Digital Industry Financial Risk Early Warning System Based on Improved K-Means Clustering Algorithm.

Corporate financial risks not only endanger the financial stability of digital industry but also cause huge losses to the macro-economy and social wealth. In order to detect and warn digital industry financial risks in time, this paper proposes an early warning system of digital industry financial risks based on improved K-means clustering algorithm. Aiming to speed up the K-means calculation and find the optimal clustering subspace, a specific transformation matrix is used to project the data.

[Non-carcinogenic Risk Assessment of Cadmium Exposure Through Drinking Water in Chinese Residents Based on Age-stratification Weight].

Drinking water is an important cadmium (Cd) exposure pathway for residents in China. In order to quantitatively characterize the risk of cadmium exposure through drinking water, the Cd concentrations of three main drinking water types in China were collected via systematic literature review. The probability distribution of the exposure parameters was estimated using regression models.

[Probabilistic Risk Assessment of Arsenic Exposure Through Drinking Water Intake in Chinese Residents].

The total arsenic concentrations of the three main drinking water types in China were determined through a systematic literature review. The distribution models of drinking water exposure parameters for different age groups were obtained using the regression method. The carcinogenic and non-carcinogenic risks of different population groups caused by arsenic exposure through different drinking water types were evaluated by a probabilistic risk assessment.

[Refined Assessment of Exposure and Health Risks of Heavy Metals in Water for the Children in Xigu District, Lanzhou].

Water is an important pathway for human exposure to heavy metals. Accurate assessment of the health risks that are related to exposure to heavy metals in drinking and household water are required for the preparation of targeted health risk prevention measures. This study explores and identifies the health risks related to exposure to heavy metals via drinking and household water pathways in Xigu District, Lanzhou, northwestern China, using household water samples and survey data obtained during July-September 2015 (wet season) and December 2015-January 2016 (dry season).

[Size Distribution Characteristics and Inhalation Exposure of Particle-Bound PAHs in an Industrial City].

Atmospheric particulate matter was collected during the heating period and the non-heating period of a typical steel industrial process in Northeast China to study the following:① the size-depended distribution and enrichment characteristics of polycyclic aromatic hydrocarbons (PAHs); ② the deposition concentrations of PAHs of different particle sizes in various organs of the human respiratory system; and 3 the risk from human respiratory exposure. The 14 priority PAHs in the samples were determined by high-performance liquid chromatography (HPLC), and respiratory exposure assessment was conducted by combining the atmospheric particle size fractionation sampling technique with an internal deposition model. The results showed that the PAH concentrations during the heating periods (743.

[Concentration Characteristics and Assessment of Model-Predicted Results of PM in the Beijing-Tianjin-Hebei Region in Autumn and Winter].

This paper discusses the concentration characteristics of PM, as well as its relationship with meteorological factors in autumn and winter (from September to the following February), from 2013 to 2018 in the Beijing-Tianjin-Hebei (BTH) region. The accuracy and uncertainty of the air quality forecast models NAQPMS(nested air quality prediction modeling system), CMAQ(community multiscale air quality modeling system), and CAMx (comprehensive air quality model with extensions) were analyzed based on the model-predicted and measured PM concentration in autumn and winter from 2015 to 2018. The accuracy of NAQPMS, CMAQ, and CAMx during typical heavy air pollution was also tested.

Wheat straw biochar-supported nanoscale zerovalent iron for removal of trichloroethylene from groundwater.

This study synthesized the wheat straw biochar-supported nanoscale zerovalent iron (BC-nZVI) via in-situ reduction with NaBH4 and biochar pyrolyzed at 600°C. Wheat straw biochar, as a carrier, significantly enhanced the removal of trichloroethylene (TCE) by nZVI. The pseudo-first-order rate constant of TCE removal by BC-nZVI (1.

Estimation of the daily soil/dust (SD) ingestion rate of children from Gansu Province, China via hand-to-mouth contact using tracer elements.

A total of 60 children (31 males and 29 females) between the ages of 3 and 12 years were randomly selected from Lanzhou City in Gansu Province, northwest China. Hand (soil/dust) SD samples from these children were collected using hand wipes. We determined the approximate amounts of hand SD and the concentrations of three tracer soil elements (Ce, Y, and V) in these samples.

Quantification for total demethylation potential of environmental samples utilizing the EGFP reporter gene.

The demethylation potential of pollutants is arguably an innate component of their toxicity in environmental samples. A method was developed for determining the total demethylation potential of food samples (TDQ). The demethylation epigenetic toxicity was determined using the Hep G2 cell line transfected with pEGFP-C3 plasmids containing a methylated promoter of the EGFP reporter gene.

Tooth loss is associated with increased risk of esophageal cancer: evidence from a meta-analysis with dose-response analysis.

Epidemiological studies have revealed the association between tooth loss and the risk of esophageal cancer (EC); however, consistent results were not obtained from different single studies. Therefore, we conducted the present meta-analysis to evaluate the association between tooth loss and EC. We conducted electronic searches of PubMed until to February 10, 2015 to identify relevant observational studies that examined the association between tooth loss and the risk of EC.

Long-Term Coffee Consumption and Risk of Gastric Cancer: A PRISMA-Compliant Dose-Response Meta-Analysis of Prospective Cohort Studies.

Association between coffee consumption and gastric cancer risk remains controversial. Hence, we performed a meta-analysis to investigate and quantify the potential dose-response association between long-term coffee consumption and risk of gastric cancer.Pertinent studies were identified by searching PubMed and Embase from January 1996 through February 10, 2015 and by reviewing the reference lists of retrieved publications.

[Source and health risk assessment of heavy metals in ambient air PM10 from one coking plant].

To investigate the sources and health risk of heavy metals in ambient air PM10 from the coking plant, the PM10 in the air around one coking plant was collected in June 2012. Then the heavy metals concentrations in PM10 were tested by the microwave-ICP-MS method. Furthermore, the USEPA's human exposure assessment model was applied to preliminarily evaluate the human health risks of the heavy metals in air particulate matter.

The molecular adjuvant mC3d enhances the immunogenicity of FimA from type I fimbriae of Salmonella enterica serovar Enteritidis.

Background: The fimbriae of Salmonella enterica serovar Enteritidis are used for colonization and invasion into host cells, and have drawn considerable interest because fimbriae can serve as potential immunogens against many pathogenic bacteria that colonize on epithelial surfaces. The purpose of the study is to use a molecular adjuvant, C3d, to enhance the immunogenicity of FimA proteins against Salmonella enterica serovar Enteritidis.

Methods: FimA of type I fimbriae from Salmonella enteritidis and FimA with one copy of mC3d, two copies of mC3d2 and three copies of mC3d3 were cloned into the expression vector pCold-TF.

Cytochrome P450 2E1 RsaI/PstI polymorphism and risk of esophageal cancer: A meta-analysis of 17 case-control studies.

The aim of this study was to explore the cytochrome P450 2E1 (CYP2E1) RsaI/PstI polymorphism and risk of esophageal cancer (EC) in mainland Chinese populations. A systematic search of PubMed, EMBASE, Web of Science, CBM, CNKI and VIP databases for publications on the CYP2E1 RsaI/PstI polymorphism and risk of EC was performed. and the genotype data were analyzed in a meta-analysis.

Association between XPD Asp312Asn polymorphism and esophageal cancer susceptibility: a meta-analysis.

Objective: To investigate the association between xeroderma pigmentosum group D (XPD) Asp312Asn polymorphism and esophageal cancer (EC) susceptibility by meta-analysis.

Methods: We searched PubMed up to April 9th, 2012, to identify relevant papers, and 8 published case-control studies including 2165 EC patients and 3141 healthy controls were yielded. Odds ratios (ORs) with relevant 95% confidence intervals (CIs) were applied to assess the association between XPD Asp312Asn polymorphism and EC susceptibility with the Comprehensive Meta-Analysis software, version 2.

Association between green tea and colorectal cancer risk: a meta-analysis of 13 case-control studies.

Objective: Experimental studies have suggested green tea to be a chemopreventive agent for colorectal cancer, and many studies have examined possible associations. However, the conclusions were inconsistent or even contradictory, so we performed a meta-analysis based on published case-control studies to explore if green tea is indeed a protective factor.

Methods: PubMed was searched up to May 10th, 2012 for relevant studies, and references of included studies were manually searched.

[Health risk assessment of heavy metals in drinking water based on field measurement of exposure factors of Chinese people].

This study was carried out in Biyang County, located in the junction of Yangtze river and Huaihe river. Drinking water samples of 20 sites in urban and rural areas in this county were collected to measure 14 heavy metals by ICP/MS. About 2 500 subjects with different age and sex were selected to measure exposure factors.

[Toll-like receptor 4 expression and cytokine secretion in microglial cells induced by IgG stimulation].

Aim: To investigate the effects of immunoglobulin G (IgG) on the expression of toll-like receptor 4 (TLR4) and secretion of cytokines in microglial cells in vitro.

Methods: Cultured primary rat microglial cells were stimulated with different concentrations of rat IgG (2 mg/L, 20 mg/L, 200 mg/L) and lipopolysaccharide (LPS) 10 mg/L for 24 h, respectively. The TLR4 expression in the microglial cells was examined by immunofluorescence staining and tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) levels in the culture medium were assayed by ELISA.

Alterations of Fc gamma receptor I and Toll-like receptor 4 mediate the antiinflammatory actions of microglia and astrocytes after adrenaline-induced blood-brain barrier opening in rats.

Blood-brain barrier (BBB) opening occurs under many physiological and pathological conditions. BBB opening will lead to the leakage of large circulating molecules into the brain parenchyma. These invasive molecules will induce immune responses.

Lipopolysaccharide up-regulates IL-6R alpha expression in cultured leptomeningeal cells via activation of ERK1/2 pathway.

To clarify the response of leptomeningeal cells to immune stimulation, the effect of lipopolysaccharide (LPS) on expression of IL-6 receptors in the cultured leptomeningeal cells was investigated. The results showed that the expression of IL-6R alpha was invisible in the purified leptomeningeal cells while it was seen in the cells when they were co-cultured with astrocytes. On the other hand, GP130 was moderately expressed in both conditions.

Up-regulation of IL-1 receptor type I and tyrosine hydroxylase in the rat carotid body following intraperitoneal injection of IL-1beta.

It is well established that reciprocal modulation exists between the central nervous system and immune system. Interleukin (IL)-1beta, a proinflammatory cytokine secreted at early stage of immune challenge, has been recognized as one of the informational molecules in immune-to-brain communication. However, how this large molecule is transmitted to the brain is still unknown.

Effect of water restrictions on the physiological parameters, psychological behavior and brain c-Fos expression in rats.

Objective: In order to characterize the feature of stress response induced by stressor with both physical and psychological natures, the effects of water restriction performed in different experimental modes on the physiological parameters, psychological behavioral manifestations and brain c-Fos expressions were observed and compared.

Methods: Fifty-eight male Wistar rats were used and randomly divided into three experimental groups (n = 18 for each) and a control group (n = 4). In control group, the rats were allowed to access drinking water freely at all experimental period.

Role of extracellular signal-regulated kinase in glutamate-stimulated apoptosis of rat retinal ganglion cells.

Purpose: To investigate the involvement of the extracellular signal-regulated kinase (ERK) signaling pathway after intravitrevous injection of glutamate in rat retina.

Methods: Three groups of five Sprague-Dawley rats each were studied. Group I was a normal control group, intravitreal saline injections.

ERK1/2 and p38 mitogen-activated protein kinase mediate iNOS-induced spinal neuron degeneration after acute traumatic spinal cord injury.

The enhanced production of nitric oxide (NO) via inducible nitric oxide synthase (iNOS) has been implicated in the pathogenesis of neuronal apoptosis after acute traumatic spinal cord injury (SCI). In the present study, to further characterize the pathways mediating the synthesis and release of NO, we examined activation of extracellular signal regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinases (p38 MAPK) in microglia/macrophages in the injured area of adult rats subjected to a complete transection at the T10 vertebrae level and assessed their role in NO production and survival of neurons by using immunohistochemistry, Western blot, RT-PCR and pharmacological interventions. Results showed activation of microglia/macrophages featured by morphological changes, as visualized immunohistochemically with the marker OX-42, in the areas adjacent to the lesion epicenter 1 h after surgery.

[Effects of electroacupuncture at "Zusanli" (ST 36) on ERK1/2 phosphorylation in the dorsal horn of spinal cord of the rat].

Objective: To observe the effect of electroacupuncture at Zusanli (ST 36) on phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2) in the dorsal horn of spinal cord induced by plantar inflammation in the rat.

Methods: All the rats were randomly divided into 5 groups: normal control group, simple electroacupuncture group, formalin group, formalin plus ipsilateral electroacupuncture group and formalin plus contralateral electroacupuncture group. The acute inflammation animal model was made by injection of 100 microL of 4% formalin into the right posterior foot pad.