Ecotoxicological assessment, oxidative response, and enzyme activity disorder of the rotifer Brachionus asplanchnoidis exposed to a toxic cocktail of spent lithium-ion battery leachate.

Spent lithium-ion batteries (LIBs) have emerged as a major source of waste due to their low recovery rate. The physical disposal of spent LIBs can lead to the leaching of their contents into the surrounding environment. While it is widely agreed that hazardous substances such as nickel and cobalt in the leachate can pose a threat to the environment and human health, the overall composition and toxicity of LIB leachate remain unclear.

Fe-TiO/TiO S-scheme homojunction for efficient photocatalytic CO reduction.

CO-to-high value-added chemicals via a photocatalytic route is of interest but strangled by the low efficiency. Herein, a novel Fe-TiO/TiO S-scheme homojunction was designed and constructed by using a facile surface modification approach whereby oxygen vacancy (OV) and Fe introducing on the TiO nanorod surface. The as-synthesized Fe-TiO/TiO S-scheme homojunction exhibits positive properties on promoting photocatalytic CO reduction: i) the nanorod structure provides numerous active sites and a radical charge transfer path; ii) the doped Fe and OV not only synergistically enhance light utilization but also promote CO adsorption; iii) the Fe-TiO/TiO S-scheme homojunction benefits photoexcited charge separation and retains stronger redox capacity.

Furfural Derivatives and Phenolic Constituents in Stemona tuberosa Lour.

Chemical investigation on the water-soluble constituents of Stemona tuberosa Lour. resulted in the isolation of a previously undescribed furfural derivative namely (S)-5-((R)-hydroxy(5-(hydroxymethyl)furan-2-yl)methyl)-5-methylfuran-2(5H)-one and twenty-five known compounds from the water decoction of the dried root tubers. Their structures were determined by analysis of the extensive spectroscopic data, including 1D/2D NMR, HR-ESI-MS, and ORD, as well as the ECD simulation and comparison.

Integration of serum metabolomics and network pharmacology reveals the immunoenhancing mechanisms of Qishenbuqi capsules.

Introduction: Qishenbuqi capsule (QSBQC), a listed Chinese patent prescription, comprises of 4 herbs. Clinically, it has been shown to improve immune functions.

Methods: Subjects with deficiency and non- deficiency were recruited, who then took QSBQC for 4 weeks.

Multi-scale variations and impact factors of carbon emission intensity in China.

China's carbon emissions have developed swiftly in recent decades, which will not only affect the nation's own sustainable development, but have a potentially negative impact on global climate stability. Given that socioeconomic development is susceptible to regional heterogeneity and geographic scales, a systematic exploration of spatiotemporal variations of carbon emission intensity (CEI) and their drivers across different levels is conducive to enacting more reasonable and efficient measures for emission reduction. However, there is still a lack of comprehensive analysis of these issues.

Hydrothermal synthesis and controlled growth of group-VIB W metal compound nanostructures from tungsten oxide to tungsten disulphide.

Two-dimensional lateral group-VIB transition metal dichalcogenides (TMDs) have attracted much attention in the fast evolving field of advanced photoelectric functional materials, but their controllable fabrication is challenging. Herein, an emerging synthetic route for sulfurization of tungsten oxide was developed. During the hydrothermal reaction, the optimization of the precursor selection and synthesis parameters led to the tunable properties of WO-WSO-WS nanostructures.

Association between complete right bundle branch block and atrial fibrillation development.

Background: Complete right bundle branch block (CRBBB) is an important predictor of atrial fibrillation (AF) recurrence after pulmonary vein isolation. However, the association between CRBBB and AF development remains unclear.

Methods: We performed a retrospective study of 2639 patients (male, n = 1549; female, n = 1090; mean age, 58 ± 13 years).

Two-step strategy, growth mechanism and optical properties of plasmonic Ag-modified ZnO nanomaterials.

In this paper, plasma silver (Ag) modified zinc oxide (ZnO) (AZO) was used to form AZO nanomaterials (including AZO nanofilms (NFm), AZO nanowires (NWs) and AZO nanoflowers (NFw)) in a two-step-controlled manner to investigate the effect of compounding different contents of Ag on the linear optical aspects of ZnO materials. The growth mechanism of the AZO nanomaterials with different strategies is discussed. If Ag nanoparticles (NPs) grow on the ZnO NFm surface, they first grow with ZnO as the core and then self-core into islands, which are undoubtedly influenced by factors such as the growth mechanism of ZnO as well as Ag.

[Geographical Detection of Spatial Heterogeneity and Drivers of PM in the Yangtze River Economic Belt].

Based on ground monitoring data, we explored the spatiotemporal characteristics and drivers of PM in the Yangtze River Economic Belt (YREB) in 2018 using spatial autocorrelation analysis and geodetector modeling methods. The results showed that:① the PM concentration in the YREB posed the obvious characteristics of low values in summer and high values in winter, seasonal variation in spring and autumn, monthly U-shaped variation, and daily pulse variation. The low value area was mainly concentrated in the south bank of the upper reaches, whereas the high value area was located in the north of the middle-lower reaches of the YREB.

Suppression of JNK/ERK dependent autophagy enhances Jaspine B derivative-induced gastric cancer cell death via attenuation of p62/Keap1/Nrf2 pathways.

Gastric cancer is one of the most common cancers with few effective treatments, a new treatment agent is desperately needed. C-2, a Jaspine B derivative, has shown anti-cancer efficacy in gastric cancer cells. The anti-cancer mechanism, however, remains unknown.

Effect of catheter ablation on clinical outcomes in patients with atrial fibrillation and significant functional mitral regurgitation.

Background: In patients with atrial fibrillation (AF) and functional mitral regurgitation (MR), catheter ablation reduces the severity of MR and improves cardiac remodeling. However, its effects on prognosis are uncertain.

Methods: This retrospective study included 151 consecutive patients with AF and functional MR, 82 (54.

Photocatalytic Decarboxylative [3 + 2] and [4 + 2] Annulation of Enynals and γ,σ-Unsaturated -(Acyloxy)phthalimides by NaI/PPh Catalysis.

A practical and eco-friendly strategy for the radical-mediated decarboxylative [3 + 2] and [4 + 2] annulation of enynals and γ,σ-unsaturated -(acyloxy)phthalimides through the photoactivation of an electron donor-acceptor (EDA) complex has been developed. A wide range of primary, secondary, and tertiary alkyl -hydroxyphthalimide (NHP) esters can be used as suitable substrates for the synthesis of fused ketones without any transition-metal catalysts or oxidants. This protocol features a broad substrate scope, excellent selectivity, and clean reaction conditions.

[Mechanism of Xiaoyao San in treatment of depression,breast hyperplasia,and functional dyspepsia based on network pharmacology].

This study aimed to explore the mechanism of Xiaoyao San(XYS) in the treatment of three diseases of liver depression and spleen deficiency, ie, depression, breast hyperplasia, and functional dyspepsia, and to provide a theoretical basis for the interpretation of the scientific connotation of "treating different diseases with the same method" of traditional Chinese medicines. Traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP) was used to screen the active components of XYS which underwent principal component analysis(PCA) with the available drugs for these three diseases to determine the corresponding biological activities. The targets of XYS on depression, breast hyperplasia, and functional dyspepsia were obtained from GeneCards, TTD, CTD, and DrugBank databases.

Hepatic metabolomics of the compatibility effect of Xiaoyaosan on CUMS-induced depression based on the TCM theory of "Treating Diseases via Regulating the Liver's Function".

This study aimed to demonstrate the scientific connotations and compatibility effects of Xiaoyaosan (XYS) based on the theory of "Treating Diseases via Regulating the Liver's Function" by hepatic metabolomics. XYS was divided into two efficacy groups, i.e.

The synergistic anti-depression effects of different efficacy groups of Xiaoyaosan as demonstrated by the integration of network pharmacology and serum metabolomics.

Compatibility investigations are vital but also the most difficult aspect of traditional Chinese medicine (TCM) prescriptions. Previous researches have demonstrated that Xiaoyaosan (XYS) is an effective treatment for depression. However, the compatibility rules of XYS and the underlying mechanisms remain unclear.

[Research progress in combination applications of antidepressant drugs].

Depression is a common affective disorder. The application of antidepressants can significantly alleviate the symptoms of depression, which is the most important way to treat depression in clinical practice. Due to the complex etiology, wide variety, as well as diversity and severity of serious concomitant symptoms, rational addition of other drugs into antidepressants can significantly improve the cure rates of depression, reduce adverse reactions, and improve patient compliances.

Synthesis and in vitro and in vivo biological evaluation of novel derivatives of flexicaulin A as antiproliferative agents.

As our research focuses on anticancer drugs, a series of novel derivatives of flexicaulin A (FA), an ent-kaurene diterpene, condensed with an aromatic ring were synthesized, and their antiproliferative activities against four human cancer cell lines (TE-1, EC109, MCF-7, and MGC-803) were evaluated. The activities of most of the new compounds were better than those of FA. Compound 2y exhibited the best activity with an IC50 value reaching 0.

Potential quality evaluation approach for the absolute growth years' wild and transplanted Astragali Radix based on anti-heart failure efficacy.

The quality of Astragali Radix (AR) was closely related to the growth period. However, the current commodity grades of AR were only divided by diameter but not directly related to the growth period, which leads to the contradiction between the grade standard and the quality evaluation index. Therefore, solving this problem will be the key for the quality evaluation of AR.

Spatiotemporal dynamics and impacts of socioeconomic and natural conditions on PM in the Yangtze River Economic Belt.

The determination of the spatiotemporal patterns and driving factors of PM is of great interest to the atmospheric and climate science community, who aim to understand and better control the atmospheric linkage indicators. However, most previous studies have been conducted on pollution-sensitive cities, and there is a lack of large-scale and long-term systematic analyses. In this study, we investigated the spatiotemporal evolution of PM and its influencing factors by using an exploratory spatiotemporal data analysis (ESTDA) technique and spatial econometric model based on remote sensing imagery inversion data of the Yangtze River Economic Belt (YREB), China, between 2000 and 2016.

Effects of Guilingji on Aging Rats and Its Underlying Mechanisms.

Guilingji (GLJ), a traditional Chinese medicine, is of wide concern because of its remarkable antiaging effect with a long application history. It mainly consists of traditional Chinese herbs, that is, . This study focused on the anti-aging effects of GLJ on natural aging rats and its underlying mechanisms.

H NMR-based metabolomics revealed the protective effects of Guilingji on the testicular dysfunction of aging rats.

Ethnopharmacological Relevance: Guilingji (GLJ), a famous and classical traditional Chinese medicine (TCM) prescription, has been used to extend the lifespan and improve the life qualities of the elderly for hundreds of years in China.

Aim Of The Study: We aimed to explore the protective effects of GLJ on the testicular dysfunction of aging rats, as well as the regulating effects of GLJ on the metabolic disturbance and metabolite changes in natural aging rats.

Materials And Methods: Forty 23-month-old rats were divided randomly into four groups, including the old control group and three groups of GLJ treatment at 37.

Doping dependence of the phase diagram in one-dimensional extended Hubbard model: a functional renormalization group study.

Using functional renormalization group method, we studied the phase diagram of the one-dimensional extended Hubbard model at different dopings. At half filling, variety of states strongly compete with each other. These states include spin-density wave, charge-density wave, s-wave and p -wave superconductivity, phase separation, and an exotic bond-order wave.

Preliminary report on Sichuan golden snub-nosed monkeys (Rhinopithecus roxellana roxellana) at Laohegou Nature Reserve, Sichuan, China.

Comparative studies of subspecies under different ecological environments offer insights into intraspecies evolutionary adaptive mechanisms. Golden snub-nosed monkeys (Rhinopithecus roxellana) include three subspecies in China classified mainly by their morphological variations: R. r.

[Molecular epidemiology of infection in infants with diarrhea in Wuhan City].

Objective: To understand the prevalence of infection in diarrhea infants under 2 years old in Wuhan City, so as to provide the epidemiological evidence for the prevention and treatment of cryptosporidiosis.

Methods: The fecal samples from infants under 2 years old with diarrhea were collected in Hubei General Hospital and Central South Hospital in Wuhan City, Hubei Province from August 2014 to July 2015. The fecal samples were stored in 2.

Cobalt disulfide nanoparticles/graphene/carbon nanotubes aerogels with superior performance for lithium and sodium storage.

A robust and interconnected three-dimensional (3D) aerogel consisting of CoS nanoparticles, graphene nanosheets (GNs) and carbon nanotubes (CNTs) is synthesized as an anode material (CoS/GCAs) for lithium ion batteries (LIBs) and sodium ion batteries (SIBs). With the introduction of CNTs, the isolated CoS nanoparticles as well as GNs are jointed closely and cross-linked to construct a 3D conductive network. Benefited from the advantages of the positive synergistic effects of the individual components, CoS/GCAs composite exhibits excellent electrochemical performances.