Publications by authors named "Xiao-jian Qiu"
Background: Long noncoding RNAs (lncRNAs) are a kind of molecule that cannot code proteins, and their expression is dysregulated in diversified cancers. LncRNA PITPNA-AS1 has been shown to act as a tumor promoter in a variety of malignancies, but its function and regulatory mechanisms in lung squamous cell carcinoma (LUSC) are yet unknown.
Methods: The mRNA and protein expression of genes were examined by RT-qPCR, western blot, and IHC assay.
Background: Self-expanding Y metal stent insertion is a safe and effective palliative method for malignant lesions involving the lower trachea, tracheal carina, and the main-stem bronchi. However, the length and degree of airway stenosis in different patients tend to vary, which leads to a call for a customized Y stent that could achieve a better treatment effect.
Methods: This retrospective analysis included patients who received customized self-expanding bare metallic Y stents for malignant carinal stenosis at Beijing Tiantan Hospital, Capital Medical University between January 2007 and June 2020.
[Effect of different root canal file tapers on fracture strength of root canal wall].
Shanghai Kou Qiang Yi Xue
October 2020
Purpose: To compare the effects of different nickel-titanium rotary tapers on fracture strength of root canal and the application value of finite element analysis in root canal therapy.
Methods: Twenty four mandibular premolars were selected and all crowns were removed. All samples were randomly divided into 4 groups: A, B, C and D.
Malignant carinal stenosis is a disease process that is not always suitable for treatment with a Y-shaped stent. When one of the main bronchi is completely obstructed and cannot be recanalized, or its distal lung tissue has lost function, inserting a Y-shaped stent is infeasible. In this complex condition, a cone-shaped stent is selected to maintain the patency of the trachea and the other main bronchus.
View Article and Find Full Text PDFBackground: Primary pulmonary malignancies (PPMs) and non-pulmonary malignancies (PNPMs) may result in airway stenosis requiring stenting. This study aimed to compare and evaluate the clinical features and stent placement outcomes of airway stenosis caused by PPMs and PNPMs.
Methods: A total of 141 patients with malignant airway stenosis who underwent Micro-Tech stent placements between January 2004 and October 2017 at Department of Respiratory Medicine, Beijing Tian Tan Hospital, Capital Medical University were divided into PPM (n = 100) and PNPM groups (n = 41).
Article Synopsis
- Scarring airway stenosis in China is primarily caused by endotracheobronchial tuberculosis (EBTB), particularly affecting young women and primarily located in the left main bronchus.
- The study analyzed data from 392 patients and determined that the average length of post-tuberculosis airway scarring was often between 1.1-2.0 cm.
- Interventional bronchoscopy is found to be a useful and safe treatment, with a clinical success rate of approximately 60.5% among patients.
Background: Tracheobronchial mucoepidermoid carcinoma (MEC) is a rare airway tumor in adults for which surgery is considered a first-line treatment. However, some patients already lost the best opportunity of a surgical intervention when diagnoses are confirmed, and surgery causes considerable trauma resulting in partial loss of pulmonary function. Moreover, the tumor is resistant to radiotherapy and chemotherapy.
View Article and Find Full Text PDFApplication of paclitaxel as adjuvant treatment for benign cicatricial airway stenosis.
J Huazhong Univ Sci Technolog Med Sci
December 2016
Article Synopsis
- Benign cicatricial airway stenosis (BCAS) is a serious condition that often recurs after treatment, prompting the investigation of paclitaxel as a potential adjuvant therapy.
- A study involving 28 patients with BCAS, caused by various factors, demonstrated a high durable remission rate of 85.7% after using paclitaxel following initial airway treatments.
- The findings suggest that paclitaxel is more effective than other BCAS treatments and shows a low incidence of complications across different causes of the disease.
Article Synopsis
- The study evaluates a new paclitaxel drug-eluting stent for treating tracheal stenosis in dogs, aiming to reduce complications like granulation tissue growth.
- Eight beagles were split into two groups, one with a standard stent and the other with the paclitaxel-eluting stent, over a five-month period to compare tissue growth and monitor safety.
- Results showed significantly less granulation tissue in the paclitaxel group, with effective drug release rates, and no harmful side effects observed, indicating potential for future human use.
Background: Benign cicatricial airway stenosis (BCAS) is a life-threatening disease. While there are numerous therapies, all have their defects, and stenosis can easily become recurrent. This study aimed to investigate the efficacy and complications of nonstent combination interventional therapy (NSCIT) when used for the treatment of BCAS of different causes and types.
View Article and Find Full Text PDF[A study on the feasibility of CT pulmonary function imaging for screening target lung lobes in bronchoscopic lung volume reduction].
Zhonghua Jie He He Hu Xi Za Zhi
October 2013
Article Synopsis
- The study assessed the effectiveness of CT pulmonary function imaging for identifying specific lung lobes that could be treated with bronchoscopic lung volume reduction in patients with chronic bronchitis.
- A total of 31 patients were divided into two groups based on lung function: 9 with normal function and 22 with obstructive issues, and various imaging and test parameters were analyzed for correlation.
- The results indicated a strong correlation between CT imaging parameters and lung function tests, suggesting that CT imaging could serve as a reliable screening tool for targeting non-functional lung areas in appropriate candidates.
[Anastomosis of the cecum and anus preserving the ileocecal valve through the rectal muscular cuff for benign colorectal diseases].
Di Yi Jun Yi Da Xue Xue Bao
May 2005
Objective: To evaluate the effect of anastomosis of the cecum and anus preserving the ileocecal valve through the rectal muscular cuff in the treatment of benign colorectal diseases.
Methods: Eight cases including 5 ulcerative colitis and 3 familial adenomatous polyposis treated with this surgical procedure between 1990 to 2000 were retrospectively reviewed.
Results: During the 5 to 10 years of follow-up, no relapse, wound infection or anal fistula occurred in these patients, who had normal urination and sexual functions.
Objective: To compare the clinical effect of anal cushion resection with Milligan-Morgan hemorrhoidectomy for the third- or fourth-degree circular hemorrhoids.
Methods: Forty-eight patients with third- or fourth-degree circular hemorrhoids were randomly assigned into two groups to receive either anal cushion resection or Milligan-Morgan hemorrhoidectomy. Comparison of the two approaches were conducted in terms of postoperative pain scores, operation time, wound healing time, mean hospital stay, incidence of postoperative complications and the curative effect.