The up-regulation of SPTAN1 expression in Pancreatic adenocarcinoma is associated with tumor immune invasion and poor clinical prognosis.

Background: Pancreatic adenocarcinoma (PAAD) is a common malignancy with a very low survival rate. More and more studies have shown that SPTAN1 may be involved in the development and progression of a variety of tumors, including rectal cancer, Pancreatic adenocarcinoma, etc., and may affect their prognosis.

A rare metachronous primary clear cell renal cell carcinoma and pancreatic ductal adenocarcinoma: case report and literature review.

Metastatic spread to the pancreas from renal cell carcinoma is a relatively rare event. Even rarer is the metachronous occurrence of clear cell renal cell carcinoma (ccRCC) and pancreatic ductal adenocarcinoma (PDAC). Our case report contributes to the existing literature by documenting the unusual occurrence of metachronous ccRCC and PDAC in a 69-year-old patient, and we review the literature.

Distinct roles of excitatory and inhibitory neurons in the medial prefrontal cortex in the expression and reconsolidation of methamphetamine-associated memory in male mice.

Methamphetamine, a commonly abused drug, is known for its high relapse rate. The persistence of addictive memories associated with methamphetamine poses a significant challenge in preventing relapse. Memory retrieval and subsequent reconsolidation provide an opportunity to disrupt addictive memories.

Surgically treating a rare and asymptomatic intraductal papillary neoplasm of the bile duct: A case report.

Background: Intraductal papillary neoplasms of the bile duct (IPNBs) are rare and characterized by papillary growth within the bile duct lumen. IPNB is similar to obstructive biliary pathology. In this report, we present an unexpected case of asymptomatic IPNB and consolidate our findings with the relevant literature to augment our understanding of this condition.

Incidence trend and prognosis of intrahepatic cholangiocarcinoma: a study based on the SEER database.

Background: Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer after hepatocellular carcinoma (HCC). ICC and HCC have different cellular origins; therefore, ICC is significantly different from HCC in terms of aetiology, mechanism, tumour biological behaviour, treatment methods, and prognosis. The objective of this study was to investigate the current incidence trend and prognosis of ICC and deepen the understanding of ICC.

Psychological distress and aggression among adolescents with internet gaming disorder symptoms.

The present study aimed to investigate the current situation of internet gaming disorder (IGD) in Chinese adolescents and explore the impact of IGD-related factors on adolescent aggression. We hypothesized that IGD symptoms in adolescents would be associated with aggressive behavior and that risk factors for IGD symptoms could increase the aggressive tendencies of adolescents. To verify the above hypothesis, a cross-sectional survey of junior and senior high school students from southern, southwestern, central, and eastern China was conducted.

[Pollution Characteristics and Sources of Heavy Metals in Soil of a Typical Pyrite Concentrated Mining Area in Anhui Province].

To identify the characteristics and sources of heavy metal pollution in the surrounding soil of a typical pyrite concentrated mining area in Anhui Province, the pH value and the concentrations of Zn, Cu, Cd, Pb, Cr, Ni, Hg, and As in 42 surface soil samples and 16 soil samples from two vertical sections in the study area were collected and measured. The distribution characteristics, pollution assessment, and source analysis of heavy metal elements were conducted using the ArcGis inverse distance weight interpolation method, Nemero comprehensive index method, principal component analysis method, and absolute factor score-multiple linear regression (APCS-MLR) receptor model. The results showed that the average concentration of the eight heavy metals was 1.

Primary intra-abdominal paraganglioma: A case report.

Background: Paragangliomas are rare neuroendocrine tumors. We hereby report a case of a localized paraganglioma found in the abdominal cavity, and review the relevant literature to improve the understanding of this disease.

Case Summary: A 29-year-old Chinese female patient was referred to our hospital due to an abdominal mass found on physical examination.

Prevalence and risk factors of post-traumatic stress disorder symptoms among Chinese health care workers following the COVID-19 pandemic.

In December 2019, coronavirus disease 2019 (COVID-19) appeared in Wuhan (Hubei, China) and subsequently swept the globe. In addition to the risk of infection, there is a strong possibility that post-traumatic stress disorder (PTSD) may be a secondary effect of the pandemic. Health care workers (HCWs) participating in the pandemic are highly exposed to and may bear the brunt out of stressful or traumatic events.

Posttraumatic stress disorder symptoms among Chinese college students following the COVID-19 outbreak.

Objective: This study examined the prevalence of posttraumatic stress disorder (PTSD) symptoms in college students 1 month after the lockdown of Wuhan to identify possible risk factors for PTSD symptoms in a cross-sectional study.

Methods: Out of 10,502 who responded, 9,274 students impacted by the COVID-19 pandemic were included in our study. PTSD symptoms was evaluated by the Impact of Event Scale-revised (IES-R).

Application of the Variational Method to the Large Deformation Problem of Thin Cylindrical Shells with Different Moduli in Tension and Compression.

In this study, the variational method concerning displacement components is applied to solve the large deformation problem of a thin cylindrical shell with its four sides fully fixed and under uniformly distributed loads, in which the material that constitutes the shell has a bimodular effect, in comparison to traditional materials, that is, the material will present different moduli of elasticity when it is in tension and compression. For the purpose of the use of the displacement variational method, the physical equations on the bimodular material model and the geometrical equation under large deformation are derived first. Thereafter, the total strain potential energy is expressed in terms of the displacement component, thus bringing the possibilities for the classical Ritz method.

Genes and pathways associated with fear discrimination identified by genome-wide DNA methylation and RNA-seq analyses in nucleus accumbens in mice.

Fear memory is critical for individual survival. However, the maladaptive fear response is one of the hallmarks of fear-related disorders, which is characterized by the failure to discriminate threatening signals from neutral or safe cues. The biological mechanisms of fear discrimination remain to be clarified.

Deficiency of Tet3 in nucleus accumbens enhances fear generalization and anxiety-like behaviors in mice.

Stress-induced neuroepigenetic programming gains growing more and more interest in the studies of the etiology of posttraumatic stress disorder (PTSD). However, seldom attention is focused on DNA demethylation in fear memory generalization, which is the core characteristic of PTSD. Here, we show that ten-eleven translocation protein 3 (TET3), the most abundant DNA demethylation enzyme of the TET family in neurons, senses environmental stress and bridges neuroplasticity with behavioral adaptation during fear generalization.

Ketamine attenuates the PTSD-like effect via regulation of glutamatergic signaling in the nucleus accumbens of mice.

Post-traumatic stress disorder (PTSD) is a devastating mental illness with high morbidity and major social and economic burden. Currently, there is no promising therapy available for the treatment of PTSD. Some clinical studies showed that ketamine could effectively alleviate PTSD symptoms.

A novel self-learning semi-supervised deep learning network to detect fake news on social media.

Social media has become a popular means for people to consume and share news. However, it also enables the extensive spread of fake news, that is, news that deliberately provides false information, which has a significant negative impact on society. Especially recently, the false information about the new coronavirus disease 2019 (COVID-19) has spread like a virus around the world.

Myopia with X-linked retinitis pigmentosa results from a novel gross deletion of RPGR gene.

Aim: To identify mutations with whole exome sequencing (WES) in a Chinese X-linked retinitis pigmentosa (XLRP) family.

Methods: Patients received the comprehensive ophthalmic evaluation. Genomic DNA was extracted from peripheral blood and subjected to SureSelect Human All Exon 6+ UTR exon capture kit.

Tβ4 suppresses lincRNA-p21-mediated hepatic apoptosis and fibrosis by inhibiting PI3K-AKT-NF-κB pathway.

Hepatic injury is one of the most challenging diseases in clinical medicine. Hepatic injury is accompanied by hepatocyte apoptosis and leads to hepatic fibrosis and cirrhosis, which may cause liver cancer and increased mortality. Therefore, it is essential to investigate the regulation mechanism and therapeutic strategies for hepatic injury.

Adsorption behaviors of branched cationic gemini surfactants and wettability in quartz-solution-air systems.

The adsorption and wetting on quartz surfaces by aqueous solutions of xylyl-substituted biquaternary ammonium salt gemini surfactants with different spacer groups (C and C), have been investigated. The interfacial properties of surfactant solutions such as contact angle, adhesional tension (γ cos θ), quartz-water interfacial tension (γ) as well as adhesion work (W) have been estimated. The obtained results show that C and C have similar adsorption behavior on quartz surfaces.

[Effects of nitrogen supplementation on forage yield and quality of a degraded grassland in Hulunbuir, China.].

Long-term overuse of grasslands results in quantitative and qualitative decline of forage yield. Nutrient supplementation is a key strategy to improve forage yield. While mounting evidence showed that nitrogen (N) supplementation can increase forage yield, little is known about its impacts on forage quality.

Ketamine Alleviates Fear Generalization Through GluN2B-BDNF Signaling in Mice.

Fear memories are critical for survival. Nevertheless, over-generalization of these memories, depicted by a failure to distinguish threats from safe stimuli, is typical in stress-related disorders. Previous studies have supported a protective role of ketamine against stress-induced depressive behavior.

Nalbuphine versus dexmedetomidine for treatment of combined spinal-epidural post-anesthetic shivering in pregnant women undergoing cesarean section.

Objective: This study aimed to compare the clinical efficacy and side effects of nalbuphine and dexmedetomidine for treatment of combined spinal-epidural anesthetic shivering in women after cesarean section.

Methods: A total of 120 pregnant women, who underwent elective cesarean section under combined spinal-epidural anesthesia, were enrolled in a double-blind, randomized study. These women were randomized into three groups of 40 pregnant women each to receive either saline (group C), nalbuphine 0.

Fear renewal activates cyclic adenosine monophosphate signaling in the dentate gyrus.

Background: Fear renewal, the context-specific relapse of a conditioned fear after extinction, is a widely pursued model of post-traumatic stress disorder and phobias. However, its cellular and molecular mechanisms remain poorly understood. The dentate gyrus (DG) has emerged as a critical locus of plasticity with relevance to memory, anxiety disorders, and depression, and it contributes to fear memory retrieval.

Facial Anthropometric Proportion of Chinese Han Nationality.

Facial anthropometric measurements play an important part not only in forensic cases but also in clinical treatments. The utilization of 2D photograph methods in facial anthropometric studies to found database with age, gender, ethnicity, and region was expanded by other races but little for Han nationality. This study was undertaken to describe reference ranges of facial anthropometric proportions of Han nationality and compare the anthropometric characteristics with other ethnicities.

Load distribution measurement instrument for oscillating follower cam mechanism.

Cam mechanism is widely applied in industry because it can help achieve various complex motions of the follower via the cam contour design. However, its performance is significantly affected by the wear condition. This study proposes a load distribution measurement instrument to assist the study on friction and wear regularities of oscillating follower cam mechanisms through obtaining the normal pressure (F) and friction force (F) distributions along the cam profile.