Publications by authors named "Xiao-feng Hao"
A Network Pharmacology to Explore the Mechanism of Membranaceus in the Treatment of Diabetic Retinopathy.
Evid Based Complement Alternat Med
November 2020
Article Synopsis
- Diabetic retinopathy (DR) is caused by retinal damage from diabetes, severely affecting vision and quality of life, making it a significant burden on individuals and society.
- Recent studies suggest that Membranaceus (AM), a traditional Chinese medicine, may have potential in treating DR, although its exact mechanism remains unclear.
- This research identifies 24 active compounds from AM and 38 core targets linked to its therapeutic effects on DR, indicating AM works through various pathways involved in oxidative stress, cell apoptosis, and inflammation.
[Relationship between selection of Pinus massoniana families and Folium Pini].
Zhongguo Zhong Yao Za Zhi
May 2015
Based on variation of Pinus massoniana families, heritablility and correlation analysis, the contents of shikimic acid and procyanidine (heritability 0.90, 0.70), dry weight of single branch (heritability 0.
View Article and Find Full Text PDFObjective: This study was aimed to confirm whether I62V and Y402H polymorphisms of complement factor H (CFH) were risk factors for age-related macular degeneration (AMD).
Method: 109 AMD patients and 165 AMD-free controls were enrolled in the study. The I62V and Y402H polymorphisms were analyzed by polymerase chain reaction-restriction fragment length of polymorphism (PCR-RFLP).
Article Synopsis
- The study investigates how Rac1 influences the induction of HIF-1α in choroidal neovascularization (CNV) in mice.
- Researchers induced CNV in 100 mice, using a Rac1 inhibitor (NSC23766) in half to assess its effects on CNV growth and HIF-1α expression.
- Findings showed that Rac1 inhibition significantly reduced CNV incidence and HIF-1α levels, suggesting that targeting Rac1 could have therapeutic benefits for CNV-related eye conditions.
[Expression of matrix metalloproteinase-2, -9 and their inhibitor-1 in hypertrophic scars].
Zhonghua Shao Shang Za Zhi
December 2007
Article Synopsis
- The study aimed to analyze the gene expression of MMP-2, MMP-9, and TIMP-1 in different stages of hypertrophic scars compared to normal skin samples.
- Researchers extracted RNA from both normal skin and hypertrophic scar samples, using RT-PCR to measure the expression levels of the target genes.
- Results indicated higher levels of TIMP-1 in hypertrophic scars, while MMP-2 and MMP-9 levels returned to normal in mature scars, suggesting a link between these genes' expression and the development and maturation of hypertrophic scars.