Publications by authors named "Xiao-fan Ding"

Article Synopsis
  • Propagation-based imaging computed tomography (PBI-CT) is gaining popularity for visualizing low-density materials thanks to its high resolution and image contrast, but it poses radiation risks in live animal imaging due to high doses.
  • This study integrates a deep learning method called Sparse2Noise with PBI-CT to significantly reduce radiation exposure (up to 90%) while preserving image quality, showing improved results over traditional low-dose imaging methods.
  • The findings indicate that Sparse2Noise provides a better signal-to-noise ratio compared to two other advanced low-dose algorithms, enhancing the effectiveness of PBI-CT for biomedical applications.
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Article Synopsis
  • - Hydrogel-based scaffolds are popular in soft tissue regeneration for their ability to create a biocompatible and tissue-like environment, but assessing their mechanical properties and microstructure post-implantation poses challenges due to the destructiveness of traditional testing methods.
  • - The study explores the use of synchrotron radiation propagation-based imaging-computed tomography (SR-PBI-CT) as a non-destructive technique for characterizing the mechanical and internal properties of these scaffolds.
  • - Researchers created hydrogel scaffolds with specific biomaterial inks, tested their compressive strength, and simultaneously imaged them under mechanical load to determine their stress-strain behavior and internal microstructure, achieving Young's modulus values between 5-25 kPa.
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Article Synopsis
  • - This study utilized advanced synchrotron-based X-ray imaging to explore the drying process of individual pharmaceutical granules during tablet manufacturing, overcoming challenges in quantifying internal changes through traditional methods.
  • - Two excipients, lactose monohydrate and microcrystalline cellulose, were tested both alone and in combination with active ingredients acetaminophen and carbamazepine, focusing on how moisture content affected drying properties.
  • - Findings indicated that drying time and composition significantly affect pore volume and moisture removal, while active ingredient nature (hydrophilicity vs. hydrophobicity) plays a crucial role in the drying behavior of certain mixtures, particularly influencing acetaminophen more than carbamazepine.
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Epidemiological studies have demonstrated the embryonic and developmental toxicity of plasticizers. Thus, understanding the in utero biotransformation and accumulation of plasticizers is essential to assessing their fate and potential toxicity in early life. In the present study, 311 infant hair samples and 271 paired meconium samples were collected at birth in Guangzhou, China, to characterize fetal exposure to legacy and emerging plasticizers and their metabolites.

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Background: Synchrotron radiation computed tomography (SR-CT) holds promise for high-resolution in vivo imaging. Notably, the reconstruction of SR-CT images necessitates a large set of data to be captured with sufficient photons from multiple angles, resulting in high radiation dose received by the object. Reducing the number of projections and/or photon flux is a straightforward means to lessen the radiation dose, however, compromises data completeness, thus introducing noises and artifacts.

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Synchrotron radiation based dynamic micro-computed tomography (micro-CT) is a powerful technique available at synchrotron light sources for investigating evolving microstructures. Wet granulation is the most widely used method of producing pharmaceutical granules, precursors to products like capsules and tablets. Granule microstructures are known to influence product performance, so this is an area for potential application of dynamic CT.

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Visualization of low-density tissue scaffolds made from hydrogels is important yet challenging in tissue engineering and regenerative medicine (TERM). For this, synchrotron radiation propagation-based imaging computed tomography (SR-PBI-CT) has great potential, but is limited due to the ring artifacts commonly observed in SR-PBI-CT images. To address this issue, this study focuses on the integration of SR-PBI-CT and helical acquisition mode (i.

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The properties of pharmaceutical powders, and the liquid binder, directly influence the penetration behavior in the wet granulation process of the pharmaceutical industry. Conventional methods encounter challenges in understanding this fast process. In this work, an emerging synchrotron-based X-ray imaging technique (having fast imaging capability) was employed to investigate the internal process from 2D and 3D to real-time (in-situ with ms time intervals) 3D (also considered 4D) perspectives.

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Alternative splicing (AS) allows generation of cell type-specific mRNA transcripts and contributes to hallmarks of cancer. Genome-wide analysis for AS in human hepatocellular carcinoma (HCC), however, is limited. We sought to obtain a comprehensive AS landscape in HCC and define tumor-associated variants.

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Ethnopharmacological Relevance: Gypenosides are major constituents in Gynostemma pentaphyllum (Thunb.) Makino. Previous studies have shown that gypenosides isolated from G.

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Background: AluScan combines inter-Alu PCR using multiple Alu-based primers with opposite orientations and next-generation sequencing to capture a huge number of Alu-proximal genomic sequences for investigation. Its requirement of only sub-microgram quantities of DNA facilitates the examination of large numbers of samples. However, the special features of AluScan data rendered difficult the calling of copy number variation (CNV) directly using the calling algorithms designed for whole genome sequencing (WGS) or exome sequencing.

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The kinetic adsorption profile at the DNA-gold nanoparticle (AuNP) interface is probed by following the binding and organization of thiolated linear DNA and aptamers of varying chain lengths (15, 30, 44, and 51 mer) to the surface of AuNPs (13.0 ± 1.0 nm diameter).

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Objective: To investigate the effects of local carbon ion irradiation on the length of survival and peripheral blood leukocyte and platelet counts of mice inoculated with pulmonary tumor cells.

Methods: Thirty tumor-bearing mice were randomly divided into control group (tumor-bearing but without carbon ion irradiation, n=10), 12 Gy group (n=10) and 24 Gy group (n=10). The right hind limbs of the mice, where the tumor cells were inoculated, were irradiated with carbon-ion beams at a single dose in 12 Gy and 24 Gy groups, and those of the control group received no irradiation.

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Synopsis of recent research by authors named "Xiao-fan Ding"

  • - Xiao-fan Ding's recent research focuses on understanding the implications of plasticizers on fetal exposure and toxicity, employing diverse analytical methodologies such as analyzing infant hair and meconium samples to assess biotransformation and accumulation in utero.
  • - Additionally, Ding has contributed to advancements in imaging techniques, particularly using synchrotron radiation for dynamic micro-computed tomography (micro-CT) to explore pharmaceutical processes and low-density tissue scaffolds, enhancing the understanding of material behavior under various conditions.
  • - His work also encompasses molecular biology, including the identification of alternative splice variants in hepatocellular carcinoma through long-read RNA sequencing, showcasing the complex genetic landscape of cancer and its potential therapeutic targets.