Genome-wide miRNAs expression profiles of Schistosoma japonicum schistosomula in response to artesunate.

Aim: miRNAs play a significant role in pharmacogenomics and are likely to be important in the molecular mechanism of atesunate (ART) effects on Schistosoma japonicum.

Methods: We sequenced the RNAs using an Illumina (Solexa) DNA sequencer and compared the relative expression levels of the miRNAs in 10-day-old schistosomula from ART and the parallel control group.

Results: We characterized 95 known miRNAs from S.

[Application of Nano Carbon-based Immunosensor in Pathogen Detection].

The biosensors exhibit many advantages such as simple operation, rapid reaction and high sensitivity in pathogen detection. The sensitivity and specificity of the biosensors can be significantly enhanced by the combined use of carbon nano-materials (such as carbon nanotubes and graphene) and bio-sensing devices. This paper reviews the characteristics of carbon nano-biosensors, its applications in pathogen detection and new development.

Quantitative proteomic analyses of Schistosoma japonicum in response to artesunate.

Artesunate (ART) has high prophylactic efficacy against Schistosoma japonicum infections and has been used to treat and prevent schistosomiasis in China since 1995. However, the molecular mechanism of ART's effects on S. japonicum remains unclear.