Curdlan/xanthan gum-based composite hydrogel with near-infrared irradiation responsive properties for infected wounds healing.

Open wounds are prone to bacterial contamination and delayed healing due to environmental exposure, necessitating the development of advanced wound dressings. Hydrogels are ideal candidates for wound care for maintaining a moist environment which benefits for the cell migration and tissue regeneration. However, conventional polysaccharide hydrogels lack intrinsic antibacterial properties, prompting the incorporation of antibacterial agents.

Protocatechuic acid grafted chitosan/oxidized glucomannan hydrogel with antimicrobial and anti-inflammatory effects for enhancing wound repair.

Oxidative stress, inflammation, and bacterial infection are critical barriers to wound healing. In this work, a composite wound dressing was designed to promote wound healing and reduce complications. A hydrogel with antibacterial, anti-inflammatory, and antioxidant properties was prepared by crosslinking chitosan (CS) and oxidized konjac glucomannan with Mg.

Hyaluronic acid-based ε-polylysine/polyurethane asymmetric sponge for enhanced wound healing.

Asymmetric sponge dressings with a hydrophobic surface and a hydrophilic inner layer can prevent bacterial infiltration and ensure efficient absorption of wound exudate. In this work, ε-polylysine/aliphatic polyurethane sponge (EPU) was prepared by prepolymer foaming process, and oxidized hyaluronic acid (OHA) was cross-linked with ε-polylysine (EPL) in EPU through schiff-base reaction to obtain EHPU. Octaisobutyl polyhedral oligomeric silsesquioxane (Oi-POSS) was uniformly sprayed onto the surface of EHPU as the hydrophobic layer, resulting in asymmetric sponge dressings denoted as P-EHPU.

Redox homeostasis disruptors enhanced cuproptosis effect for synergistic photothermal/chemodynamic therapy.

The combination of chemodynamic therapy (CDT) with photothermal therapy (PTT) is a promising approach to enhance antitumor efficacy of chemotherapeutics. In this paper, we developed novel copper-chelated polydopamine (PDA) nanoparticles (NPs) functionalized with hyaluronic acid (HA) (Cu-PDA-HA NPs) to induce apoptosis and cuproptosis-induced cell death, synergistically combining PTT and CDT. Experimental results revealed that Cu-PDA-HA NPs can respond to excessive glutathione (GSH) and hydrogen peroxide (HO) in the tumor microenvironment (TME), which will enable their specific degradation, thereby leading to efficient accumulation of Cu within tumor cells.

Heterojunction functionalized sodium alginate/carboxylated cellulose nanocrystals film enhancing sterilization performance for wound healing.

In the realm of natural polysaccharides, hydrogen bonding is a prevalent feature, yet its role in enhancing photocatalytic antimicrobial properties has been underexplored. In this paper, heterojunctions formed by graphene oxide (GO) and ZIF-8 were locked in sodium alginate/ carboxylated cellulose nanocrystals via hydrogen bonding networks, designated as SCGZ. The SCGZ films exhibit superior photocatalytic performance compared to either ZIF-8 or heterojunctions.

Zeolitic imidazolate framework-8@polydopamine decorated carboxylated chitosan hydrogel with photocatalytic and photothermal antibacterial activity for infected wound healing.

Open wounds are susceptible to bacterial infections, and antibiotics are commonly used to treat these infections. However, widespread use of antibiotics will easily induce bacterial resistance. Green antibacterial agents serve as excellent alternative for antibiotics in infection therapy.

Disulfiram-loaded CuO nanocarriers for enhanced synergistic chemodynamic chemotherapy.

Disulfiram (DSF) metabolites exhibit antitumor properties when bound to Cu. This combination also promotes the generation of reactive oxygen species (ROS), ultimately leading to tumor cell death. In this study, CuO served as a carrier for DSF, forming a dual-drug delivery system with Cu and DSF encapsulated in polydopamine (PDA).

Dextran-Based Antibacterial Hydrogel Dressings for Accelerating Infected Wound Healing by Reducing Inflammation Levels.

Infected wounds pose challenges such as exudate management, bacterial infections, and persistent inflammation, making them a significant challenge for modern dressings. To address these issues in infected wounds more effectively, aerogel-hydrogel biphase gels based on dextran are developed. The gel introduced in this study exhibits antibacterial and anti-inflammatory properties in the process of wound therapy, contributing to accelerated wound healing.

Polydopamine-Modified Copper Coordination Mesoporous Silica Nanoparticles Loaded with Disulfiram for Synergistic Chemo-Photothermal Therapy.

Disulfiram (DSF) degrades to diethyldithiocarbamate (DTC) in vivo and coordinates with copper ions to form CuET, which has higher antitumor activity. In this study, DSF@CuMSN-PDA nanoparticles were prepared using mesoporous silica with copper ions, DSF as a carrier, and polydopamine (PDA) as a gate system. The nanoparticles selectively released CuET into tumor tissue by taking advantage of the tumor microenvironment, where PDA could be degraded.

In situ generation of copper(Ⅱ)/diethyldithiocarbamate complex through tannic acid/copper(Ⅱ) network coated hollow mesoporous silica for enhanced cancer chemodynamic therapy.

The Cu complex formed by the coordination of disulfiram (DSF) metabolite diethyldithiocarbamate (DTC), Cu(DTC), can effectively inhibit tumor growth. However, insufficient Cu levels in the tumor microenvironment can impact tumor-suppressive effects of DTC. In this study, we proposed a Cu and DSF tumor microenvironment-targeted delivery system.

pH/glutathione dual-responsive copper sulfide-coated organic mesoporous silica for synergistic chemo-photothermal therapy.

Nanodrug delivery systems (NDSs), such as mesoporous silica, have been widely studied because of their high specific surface area, high loading rate, and easy modification; however, they are not easily metabolized and excreted by the human body and may be potentially harmful. Hence, we aimed to examine the synergistic anti-tumor effects of ex vivo chemo-photothermal therapy to develop a rational and highly biocompatible treatment protocol for tumors. We constructed a biodegradable NDS using organic mesoporous silica with a tetrasulfide bond structure, copper sulfide core, and folic acid-modified surface (CuS@DMONs-FA-DOX-PEG) to target a tumor site, dissociate, and release the drug.

Redox and pH dual sensitive carboxymethyl chitosan functionalized polydopamine nanoparticles loaded with doxorubicin for tumor chemo-photothermal therapy.

The high expression of reduced glutathione (GSH) and low pH in tumor sites have encouraged new ideas for targeted drug release. The tumor microenvironment is a crucial target for studying the anti-tumor efficiency of photothermal therapy because the microenvironment plays a key role in cancer progression, local resistance, immune escaping, and metastasis. Herein, active mesoporous polydopamine nanoparticles loaded with doxorubicin and functionalized with N,N'-bis(acryloyl)cystamine (BAC) and cross-linked carboxymethyl chitosan (CMC) were used to induce simultaneous redox- and pH-sensitive activity to achieve photothermal enhanced synergistic chemotherapy.

A quaternized chitosan and carboxylated cellulose nanofiber-based sponge with a microchannel structure for rapid hemostasis and wound healing.

A hemostatic sponge should perform rapid hemostasis and exhibit antibacterial properties, whilst being non-toxic, breathable, and degradable. This study prepared a hemostatic sponge (CQTC) with microchannels, specifically a microchannel structure based on quaternized chitosan (QCS) and carboxylated cellulose nanofibers (CCNF) obtained by using tannic acid and Cu complex (crosslinking agent). The sponge had low density and high porosity, while being degradable.

In vitro Antitumor Properties of Fucoidan-Coated, Doxorubicin-Loaded, Mesoporous Polydopamine Nanoparticles.

Chemotherapy is a common method for tumor treatment. However, the non-specific distribution of chemotherapeutic drugs causes the death of normal cells. Nanocarriers, particularly mesoporous carriers, can be modified to achieve targeted and controlled drug release.

Cellulose nanocrystal/calcium alginate-based porous microspheres for rapid hemostasis and wound healing.

Porous microsphere hemostatic materials, which possess rapid hemostatic, antibacterial, and wound healing-promotion properties, have key advantages over hemostatic dressings with a single hemostatic function. Using rod-shaped cellulose nanocrystals as the supporting framework, sodium alginate/cellulose nanocrystal porous microspheres (SA/CNC) were prepared using an inverse emulsion method. After SA/CNC self-assembly with the antibacterial polymer ε-polylysine, the hemostatic porous microspheres (PSLMs) showed high porosity, high liquid absorption capacity, and excellent coagulation properties.

Efficient Delivery of Curcumin by Alginate Oligosaccharide Coated Aminated Mesoporous Silica Nanoparticles and In Vitro Anticancer Activity against Colon Cancer Cells.

We designed and synthesized aminated mesoporous silica (MSN-NH), and functionally grafted alginate oligosaccharides (AOS) on its surface to get MSN-NH-AOS nanoparticles as a delivery vehicle for the fat-soluble model drug curcumin (Cur). Dynamic light scattering, thermogravimetric analysis, and X-ray photoelectron spectroscopy were used to characterize the structure and performance of MSN-NH-AOS. The nano-MSN-NH-AOS preparation process was optimized, and the drug loading and encapsulation efficiencies of nano-MSN-NH-AOS were investigated.

Delivery of curcumin by fucoidan-coated mesoporous silica nanoparticles: Fabrication, characterization, and in vitro release performance.

Mesoporous silica nanoparticles (MSN) are effective drug delivery carriers because of their adjustable large pore size and high porosity. In this study, complex nanoparticles containing disulfide bonds (SS) were designed and prepared as curcumin (Cur) carriers by using fucoidan (FUC) and MSN as the polymer matrix. The product was characterized using scanning electron microscopy, transmission electron microscopy, dynamic light scattering, Fourier-transform infrared spectroscopy, and an N adsorption and desorption test.

The Simultaneous Production of Two Distinct Types of Cellulose Nanocrystals.

We develop a route to prepare two types of cellulose nanocrystals (CNCs, CNC1 and CNC2) from a unique biomass resource, the fruit shell of Abel (SCOA), by integrating sulfuric acid hydrolysis and high-pressure homogenization and examine the effects of hydrolysis time on characteristics of the CNCs during the process. The CNCs exhibit different evolutions in size, morphology, surface charge, and crystallinity with increasing hydrolysis time. While both the CNCs have high crystallinity, CNC1 is of rod-like character with a relatively low aspect ratio, and CNC2 exhibits a hairy appearance with a high aspect ratio.

Oxidative stress-amplified nanomedicine for intensified ferroptosis-apoptosis combined tumor therapy.

Ferroptosis, as an effective sensitizer for apoptosis-based cancer treatments, has been elucidated to rely on high levels of intracellular oxidative stress mediated by the accumulation of reactive oxygen species (ROS). However, ferroptosis-related oxidation effect is largely counteracted by the endogenous reductive glutathione (GSH). Here, we constructed a self-assembled metal-organic nanomedicine p53/Ce6@ZF-T, which was composed of p53 plasmid-complexed chlorin e6 (Ce6)-poly(amidoamine), Fe-containing mesoporous zeolitic imidazolate framework-8 and naturally derived tannic acid (TA).

Polyphenol-based hydrogels: Pyramid evolution from crosslinked structures to biomedical applications and the reverse design.

As a kind of nature-derived bioactive materials, polyphenol-based hydrogels possess many unique and outstanding properties such as adhesion, toughness, and self-healing due to their specific crosslinking structures, which have been widely used in biomedical fields including wound healing, antitumor, treatment of motor system injury, digestive system disease, oculopathy, and bioelectronics. In this review, starting with the classification of common polyphenol-based hydrogels, the pyramid evolution process of polyphenol-based hydrogels from crosslinking structures to derived properties and then to biomedical applications is elaborated, as well as the efficient reverse design considerations of polyphenol-based hydrogel systems are proposed. Finally, the existing problems and development prospects of these hydrogel materials are discussed.

Enhancing the stability of zein/fucoidan composite nanoparticles with calcium ions for quercetin delivery.

In this study, zein and fucoidan-based composite nanoparticles were prepared by the antisolvent precipitation method. The effects of different calcium ion (Ca, 0-3.0 mM) concentrations on the stability of the composite nanosystems loaded with quercetin were studied under different conditions (pH, temperature, salt concentration, and ultraviolet light irradiation), and the composite nanoparticles were characterized.

Delivery of curcumin using a zein-xanthan gum nanocomplex: Fabrication, characterization, and in vitro release properties.

This study aimed to use xanthan gum as a stabilizer to improve the stability of zein nanoparticles. Zein-xanthan gum composite nanoparticles were prepared via anti-solvent precipitation at pH 4.0.

Adsorption of Pb(II) from Aqueous Solution by Mussel Shell-Based Adsorbent: Preparation, Characterization, and Adsorption Performance.

As a natural biological adsorbent, shell powder is inexpensive, highly efficient, and does not leave any chemical residue; thus, it can be used to remove contaminants from water. In this study, we used mussel shells as a raw material to prepare an adsorbent. Scanning electron microscopy was used to observe the surface morphology of the mussel shell powder before and after calcination, and X-ray diffraction measurements, Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray photoelectron spectroscopy, and Brunauer-Emmett-Teller measurements were performed to analyze the structure and composition of calcined mussel shell powder.

Development and characterization of soybean protein isolate and fucoidan nanoparticles for curcumin encapsulation.

Curcumin (Cur) is a natural polyphenol with beneficial biological and pharmacological activities; however, it has limited applications owing to its low solubility and light sensitivity. The protein-polysaccharide complex can effectively embed lipid-soluble drugs to increase their stability and dispensability in aqueous solutions. Soybean protein isolate (Spi) and fucoidan (Fuc) were used as a polymer matrix, and core-shell nanoparticles were prepared to encapsulate Cur via electrostatic interaction under acidic and neutral conditions.