inflammatory activity from the fruits of (Wurmb) Merr.

Two new terpenoids ( and ), arenterpenoid D () and pinnasesquiterpene A (), along with 16 phenylpropanoids (-) and 8 known terpenoids (-) were isolated from 70% EtOH extract of the (Wurmb) Merr. fruits. Their structures were elucidated by spectroscopic methods including HR-ESI-MS, 1D, and 2D NMR.

Phenylpropanoids from and their anti-inflammatory activity.

Two new phenylpropanoids, 4-O-(1''-O-cis-caffeoyl)--glucopyran osyl-1-allyl-3-methoxy-benzene (), 4'-O-(1''-O-cis-caffeoyl)--glucopyranosyl-hydroxymegastigm-4-en-3-one (), together with nine known compounds were obtained from the leaves of . Their structures were elucidated based on spectroscopic methods, and comparing spectral data with those in literature. Meanwhile, their anti-inflammatory activities were evaluated on (LPS)-induced RAW 246.

Eight undescribed steroidal saponins including an unprecedented 16, 26-epoxy-furostanol saponin from Solanum xanthocarpum and their cytotoxic activities.

Eight undescribed steroidal saponins named solasaponins A-H were isolated from the fruits of Solanum xanthocarpum, including an unusual 16,26-epoxy-furostanol saponin, two furostanol saponins, three isospirostanol saponins, two pseudo-spirostanol saponins. The structures of all compounds were elucidated by extensive spectroscopic data analyses (1D, 2D NMR, and HRESIMS) combined with physico-chemical analysis methods (acid hydrolysis, optical rotation, and IR). The cytotoxicities of all compounds in vitro against two human cancer cell lines (A-549 and HepG2) were evaluated by CCK-8 assay.

Four new withanolides with anti-inflammatory activity from Datura inoxia Mill. leaves.

Four previously undescribed withanolides, datinolides A-D (1-4) and eight known withanolides (5-12), were separated from the 70% ethyl alcohol extract of Datura inoxia Mill. leaves. All structures were clarified by comprehensive spectroscopic analysis.

Triterpenoid Saponins From the Fruit of (Rupr. & Maxim.) Harms.

Five new oleanane-type triterpenoid saponins (), together with 24 known saponins () were isolated from the fruit of . Their structures were determined by extensive spectroscopic analysis, including 1D, 2D nuclear magnetic resonance (NMR), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), in combination with chemical methods (acid hydrolysis). The neuroinflammation model was established by lipopolysaccharide (LPS)-induced BV2 microglia, and the neuroprotective effects of all compounds () were evaluated.

Chemical Constituents of the Roots of Schisandra chinensis.

One new phenylpropanoid schineolignin D (1), one new sesquiterpene (-)-(7S,10S)-3,11,12,13-tetrahydroxycalamenene (2), one new quinic acid 4-(E)-O-coumaroylquinic acid ethyl ester (3), and seven known compounds 4-10 were separated from the roots of Schisandra chinensis. The chemical structures of all compounds were characterized by NMR spectroscopic experiments. All compounds were assessed for their neuroprotective effects on PC12 cell lines induced by H O .

Elesesterpenes A-K: Lupane-type Triterpenoids From the Leaves of .

Elesesterpenes A-K (-), eleven new lupane-type triterpenoids, triterpenoid glycosides, and nortriterpenoid were isolated from the leaves of . Their structures and relative configurations were completely elucidated by a combination of diverse methods including physical, spectroscopic data. The absolute configuration of elesesterpenes A-B (-) was defined by single-crystal X-ray diffraction.

Discovery of Active Ingredients Targeted TREM2 by SPR Biosensor-UPLC/MS Recognition System, and Investigating the Mechanism of Anti-Neuroinflammatory Activity on the Lignin-Amides from Seeds.

As a new target protein for Alzheimer's disease (AD), the triggering receptor expressed on myeloid Cells 2 (TREM2) was expressed on the surface of microglia, which was shown to regulate neuroinflammation, be associated with a variety of neuropathologic, and regarded as a potential indicator for monitoring AD. In this study, a novel recognition system based on surface plasmon resonance (SPR) for the TREM2 target spot was established coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-MS), in order to screen the active ingredients targeting TREM2 from seeds. The results showed that four lignan-amides were discovered as candidate compounds by SPR biosensor-UPLC/MS recognition analysis.

Ecdysteroids from the Aerial Parts of Paris verticillata.

Two new ecdysteroids 14-epi-polypodine B (1) and 22-oxo-hydroxyecdysterone (2), along with nine known compounds, polypodine B (3), viticosterone E (4), 20-hdroxyecdysone-2-acetate (5), 22-oxo-20-hydroxyecdysone (6), 5-hydroxyecdysone (7), pinnatasterone (8), 3-epi-20-hydroxyecdysone (9), ecdysterone (10) and stachysterone B (11), were isolated from the aerial parts of Paris verticillata. The structures of all compounds were elucidated by extensive spectroscopic analysis, quantum chemical calculations and ANN-PRA/DP4 probability analysis. Among them, the absolute configuration of compound 1 and 2 was unambiguous determined by ECD.

Two new quinic acid derivatives from the leaves of .

Two new () and three known quinic acid derivatives () were isolated from the leaves of (Turcz) Baill. The structures of the compounds were determined by spectroscopic methods, especially the NMR techniques, and also by comparison with reported data in the literature. The cytotoxicity activities of these compounds were evaluated on human tumor cell lines LN229 and three of them showed a certain activity.

Four new secoiridoids from the stem barks of (Bl.) Hara.

Four new secoiridoids, syrretoside A (), syrretoside B (), 5, 8-syrretaglucone C(), 5, 8-syrretaglucone C (), together with eight known secoiridoids (-), were isolated from the stem barks of (Bl.) Hara. The structures of isolated compounds were established based on the physical and chemical means, NMR spectroscopy, high-resolution mass spectrometry (HR-ESI-MS), and circular dichroism spectrum (CD), as well as in comparison with the literature.

Four new polyacetylenes from the roots of .

Four new polyacetylene substances, sadivaethynes A-D, were isolated from the ethanol extract of the roots of (Turcz.) Schischk using repeated column chromatography. Structural elucidation of compounds was established by 1D and 2D NMR spectra referring to the literature, together with high-resolution mass spectrometric analysis.

Three new sesquiterpenoid alkaloids from the roots of and its cytotoxicity.

Three new sesquiterpenoid alkaloids, cangorin K (), dimacroregelines C () and D (), as well as two known sesquiterpenoids (-), were isolated from the roots of The structures of new compounds were characterised by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data, and the known compounds were established by 1 D NMR spectra referring to the literatures. Cytotoxicity evaluation of these compounds against two human tumour lines (SMMC7721, LN229) was investigated by CCK-8 assay and displayed that compounds - showed potent cytotoxicity against SMMC7721 cell with IC value in the range of 0.26-9.

Two new terpenes from the aerial parts of Osbeck.

Two new acyclic sesquiterpenoids () and fourteen known monocyclic monoterpenoids () were isolated from the aerial parts of Osbeck. All compounds were isolated from for the first time. The structures of all compounds were characterized by spectroscopic methods (1 D, 2 D NMR and HRESIMS).

Five new sesquiterpenoids from the fruits of Acanthopanax senticosus (Rupr. & Maxim.) Harms.

Five new sesquiterpenoids named acasenterpene A-E (1-5) were isolated from the fruits of Acanthopanax senticosus. The structures of all compounds were elucidated by extensive spectroscopic data analyses (1D, 2D NMR, and HR-ESI-MS) combined with physico-chemical analysis methods (enzyme hydrolysis, optical rotation, and CD). The cytotoxicity of all compounds in vitro against four human cancer cell lines (MGC-803, Ishikawa, LN-229 and SMMC-7721) were evaluated by CCK-8 assay.

Seven new glycosides from the leaves of L.

Seven new glycosides () and seventeen known analogues () were isolated from the leaves of L. The structures of these compounds were all elucidated by detailed spectroscopic analyses and comparison with literature values. All isolates were evaluated for cytotoxicity against Hela, MGC-803, Ishikawa cell lines and compounds and exhibited different degrees of antiproliferative effects.

Lignans and Terpenoids from the Leaves of Schisandra chinensis.

Fifteen constituents, including one new lignan (schisandroside E) and one new terpenoid (schisandenoid A) as well as nine known lignans and four known terpenoids, were isolated from Schisandra chinensis leaves. The structures of schisandroside E and schisandenoid A were established by entirely meticulous spectroscopic analysis (NMR, MS, CD, IR and UV). All compounds were tested for cytotoxicity against MGC-803, Caco-2 and Ishikawa cell lines.

Sesquiterpenoids with diverse carbon skeletons from the sepals of Solanum melongena L.

Eight new sesquiterpenoids named melongenaterpenes M-T (1-8), together with nine known compounds (9-17), were isolated from the 70% ethanol extract of the sepals of Solanum melongena L. The structures of all isolated compounds were elucidated based on 1D and 2D NMR spectra and a comprehensive comparison of their spectroscopic and physical data with values from the published literatures. Meanwhile, the cytotoxicity of all the isolated compounds was evaluated on the three human cancer lines of Hela, Ishikawa and MGC-803 by CCK8 assay, respectively.

Two new alkaloids from the sepals of L.

Two new alkaloids named Melongenamides H-I (-), together with twenty-one known compounds (-), were isolated from the 70% ethanol extract of the sepals of L. The structures of all isolated compounds were determined by 1D and 2D NMR spectra and by comparing their spectroscopic and physical data with values from the published literatures. All the isolated compounds were evaluated the cytotoxicity against three human canner lines (Hela, Ishikawa and MGC-803) by CCK8 assay.

Effects of Lignans from Schisandra chinensis Rattan Stems against Aβ-Induced Memory Impairment in Rats and Neurotoxicity in Primary Neuronal Cells.

Oxidative stress, which is caused by Amyloid-β deposition in brain, plays an important role in Alzheimer's disease. In this study, we found that lignans from rattan stems (rsSCH-L) could reduce the escape latency and the distance travelled by the Aβ injected rats while the crossing platform time was enhanced in the Morris water maze test. Further research demonstrated that lignans from rsSCH-L attenuated Aβ-induced neuronal cell injury by increasing the content of SOD and GSH-Px and decreasing the levels of LDH, ROS, and MDA.

Phenylpropanoids from the fruits of Nicandra physaloides and their anti-inflammatory activities.

Twenty-one phenylpropanoids, including 1 new (1) and 20 known phenylpropanoids (2-21), were isolated and identified from the fruits of Nicandra physaloides. The structures of these compounds were established by 1D and 2D NMR spectra referring to the literatures, together with mass spectrometry. It was found that the isolated compounds, except for 7, 18 and 19, showed the different levels of inhibitions on NO production by LPS-induced RAW 264.

The Semiflexible Polymer Translocation into Laterally Unbounded Region between Two Parallel Flat Membranes.

Using the dynamic Monte Carlo method, we investigate dynamics of semiflexible polymer translocation through a nanopore into laterally unbounded region between two parallel flat membranes with separation in presence of an electric field inside the pore. The average translocation time τ initially decreases rapidly with increase of in the range of < 10 and then almost keeps constant for ≥ 10, and the decline range increases with increase of dimensionless bending stiffness κ. We mainly study the effect of chain length , κ and electric field strength on the translocation process for = 5.