The value of vestibular graviceptive pathway evaluation in the diagnosis of unilateral peripheral vestibular dysfunction.

Background: Evaluation of vestibular graviceptive pathway (VGP) in patients with unilateral peripheral vestibular dysfunction (UPVD) has received increasing attention from researchers. The study aimed to investigate the value of VGP evaluation in the diagnosis of UPVD.

Methods: Ninety-five UPVD patients were divided into attack and remission phase groups.

Inhibition of Delayed Cerebral Ischemia by Magnesium Is Insufficient for Subarachnoid Hemorrhage Patients: A Network Meta-Analysis.

Objective: After subarachnoid hemorrhage, magnesium could reduce the incidence of delayed cerebral ischemia; however, it is still controversial. This study updated the results of recently published magnesium-related studies and conducted an exploratory analysis of the impact of application strategies and intervention factors on the results.

Methods: Public databases were searched from the date of their inception to May 10, 2021.

Effects of exogenous vitamin D on endoplasmic reticulum stress-related factors in the vitamin D deficiency rats with cerebral ischemia.

We observed the potential neuroprotective effect of exogenous vitamin D on cerebral ischemia in vitamin D deficiency rats and explored its mechanism. Sixty Sprague Dawley rats were randomly divided into three groups including control (CON) group, vitamin D deficiency (VDD) group and vitamin D deficiency combined with exogenous vitamin D (VDD + VD) group, with 20 rats in each group. The rats in the CON group were fed with normal diet, while the rats in the VDD and VDD + VD groups with vitamin D-deficient diet for 8 weeks, and then underwent middle cerebral artery occlusion (MCAO).

Role of ornithine decarboxylase/polyamine pathway in focal cerebral ischemia-reperfusion injury and its mechanism in rats.

Objective: To observe the role of ornithine decarboxylase (ODC)/polyamine pathway in focal cerebral ischemia-reperfusion injury and to explore its mechanism in rats.

Methods: This study was randomly divided into 3 groups including sham-operation (sham) group, ischemia-reperfusion (I/R) group and α-difluoromethylornithine (DFMO) group (each group with 80 rats). In DFMO group, 300 mg/kg of DFMO was injected by tail vein 24 h before reperfusion.

Effects of Ginkgo biloba extract on the apoptosis of oxygen and glucose-deprived SH-SY5Y cells and its mechanism.

Objective: The aim was to observe the effects of the extract of Ginkgo biloba (EGb761) on the apoptosis of oxygen and glucose-deprived (OGD) human neuroblastoma cells (SH-SY5Y) cells and explore its mechanism.

Materials And Methods: SH-SY5Y cells were divided into normal control group, OGD group, OGD for 4 h and EGb761-pretreated groups including very low-concentration (20 μg/ml), low-concentration group (25 μg/ml), moderate-concentration group (50 μg/ml) and high-concentration group (100 μg/ml). Twenty four hours after reoxygenation, cell viability was determined with 3-[4, 5-dimehyl-2-thiazolyl]-2, 5-diphenyl-2H-tetrazolium bromide assay, apoptosis rate was detected with annexin V-fluorescein isothiocyanate/propidium iodide double staining flow cytometry and the protein level of apoptosis-inducing factor (AIF) was observed with immunofluorescence technique in each group.

Therapeutic effects of GM1 on Parkinson's disease in rats and its mechanism.

Objective: To observe the effects of GM1 on apomorphine (APO)-induced rotational behavior and the expression of inflammatory factors in 6-hydroxydopamine-induced Parkinson's disease (PD) rat models.

Methods: Mature and healthy Wistar rats of either sex with body weight of 150-200 g were randomly divided into control group, PD+APO group and PD+APO+GM1 group (10 mg/kg of GM1, intraperitoneally, once a day, for 14 days; each group with 15 rats). PD rat models were prepared by injecting 6-hydroxydopamine into rat's right striatum, and then rotational behavior was induced by intraperitoneal injection of APO 7 days after operation.

Effect of cilostazol pretreatment on the PARP/AIF-mediated apoptotic pathway in rat cerebral ischemia-reperfusion models.

The aim of this study was to observe the expression of poly ADP-ribose polymerase (PARP) and apoptosis-inducing factor (AIF) in the CA1 region of the hippocampus and to explore whether cilostazol pretreatment exerts a protective effect on the brain through the PARP/AIF-mediated pathway in a rat model of cerebral ischemia-reperfusion. Rats were randomly divided into three groups: Sham-surgery, ischemia-reperfusion and cilostazol (n=45 rats/group). Rat models of middle cerebral artery occlusion were prepared using a thread occlusion method.