Publications by authors named "Xiao-li Li"

Among the existing research on the treatment of disorders of consciousness (DOC), deep brain stimulation (DBS) offers a highly promising therapeutic approach. This comprehensive review documents the historical development of DBS and its role in the treatment of DOC, tracing its progression from an experimental therapy to a detailed modulation approach based on the mesocircuit model hypothesis. The mesocircuit model hypothesis suggests that DOC arises from disruptions in a critical network of brain regions, providing a framework for refining DBS targets.

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In the present investigation, fourteen unprecedented podocarpane diterpenoids strophiolosas A-J, L-N and P (1-10, 12-14, 16), two new cleistanthane derivatives strophiolosas Q-R (17-18), two new dibenzopyroan-ones and one new tetralone strophiolosas S-U (19-21), were isolated from the whole plant of Strophioblachia glandulosa. The structures were elucidated via various spectroscopic analysis, quantum chemistry calculations, and X-ray diffraction. Bioactivity test indicated that compounds 5 and 17 possessed promising anti-cardiac hypertrophy effect in vitro (IC values of 16.

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  • - Orthosiphon wulfenioides is a medicinal plant traditionally used to treat conditions like arthritis and inflammation, with a study identifying 12 new diterpenes (wulfenioidones L-W) that might contribute to its healing properties.
  • - The study found that four of these compounds significantly inhibited macrophage pyroptosis, with compound 1 being the most effective at a concentration of 5.81 μM, showcasing its potential for reducing inflammation.
  • - Compound 1 also demonstrated the ability to inhibit key inflammatory pathways and protect mitochondrial function, suggesting that it prevents the release of harmful inflammatory factors while maintaining cellular health.
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Six new prenylated flavonoids, named visconaeas A-F (1-6), and eleven known isopentenyl flavonoids (7-17) were isolated from Dodonaea viscosa (L.) Jacq. The structures of the separated compounds were determined through comprehensive spectral analysis and quantum chemical calculations.

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  • - The study examined how non-exercise estimated cardiorespiratory fitness (eCRF) affects mortality rates in hypertensive adults, showing that better eCRF is linked to lower risks of death from all causes and cardiovascular diseases but not from cancer.
  • - Data from 27,437 participants indicated that for each 1 metabolic equivalent increase in eCRF, there were significant decreases in all-cause mortality (HR 0.78) and CVD mortality (HR 0.79), with a stronger effect seen in females than in males.
  • - The findings highlight the importance of eCRF in health outcomes for hypertensive individuals and suggest that further research is required to explore these relationships across different populations.
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  • The NLRP3 inflammasome plays a critical role in innate immunity and is linked to liver damage, with isolicoflavonol (ILF) from Macaranga indica identified as a potential inhibitor, although its mechanisms were not fully understood.
  • Research methods involved fluorescent imaging and Western blot assays to assess ILF's impact on pyroptosis and NLRP3 activation in macrophages, along with the investigation of the Nrf2 signaling pathway, using an inhibitor called ML385 for validation.
  • Results showed that ILF effectively reduced macrophage LDH release and IL-1β secretion in a dose-dependent manner, inhibited pyroptosis, and enhanced Nrf2 signaling, indicating its potential as a protective
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  • Autoimmune nodopathy (AN) is a rare disease that can occur alongside membranous nephropathy (MN), and it involves the presence of specific antibodies in the serum.
  • A study was done on a 65-year-old male with MN who exhibited symptoms like limb numbness and walking instability, revealing positive anti-CNTN1 antibodies, primarily of the IgG4 subtype, and significant nerve damage.
  • The comparison of 35 cases of AN with MN to 51 cases of AN without MN found similar clinical characteristics, suggesting that while AN's symptoms may appear with MN, they do not worsen or improve with the presence of MN.
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Ethnopharmacological Relevance: Traditional Chinese Medicine (TCM) formula Wenjing Decoction (WJD) longstanding efficacy in enhancing blood circulation, resolving blood stasis, and mitigating dysmenorrhea symptoms. Despite its prevalent application, the specific mechanism underlying effect of WJD remains elusive.

Objective: The purpose of this study is to examine the material basis of Wenjing Decoction and explore the effect of WJD on rat models of dysmenorrhea with blood stasis syndrome and elucidate its mechanism.

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Serine protease 50 (PRSS50/TSP50) is highly expressed in spermatocytes. Our study investigated its role in testicular development and spermatogenesis. Initially, PRSS50 knockdown was observed to impair DNA synthesis in spermatocytes.

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Three previously undescribed protoilludane-type sesquiterpene aryl esters, armillanals A-C (1-3), along with seven known ones (4-10) were obtained from Armillaria gallica Marxm. & Romagn. Compounds 1 and 2 were a rare class of sesquiterpenes featuring the Δ and Δ-protoilludane skeleton.

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In the present study, six new compounds namely, picralactones CH (1-6) along with nine known compounds (7-15) were isolated from the branches and leaves of Picrasma chinese P.Y. Chen.

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JOURNAL/nrgr/04.03/01300535-202501000-00035/figure1/v/2024-05-14T021156Z/r/image-tiff Our previous study found that rat bone marrow-derived neural crest cells (acting as Schwann cell progenitors) have the potential to promote long-distance nerve repair. Cell-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular communication.

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Two new triterpenes mayteneri A (), mayteneri B (), and seven known compounds () were isolated from stems of Loes. The chemical structures of compounds and were established by 1D, 2D NMR, HRESIMS analysis, and calculating electronic circular dichroism (ECD). The structures of known compounds - were determined by comparison of their spectral with those reported.

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Here, we presented 6 patients who were admitted to our institution and diagnosed as myasthenia gravis (MG) with tongue muscle atrophy. All these 6 patients developed symptoms of bulbar muscle weakness in acetylcholine receptor antibodies positive MG (AChR-MG) (3/6), muscle-specific receptor tyrosine kinase antibodies positive MG (MuSK-MG) (1/6), and sero-negative MG (2/6). Most of patients had "triple-furrowed" tongue except for patient 2 with irregular atrophy of tongue muscle.

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Ethnopharmacological Relevance: Leonurus japonicus Houtt (L. japonicus, Chinese motherwort), known as Yi Mu Cao which means "good for women", has long been widely used in China and other Asian countries to alleviate gynecological disorders, often characterized by estrogen dysregulation. It has been used for the treatment of polycystic ovary syndrome (PCOS), a common endocrine disorder in women but the underlying mechanism remains unknown.

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Objective: To investigate the differences in the metabolic indicators and sex hormones between obese and non-obese patients with polycystic ovary syndrome (PCOS), and their impacts on endometrial receptivity (ER).

Methods: We selected 255 individuals with PCOS, and categorized them into the obese groups, including the OP group (obese patients with PCOS) and the ON group (obese patients without PCOS), and selected 64 individuals who were categorized in the non-obese groups, namely, the control groups, which comprise the NP group (non-obese patients with PCOS) and the NN group(non-obese patients without PCOS). The one-way analysis of variance (ANOVA) and Mann-Whitney U tests were used to compare the metabolic indicators, and sex hormone-associated and ER-associated indicators between the groups.

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Pathological cardiac hypertrophy (CH) is driven by maladaptive changes in myocardial cells in response to pressure overload or other stimuli. CH has been identified as a significant risk factor for the development of various cardiovascular diseases, ultimately resulting in heart failure. Melanoma differentiation-associated protein 5 (MDA5), encoded by interferon-induced with helicase C domain 1 (IFIH1), is a cytoplasmic sensor that primarily functions as a detector of double-stranded ribonucleic acid (dsRNA) viruses in innate immune responses; however, its role in CH pathogenesis remains unclear.

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  • Researchers isolated 15 new prenylated coumarins (called asiaticasics A-O) from the ethyl acetate fraction of Toddalia asiatica, along with 9 known derivatives.
  • The structures of these new compounds were confirmed using spectroscopic analysis and reference data.
  • Biological tests showed compounds 3 and 12 exhibited anti-inflammatory effects, with compound 12 reducing pyroptosis in J774A.1 cells by inhibiting the NLRP3 inflammasome, supported by both biochemical and morphological evidence.
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: Lupus Nephritis (LN) is the primary causation of kidney injury in systemic lupus erythematosus (SLE). Ferroptosis is a programmed cell death. Therefore, understanding the crosstalk between LN and ferroptosis is still a significant challenge.

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The aim of this study was to investigate the role and mechanism of circ-RNF111 in the human ovarian cancer cell line SKOV-3. First, qRT-PCR was used to detect circ-RNF111 and miR-556-5p expression levels in human normal ovarian epithelial cells IOSE80 and human ovarian cancer cells SKOV-3. CCK-8 and colony formation assays were adopted to determine the proliferation rate and cell viability of SKOV-3 cells, respectively.

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Surgical adhesives play a crucial role in tissue integration and repair, yet their application in wet conditions has been severely limited by inadequate adhesive strength and subpar biocompatibility. Furthermore, tissue adhesives have rarely been reported in cartilage tissue repair. In this study, a three-armed dopamine-modified hyaluronic acid derivative adhesive was prepared to function as a bio-inspired adhesive in moist environments.

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