Cu(OTf)-catalyzed C3 aza-Friedel-Crafts alkylation of indoles with ,-acetals.

An efficient approach to access functionalized indole derivatives has been developed through Cu(OTf)-catalyzed C3 aza-Friedel-Crafts alkylation of substituted indoles 5a-5m, -methyl-pyrrole with linear ,-acetals 4a-4l. As a result, a series of C3 amide aza-alkylated indole derivatives 6a-6ag and 7 were synthesized in moderate to excellent yields.

Nickel-Catalyzed Regioselective Hydroamination of Ynamides with Secondary Amines.

The first Ni(OTf)-catalyzed hydroamination of ynamides was developed by reacting with secondary amines ( and ). This protocol features excellent regioselectivity, a broad substrate scope of secondary aryl amines, and good functional group tolerance for ynamides. Using this method, a variety of substituted ethene-1,1-diamine compounds were prepared in moderate to excellent yields with high regioselectivities.

Sc(OTf)-catalyzed [3 + 2]-cycloaddition of nitrones with ynones.

An efficient approach to access functionalized (2,3-dihydroisoxazol-4-yl) ketones has been developed by reacting nitrones 4 with ynones 7 or terminal ynones 10 in a one-pot fashion. The reaction went through a formal Sc(OTf)3-catalyzed [3 + 2]-cycloaddition process to generate a number of functionalized (2,3-dihydroisoxazol-4-yl) ketones 11aa-11aw, 11ba-11la and 12aa-12ae in moderate to good yields.

Synthesis of a 3,4-Dihydro-1,3-oxazin-2-ones Skeleton via an Intermolecular [4 + 2] Process of -Acyliminium Ions with Ynamides/Terminal Alkynes.

An approach to access functionalized 3,4-dihydro-1,3-oxazin-2-ones has been developed by reacting semicyclic ,-acetals and with ynamides or terminal alkynes in a one-pot fashion. The reaction went through a formal [4 + 2] cycloaddition process to generate a number of functionalized 3,4-dihydro-1,3-oxazin-2-ones and in yields of 34-97%. In addition, the utility of this transformation was demonstrated by the synthesis of (±)-sedamine .

The effect of early versus late initiation of renal replacement therapy in patients with acute kidney injury: A meta-analysis with trial sequential analysis of randomized controlled trials.

Background: The optimal timing for initiating renal replacement therapy (RRT) in patients with acute kidney injury (AKI) remains controversial.

Methods: We conducted a meta-analysis with trial sequential analysis (TSA) of randomized controlled trials (RCTs) using PUBMED, Cochrane Library databases, and Web of Science (from January 1, 1985, to August 21, 2016). Adult patients with AKI who received RRT with different timing were included.

Effects of bone marrow-derived mesenchymal stem cells transfected with survivin on pulmonary fibrosis in mice.

The aim of the present study was to investigate the effects of bone marrow-derived mesenchymal stem cells (BMSCs) transfected with survivin on lung fibrosis in mice. Mice with bleomycin-induced pulmonary fibrosis were allocated at random to group A, B or C, and injected with 1×10 survivin gene-expressing BMSCs, 1×10 BMSCs or normal saline, respectively. A total of 6 mice were sacrificed from each group on days 7, 14 and 28 after treatment.

[Statistical analysis of residues of heavy metals in Chinese crude drugs].

Objective: To analyze the residues of heavy metals in Chinese crude drugs.

Method: The SPSS 13.0 software was used to analyze the data of Cu, Pb, As, Cd, Hg collected in literatures.

[Study on the prognostic factors of colorectal cancer after radical resection and on suggested model for prediction].

Objective: To study the factors of colorectal cancer (CRC) after radical resection to provide data predicting the prognosis of the patients.

Methods: 120 cases of CRC were collected in this study. Medical clinical records and 5-year follow-up data were reviewed.