Glucometabolic-Related Genes as Diagnostic Biomarkers and Therapeutic Targets for Alzheimer's Disease and Type 2 Diabetes Mellitus: A Bioinformatics Analysis.

Background: Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are two widespread chronic disorders characterized by shared risk factors and molecular pathways. Glucose metabolism, pivotal for cellular homeostasis and energy supply, plays a critical role in these diseases. Its disturbance has been linked to the pathogenesis of both AD and T2DM.

Tailoring Efficient Fluorogenic Tactic for Ultrasensitive Detection of Dopamine in Urine and Rat Brain through Real-Time and In Situ Formation of High-Performance Fluorophore.

Owing to the predominance of dopamine (DA) in controlling mental health, planning an innovative method for DA detection with simplicity and high efficacy is conducive to the assessment of neurological disorders. Herein, an efficient fluorogenic tactic has been elaborated for ultrasensitive detection of DA with remarkably enhanced turn-on response. Utilizing a twisted intramolecular charge-transfer (TICT)-suppressing strategy, a highly emissive azocine derivative 11-hydroxy-2,3,6,7,11,12,13,14-octahydro-1,5,10-11,14a-methanoazocino[5',4':4,5]furo[2,3-]pyrido[3,2,1-]quinolin-10-one () is generated via a one-step reaction between DA and 8-hydroxyjulolidine.

Controllable atomic collision in a tight optical dipole trap.

Single atoms are interesting candidates for studying quantum optics and quantum information processing. Recently, trapping and manipulation of single atoms using tight optical dipole traps has generated considerable interest. Here we report an experimental investigation of the dynamics of atoms in a modified optical dipole trap with a backward propagating dipole trap beam, where a change in the two-atom collision rate by six times has been achieved.

Management Strategy for Gallbladder Polypoid Lesions: Results of a 5-Year Single-Center Cohort Study.

Introduction: Controversy remains about the classification, differential diagnosis, and treatment strategy for gallbladder polypoid lesions (GPLs). This study sought to explore the individualized treatment strategy for GPLs.

Methods: We retrospectively studied 642 consecutive patients with GPLs from January 2015 to May 2020.

Combining of chemotherapy with targeted therapy for advanced biliary tract cancer: A systematic review and meta-analysis.

Background: Targeted therapy (TT) has resulted in controversial efficacy as first-line treatment for biliary tract cancer (BTC). More efficacy comparisons are required to clarify the overall effects of chemotherapy (CT) combined with TT and CT alone on advanced BTC.

Aim: To conduct a meta-analysis of the available evidence on the efficacy of CT combined with TT for advanced BTC.

Efficacy of the No. 10 lymphadenectomy with spleen preservation on patients with gastric cancer and/or esophagogastric junction adenocarcinoma who underwent total gastrectomy: a systematic review and meta-analysis.

Background: Surgery with total gastrectomy and D2 lymph node dissection (LND) has been recommended as the standard treatment for patients with advanced upper and middle gastric carcinoma and/or Siewert type II/III adenocarcinoma of the esophagogastric junction (AEG). However, whether the No. 10 lymph node (No.

Characteristics of lymph node (No.5 and No.6) metastasis and significance of lymph node dissection in Siewert type II esophagogastric junction adenocarcinoma (AEG): No.5 and No.6 lymph node metastases of AEG and clearance.

Background: To analyze the characteristics, related risk factors, and prognosis of lymph node metastasis (Number [No.] 5 and No.6) in the group of adenocarcinoma of esophagogastric junction (AEG).

Risk factors for preoperative carcinogenesis of bile duct cysts in adults.

Background: Bile duct cyst (BDC) is a rare congenital bile duct malformation. The incidence of bile duct malignancy in BDC patients is markedly higher than that in the general population. However, few studies have been conducted on the risk factors for preoperative carcinogenesis in BDC patients.

Multi-omics: Opportunities for research on mechanism of type 2 diabetes mellitus.

Type 2 diabetes mellitus (T2DM) is a burdensome global disease. In-depth understanding of its mechanism will help to optimize diagnosis and treatment, which reduces the burden. Multi-omics research has unparalleled advantages in contributing to the overall understanding of the mechanism of this chronic metabolic disease.

Mussel Adhesive Mimetic Silk Sericin Prepared by Enzymatic Oxidation for the Construction of Antibacterial Coatings.

With the rapid development and advancement in orthodontic and orthopedic technologies, the demand for biomedical-grade titanium (Ti) alloys is growing. The Ti-based implants are susceptible to bacterial infections, leading to poor healing and osteointegration, resulting in implant failure or repeated surgical intervention. Silk sericin (SS) is hydrophilic, biocompatible, and biodegradable and could induce a low immunological response .

Hollow-Sphere-Structured NaFe(PO)(PO)/C as a Cathode Material for Sodium-Ion Batteries.

The mixed polyanionic material NaFe(PO)(PO) combines the advantages of NaFePO and NaFePO in capacity, stability, and cost. Herein, we synthesized carbon-coated hollow-sphere-structured NaFe(PO)(PO) powders by a scalable spray drying route. The optimal sample can deliver a high discharge capacity of 107.

Stabilizing a laser frequency by the Pound-Drever-Hall technique with an acousto-optic modulator.

We develop and demonstrate a method of optical phase modulation in the Pound-Drever-Hall (PDH) technique. The phase modulation in this paper is realized by an acousto-optic modulator (AOM) operating in the Bragg diffraction regime. In this process, a light beam separated from a laser (780 nm) is sent through the AOM twice and coupled to a high finesse Fabry-Perot cavity.

Self-Template Synthesis of NaCrO Submicrospheres for Stable Sodium Storage.

Sodium-ion batteries (SIBs) are the appropriate alternatives to lithium-ion batteries (LIBs) for the large-scale energy storage applications because of the abundant resources and wide distribution of sodium on earth. O3-NaCrO is a promising cathode material for SIBs due to its stable structure and low-cost raw materials. In this paper, we design and synthesize a powder consisting of submicrometer-sized O3-NaCrO spheres (s-NaCrO) self-assembled with nanoflakes, which exhibits faster ion migration ability and strong structure robustness.

In Situ-Formed CrO Coating on NaCrO with Improved Sodium Storage Performance.

CrO is generally considered as an impurity phase with negative effects on the electrochemical performance of NaCrO because it may cause a certain degree of capacity loss. In this study, however, we have found the bright side of CrO as a protective coating material, which greatly improves the Na storage capability, especially the cycling stability, of NaCrO. After 1000 cycles at 10C, a capacity of 100.

Erratum: Andrographolide Suppress Tumor Growth by Inhibiting TLR4/NF-κB Signaling Activation in Insulinoma: Erratum.

[This corrects the article DOI: 10.7150/ijbs.7723.

Dab2 gene variant is associated with increased coronary artery disease risk in Chinese Han population.

Disabled-2 (Dab2) is a clathrin and cargo-binding endocytic adaptor protein that plays a role in cellular trafficking of low-density lipoprotein receptor (LDLR). However, little is known about its involvement in coronary artery disease (CAD). Here, we aimed to investigate the association between Dab2 single-nucleotide polymorphisms (SNPs) and CAD in Chinese Han and Uyghur populations.

Huge brown tumor of the rib in an unlocatable hyperparathyroidism patient with "self-recovered" serum calcium and parathyroid hormone: A case report.

Background: The brown tumor is a kind of complication of hyperparathyroidism (HPT). The ultimate therapy usually is the resolution of HPT. We herein report an unlocatable HPT patient who received resection of a huge brown tumor of the rib, and experienced "self-recovery" of serum calcium and parathyroid hormone.

LaNiLiO-Shielded Layered Cathode Materials for Emerging High-Performance Safe Batteries.

Low theoretical capacities of the commercial cathode materials (olivine: ∼170 mA h g and spinel: ∼140 mA h g) dictate the need for higher energy density alternates such as nickel-rich (denotes as NCM) materials with a theoretical capacity of ∼270 mA h g. However, low conductivity and the bulk degradation after direct contact with liquid electrolytes, especially at temperatures higher than 50 °C, are the biggest issues to resolve for safe use and confident commercialization of the NCM materials. In this context, we first report "LaNiLiO shields" to simultaneously boost charge conduction characteristics and circumvent the electrolytic degradation of NCM.

Surface Li/K Exchange toward Double-Gradient Modification of Layered Li-Rich Cathode Materials.

Surface coating and lattice doping are widely used to enhance the interfacial and structural stabilities of LiNiCoMnO (LNCM). In this paper, KF is used to modify LNCM for the first time. A Li/K exchange in the Li slabs is realized via a high-temperature treatment.