Publications by authors named "Xiao-fei Liang"

Mitochondrial DNA (mtDNA) encodes genes essential for oxidative phosphorylation. The m.3243A>G mutation causes severe disease, including myopathy, lactic acidosis and stroke-like episodes (MELAS) and is the most common pathogenic mtDNA mutation in humans.

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Aging is a social problem that people pay particular attention to. Oxidative stress is closely related to aging. Natural polysaccharides have numerous biological activities, and they show good application prospect in preventing oxidative stress and aging prospects.

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Lycium barbarum polysaccharides (LBPs) are recognized as key bioactive constituents of Lycium barbarum with diverse biological activities. However, current research on LBPs is largely confined to crude extracts, offering limited insight into the structural properties underlying their biological effects. In this study, we separated crude LBP into acidic LBP (ALBP) and neutral LBP (NLBP), which exhibited distinct physicochemical properties.

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The pro-tumorigenic M2-type tumor-associated macrophages (TAMs) in the immunosuppressive tumor microenvironment (TME) promote the progression, angiogenesis, and metastasis of breast cancer. The repolarization of TAMs from an M2-type toward an M1-type holds great potential for the inhibition of breast cancer. Here, we report that Lycium barbarum polysaccharides (LBPs) can significantly reconstruct the TME by modulating the function of TAMs.

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Article Synopsis
  • The fruits of Lycium barbarum, a traditional Chinese herb, have been used for thousands of years and contain active components called Lycium barbarum polysaccharides (LBPs) that offer various health benefits.
  • LBPs have notable properties including immunomodulatory effects, antioxidant capacity, and potential anti-tumor and neuroprotective activities, which are influenced by factors like molecular weight and structure.
  • The research reviews the current understanding of LBPs’ structure and functions, identifies challenges in studying their health benefits, and aims to guide future research and practical applications.
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The sensilla on the antennae and maxillary palps are the most important olfactory organs, via which the insect can perceive the semiochemicals to adjust their host seeking and oviposition behaviors. The oriental fruit fly, (Hendel) (Diptera: Tephritidae), is a major agricultural quarantine pest infesting more than 250 different fruits and vegetables. However, the sensilla involved in olfaction have not been well documented even though a variety of control practices based on chemical communication have already been developed.

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Background: Developing the natural medicine that allow for the specific targeting cytotoxicity is a very important research area in the development of anti-tumor drugs.

Aims And Objectives: This study was conducted to determine the targeted inhibitory effects of luteolin-loaded Her-2-poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) on gastric cancer cells and to delineate the mechanism underlying the inhibition of tumors by luteolin.

Materials And Methods: Luteolin-loaded Her-2-PLGA NPs (Her-2-NPs) were prepared, physically and chemically characterized, and their effects on gastric cancer cells were investigated.

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Article Synopsis
  • * The study focused on creating nanoparticles that combine magnetic properties and a targeting peptide to enhance drug delivery specifically to liver tumors in mice.
  • * Results showed that these nanoparticles not only gathered in the liver using magnetic forces but also penetrated tumor cells effectively, making them a promising system for targeted liver cancer therapy using paclitaxel.
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Thibetanosides E-H (1-4), four new steroidal constituents including three rare sulfonates (2-4), were isolated from the roots and rhizomes of Helleborus thibetanus, together with nine known steroidal compounds (5-13). Their structures were elucidated by detailed spectroscopic analysis, including 1D and 2D NMR techniques and chemical evidence. In this study, compounds 2-13 were evaluated for their cytotoxic activities against HCT116, A549 and HepG2 tumor cell lines in vitro.

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In this study, a halotolerant strain was isolated from high salinity leachate and identified as Bacillus cereus NT-3. It can produce a high concentration of polyhydroxyalkanoates (PHAs) with no significant changes when NaCl concentration is up to 50 g/L. FTIR and NMR spectra of PHAs synthesized by Bacillus cereus NT-3 were similar to the standard or previous results.

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A metabolomics method was established to analyze changes of intracellular metabolites and study the mechanism for enhancing polyhydroxyalkanoates production by halotolerant bacteria, strain HY-3, using acetic acid as carbon source. Maximum poly(3-hydroxybutyrate) (PHB) contents for the medium with 0.5 g/L and 5.

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Objective: To explore the effects of calcium pump inhibitor thapsigargin (TG) on intracellular Ca and the expression of caspase-3 protein in mouse lung fibroblast.

Methods: Mice lung fibroblast cells were divided into three groups: the blank control group,transforming growth factor-β (TGF-β) group and TG treated group. The cells were induced by 5 ng/mL TGF-β for 24 h in TGF-β group and TG group,4 μmol/L TG was added in TG group for 24 h.

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Highly effective targeted tumor recognition via vectors is crucial for cancer detection. In contrast to antibodies and proteins, peptides are direct targeting ligands with a low molecular weight. In the present study, a peptide magnetic nanovector platform containing a lipid bilayer was designed using a peptide amphiphile (PA) as a skeleton material in a controlled manner without surface modification.

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Objective: To observe the effects of different concentration of 17P-estradiol (17p-E2) on the expression of Caveolin-1 and type 11 collagen in the mouse lung fibroblast stimulated by SiO2.

Methods: Fibroblast cells were devided into five groups: blank control group, Si02 (100 mg/L) group and SiOz (100 mg/L)+ different concentration of 17beta-E2 (10(-8),10(-6),10(-6) mol/L) groups. After treated with different concentration of 17beta-E2, for 48 h, the cells were collected, then the expression of Caveolin-1 and of type III collagen were examined with immunohistochemistry method.

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Objective: To evaluate the ability of a kind of novel magnetic liposomes modified with polyethylene glycol (PEG) and transactivating-transduction protein (TAT) to cross the blood spinal cord barrier (BSCB) so as to demonstrate whether or not they can accumulate at the lesions of injured spinal cord.

Methods: The novel liposomes were made through reverse-phase evaporation method modified with polyethylene glycol (PEG) and transactivating-transduction protein (TAT) with an iron core. Thirty-six Wistar rats subject to spinal cord injury (SCI) at T10 were randomly divided into three groups (Groups I, II and III).

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