Publications by authors named "Xiao-liang Lan"
Purpose: Adults with T-cell lymphoblastic lymphoma (T-LBL) generally benefit from treatment with acute lymphoblastic leukemia (ALL)-like regimens, but approximately 40% will relapse after such treatment. We evaluated the value of CpG methylation in predicting relapse for adults with T-LBL treated with ALL-like regimens.
Experimental Design: A total of 549 adults with T-LBL from 27 medical centers were included in the analysis.
Article Synopsis
- Researchers developed a gene-expression classifier to predict survival in patients with T-cell lymphoblastic lymphoma (T-LBL), identifying 43 key mRNAs after comparing gene profiles of progressive and progression-free cases.
- The classifier, based on 11 specific genes, was shown to significantly lower progression-free survival, disease-free survival, and overall survival rates for high-risk patients in a training cohort of 169 individuals.
- A prognostic nomogram incorporating the classifier and other factors further improved prediction accuracy for treatment outcomes, indicating that patients with higher scores respond better to the BFM treatment protocol.
F-box only protein 8 (FBX8), as a critical component of the SKP1-CUL1-F-box (SCF) E3 ubiquitin ligases, has been associated with several malignancies through interacting with a member of proteins. However, the substrates of FBX8 for destruction in the progression of colorectal carcinoma (CRC) need to be explored. Here, we show that loss of FBX8 accelerates chemical-induced colon tumorigenesis.
View Article and Find Full Text PDFNew prognostic factors are needed to establish indications for haematopoietic stem cell transplantation (HSCT) in first complete remission (CR1) for T-cell lymphoblastic lymphoma (T-LBL) patients. We used microarray to compare T-LBL tissue samples (n = 75) and fetal thymus tissues (n = 20), and identified 35 differentially expressed miRNAs. Using 107 subjects as the training group, we developed a five-miRNA-based classifier to predict patient survival with LASSO Cox regression: lower risk was associated with better prognosis (disease-free survival (DFS): hazard ratio (HR) 4.
View Article and Find Full Text PDF[Risk factors associated with postoperative complications of D2 radical resection for local advanced gastric cancer].
Zhonghua Wei Chang Wai Ke Za Zhi
August 2013
Objective: To evaluate the risk factors of postoperative complications following D2 radical resection for advanced gastric cancer.
Methods: From June 2004 to May 2011, 483 patients with local advanced gastric cancer who underwent radical gastrectomy with D2 lymph node dissection were enrolled in the study, including 132 patients of LAG (27.3%) and 351 patients of open procedure (72.